Gene MRCKb (Human)

MRCKb

Species: Human
Alias: MRCKb, MRCKB, KIAA1124, CDC42BPB
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 14q32.32,

Classification

Group: AGC
Family: DMPK
Subfamily: GEK

Sequence

Name Sequence Type Origin Length Description Download
MRCKb.NA RNA Sugen Kinome 6757 None Fasta, JSON
MRCKb.AA Protein Sugen Kinome 1711 None Fasta, JSON
MRCKb.kin_dom Protein Kinase Domain Sugen Kinome 267 None Fasta, JSON

Protein domain

Protein domains of MRCKb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MRCKb.AA DMPK 76-342 74 1.1e-305 767.93 In-house 1-270 (270) Show / Hide 
Range on Protein: 76-342
Range on HMM: 1-270/270
Sequence Identity: 74% (200 aa)

FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPED
|||.||||||.||||.||..|.|...||||..||||||||||||||.||||..|.|...|||.|||||||||.||.||.|..|||||||.|..||..|||
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

MARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDG-MGKYGPECDWWSLGVCMYEM
|||||. ||||||.||||..||||||||||.|||..|||.|||||||.|||.||.|.|.||||||||||||.||||||. .|.|||||||||.|||||||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

LYGETPFYAESLVETYGKIMNH-EERFQFPSHVT-DVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFF
|||||||||.|||||||||||| .....||.... ||||||||||..|.|.||.|||.||.||||.| ||
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF
Kinase MRCKb.AA GEK 76-342 87 5.5e-212 710.54 In-house 1-269 (269) Show / Hide 
Range on Protein: 76-342
Range on HMM: 1-269/269
Sequence Identity: 87% (236 aa)

FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPED
|||.|||||||||||||||||||...|||||||||||||||||||||||||||||||..|||.|||||||||.||||||||||||||||||||||.||||
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

MARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEML
||||||.|||.||||.||||||||||||||||||.|||||||||||||.||.||.|||.||||||||||||||||||||.|.||||||||||||||||||
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML

YGETPFYAESLVETYGKIMNHEERFQFPSHVT--DVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFF
|||||||||||||||||||||...|||||..|  ||||||||||..||||.|.|||.|||.|||||.||
YGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase MRCKb.AA AGC 76-342 30 4.4e-177 462.54 In-house 1-395 (395) Show / Hide 
Range on Protein: 76-342
Range on HMM: 1-395/395
Sequence Identity: 30% (123 aa)

FEIIKVIGRGAFGEVAVVKMK------NTERIYAMKILNKWE--------MLKRAETAC-------FREERDVLVNGD----------CQWITA-LHYAF
||..||||.|.||.|  |..|       |...||||.|.|..        |.... |..       ..|||..|.. .          ...|.  |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDENH--LYLVMDYYV---------GG-DLLTLLSK--FEDKLPEDMARFYIGE-------MVLAIDSIHQ-LHYVHRD-IKPDNVLLDVNGHIRLADFG
||..|  ||.||.|.          || .|.. | .   | ...|..||||. |       .|||....|. ....||| .||.|.||| .|||.|.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

SCLKMNDDG-------------------------------------------------TVQSSVAVG--TPDYISPEILQAMEDGMGKYGPECDWWS--L
.| ....||                                                 ... .  .|  ||.|..||||         ||..|||||  |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL---------YGKACDWWSFGL

GVCMYEMLYGETPFYAESLV----------ETYGKIMNH----EERFQFPSHV-------TDVSEEAKDLIQRLIC-SRERRLGQN-------GIEDFKK
|..|||||.| .|||... .          |.. ||||.    ... .||..          .|.||||||..|.|  .|.||| .       |.|. |.
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

HAFF
| .|
HPWF
Kinase MRCKb.AA ROCK 76-342 56 5.69999999999e-137 461.33 In-house 1-263 (263) Show / Hide 
Range on Protein: 76-342
Range on HMM: 1-263/263
Sequence Identity: 56% (151 aa)

FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPED
|..|||||||||||| .|. | ....||||.|.| ||.||.. | | ||||..     .||  |||||||. .||.||||  ||||  |.|...  .|| 
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYD--VPEK

MARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEML
 ||||  |.|||.|.|| . ..|||.||||.|||  ||..||||| |.||| .| |... |||||||||||.|..   . |.|| |||||| || .||||
WARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKSQG-QDGEYGRECDWWSVGVFIYEML

YGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFF
 |.|||||.||| ||.|||.| .  .||  | ..|..|||||.. .  ||.|||.||..| |.| ||
VGDTPFYADSLVGTYSKIMDHKNSLKFPDDV-EISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF
Kinase MRCKb.AA CRIK 76-342 45 1.2e-128 412.39 In-house 1-272 (272) Show / Hide 
Range on Protein: 76-342
Range on HMM: 1-272/272
Sequence Identity: 45% (126 aa)

FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPED
||.  .||.| ||.| ||  | |  |||||.. | ..| . . . | ||||..      |.. | |||||...|||.| |  ||||| |.. ..| . |.
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

MARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED---GMGKYGPECDWWSLGVCMY
|||||  | ..|. |.|.  ||||||||.|.|.|  ||| ||||||  |||....|.|   ||||||. ||.|| |     . | || .|||||.|.  |
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

EMLYGETPFYAESLVETYGKIMN------HEERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFF
|| .| |||   . ..|| .|||        .   ||     || .. |||| |.| .  ||   . |  . | ||
EMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDP-KVSPNYRDLIQSLLCNQSKRL---KYEQLCCHPFF
Kinase MRCKb.AA S_TKc 76-342 32 3.6e-90 306.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 76-342
Range on HMM: 1-231/231
Sequence Identity: 32% (92 aa)

FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVG--GDLLTLLSKFEDK--
.||...||.||||.|  .. |.| ||.|.||..            .| |...| . .. .|  |...||| .|||.||.|  |  |||.... |   .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGP-ECDWWSL
   .|| .||||. ....|.. .|... .|||.||.|.|||   || ..|||.. ..        .  .|||.|..||.|        .||. .|||||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL--------GYGKCKCDWWSC

GVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLIC-SRERRLGQNGIED----FKKHAFF
|...||||.|..||.   . ... ||.               |.||||.|... .   |.|..   .       |.| .|
GCILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MRCKb.AA NDR 76-220 55 1.5e-86 266.89 In-house 1-149 (350) Show / Hide 
Range on Protein: 76-220
Range on HMM: 1-149/350
Sequence Identity: 55% (83 aa)

FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGD--CQWITALHYAFQDENHLYLVMDYYVGGDLLT---LLSKFED
|||||.||.|||||| .|..|.|. ||||||..| ||... ..|  | |||...  |  ..|.. | |.|||...|||||.|  |||. |   ||.|. |
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKM-D

KLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFG
 ..||.||||| |||.||.|.|.. |.|||||||| |.|  ||| | |||
IFTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG
Kinase MRCKb.AA RSK 79-342 37 2.9e-86 292.87 In-house 1-278 (278) Show / Hide 
Range on Protein: 79-342
Range on HMM: 1-278/278
Sequence Identity: 37% (105 aa)

IKVIGRGAFGEVAVVKMK---NTERIYAMKILNKWEMLKRAE-TACFREERDVLVNGD-CQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDK--
.|| |.|..|.| ... .   .|..|||||.|.| .. .|.  |.  ..||..|     .. |  ||||||.| .|||.|.|  ||.|.| |.| . .  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDV---NGHIRLADFGSCLKM-NDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSL
. || |.||. | |||.. .||.. .|||.||.|.|.|    .|||.| ||| | .. .|..    .  ..| .|. ||.|   . . | ..  ||||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT-FCYTIEYMAPEMLKRAN-QQGGHDKACDWWSL

GVCMYEMLYGETPFYA---ESLVETYGKIMNHEERFQFPSH-VTDVSEEAKDLIQRLIC-SRERRLG--QNGIEDFKKHAFF
|| ||||| | .||..   ..  |.  .|.. .  | ...     .|.||||||... .   ..|||   ...|. |.|..|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGK--FSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MRCKb.AA Akt 76-342 38 9e-83 264.41 In-house 1-264 (264) Show / Hide 
Range on Protein: 76-342
Range on HMM: 1-264/264
Sequence Identity: 38% (106 aa)

FEIIKVIGRGAFGEVAVVKMKNTERIY-AMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPE
|...||.|.|.|| |  || |.|...| |||.| |   ... . .    || .|.. ... |. |||.||....||.||||  ||.| ..|.. . . .|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQR-KRRFSE

DMARFYIGEMVLAIDSIHQLHYVHRD-IKPDNVLLDVNGHIRLADFGSCLKM-NDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWS-LGVCM
| ||||. |..|||.  |.   . ||  || |.|.| .|||.|.||| | ..   |. .  ..  ||| |..||||.    | .|    .|||. ||. |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTF-CGTPEYLAPEILNG--NGHTK---AVDWWGSLGCVM

YEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSR--ERRLG--QNGIEDFKKHAFF
|||..|  |||..   . . ||.| .   .||     .| |.|||| .| ...  ..|||   |.... | | .|
YEMMCGRPPFYNQDHHQMFKKIKNQP--VKFPDK-DWISPECKDLISGL-LNKDPKKRLGGGPNDAQEIKRHPWF
Kinase MRCKb.AA Pkinase 76-342 28 1.8e-62 218.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 76-342
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFR-EERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGG----DLLTLLS-KFE
..|...||.|.||.|   . |.|..|.|.||..| .  .  . . .|  |  .. . ..  |  |...|.|..|.|.||.|  ||    || ...| . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DKL--PEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHI----RLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECD
 ..  .|. ..||. ... ... .|.   .|||.||.|.|.| ||||    ...|||.. ...    .  .. .|||.|..||...    |  .|||..|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVD

WWSLGVCMYEMLYGETPFYAE------SLVETYGKIMNHEERFQFPSHVT----------------DVSEEAKDLIQRLIC-SRERRLGQNGIEDFKKHA
.||.|. .|||| |..||. .      .  . . .||  . .|..|   .                 .|||.||.| ...|   ..|..   .|. ..| 
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHP

FF
.|
WF
Kinase MRCKb.AA MAST 76-220 42 2.3e-62 199.73 In-house 1-144 (334) Show / Hide 
Range on Protein: 76-220
Range on HMM: 1-144/334
Sequence Identity: 42% (61 aa)

FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPED
||.||.|..||.| |  || |.| ...|||...| .|...  .   . ||..| . .....  . |.|| .|.|..||.| .|||. .||. .   ..|.
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYG-YFDEW

MARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFG
||..|| |.||... .|.   ||||.||||.|.| |||| |.|||
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase MRCKb.AA MAST 76-220 40 4.3e-62 188.22 In-house 1-147 (337) Show / Hide 
Range on Protein: 76-220
Range on HMM: 1-147/337
Sequence Identity: 40% (60 aa)

FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQD--ENHLYLVMDYYVGGDLLTLLSKFEDKLP
||.||.|..||.| |  || |.|  ..|||..|.  ....      . ||..|.. .....  . |.||   ...|..||.|  |||  .||. .   .|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFG
|.||..|| | ||... .|    ||||.||||.|.| |||| |.|||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase MRCKb.AA NDR 236-342 43 1.6e-51 156.82 In-house 241-350 (350) Show / Hide 
Range on Protein: 236-342
Range on HMM: 241-350/350
Sequence Identity: 43% (50 aa)

AVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERF-QFPSHVT---DVSEEAKDLIQRLIC-SRERRLGQ
.||||||. ||..|  . |   |...|||||||. ||||| | .||....  ||. |||| .. . ... |.     .|.||.|||.||.|  ...||| 
TVGTPDYMAPEVFQQ-KTG---YNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGS

NG--IEDFKKHAFF
.|  ....|.| ||
HGKGVDEIKSHPFF
Kinase MRCKb.AA MAST 237-342 39 1.9e-35 105.29 In-house 229-337 (337) Show / Hide 
Range on Protein: 237-342
Range on HMM: 229-337/337
Sequence Identity: 39% (45 aa)

VGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVE-TYGKIMNHEERFQFPSH-----VTDVSEEAKDLIQRLI-CSRERRLG
.||||||.||..     | | ||.  ||||.|. ||| | |..|| ...  | . ..| ||...  .|.         .|.||.|||..|       |||
CGTPDYIAPEVIL----GQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLG

QNGIEDFKKHAFF
 || .. |.|.||
ANGADEIKQHPFF
Kinase MRCKb.AA MAST 237-342 37 1.4e-30 95.58 In-house 225-334 (334) Show / Hide 
Range on Protein: 237-342
Range on HMM: 225-334/334
Sequence Identity: 37% (43 aa)

VGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHE-ERFQFPSH-----VTDVSEEAKDLIQRLICS-RERRLG
.||||||.||..     | | .|.  ||||.|..||| | | .||  ..  |....| |..     .|           |.||.|||..|     . |||
CGTPDYIAPEVIL----GQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLG

QN-GIEDFKKHAFF
 | | .. |.| ||
ANNGADEVKQHPFF
Kinase MRCKb.AA S_TK_X 343-405 24 2.8e-12 48.05 SMART 1-79 (79) Show / Hide 
Range on Protein: 343-405
Range on HMM: 1-79/79
Sequence Identity: 24% (20 aa)

EGLNWENIRN----LEAPYIPDVS----SPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLP----------FIGFTFTT
 |..|....|    .|.|..|...    || |||||| . .    .  | | . . ... . .          |.|||.  
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM--LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase MRCKb.AA TyrKc 76-342 22 4.5e-12 -27.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 76-342
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNG--DCQWITALHYAFQDE-------NHLYLVMDYYVGGDLLTLLS
 . .|..|.||||||   ..|   .  | | |..         . |..|  .. .   . . | .|. .  ..         |..|| |  .|||.  | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDD---GTVQSSVAV----GTPD-----YISPEILQAMEDG
| ..||. .    .        . .|. ...|||.   |.|.. |.... .||| . .  ||   |  ..   .    |. .       .|| ..     
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY----

MGKYGPECDWWSLGVCMYEML-YGETPFYA-----ESLVETYGKIMNHEERFQFPSHVTD-----VSEEAKDLIQRLICS-RERRLGQNGIEDFKKHAFF
 ||. .. | || ||||.|.. ||..| .       |  | . .... . . | |..         ..|  .....      | |   . |     | .|
-GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase MRCKb.AA Pkinase_C 360-407 35 4.8e-10 38.62 Pfam 1-46 (46) Show / Hide 
Range on Protein: 360-407
Range on HMM: 1-46/46
Sequence Identity: 35% (17 aa)

DVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTES
 |.|| ||||||....  . ..   | .   .|| ..||.|||.. ..
QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD
Kinase MRCKb.AA Pkinase_Tyr 76-90 53 0.002936 11.66 Pfam 1-15 (270) Show / Hide 
Range on Protein: 76-90
Range on HMM: 1-15/270
Sequence Identity: 53% (8 aa)

FEIIKVIGRGAFGEV
 ...|..|.||||||
ITFGKKLGEGAFGEV
Kinase MRCKb.AA Pkinase_Tyr 265-295 38 0.012324 9.55 Pfam 198-231 (270) Show / Hide 
Range on Protein: 265-295
Range on HMM: 198-231/270
Sequence Identity: 38% (13 aa)

WSLGVCMYEMLY-GETP-FYAESLVETYGKI-MN
|| ||.|.|..  ||.| ..  |  | | .|  .
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase MRCKb.AA Pkinase_Tyr 192-220 31 0.11618 6.25 Pfam 128-156 (270) Show / Hide 
Range on Protein: 192-220
Range on HMM: 128-156/270
Sequence Identity: 31% (9 aa)

HQLHYVHRDIKPDNVLLDVNGHIRLADFG
.. ...|||.   |.|.. |.... .|||
ESKNCIHRDLAARNCLVTENNVVKICDFG
TMF_DNA_bd MRCKb.AA TMF_DNA_bd 580-623 20 0.008741 12.98 Pfam 78-122 (75) Show / Hide 
Range on Protein: 580-623
Range on HMM: 78-122/75
Sequence Identity: 20% (9 aa)

LNERMAELRAQKQKVSRQLRDKE-EEMEVATQKVDAMRQEMRRAE
.|. .  ||.. ..   |...   ...| ...... ..|...|||
HNNTIKKLRKKNKELEKQISELKHKKIEKLEKEIENLEQRLKRAE
DMPK_coil MRCKb.AA DMPK_coil 563-590 32 4.561775 2.8 Pfam 34-61 (61) Show / Hide 
Range on Protein: 563-590
Range on HMM: 34-61/61
Sequence Identity: 32% (9 aa)

LKDAHQQRKLALQEFSELNERMAELRAQ
|..|  . .  .||  .| ..| .|||.
LQEAEKKNRELEQEMEQLKKEMEMLRAR
M MRCKb.AA M 579-595 35 5.321139 4.32 Pfam 5-21 (21) Show / Hide 
Range on Protein: 579-595
Range on HMM: 5-21/21
Sequence Identity: 35% (6 aa)

ELNERMAELRAQKQKVS
.|  ...|| .|.||..
QLEAEHQELEEQNQKLE
M MRCKb.AA M 624-644 23 61.894566 0.72 Pfam 1-21 (21) Show / Hide 
Range on Protein: 624-644
Range on HMM: 1-21/21
Sequence Identity: 23% (5 aa)

KLRKELEAQLDDAVAEASKER
.  |.|||.. .. ..  |  
EAKKQLEAEHQELEEQNQKLE
DMPK_coil MRCKb.AA DMPK_coil 721-746 23 0.513869 6.05 Pfam 36-61 (61) Show / Hide 
Range on Protein: 721-746
Range on HMM: 36-61/61
Sequence Identity: 23% (6 aa)

DSESHQLALQKEILMLKDKLEKSKRE
..|.   .|..|. .||  .| .. .
EAEKKNRELEQEMEQLKKEMEMLRAR
M MRCKb.AA M 792-812 28 0.020199 12.49 Pfam 1-21 (21) Show / Hide 
Range on Protein: 792-812
Range on HMM: 1-21/21
Sequence Identity: 28% (6 aa)

AQNRQLEDELQDLAAKKESVA
....||| |.|.| .... . 
EAKKQLEAEHQELEEQNQKLE
M MRCKb.AA M 771-791 33 0.226061 8.95 Pfam 1-21 (21) Show / Hide 
Range on Protein: 771-791
Range on HMM: 1-21/21
Sequence Identity: 33% (7 aa)

DENKKLTAENEKLCSFVDKLT
...|.|.||. .|    .||.
EAKKQLEAEHQELEEQNQKLE
TMF_DNA_bd MRCKb.AA TMF_DNA_bd 774-812 25 0.684944 6.21 Pfam 36-75 (75) Show / Hide 
Range on Protein: 774-812
Range on HMM: 36-75/75
Sequence Identity: 25% (10 aa)

KKLTAENEKLCSFVDKLT-AQNRQLEDELQDLAAKKESVA
|||...|..| . ...|. ..  .|| |...| ....   
KKLRKKNKELEKQISELKHKKIEKLEKEIENLEQRLKRAE
DMPK_coil MRCKb.AA DMPK_coil 878-939 66 4.5e-32 112.5 Pfam 1-61 (61) Show / Hide 
Range on Protein: 878-939
Range on HMM: 1-61/61
Sequence Identity: 66% (41 aa)

ELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRAD
||||||||||||||...|||.|||.||.  |.||...|.|||||..||| ||| ||. .||.
ELQSALEAEIRAKQSIHEELNKVKAANIQFECKLQEAEKKNRELEQEMEQLKKEMEM-LRAR
M MRCKb.AA M 909-929 33 4.366112 4.61 Pfam 1-21 (21) Show / Hide 
Range on Protein: 909-929
Range on HMM: 1-21/21
Sequence Identity: 33% (7 aa)

SKLKDSEAKNRELLEEMEILK
.. |. ||.. || |. ..|.
EAKKQLEAEHQELEEQNQKLE
C1_1 MRCKb.AA C1_1 1026-1078 32 4.8e-15 58.88 Pfam 1-55 (55) Show / Hide 
Range on Protein: 1026-1078
Range on HMM: 1-55/55
Sequence Identity: 32% (18 aa)

HQFSIK-SFSSPTQCSHCTSLMVG-LIRQGYACEVCSFACHVSCKDGAPQVCPIP
|..  . .| .|| |.|| ... | |..||. |..| . ||  |   .|  |.  
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 MRCKb.AA C1 1026-1075 32 7.3e-14 53.29 SMART 1-61 (61) Show / Hide 
Range on Protein: 1026-1075
Range on HMM: 1-61/61
Sequence Identity: 32% (20 aa)

HQFSIKSFSSPTQCSHCTSLMVGLIRQ-----GYACEVCSFACHVSCKDGAPQ-------VC
|......| .|| |.|| ... |. .|     || |..| ..|| .|.| .||        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
PH MRCKb.AA PH 1096-1216 10 2.6e-08 34.87 SMART 1-82 (82) Show / Hide 
Range on Protein: 1096-1216
Range on HMM: 1-82/82
Sequence Identity: 10% (13 aa)

TAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPGVIASQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLIL
. ..|.... .    | .|.. ..|...  |..|. .           . ...|.| ....                   |...           .... 
VIKEGWLYKKS----K-RWKKRWFVLFNDCLYYYKDK---------KPKGSIPLSDCTVRE-P----------------CFEIHH-DR-------TYYFQ

TENENEKRKWVGILEGLQSIL
.|.| |...|.  .. ... .
CESEEEMQEWMQAIQKAIHNN
PH MRCKb.AA PH 1096-1214 10 2e-06 25.71 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1096-1214
Range on HMM: 1-92/92
Sequence Identity: 10% (13 aa)

TAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPGVIASQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLIL
  ..|.... .    .|.|.. ..|... .|..|. .  .. .  .  | . ...... .               . |..|...           .... 
VIKEGWLHKKG---KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDC-QVTKVPDN---------------KRPHCFQIRT-DR------RTYYFQ

TENENEKRKWVGILEGLQS
.|.| |.. |.  .. ...
AESEEEMNDWMQAIQSACR
CNH MRCKb.AA CNH 1245-1510 27 9.6e-98 335.82 Pfam 1-336 (336) Show / Hide 
Range on Protein: 1245-1510
Range on HMM: 1-336/336
Sequence Identity: 27% (92 aa)

TAAIVDADRIAVG-LEEGLYVIEV--TRDVIVRAADCKK----VHQIELAPREKIVILL--CGRNHHVHLYPWSSLDGAEGSFDI---------------
.... . ....||  .|||||...  ||| . .. .|.|    |.||.. ....|.|..  |..|.|....|...||..|.....               
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSRRVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRIERI

---------KLPETKGCQLMATATLKRNSGTCLFVAVKR-----LILCYEIQRT-KPFH------------RKFNE-IVAP----GSVQCLAVL---RDR
         |||.||.|....... ... |.|| .||||      |.|||. .. |.||            |||.| . .|      ......|   ...
MPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLPPMTECFSMHWLPQEKPK

LCVGYPSGFCLLSIQGDGQPLNLVNPNDPS--LAF-LSQQSFDALCAVELESE-EYLLCFSHMGLYVDPQGR-RAR--AQELMWPAAPVACSCSPTHVTV
||||...|| .....| |||  |..|.|.|  . | .. ......|....... |.|||.. .. ||. ||. |.|   .|.||...| .. |.  ....
LCVGCQKGFHIVNLDGTGQPWWLHDPADHSVQQDFMARRENCKPICMHRINDDEEFLLCYDECCVYVNKQGWPRSRKHDWEIMWEGMPQSFACCYPYLLA

YSEYGVDVFDVRTM-EW---VQTIGLRRIRPLNSEG
..........|.|. ||   ||.| ...||.|.|..
FHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS
CNH MRCKb.AA CNH 1244-1519 15 3.3e-15 57.77 SMART 1-375 (375) Show / Hide 
Range on Protein: 1244-1519
Range on HMM: 1-375/375
Sequence Identity: 15% (59 aa)

LTAAIVDADRIA--------VGLEEGLYVIEVTR-------DVIVRAADCKKVHQIELAPREKIVILLCGRNHHVHLYPWSSL---------------DG
.|......  ..        || |.|.|.... .       .  .. .  . | .....  ....... |.. |.  .| ..|               . 
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

AEGSFDIK---L----PETKG-CQLMAT-ATLKRNSGTCLFVAVKRLILCY-EIQRTKPFHRKFN------------------EIVAPGSVQCLAVLRDR
.   ....   .    |.||| | . .  .  ||   ..| .|..  .  | .. .   .. ..                    .  |..|  . . ...
CNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDSF

----LCVGYPS------GFCLLSIQGDGQP------LNLVNPNDPSLAFLSQQSF------DALCAVELES------EEYLLCFSHMGLYVDPQG---RR
    .|.|  .      ||. ...  .           .||.||.||.|..||..      ...... ..       ..||||.   |..|...|   ||
ERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEWRR

ARAQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTMEW-VQTIG------LRRIRPLNS---EGTLNLLNCEP
 |...|.|. .| . ...  .. . .. |...... | || .|.|       .|..| | .        ..  .|
WRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
PBD MRCKb.AA PBD 1583-1618 36 1.4e-10 42.41 SMART 1-38 (38) Show / Hide 
Range on Protein: 1583-1618
Range on HMM: 1-38/38
Sequence Identity: 36% (14 aa)

ISNPT-NFNHVAHMGPGDG-MQVLMDLPLSAVPPSQEE
||.|| ||.|..|.||.|| ......||..     .  
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
PBD MRCKb.AA PBD 1582-1596 62 0.000207 18.32 Pfam 1-16 (60) Show / Hide 
Range on Protein: 1582-1596
Range on HMM: 1-16/60
Sequence Identity: 62% (10 aa)

MISNP-TNFNHVAHMG
|||.| ||| |..| |
MISTPLTNFKHTMHVG