Gene MNK1 (Human)

MNK1

Species: Human
Alias: MKNK1, MNK1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1p33-p34.1,

Classification

Group: CAMK
Family: MAPKAPK
Subfamily: MNK

Sequence

Name Sequence Type Origin Length Description Download
MNK1.NA RNA Sugen Kinome 2815 None Fasta, JSON
MNK1.AA Protein Sugen Kinome 465 None Fasta, JSON
MNK1.kin_dom Protein Kinase Domain Sugen Kinome 327 None Fasta, JSON

Protein domain

Protein domains of MNK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MNK1.AA MNK 206-374 78 6.9e-141 474.36 In-house 118-292 (292) Show / Hide 
Range on Protein: 206-374
Range on HMM: 118-292/292
Sequence Identity: 78% (137 aa)

GIAHRDLKPENILCESPEKVSPVKICDFDLGSG---MKLNNSC-TPITTPELTTPCGSAEYMAPEVVEVFT-DQATFYDKRCDLWSLGVVLYIMLSGYPP
|||||||||||||||.|..|.||||||||||||   ..||..| .|||||||.|||||||.||||||..|. |.|..||||||||||||.|||||.||||
GIAHRDLKPENILCEHPNHVCPVKICDFDLGSGRPPIHLNHDCSQPITTPELLTPCGSAEFMAPEVVDAFVYDEAHYYDKRCDLWSLGVILYIMLCGYPP

FVGHCG-ADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV
|||||| .||||||||.||.|||.||..||||.||||.|.|.|||.|||||||.||||||||||||||||.||||
FVGHCGDEDCGWDRGEACRDCQNMLFHCIQEGHYEFPEKEWHHISEEAKDLISNLLVRDAKQRLSAAQVLNHPWV
Kinase MNK1.AA MAPKAPK 206-374 63 3.1e-135 421.38 In-house 123-292 (292) Show / Hide 
Range on Protein: 206-374
Range on HMM: 123-292/292
Sequence Identity: 63% (108 aa)

GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSC-TPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGH
.|||||||||||||.......|||.|||.......||..| ||||||||.|||....|||||||..|  .|..|||.||.|||||..||||.|||||...
NIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFK-EAHTYDKSCDMWSLGVIMYIMLCGYPPFYSN

CG-ADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV
|| .||.|||||.||.|||..|..||||.|||||..|.||| ||||||.|||.||..|||...||..|||.
CGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI
Kinase MNK1.AA MNK 49-164 70 2.7e-83 283.01 In-house 1-117 (292) Show / Hide 
Range on Protein: 49-164
Range on HMM: 1-117/292
Sequence Identity: 70% (82 aa)

KLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQ-AGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREA
|||.|.|||||||.||..|..|.|||||||||.|| .||||.||||||||.|.|||..|||.|||.||||.||||||||..||..|.|||..|||.|.||
KLTDEHLGEGAYASVQTCVNIQSGKEYAVKIIDKQGPGHSRKRVFREVETFYHCQGHRNILQLIEWFEDDDRFYLVFEKMRGGPLLQHIQQRKHFTEHEA

SRVVRDVAAALDFLHTK
|.|..|.|.||||.|.|
SQVIKDIASALDFMHNK
Kinase MNK1.AA MAPKAPK 49-165 50 4.8e-75 231.68 In-house 1-123 (292) Show / Hide 
Range on Protein: 49-165
Range on HMM: 1-123/292
Sequence Identity: 50% (62 aa)

KLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFED----DTRFYLVFEKLQGGSILAHIQK--QKHF
||..|.||||.|.||| .|... |.||||||.|.|.||||....||||....|||..||...|..||.    |..||||.|...||....|||.  .|||
KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQPGHSRQKARREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKHF

NEREASRVVRDVAAALDFLHTKD
.|||||....|...|.||||...
TEREASQIMKDICSAVDFLHSMN
Kinase MNK1.AA S_TKc 49-374 26 5.5e-73 249.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 49-374
Range on HMM: 1-231/231
Sequence Identity: 26% (92 aa)

KLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQG--GSILAHIQKQKH-----
    ...|.||..||  ..    |...|.|||         .. ||.. | .  . .||  |...|.| ...|.|.| . |  |. . .|.|...     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
 |.| .| .... .. ||...| .                                          | ||||||||||. .      .||||| |   . 
PFPE-HARFYMYQICCALEYCHSHG-----------------------------------------IIHRDLKPENILLDE-----HIKICDFGLARQL-

LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDK-RCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKD
             || ||. .||||||.         |.| .|| ||.|..||.||.|||||                   ....|. |           
-------------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCILYEMLCGYPPFP-----------------QMQMMFKKIG----------

WAHISSEAKDLISKLLVRDAKQRLSAAQVLQ-------HPWV
    |.||||.|.|.|..| ..|..| ..||       |||.
----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MNK1.AA Pkinase 49-374 27 1.1e-71 249.24 Pfam 1-293 (293) Show / Hide 
Range on Protein: 49-374
Range on HMM: 1-293/293
Sequence Identity: 27% (97 aa)

KLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHS--RSRVFR--EVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGG----SILAHIQ--K
  . . .|.|....|  ..   .||..|||||.|.  .|  . . .|  |.. .  . . .||..|...|||... |.|.| ..||    .  ..|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

QKHF--NEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKV-SPVKICDFDL
.. |   |.|. .... .. .|...| .                                         || ||||||||||. .   . ..|||||| |
HGCFYFSEWECKFYMYQILRGLEYCHSM-----------------------------------------GIIHRDLKPENILIDNNGHIDACVKICDFGL

GSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEF
   ..          . .||.||. .||||||.      .. |....| ||.|..||.||.|.||| |||  . . .       .|..... | .....|
AKQFD------Y-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-H-------DQMQMICRIMGPPLHF

PDKDWAHIS-----------------SEAKDLISKLLVRDAKQRLSAAQVLQHPWV
.   |  ||                 .|.||.|...| .| |.|..|.|.|||||.
DWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MNK1.AA CAMK 206-374 31 1.8e-69 222.76 In-house 199-425 (425) Show / Hide 
Range on Protein: 206-374
Range on HMM: 199-425/425
Sequence Identity: 31% (74 aa)

GIAHRDLKPENILCESPE--------------KVSPVKICDFDLGSGMKLNNSCT----------------PITTPELTTPCGSAEYMA-PEVVEVFT--
.|.||||||||||. . .              .. ..||.|| .   .. .....                |.... ..|.||. |||| |||..  .  
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

-------DQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCG-ADCGWDRGEVCR--VCQNKLFESIQEGKYEFPDKD------------WAHISSE----
       .. . |.. || ||.||.|||||.||||| | |.  .|. |  |  .  .....||| |..|||.||..             | .|| |    
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-D--E--WIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHF

----AKDLISKLLVRDAKQRLSAAQVLQHPWV
    .||||.|.|..| ..|....|.|.|||.
VSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MNK1.AA RSK 206-374 36 2.2e-51 177.01 In-house 124-278 (278) Show / Hide 
Range on Protein: 206-374
Range on HMM: 124-278/278
Sequence Identity: 36% (65 aa)

GIAHRDLKPENILCESPEKV-SPVKICDFDLGSGMKLNNSCTPIT-TPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVG
|| |||||||||| .. .     .|..||..   .       ..  .  . |.|...||||||.. .   |   .|| ||.|||||..| ||.|.||| |
GIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQF-------RCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSLGVLMYEMLTGCPPFQG

HCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLS-----AAQVLQHPWV
  ..|            ...... ||.||. .. . |. .| ||||||.|.| || ..||.     |....|||| 
--PND----------NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MNK1.AA Ciliate-E2 206-374 28 9.2e-48 162.03 In-house 180-365 (365) Show / Hide 
Range on Protein: 206-374
Range on HMM: 180-365/365
Sequence Identity: 28% (63 aa)

G-IAHRDLKPENILCESPEKVSPVKICDFDL---------------GSGMKLNNSCTPITTPE----------LTTPCGSAEYMAPEVVE-VFTD---QA
. | |||.||||||         .||.|| |               ....... .    .||             | ||...|||||...    |   . 
NNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQ

TFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDK--------------DWAHISSEAKDLISK----LLVR
. ||. ||.|||||.||.||.|.|||                       .. |...|..|| .              .| ..| |.||||.|    .|..
KGYDYKCDIWSLGVILYEMLFGKPPF-----------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQK

DAKQRLS-AAQVLQHPWV
| ..|.. . |.|.||| 
DPEKRITGWEQILNHPWF
Kinase MNK1.AA CAMK1 206-301 44 6.1e-39 110.79 In-house 128-216 (276) Show / Hide 
Range on Protein: 206-301
Range on HMM: 128-216/276
Sequence Identity: 44% (44 aa)

GIAHRDLKPENILCESPEKVSPVK--ICDFDLGSGMKLN-NSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPF
||.||||||||.|.....  |..|  |.|| |    . . |         ..|.||. .|.||||.|     ...||| ||.|| ||..||.| |||||
GIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN--------LMKTACGTPGYVAPEVLECKK--DKPYDKACDMWSIGVITYILLCGYPPF
Kinase MNK1.AA CAMKL 206-374 34 2.8e-38 119.68 In-house 147-297 (297) Show / Hide 
Range on Protein: 206-374
Range on HMM: 147-297/297
Sequence Identity: 34% (60 aa)

GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK-LNNSCTPITTPE--LTTPCGSAEYMAPEVVEVFTDQA--TFYD-KRCDLWSLGVVLYIMLSGYP
||.|||.||||||  .  .   .||.|| ..  ..        | .|.  |.| ||| .|||||..     |   . || .  | ||.||.|| |. || 
GIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPC------IFGPGQKLKTFCGSPPYMAPEIF-----QGNNKPYDGPKVDIWSCGVILYAMVCGYL

PFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV
|| . . .            .. .|.. | .| |..|   | |.| ...|||.|.|... ..| .. |...|||.
PFDDDTYN-K------QGKDNI-YLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase MNK1.AA CAMK 54-165 19 7.2e-38 119.1 In-house 1-199 (425) Show / Hide 
Range on Protein: 54-165
Range on HMM: 1-199/425
Sequence Identity: 19% (39 aa)

LLGEGAYAKVQGAVSLQNG------------KEYAVKIIEKQ----------------------------AGHSRSRVFREVETLYQCQG------NKNI
 ||.|...||  ..  ...            ...|.|||.|.                             ...| .|.||.| . ..||       .||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LELIEFFED-------------------DTRFYLVF---EKLQGG----SILAHIQKQKH---------------FNEREASRVVRDVAAALDFLHTKD
. |.|..||                   |...|.|.   |  .||     .. .|.....               |.||||.|..| .. |....| ..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
Kinase MNK1.AA CAMK1 48-165 25 6.7e-33 92.93 In-house 1-128 (276) Show / Hide 
Range on Protein: 48-165
Range on HMM: 1-128/276
Sequence Identity: 25% (33 aa)

YKLTSELLGEGAYAKVQGAVSLQN---GKEYAVKIIE-KQ--AGHSR---SRVFREVETLYQCQ--GNKNILELIEFFEDDTRFYLVFEKLQGGSILAHI
|....| .|.|| ..|  ..  ..   ||.||.|.|. |.  .....    .. .|.| . ..      ||  ..|..|.|. |||| | ..|| ..  |
YEFGKE-IGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

QKQKHFNEREASRVVRDVAAALDFLHTKD
 . ....|..|..... .. |. ..| |.
VEKGNYTEKDARHIMKQILSAVEYMHSKG
Kinase MNK1.AA CDPK 325-374 56 4.2e-32 95.93 In-house 222-271 (271) Show / Hide 
Range on Protein: 325-374
Range on HMM: 222-271/271
Sequence Identity: 56% (28 aa)

FESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV
.|....|||.| ...|.|||.||||||.|.|..| |.|.||.|.|||||.
MEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase MNK1.AA CAMK1 321-374 45 3.8e-30 84.79 In-house 222-276 (276) Show / Hide 
Range on Protein: 321-374
Range on HMM: 222-276/276
Sequence Identity: 45% (25 aa)

QNKLFESIQEGKYEFPDKDWAHISSE-AKDLISKLLVRDAKQRLSAAQVLQHPWV
.|.||| | ...|||| . | .||.. |||.|...|. | |.|....|.|.|||.
DNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase MNK1.AA MSK 206-301 42 2.8e-29 96.1 In-house 121-210 (277) Show / Hide 
Range on Protein: 206-301
Range on HMM: 121-210/277
Sequence Identity: 42% (41 aa)

GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPF
|| |||||||||| .. |   .||. || . . .....   .  .     ||.. .|||||....   | . ||. ||.|||||.|| ||.|  ||
GIIHRDLKPENILFDDEEDNGHVKLIDFGF-ARLFPQDEEWRMKS-----PCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQVPF
Kinase MNK1.AA CAMKL 48-162 24 2.8e-28 87.22 In-house 1-144 (297) Show / Hide 
Range on Protein: 48-162
Range on HMM: 1-144/297
Sequence Identity: 24% (36 aa)

YKLTSELLGEGAYAKVQGAVS-LQNGKEYAVKIIEKQ----AGHSRSR-----------VFREVETLYQCQ--GNKNILELIEFFEDDTR------FYLV
|..    ||.|...||. |.  . .|...|.|||.|.      .....           ..||.. . . .  . .||  | | .|...       .|||
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

FEKLQGGS--ILAHIQKQKH----FNEREASRVVRDVAAALDFLH
 |  .||.   . .|.|..|    . |.|| |  | . .|....|
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCH
Kinase MNK1.AA CDPK 206-303 39 3.8e-27 80.48 In-house 123-215 (271) Show / Hide 
Range on Protein: 206-303
Range on HMM: 123-215/271
Sequence Identity: 39% (40 aa)

GIAHRDLKPENILCESPEKVS----PVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPF
.| |||||||||| .| .. |    ..|. |...    . | .        ... ||   |.|||| .    .   |.. ||.||.||.|||.|.|||||
NIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKI---EDKKMSQRCGTPYYIAPEVLQ----KK--YNEKCDIWSCGVILYILLCGYPPF

VG
 |
YG
Kinase MNK1.AA MSK 50-164 31 6.8e-26 84.52 In-house 1-120 (277) Show / Hide 
Range on Protein: 50-164
Range on HMM: 1-120/277
Sequence Identity: 31% (38 aa)

LTSE-LLGEGAYAKVQGAVSLQNGKEYAVKIIE----KQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNE
| .   .|.|..  .   |  . ||.||.||.      |     . . .|. .|  ||...|| .| . | |.. .||| | ..||  ..|| | .|| |
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

REASRVVRDVAAALDFLHTK
 |.. ..| .  |.|..| |
SECRMIMRELVMAVDHMHQK
Kinase MNK1.AA RSK 206-303 42 1.6e-24 84.59 In-house 121-207 (271) Show / Hide 
Range on Protein: 206-303
Range on HMM: 121-207/271
Sequence Identity: 42% (42 aa)

GIAHRDLKPENILCESP-EKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVG
||.||||||||||  .   . . .||||| .   ..  |         | |.|..|.||||||.    .|   .|. || ||.||..|.||.|..||..
GIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGM-------LMTFCYTANYMAPEVL---KRQG--HDQACDWWSFGVLMYEMLTGCTPFQN
Kinase MNK1.AA RSK 51-165 26 1e-23 83.75 In-house 1-124 (278) Show / Hide 
Range on Protein: 51-165
Range on HMM: 1-124/278
Sequence Identity: 26% (33 aa)

TSEL--LGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSR----VFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKH---
 ..|  .| |..  ..  .  ..|..||.|...|     | .    ...|.. |  ||. ..| .| . |.... .||. | . ||  . |.||.||   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FNEREASRVVRDVAAALDFLHTKD
| |.||. . . .. |...||...
FSEDEACFYMAEIVLAVEHLHQQG
Kinase MNK1.AA RSK 48-165 26 9.7e-21 70.89 In-house 1-121 (271) Show / Hide 
Range on Protein: 48-165
Range on HMM: 1-121/271
Sequence Identity: 26% (32 aa)

YKLTSELLGEGAYA---KVQGAVSLQNGKEYAVKIIEKQAGHSRSRVF-REVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFN
| |  | .|.|..     ..  .  .....||.|||.| .   ..||   |.. .       .|  | . |.| .  |.. . ..|| .. ...||| | 
YELH-ECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EREASRVVRDVAAALDFLHTKD
|||.. . . .| |...||...
EREVKFYMAEIALAMEYLHSQG
Kinase MNK1.AA Ciliate-E2 48-164 21 7.4e-19 61.34 In-house 1-179 (365) Show / Hide 
Range on Protein: 48-164
Range on HMM: 1-179/365
Sequence Identity: 21% (39 aa)

YKLTSELLGEGAYAKVQGA-VSLQNG----------------------KEYAVKIIEKQAGHSRSR---VFREVE----------TLYQCQGNKNILELI
||.  ...|.|....|  . | ...                       |.||.||..|.   . ..   ..||..           | | . ..||....
YKFI-KKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN-HPNIIKMY

EFFE--DDTRFYLVFEKLQGGSILAHIQKQKH-----------FNEREASRVVRDVAA---------------ALDFLHTK
|.|.  ||. .|||.| .|||. . .|...|.           |.|.|.... . ..                || .|| |
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSK
Kinase MNK1.AA RSK 328-374 40 7.5e-16 53.23 In-house 220-271 (271) Show / Hide 
Range on Protein: 328-374
Range on HMM: 220-271/271
Sequence Identity: 40% (21 aa)

IQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSA-----AQVLQHPWV
|..|.. .    |. || |||||....| ||  .||.|     .|..||||.
IKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase MNK1.AA MSK 328-374 40 3.8e-12 37.37 In-house 231-277 (277) Show / Hide 
Range on Protein: 328-374
Range on HMM: 231-277/277
Sequence Identity: 40% (19 aa)

IQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV
|..|.  ||   |  .| .|||||..|| .| | ||..   ..| | 
ICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase MNK1.AA CDPK 106-152 34 6.9e-12 32.97 In-house 62-110 (271) Show / Hide 
Range on Protein: 106-152
Range on HMM: 62-110/271
Sequence Identity: 34% (17 aa)

NILELIEFFEDDTRFYLVFE--KLQGGSILAHIQKQKHFNEREASRVVR
||. . ||..|.  .|.|.|   . ||  .  |. ..||.|.||. ..|
NIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHFTEKEAAYIMR
Kinase MNK1.AA TyrKc 49-372 16 8.4e-10 -64.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 49-372
Range on HMM: 1-280/280
Sequence Identity: 16% (56 aa)

KLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQC-QGNKNILELIEFFEDD-------TRFYLVFEKLQGGSILAHIQKQK
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ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

H-FNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGM
. .. ..      ..|.  ..|| |                                         .. ||||   |.|  ..     |||.||    |.
PKLCMKDLLSFCWQIACGMEYLHSK-----------------------------------------NCIHRDLAARNCLVGENH---TVKISDF----GL

KLNNSCT-------PITTPE---LTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLY-IMLSGYPPFVG---HCGADCGWDRGEVCRVCQNKLF
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SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQ--EVIEYVKQGYR

ESIQEGKYE--FPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHP
  . .  |.  |      . ..|  .....   .|...| . ... .  
MPQPPNDYPMSF-----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MNK1.AA CDPK 48-96 27 0.010077 4.42 In-house 1-53 (271) Show / Hide 
Range on Protein: 48-96
Range on HMM: 1-53/271
Sequence Identity: 27% (15 aa)

YKLTSELLGEGAYAKVQGAVSL-QNGKEY-AVKIIEKQ-AGHSR--SRVFREVE
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YKIKKV-LGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIE