Gene MLK1 (Human)

MLK1

Species: Human
Alias: MAP3K9, PRKE1, MLK1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 14q24.2-q31,

Classification

Group: TKL
Family: MLK
Subfamily: MLK

Sequence

Name Sequence Type Origin Length Description Download
MLK1.NA RNA Sugen Kinome 5602 None Fasta, JSON
MLK1.AA Protein Sugen Kinome 1118 None Fasta, JSON
MLK1.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON

Protein domain

Protein domains of MLK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 MLK1.AA SH3 55-115 42 6.5e-23 83.37 SMART 1-58 (58) Show / Hide 
Range on Protein: 55-115
Range on HMM: 1-58/58
Sequence Identity: 42% (27 aa)

PYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLN--QRVGIFPSNYVTPRS
||  |.. |.| ..|||... ||...||.||     |.||| |..|   ..|.||||||..  
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-----DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 MLK1.AA SH3_1 58-108 35 5.3e-13 46.87 Pfam 1-49 (49) Show / Hide 
Range on Protein: 58-108
Range on HMM: 1-49/49
Sequence Identity: 35% (19 aa)

TAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDE-GWWTGQLN--QRVGIFPS
.| . |.| ..|||... ||...|..|.     |. .||.|..|   ..|.|||
VALYDYQAQQPDELSFKKGDIIHVIEKS-----DDWDWWKGRCNNTGQEGWFPS
SH3_2 MLK1.AA SH3_2 56-114 24 2.9e-12 45.83 Pfam 1-68 (68) Show / Hide 
Range on Protein: 56-114
Range on HMM: 1-68/68
Sequence Identity: 24% (18 aa)

YWTAVFEYEA-AGEDE-----LTLRLGDVVEVL---SKDSQVSGDEGWWTG-QL--NQRV--GIFPSNYVTPR
|  ....|.. ....|     |... |||..|.   .||.      .|| .     . |.  | |||..| . 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWD-----NWWWCWETIWGGRRMRGWFPSQWVEEC
Kinase MLK1.AA MLK 144-403 73 6.8e-204 680.13 In-house 1-280 (280) Show / Hide 
Range on Protein: 144-403
Range on HMM: 1-280/280
Sequence Identity: 73% (206 aa)

LTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQT---IENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD
|...||||.|||||||||.| |.||||||.|.||..|..||   .|.|||||.||.|||||||||||||||..|.||||||..|||.||||..||||||.
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGKRIPPH

ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVE-----------------NGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRA
.||||||||||||||||.||.||||||||||||||||.|..                 . |..||.|||||||||||||.||.|||||||||||||||..
VLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFGLAREWHKTTRMSAAGTYAWMAPEVIKE

SMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL
|..||||||||||||||||||||||.||||.||||||||||||.||||||||||.||||.||||.|||.||.|..||.||
STWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL
Kinase MLK1.AA MLK 144-403 46 2e-160 539.26 In-house 1-291 (291) Show / Hide 
Range on Protein: 144-403
Range on HMM: 1-291/291
Sequence Identity: 46% (137 aa)

LTLEEIIGIGGFGKVYRAFWIGDE-----VAVKAARHDPDEDISQT---IENVRQEAKLFAMLKHPN----IIALRGVCLKEPN-LCLVMEFARGGPLNR
....|.|| |.||||... | . .     ||||..|.... |.|.|   ......|......|.|||    ||...||||..|. .|.|||...||.|..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

VLSGKR---------------IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRT-T-KMSAAGTY
|| |.|               ...| ..|||.|.||||.||| .| .|||||||||.||||.. ... |. ...|||.|||..|.||.. | .||.||||
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTY

AWMAPEVI---RASMFSKGSDVWSYGVLLWELLTGEVPFR-GIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL
||||||||   |....|. .||||.||.|||.||.|||.. ..|..|.|..||.|.| .||||||||...|||..|||.|||.||||  |. .|
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK1.AA TKL 150-403 28 7.2e-106 358.03 In-house 1-364 (364) Show / Hide 
Range on Protein: 150-403
Range on HMM: 1-364/364
Sequence Identity: 28% (107 aa)

IGIGGFGKVYRAFWIG----------DEVAVKAARHDP-----------------------DEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPN-
|| ||||.||.. | |           .||||  . .                        |...|.  .  ..|...  .|.||||. . |.|. .|. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCLVMEFARGGP-LNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAI-----VPIIHRDLKSSNILILQKVE--NGDLSNKI------
            ||.|||.. ||  |....      .. ...|| .||||||||| .        |||||||||.|||. .. .  . . .  .      
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYM--YNPNADW

-LKITDFGLAREWHRT---------------------TKMSAAGTYAWMAPEVIRAS----------------MFSKGSDVWSYGVLLWELLTGEVPFRG
 .||.||||.|.....                     |.|.  ||..||||||.| .                 .|. .||.|.|..|||.||...|...
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

IDGLAVA---------YGVAMNKLALPIP------------STCPEPFAKLMEDCWNPDPHSRPSFTNILDQL
..   .          ..|. ..| .|||            ..||....|||.|||..||..||||. ||..|
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK1.AA Pkinase 144-403 27 7.5e-94 322.9 Pfam 1-293 (293) Show / Hide 
Range on Protein: 144-403
Range on HMM: 1-293/293
Sequence Identity: 27% (84 aa)

LTLEEIIGIGGFGKVYRAFWIGDE--VAVKAARHDPDEDISQTIENVR-QEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGG----PLNRVLS---
......|| |.||.||.. ..|..  ||||  . . .|. .. ....| .|... ..|.||||. |....  ......|||...||     | ...|   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

GKRI--PPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR---EWHRTTKMSAAGTYAWMAPEVIR-ASMFS
....  ... . ... ||.||..|.|..    |||||||..|||| .. ....    ..||.|||||.   . . .  .. .||. .||||||| ... .
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA----CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

KGSDVWSYGVLLWELLTGEVPFRGI------DGLAVAYGVAMNKLALPIPSTCP-------------------EPFAKLMEDCWNPDPHSRPSFTNILDQ
. .|.||.|..|.|.|.|. ||.|       | ... . . . .|  ..| .|.                   |.. .....|...||..||... ||  
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF
Kinase MLK1.AA TyrKc 144-403 30 3.4e-93 316.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 144-403
Range on HMM: 1-280/280
Sequence Identity: 30% (90 aa)

LTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAML--KHPNIIALRGVCLKE-------PNLCLVMEFARGGPLNRVLSG
.||....| | ||.||.. |.  .||||  ..|        .|  ..||..  .|  .||||..| |||...       . |..|||.. .| |.  |  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KR--IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRT--------TKM-----SAA--GTYAWMA
.|  .... |.....|||.||.|||.    ..|||||   |.|.  .         . ||.||||.|...          ...     ..     . |||
HRPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGI----DGLAVAYGVAMNKLALPIPST--------CPEPFAKLMEDCWNPDPHSRPSFTNILDQL
||.|. ..|.  |||||.||..||..| |. |  |.       . ..   ..   .|.|          ||.   ..|..||. ||..||.|..| ...
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLK1.AA LZK 198-403 49 2.7e-84 284.09 In-house 44-241 (241) Show / Hide 
Range on Protein: 198-403
Range on HMM: 44-241/241
Sequence Identity: 49% (103 aa)

LKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFG
|||||||...||| . |  | .||.   |.|  || ... |.|  .|.|  ||| ||.|||   .  |||||||| |||| .        | ..|| |||
LKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVLRERRTITPQLMVDWSKQIAQGMHYLH---QHKIIHRDLKSPNILISH--------NDVVKICDFG

LAREWHRT--TKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRP
  ..|     |||| .|| |||||||||    |   |.||.|| |||.||.|.|.. .|  |. .||  | | ||.|||||| |  ||  ||.  |  ||
TSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVGSNSLHLPMPSTCPEGFKLLMKQCWSQKPRNRP

SFTNILDQL
||  ||  .
SFRQILMHW
Kinase MLK1.AA Dicty4 144-405 33 2.9e-76 253.86 In-house 1-277 (277) Show / Hide 
Range on Protein: 144-405
Range on HMM: 1-277/277
Sequence Identity: 33% (95 aa)

LTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCL----KEPNLCLVMEFARGGPLNRVLSG-----
.. |..|| |.||.||.. | | ||||| .  . . . . ...  |.|... . . ||||. . | |.    . . .| |.|.   | | ..|       
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-KRIPPD-ILVNW----AVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR----EWHRTT-KMSAAGTYAWMAPEVIRA
 ..|..| .|.      |  .|||||.|| . .. ||||||||.|.|.       | .... |..||||..    .   ..  |.|.|| .|||||| . 
QQSIKLDWPLIKRAMRMAFDAARGMNWLH-CCNPVIIHRDLKSHNLLV-------DKNWRV-KVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMH

SMFSKGSDVWSYGVLLWELLTGEVPFR--GIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQ--LTT
  .   .|| |.| .|||.||.. |.   ...   .. .|.  || .|||. || ....|...||..|| .||||  |. .  | .
QPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK1.AA TKL-Unique 146-403 33 9.9e-75 254.58 In-house 1-290 (290) Show / Hide 
Range on Protein: 146-403
Range on HMM: 1-290/290
Sequence Identity: 33% (100 aa)

LEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDIS-QTIENVRQEAKLFAMLK-HPNIIALRGVCL----KEPNLCLVMEFARGGPLNRVLS------
  . || ||.|.||.. | |..||.|       ||.| . ... . | ..  .|. ||||  . |.|     ..||.|.|||.  || |. ||.      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-----GKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQK-VENGDLSNKILKITDFGLAREWHRTTKMSAA-----------GTYAWM
      . ...   |. | .||.||.||| .    ||||||||||.|. ..  ..        || ||||..   . .||..            |.. ||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIA----EWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWM

APEVIRA--SMFSKGSDVWSYGVLLWELLTGEV------PFRGIDGLAVAYGVAM--NKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL
||||.|   ...|. |||.|.|. |||..|...      |..|.|  ...  |.    .. .|||. ||. . .|...||..||  ||||..|.  |
APEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLK1.AA Pkinase_Tyr 144-403 33 3.8e-73 248.37 Pfam 1-270 (270) Show / Hide 
Range on Protein: 144-403
Range on HMM: 1-270/270
Sequence Identity: 33% (95 aa)

LTLEEIIGIGGFGKVYRAFWI------GDEVAVKAARHDPDED-ISQTIENVRQEAKLFAML-KHPNIIALRGVCL-KEPN--LCLVMEFARGGPLNRVL
.|. . .| | ||.||.. |       . .||||  ... ...     .|   .|||.   | .||||. | |||. ..    ...|||.. .| |   |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN--CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

SGK-----RIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREW-----H-RTTKMSAAGTYAWMAPEVI
  .     ....  |.....|||.||.||..    ..|||||   |.|.          |.. ||.||||||         |... .      |||||.|
RKHREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTE--------NNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECI

RASMFSKGSDVWSYGVLLWELLT-GEVP-FRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL
. . |.  |||||.|||.||..| || | . |..   |   .. .   .|.|  ||..  .|| .||..||  ||.|. |. ||
NYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK1.AA TK 144-403 19 1.2e-68 229.01 In-house 1-486 (486) Show / Hide 
Range on Protein: 144-403
Range on HMM: 1-486/486
Sequence Identity: 19% (93 aa)

LTLEEIIGIGGFG---KVYRAFWIGD---------------------------EVAVKAARHDPDEDISQTIE-------------NVRQEAKLFA--ML
.||.. .| | ||   .||.. |.|.                           .||||  . . ...  . ..             .  .|.|..   ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHPNIIALRGVCLKE------------PNLCLVMEFARGGP----LNRVLSGKR----------------------------------------------
.||||. | |||...            . ...|||.. .|     |   |  .|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IPPDILVNWAVQIARGMNYLHDEAIVPI----IHRDLKSSNILILQKVENG---DLSNKILKITDFG--
                               ...  |. ...|||.|| |||.  .       .||||   |.|. ..  .    | .  . ||.|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAREWHRTTKMSAAGTYA----------------------------WMAPEVIRASM---------FSKGSDVWSYGVLLWELLT-GEVPFRG-
      |||. .. .   ....|                             |||||...            |.  |||||.|||.||..| |..|. | 
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

IDG---------LAVAYGVAMN-------------KLALPIPSTCP--------------EPFAKLMEDCWNPDPHSRPSFTNILDQL
..            |   . .              .. .| |  ||              | .. || .||..||  ||.|. ...||
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK1.AA S_TKc 144-412 27 2.1e-67 231.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 144-412
Range on HMM: 1-231/231
Sequence Identity: 27% (76 aa)

LTLEEIIGIGGFGKVYRAFWIG--DEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARG--GPLNRVLSGKR---
 .. ..|| |.|||||.. ...   .||.|  .           |..|.| ..  . .||||. | .|.    .|..|||.. |  | | ...  ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSK-GSD
    .|.     .. ||.....|.|.     ||||||| .|||. .           .||.||||||.      ..  ||  .|||||.    ..|  .|
LRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE----------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCD

VWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFF
.|| |..|.|.|.|. ||.    ... . . .           ....  ... |.. ||  ||.   .|     |    .|
WWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLK1.AA LRRK 144-405 29 6.2e-67 228.69 In-house 1-351 (351) Show / Hide 
Range on Protein: 144-405
Range on HMM: 1-351/351
Sequence Identity: 29% (106 aa)

LTLEEIIGIGGFG-KVYRAFWIG----------------------------DEVAVKAARHDP------------------------------DEDISQT
|  || || |||| .|||| |.|                             .||.|    ||                              .|| .  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

IENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR----------IPPDILVNWAVQIARGMNYLHDEAIV-PIIHRDLKSSN
    |.|. .   |.||||. | |.|. .| ||.|||.|. | |...|. |.          |.. ..   |.|||.||.|||.     ||||||||| |
FREFRHEVWIMSHLNHPNIVSLKGFCI-HP-LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS--HNPPIIHRDLKSPN

ILILQKVENGDL-----SNKILKITDFGLAR--EWHRTT-KMSAAGTYAWMAPEVIRA---SMFSKGSDVWSYGVLLWELLTGE-VPFRGIDGLAVAYGV
|| |..  ...       . . || |||. |     ...  .   |.  |||||..|.   . ..  .|. |.|..||||||..  ||...|.    ...
IL-LWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDF----FDH

A--MNKLAL--------PIPST-CPE-----PFAKLMEDCWNPDPHSRPSFTNILDQLTT
   |... .        .||.. ||.      . .|...||. || .||.|. |...| .
MQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK1.AA ZAK 240-402 43 1.5e-61 210.84 In-house 101-257 (257) Show / Hide 
Range on Protein: 240-402
Range on HMM: 101-257/257
Sequence Identity: 43% (72 aa)

DILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR-EWHRTTKMSAAGTYAWMAPEVI-RASMFSKGSDVWSYGV
|  . || |||.|| ||| .| . |||||||| |. |          | ..|| |||  |   | .| ||  || .|||||.|      .   |||||||
DHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVIDK--------NGVCKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQSEPVTETCDVWSYGV

LLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQ
 |||.|| |||... ... ..  .      | ||. || ||..|| .||  ||  ||..  |   
VLWEMLTREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI
Kinase MLK1.AA Dicty4-Unclassified 144-403 32 4.3e-60 204.49 In-house 1-263 (263) Show / Hide 
Range on Protein: 144-403
Range on HMM: 1-263/263
Sequence Identity: 32% (89 aa)

LTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEP-----NLCLVMEFARGGPLNRVLS-----
.     || | | ||..  | | .||||      .      |.. . |  .   . ||| . ..| |.  |      .| ||||   | |  |       
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCI-NPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE

-GKRIPPDI--LVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAG-TYAWMAPEVIRASMFSKG
  . |  |    .  |  ||.|| .||    . .||||.||||||.       |  . | || |||..|.   .  | . . | .| .||. .   .   
QQQPIKLDDTLIIKYAFDIAQGMQHLH---TRNFIHRDIKSSNILM-------DKHFNI-KIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQK

SDVWSYGVLLWELLTGEVPFRGID-GLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL
|||.||...|.||.||. |. .|   . .|  |.  ||   ||. |.  . ||  .||  ||  ||..  | . |
SDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLK1.AA ZAK 144-228 30 6.7e-08 24.38 In-house 1-79 (257) Show / Hide 
Range on Protein: 144-228
Range on HMM: 1-79/257
Sequence Identity: 30% (28 aa)

LTLEEIIGIGGFGKVYRAFWIGDE-----VAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPN-LCLVMEFARGGPL
. . . .| | || |||| ||        .|||             .  .  ||     ..| |||   |.|.  ||    | |.|  | |
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKK------------VFKIEKEAEILSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSL