Gene MET (Human)

MET

Species: Human
Alias: MET, C-MET, RCCP2, HGFR
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 7q31,

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
MET.NA RNA Sugen Kinome 6695 None Fasta, JSON
MET.AA Protein Sugen Kinome 1408 None Fasta, JSON
MET.kin_dom Protein Kinase Domain Sugen Kinome 262 None Fasta, JSON

Protein domain

Protein domains of MET.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Sema MET.AA Sema 55-500 26 2.4e-173 586.97 Pfam 1-484 (484) Show / Hide 
Range on Protein: 55-500
Range on HMM: 1-484/484
Sequence Identity: 26% (130 aa)

VILHEHH-----IFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVN-RGTCQRHVFPH
.....|.     .. ||.|..|||| ..|......|...  .| .|..|..| .|..... ||... |...|...|.|..|..||... ...|..|...|
FHTLLHDEDRDRLYVGARNHVYVLNLNNLSERCYQKIHWPSSH-GCEHCEECYMKGKDPP-VWTECQNYIRVLHPYNDTHLYVCGTNAFHPVCWYHNLGH

NHTADIQSEVHCIFSP-QIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPI
.||||.|.|.||.||. ...|...|..|......... . |.||| ....|..|.|..............|.|.....|......|.....| |.|||||
HHTADHQAEEHCLFSYDHDKEEDGCGRCPYDPKHNTTSVMVQDRFGELYSGTYIDSKVAYSFMGRDPWIYRSKGSHHPFRTEQHDSKWLNEPNFVDSYPI

KYVHAFESNNFIYFLTVQRETLDA----QTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKK-----EVFNILQAAYVSKPGAQLARQIGASLN
.|||.| ...|.||....... ..    .|.|.|..|.|.  .|.|.|.||...|. ...| ..|        ..||.||...| .....||...|.|..
HYVHDF-DDDFVYFFFRETAVEYSMNCGKTIHSRVARVCKNDMGGHRYLEMNKWCTFLKARLNCSVPGPDGYPFYFNELQDVFVLPTDNWLAHELGISWR

DDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNH-EHCFNR-TLLRNSSG--------------CEARRDEYRTEFTT
.....|||.........||..||.|||.....|..||....|.. .| ..... .. ... .|    .|...              . .|......|...
NPVIYGVFTTPWNIFRGPMHNSAVCAFHMNDINQVFNNGPFKHQEGCNHQWLPYRGLRVPYPRPGQCPNDPNHGNMSTKDLPDNTCNFIRCHPLMYEVVY

ALQRVDLFMGQFSEVLLTSISTF---IKGD---LTIANLGTSEGRFM--QVVVSRSGPSTPHVNFLLDSHPVSPE-VIVEHTLNQNG
......|||.|......|.|  .    .||   .|....||..||..  ||||||......|...|...|..... .|..... |  
PVHNRPLFMRQSVNYRFTQIAVDPRVRAGDGQWYTVMFIGTDDGRVHKKQVVVSRDSWPHYHEVVLEEIHVFPDPEPIQNMEISQKQ
Sema MET.AA Sema 52-496 24 3.5e-141 476.26 SMART 1-532 (532) Show / Hide 
Range on Protein: 52-496
Range on HMM: 1-532/532
Sequence Identity: 24% (132 aa)

IQNVILHEH----HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFP-------CQDCSSKAN---LSGGVWKDNINMALVVDT--YYDDQLISCGS
 ....|.|.    ....||.|.||.|. ..|.|..|..||||...|.| .       || |..| .   .... |.|| ...|....  |||..|..||.
YNHMLLDEDRGNWRLYVGARNHIYQLSLPNLSKEWEHVTGPVIDWPSCPEPNEKCIKCQECQMKGKHFCPHNETWCDNYIRVLQPYNDHYYDTHLYVCGT

VNRGT---CQRHVFPHNHTAD-----IQSEVHCIFSPQIE-EPSQCPDCVVSALGAKVLSSVKDRF---INFFVGNT-INSSYFPD-HPLHSISVRRLKE
. .|    |..|. .. ...|     .|. .|| .|.|.. ..| |..|....|....   |....   .....|..  .|..... |. ..|..|||..
NAFGPDVMCWYHNLGNHEPWDEMEQEDQIFTHCPHSKQHNRSESGCGKCPYDPLHNSTSVFVDGYNPDGGELYSGTVADFSGVAQSYHRSDPIIYRRLGM

TKDGFMFLTDQSYIDVLPEFR--DSYPIKYVHAFES-----NNFIYFLTVQRETLD-----A--QTFHTRIIRFCSIN--------SGLHSYMEMPLECI
. |||.|....|..|... ..  |.|....|||||.     ..|.||....|.. .     .  ...|.|. |.|           .  .||....|.|.
FQDGFHFWFHPSRTDQYDSKWGYDLYEPHFVHAFEIPESNDGDFVYFFFRERAHEHMNRDCGYEKHYHSRVARVCKNDMGGQRLLQKKWTSYLKARLNCS

LTEKRKKRSTKKE-VFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSA----EPMDRSAMCAFPIKYVNDFFNKIVNKNNVRC--LQHFYGP
 ..|. ..    | .||.||...|..||| ||.. |   .||.|.|||.|... |     .|   ||.|||..| .|..||. ..| . ..   .|.|. 
VPDKGRRP----EFYFNELQDVFVLPPGA-LAQDWGW-EQDDVLYGVFTQGQQWSSRDAANPWPGSAVCAFSMKDINRVFNEGPFKCYEGPNHQWHPYNG

NHEHCFN--------------RTLLRN--SSGC-EARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGD-------LTIANLGTSEGRFMQVVVS
|   ...               .. ..   . .  ...  ...| ........||.........|.|     ..        |.. |||. ||...|||.
NKVPWPRPGTCPSNHFREQRNCCHTKDLPDDVLCFIKHHPLMDEAVQPIHGRPLFVKTNTDYRFTHIAVDRVHNLDGHHNWYTVMFLGTDDGRIHKVVVW

RSGP--------STPHVNFLLDSHP--VSPEVIVEHTL
||.         | .. .| ...|.  ..... . |. 
RSRHNQSWHGWESHVYEEFQVFPHGSEPIRDMQFSHKQ
IPT MET.AA IPT 656-739 25 1.3e-24 89.0 SMART 1-111 (111) Show / Hide 
Range on Protein: 656-739
Range on HMM: 1-111/111
Sequence Identity: 25% (28 aa)

DPVITSISPKYGPMAGGT-LLTLTGNYLNS-GNSRHISIG------GKTCTLKSV------SNSILECYTPAQT----ISTEFAV----KLKIDLANRET
|||||.|.|..|| .||| ..|..|....| ...| ....      .  ||. ..      | . ..|.||...    |  .  |    .......|..|
DPVITRIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQFCNDNVRT

-----SIFSYR
     . |.|.
QLSWPQPFTYV
IPT MET.AA IPT 562-655 19 2.5e-19 71.47 SMART 1-111 (111) Show / Hide 
Range on Protein: 562-655
Range on HMM: 1-111/111
Sequence Identity: 19% (23 aa)

LPAIYKVFPNSAPLEGGT-RLTICGWDFGFRRNNKFDLKKTRVLLG------NESCTLTLSES----TMNTLKCTVG-------PAMNKHF----NMSII
.| |....||..|..||| |.||||..|.       | .  .| ..      ...||.. ...     .... |...       .. . ..    .....
DPVITRIHPNCGPCSGGTERITICGKNFDS------DIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQFC

ISNGHGT-TQYSTFSYV
..|...  .....|.||
NDNVRTQLSWPQPFTYV
TIG MET.AA TIG 657-738 32 4.7e-17 60.1 Pfam 1-82 (82) Show / Hide 
Range on Protein: 657-738
Range on HMM: 1-82/82
Sequence Identity: 32% (28 aa)

PVITSISP-KYGPMAGGTLLTLTGNYL-NSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDL-ANRETSIFSY
|.|||||| ..|| .|||..|.||... |.  .  . .||  ||  ..|.. ..|.||. | .  . |.. ..   .  .. |.|
PTITSISPNTTGPPSGGTTITITGQNFGNDS-DTKCYFGGTPCTVIWWSSTQIVCTTPPHTPG-THNVSV-VNGQWSSNPTTFTY
TIG MET.AA TIG 563-654 25 6.3e-17 59.65 Pfam 1-82 (82) Show / Hide 
Range on Protein: 563-654
Range on HMM: 1-82/82
Sequence Identity: 25% (24 aa)

PAIYKVFP-NSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSY
| |....| ...| .|||..|| | .|        |  .|....|.. || .   .. ....||. |. . ..| |. ...  ......||.|
PTITSISPNTTGPPSGGTTITITGQNF------GNDS-DTKCYFGGTPCTVI--WWSSTQIVCTTPPHTPGTHNVSV-VNG-QWSSNPTTFTY
PSI MET.AA PSI 519-562 31 8.3e-17 53.56 Pfam 1-57 (57) Show / Hide 
Range on Protein: 519-562
Range on HMM: 1-57/57
Sequence Identity: 31% (18 aa)

GCRHFQSCSQCLSAPPFVQCGWCHD--KCVRSE-----ECLSGT------WTQQICL
.|....|||.||||.....||||..  .|.| .     .| ...      |.|. | 
NCSQHTSCSSCLSARDPFYCGWCSSQHRCTRGHAYTYGQCPRWWQWMWWSWSQSQCP
PSI MET.AA PSI 519-562 30 1.1e-11 46.03 SMART 1-56 (56) Show / Hide 
Range on Protein: 519-562
Range on HMM: 1-56/56
Sequence Identity: 30% (17 aa)

GCRHF--QSCSQCLSAPPFVQCGWC--HDKCVRSEECLS-----GTWTQ---QICL
.|.|.  .|||.||||... .||||  . .|.....| .       |..   . | 
NCSHYGVTSCSECLSARDPYRCGWCSWQHRCTHRHRCDERRFWRQNWEHGPHKQCP
IPT MET.AA IPT 741-854 22 1.2e-14 55.92 SMART 1-111 (111) Show / Hide 
Range on Protein: 741-854
Range on HMM: 1-111/111
Sequence Identity: 22% (29 aa)

DPIVYEIHPTKSFISTWWKEPLNIVSFLFCFASGGS-TITGVGKNLNSVSVPRMVINVHEAGRNF-TVACQHR--------SNSEIICCTTPSLQQ--LN
||...                   ..  ....|||  .||  |||..| .. . .. |...|| . .|.|..         | ..|.||| |.. |  ..
DPVIT------------------RIHPNCGPCSGGTERITICGKNFDS-DIQVRFVRVNVGGR-VWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIP

LQLPLKT--KAFF-MLDGIL--SKYFDLIYV
 | |...  ...| . ..    | .... ||
GQVPVRVTQEVQFCNDNVRTQLSWPQPFTYV
TIG MET.AA TIG 762-848 18 0.00235 13.72 Pfam 1-82 (82) Show / Hide 
Range on Protein: 762-848
Range on HMM: 1-82/82
Sequence Identity: 18% (17 aa)

LNIVSFL---FCFASGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKY
. | |.      ..|||.|||  |.|. . .   . . .  .  . .      ..|  |.||||.. . .... . .  .   ..    |
PTITSISPNTTGPPSGGTTITITGQNF-GNDS-DTKCYFGGTPCTVI-----WWSSTQIVCTTPPHTPGTHNVSV-VNGQWSSNPTTFTY
IPT MET.AA IPT 856-952 16 8.8e-11 43.07 SMART 1-111 (111) Show / Hide 
Range on Protein: 856-952
Range on HMM: 1-111/111
Sequence Identity: 16% (18 aa)

NPVFKPFEKPVMISMGNENVLEIKGNDIDP-EAVKGEVLKVG----NKSCENIHL------HSEAVLCTVPNDLLK--LNSELNIEWKQAISSTVLGKVI
.||.  ....  . .|..... |.|.. |.   |    ..||    . .|. ..       .... .|..|  . .  .... .....| ..   ...| 
DPVITRIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQF-CNDNVR

VQ--PDQNFTGL
.|  ..|.|| .
TQLSWPQPFTYV
TIG MET.AA TIG 857-915 18 1.495665 4.23 Pfam 1-57 (82) Show / Hide 
Range on Protein: 857-915
Range on HMM: 1-57/82
Sequence Identity: 18% (11 aa)

PVFKPFEKP-VMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVP
|.   .. | .. . .  ... |.|..    .  .   ..|.  | .|   |  . ||.|
PTITSIS-PNTTGPPSGGTTITITGQNF-GNDS-DTKCYFGGTPCTVIWWSSTQIVCTTP
Kinase MET.AA Met 1097-1349 69 8.60000000001e-215 711.1 In-house 1-271 (271) Show / Hide 
Range on Protein: 1097-1349
Range on HMM: 1-271/271
Sequence Identity: 69% (187 aa)

HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN--RITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG-SPLVVLPYMKHGDLRNFIRNETHN
||..|||.|||||||||...||||...|||.|||.  |||||...||||.|||.||.|.|||||||.||||..|| .|.|||||||||||..||||...|
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNN

PTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDM-YDKEYYSVHNKTG-AKLPVKWMALESLQ--------TQK-FTTKS
|.|.|||.|..||||||.|.||.||||||||.|||||||.||||||||||.||| |||||||....|. |.|||||||.|.||        |.. |||||
PCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTKS

DVWSFGVLLWELMTRGAPPYPDVNT-FDITVYLLQG--RRLLQPEYCPDPLY-EVMLKCWHPKAEMRPSFS
|||||||..||||||||||||.|.. ||||..| ||  |||.||||||| || .|||.|||...|.||.||
DVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Pkinase_Tyr MET.AA Pkinase_Tyr 1096-1355 44 7.50000000001e-147 497.97 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1096-1355
Range on HMM: 1-270/270
Sequence Identity: 44% (120 aa)

VHFNEVIGRGHFGCVYHGTLL-DNDGKKIHCAVKSLNRITDIGE--VSQFLTEGIIMKDF-SHPNVLSLLGICLRSEGS--PLVVLPYMKHGDLRNFIRN
..|....|.|.|| ||.||.  | |..||..|||.|.  ..  .     |. |  ||| . .|||...|.|.|.. ...  ...|..||.||||... |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E---THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWS
     ...|.|||... .|.|||| ||.||...|||||||||...|...||..|||||||.|...|| .. ..|.|||.||||.|.... ||||||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVLLWELMTRGAPP-YPDVNTFDITVYL-LQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRI
||||.||..|.|. | ||..  ...  |.  .|.|. .||.|||..|..|..|||...|.||.|||.....
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc MET.AA TyrKc 1096-1355 39 2.9e-136 459.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 1096-1355
Range on HMM: 1-280/280
Sequence Identity: 39% (114 aa)

VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDF--SHPNVLSLLGICLRSE------GSPLVVLPYMKHGDLRNFI
.......|.|.|| ||.||.       | .|||.|.  .    .  |. |  ||. .  .|||.. |.|.|. ..      . ...|. ||.||||....
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDK-------EYYSVHNKTGAK--LPVKWMALESLQTQKF
|.  .. ..|||. | .|.|.|| ||.||...|||||||||...|..|||..||||.|| ||.       .||..  . |.|  ||..|||.|.... ||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TTKSDVWSFGVLLWELMTRGAPPYPD-----VNTFDITVYLLQGRRLLQPEY--------CPDPLYEVMLKCWHPKAEMRPSFSELVSRI
|||||||||||..||..|.|..|||.     .. ...  |. ||.|. ||..        ||| .|..|..||| ..|.||.|||.....
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MET.AA TK 1096-1355 24 8e-120 403.6 In-house 1-486 (486) Show / Hide 
Range on Protein: 1096-1355
Range on HMM: 1-486/486
Sequence Identity: 24% (119 aa)

VHFNEVIGRGHFG---CVYHGTLLDND----------------------GKKIHCAVKSLNR--ITDIGEVSQ-----------FLTEGIIMKDFS----
... ...|.|.||    || |.. . .                      |.|. .||| |     ..  |  .           || |  .|| ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVLSLLGICLRSEGS-----------PLVVLPYMKHGD----LRNFIRNE-----------------------------------------------
 |||...|.|.|...|..           ...|. ||.|||    ||.. |.                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------THNPTVKDLIGFGLQVAKGMKYLASK------KFVHRDLAARNCMLDEKFT-----------VKVADFG---
                            .|..|...|. . .|.|.|| ||.||      .|||||||||||...|. .           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARDMY-DKEYYSVHNKT---------------------GAKLPVKWMALESLQ---------TQKFTTKSDVWSFGVLLWELMTRG-APPYPDV
     ||||.| |..||......                     |.|||..||| |.|.         . ||||||||||||||.||..|.| .|.|...
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NT---------FDITVYLLQG--------------RRLLQPEYCP--------------DPLYEVMLKCWHPKAEMRPSFSELVSRI
.           ..  || .|               |. ||..||              . .|..|..|||...| ||.||.|....
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MET.AA UTK 1096-1355 32 4.8e-100 338.66 In-house 1-296 (296) Show / Hide 
Range on Protein: 1096-1355
Range on HMM: 1-296/296
Sequence Identity: 32% (98 aa)

VHFNEVIGRGHFGCVYHGTLLDND--GKKIHCAVKSLNRITDIGEVS-----QFLTEGI---IMKDFS-HPNVLSLLGICLRSEGSPLVVLPYMKHGDLR
|.. . .|.|.|| |..... . .  ... ..||| ..  .. .. .     .|. |     .|| |. ||||| |.|.|...|. ...|. ||. ||||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ-HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLR

NFIRNETHNPT-------VKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEK-------FTVKVADFG---LARDMY-------DKEYYSVHNKTG
.. |. ...|          ..... ...| || ||.|..||||||||||| ...         ..|.||||   ..|...       ..|.| .     
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

AKLPVKWMALESLQTQ-KFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQG--RRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRI
 ..|..||| |.|  . .||||||||||||..||..|.|. |||. .. .... .. |  .|. .|. ||.|.|..|..|||.  ..||.| .||...
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase MET.AA TK-Unique 1096-1355 35 6.4e-95 321.65 In-house 1-294 (294) Show / Hide 
Range on Protein: 1096-1355
Range on HMM: 1-294/294
Sequence Identity: 35% (106 aa)

VHFNEVIGRGHFGCVYHGTLLDND---GKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFS-HPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR---
. ...|||.| ||.|..|..  ..   .|... ||| |..  .  ....|| |  .||    |||....||.| .|..... ...|.  |.|....|   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-------------------NETHNPT-VK--DLIGFGLQVAKGMKYLAS--KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTG--AK
                   ... ... ..  ||. |. |.|.||.||||  ||.|||||.|||..| |....|..|||.||| |.     |.....   .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT---NGVYSMMCSQGR

LPVKWMALESLQ--TQKF-TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYC-PDPLYEVMLKCWHPKAEMRPSFSELVSRI
.|..|||.|||.  .. . ||||||||||||.||..| ||.|||..   ||   . .| |..|||.| .. .|..|  ||. ..|.||||.....|.
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase MET.AA Axl 1096-1353 44 1.9e-94 320.05 In-house 1-267 (267) Show / Hide 
Range on Protein: 1096-1353
Range on HMM: 1-267/267
Sequence Identity: 44% (119 aa)

VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN-RITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG-----SPLVVLPYMKHGDLRNF---
.    ..|.| || |  | |  .||  .  ||| .   |    |. .|| | . ||.|.||||. |.|.|...        |.|.||.||||||  |   
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

--IRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDV
  . ..  .  .. |. | . .| || ||....|.||||||||||| |  || ||||||.. .|. .||       ||.||||.|.|||  . .| ||||
SRLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYY--RQGCIAKMPVKWIAIESLADRVYTSKSDV

WSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVS
|.||| .||.||||  ||| |.  ..  ||..| || ||| | | ||..| .||.   . |||||.|  
WAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase MET.AA Src 1096-1355 40 4.8e-88 298.81 In-house 1-255 (255) Show / Hide 
Range on Protein: 1096-1355
Range on HMM: 1-255/255
Sequence Identity: 40% (107 aa)

VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLRNFIR--NETH
... . .|.|.|| |. |.  .|    .. |||.| . |   .. .|| |  ||| ..|.....|. .| . |  | . |  ||.|| |  . .   |..
IKLCRKLGQGQFGEVWMGYWNGN----TKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE--PIYIVTEYMSHGSLLDYLKKDGEGR

NPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMY--DKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVL
.  ...|| .. |||.||.|| |....||||||||   .|.  .||||||||| .   | || . |   |||.|.||.| | .. ..||.||||||||.|
HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH---GAKFPIKWTAPEAINYGRFTIKSDVWSFGIL

LWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYE-VMLKCWHPKAEMRPSFSELVSRI
|.|..|.|  |||  .  .    . .| |. .|. ||| ||| .||.||| ..| || |  | .  
LTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase MET.AA InsR 1096-1357 37 1.3e-83 280.65 In-house 1-278 (278) Show / Hide 
Range on Protein: 1096-1357
Range on HMM: 1-278/278
Sequence Identity: 37% (107 aa)

VHFNEVIGRGHFGCVYHG--TLLDNDGKKI--HCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLRNFIR--
.  .   | | || || |    .  |.. .   ||.|..|      |   || |  .|| | . .|  |||.|  | | | .||   |..|||... |  
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVC--SRGQPMYVVMEMMTYGDLKSYLRSR

------NETHNP------TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQ
      |..  .      .  ...    ... || |||.|||||||||.|||| .. ||||..|||..|| |.  ||     .. .||| ||| |||   
RPEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYY--RKGGKGMLPVRWMAPESLKDG

KFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYL-LQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISA
.|||.||||||||.|||  | |. ||       .  |    |  | .|| ||. ..|.|  ||. .  |||.| .... .  
VFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase MET.AA EGFR 1096-1356 38 1.2e-82 274.25 In-house 1-258 (258) Show / Hide 
Range on Protein: 1096-1356
Range on HMM: 1-258/258
Sequence Identity: 38% (102 aa)

VHFNEVIGRGHFGCVYHGTLLDNDGK--KIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHN
.    | | | || || |    . |.  ||  |.| |.  |.      .| |  .|    ||... |||.|. |.    .|  || .| | ...|.   |
LKKVKVLGSGAFGTVYKGIWIPE-GENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ--MQLVTQYMPYGCLLDYVRQHKDN

PTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWE
   ..|. ...|.||||.||  .. ||||||||| ..     ||..|||||. . ...  ..| . |.|.|.||||||... ...| .|||||.|| .||
IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAK-LLEHDEKEYHAQ-GGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWE

LMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRIS
||| |. ||  . . .|   | .| || ||. |   .| ||.|||.  ..||| | ||... .
LMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase MET.AA Fer 1096-1356 30 1.5e-74 253.27 In-house 1-283 (283) Show / Hide 
Range on Protein: 1096-1356
Range on HMM: 1-283/283
Sequence Identity: 30% (86 aa)

VHFNEVIGRGHFGCVYHG--TLLDNDGKKIH-----CAVKSL-NRITDIGEVSQFLTEGIIMKD-FSHPNVLSLLGICLRSEGSPL-VVLPYMKHGDLRN
|......|.|.|| || |  ||   .||..      ..|| .    ..  .   |. |  ||.  ..||||  . |.|   .  |. .|. ....|.|..
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQ--PIMIVMEFCNGGSLDS

FIRNETH-NPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE-KFTVK--VADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTK
... . . . .....| . .|.|.||.|| ||. .|||.||||| ... |. .|  ..|||..|.  | .| . .  .  |.|..|.| |..||  ...|
YLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPK

SDVWSFGVLLWELMTRGAPPYPD------VNTFD---ITVYLLQGRRLLQPEYCPDPLYEVML-KCWHPKAEMRPSFSELVSRIS
.|||||||..|| .|.|| |||.      ... .   . ..   |...  |. .|......|. .||. . |.||...|.. .. 
TDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase MET.AA FGFR 1195-1355 46 7.6e-72 244.15 In-house 134-293 (293) Show / Hide 
Range on Protein: 1195-1355
Range on HMM: 134-293/293
Sequence Identity: 46% (76 aa)

TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWEL
| |||. .  |||.|| ||||.| .||||||||    . .  |..|||||||  . .||    .|   ||.||||.|.|. ...|..|||||.|||||| 
TQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYY--RKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEI

MTRGAPPYPDVN-TFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRI
|| |  ||| .    ..  ||  |.|.  |. |.  .| .|  ||| |.. ||.| .||  .
MTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase MET.AA S_TKc 1096-1359 22 1.8e-48 168.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 1096-1359
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKH--GDLRNFIRNETHN
 .. ..||.| ||.|| ..  .    . ..|.| ..         ... |  |.|   |||.  |....    ..  .|. |. .  |||. .|..  ..
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

P-----TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTT-KSDVWSF
.     .  .   .  |......|. |....||||   | .|||  ..|..|||||| .           |       .|| | |   .... |.|.||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVS-----RISAIF
|..|.|... | ||.|   . . .  ..           .... . . ||..   | ||.  |.       ..   |
GCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MET.AA Pkinase 1096-1355 20 1.3e-38 137.64 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1096-1355
Range on HMM: 1-293/293
Sequence Identity: 20% (61 aa)

VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIG--EVSQFL-TEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHG----DLRNFIR
 |. ..||.| |||||...  ..       ||| ... ..    ... .. .|  ||| ..|||.. |.... . .... .|..|. .|    ||  .|.
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIS

--NETHN-PTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTV----KVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQ-TQKFTT
  ...    . .... . .|...|..|. |....||||   |...|.. ..    |..|||||. ..   | . .  |.      .|| | ..  |. ..
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KSDVWSFGVLLWELMTRGAPPYPD-----VNTFDITVYLLQGRRLLQ-PEYCP-------------------DPLYEVMLKCWHPKAEMRPSFSELVSR-
|.|.||.|..|.|....  | . .     ..   . .  ....   . |. |.                   ... ... .|.... . ||.. ...   
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-I
 .
WF
Kinase MET.AA FGFR 1096-1188 33 0.000101 11.96 In-house 1-97 (293) Show / Hide 
Range on Protein: 1096-1188
Range on HMM: 1-97/293
Sequence Identity: 33% (33 aa)

VHFNEVIGRGHFGCVYHGTLL--DND--GKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR
    ...| | || |  ..    |.|   |.|  ||| |       . |    |  .||    |.|.. ||| |   || . |.  | .|| || | |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQ-EGPLYVIVEYCHHGNLRDFLR