Gene MELK (Human)

MELK

Species: Human
Alias: MELK, HPK38, KIAA0175
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 9p13.2,

Classification

Group: CAMK
Family: CAMKL
Subfamily: MELK

Sequence

Name Sequence Type Origin Length Description Download
MELK.NA RNA Sugen Kinome 2533 None Fasta, JSON
MELK.AA Protein Sugen Kinome 651 None Fasta, JSON
MELK.kin_dom Protein Kinase Domain Sugen Kinome 253 None Fasta, JSON

Protein domain

Protein domains of MELK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MELK.AA MELK 11-263 83 5.9e-192 644.0 In-house 1-254 (254) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-254/254
Sequence Identity: 83% (212 aa)

YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETR
||.|..|||||||||||||||||..||||||||||.||.||||.|||..|||||||||||||||..||..|||||.|||||||.|||||.||||.|||||
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETR

VVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYH-LQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPF
..|||||||.||||||||||||||||||||||.|.|||||||||||.||.|||| |||||||.|||||||||||.|.|||||||||||||||||||||||
HFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPF

DDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWI
||||.|..|||||.|.|..||||||.|..||..||||||||||||||||||||.
DDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase MELK.AA CAMKL 11-263 43 5.5e-146 468.97 In-house 1-297 (297) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-297/297
Sequence Identity: 43% (131 aa)

YELHETIGTGGFAKVKLACH-ILTGEMVAIKIMDKNTLG---------------SDLPRIKTEIEALKNLR---HQHICQLYHVLETANK------IFMV
|.. .|.|.|.|.|||||.| ..|||.|||||.||. .                ||. ||. ||. .| |.   |..|..||.|.|| ..      |..|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LEYCPGGE--LFDYIISQ----DRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYH--KLKLIDFGLCAKPK-G-NKDYH-LQTCCGSLAY
.|||.|||  |||||...    .|..|.|.|  ||||||||.| ||.| .|||.||||.|.|| .  ..|.||||.... . . ... . | |.|||..|
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

AAPELIQG--KSYLGSEADVWSMGILLYVLMCGFLPFDDD--------NVMALYKKIMRGKYDVPKW--LSPSSILLLQQMLQVDPKKRISMKNLLNHPW
.|||..||  |.| | ..|.||.|..||...|| ||||||        |.  ||.|||.| |  |.|  .| . . |...||||.|.||.......||||
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

I
 
M
Kinase MELK.AA AMPK 11-263 52 3.1e-143 428.06 In-house 1-254 (254) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-254/254
Sequence Identity: 52% (135 aa)

YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTL--GSDLPRIKTEIEALKNLRHQHICQLYHVL-ETANKIFMVLEYCPGGELFDYIISQDRLSEE
| . .|||.| | |||.. |||||| |||||..|  .   ..  ||. ||. || .||.|| ||| |. ||   ||||.|| .||||||||.. .||.|.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

ETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFL
|.. .| ||.|.| |.|  . .||||||||||.|. ...|. ||||    | .    | |.|||  |||||.|.|| | | | |.|| |. ||...|| |
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDG--EFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYL

PFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWI
||||.|. .|||||. |.| .||.|||..  |...|||||| |||. . . |||| 
PFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase MELK.AA CAMK 16-263 28 2.7e-131 425.6 In-house 1-425 (425) Show / Hide 
Range on Protein: 16-263
Range on HMM: 1-425/425
Sequence Identity: 28% (123 aa)

TIGTGGFAKVKLACHILTG------------EMVAIKIMDKNTLGS---------------------------DLPRIKTEIEALKN-------LRHQHI
|.|.|.|.||||..|..|.            . |||||.||. | .                           |. ... ||| .|.       |.| .|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

CQLYHVLE------------TANK--------IFMVL---EYCPGGEL----FDYIISQ---------------DRLSEEETRVVFRQIVSAVAYVHSQG
..||.| |            | .|        ..||.   |||.||||    ||||...                |..|.|.| .||||.|||.| ||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

YAHRDLKPENLLFDEYH-----------------KLKLIDFGLCAKPKGNKDYH----------------------LQTCCGSLAYAA-PELIQG-----
 .||||||||.|.|. .                 ..|.||||. .| .......                      ..|.||...|.| ||...|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------KSYLGSEADVWSMGILLYVLMCGFLPFDDD-------------NVMALYKKIMRGKYD-VPKWLSP-----------------------SSI
        | | | ..|.||.|..||.. ||..||..|             |   |..|||.||||  |...||                       . .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

LLLQQMLQVDPKKRISMKNLLNHPWI
 |...||||||.||.. .  |||||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MELK.AA MARK 11-263 46 3.8e-120 394.36 In-house 1-262 (262) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-262/262
Sequence Identity: 46% (123 aa)

YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG--SDLPRIKTEIEALKNLRHQHICQLYHVLE--TANK-IFMVLEYCPGGELFDYIISQ--DR
|..  |||.|..||||||||..||. |||||..|. |     .  .. ||| .| | | .| .|.|| |  | .. |....||..||||.|||...   |
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYH--KLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLY
|.|||.|. |||||||| | ||.. .|||.||||.| ||    . |.||||.... | |.|   | |.||...|.|||....| | | ..|.||.|..||
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQK---LNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLY

VLMCGFLPFDDDN--VMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWI
.. || .|||.|.     ||||| |||||.|  .|..   |.|..|.|.|..|........|||.
FMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase MELK.AA S_TKc 11-263 36 1.2e-107 364.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-231/231
Sequence Identity: 36% (97 aa)

YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPG--GELFDYIISQDR-----
||....|| |.|.||... |. ||. |||||..         .|. ||. ||. .| .|..|| | .. ....||.|||.|  |.||||| .. |     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVL
 ..| ..| ...||..|..| ||.|  ||||||||.|.||   .|..||||...          |.||.. | |||..   .| . ..|.|| |..|| .
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

MCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLN-------HPWI
.||  ||.  ......|||.          ||. . .....||.||.||..   .|.       |||.
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MELK.AA QIK 11-263 40 1.1e-105 357.45 In-house 1-272 (272) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-272/272
Sequence Identity: 40% (111 aa)

YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTL-GSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDR------
|..  ||| | || |||| |. | . |||||.||  |  ..| ... |.. .| |.| ||  || |.|| . ...| |||..||.|||.... |      
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------LSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSE
              ..|.|.| .| ||.|||.| |... .||||| ||.|.|.    |..|||.    |  ..  |.|.||| .|||||. .||.| | .
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFK--QGQLLMTWCGSPPYAAPEMFEGKEYDGPK

ADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWI
.|.||||..|||| || |||| ...  | .... ||. .| ..|     |  .|| |||..|..... ..|.|.
VDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase MELK.AA CAMK1 11-263 38 1.7e-100 292.88 In-house 1-276 (276) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-276/276
Sequence Identity: 38% (107 aa)

YELHETIGTGGFAKVKLACHILT---GEMVAIKIMD--KNTLGSDL---PRIKTEIEALKN---LRHQHICQLYHVLETANKIFMVLEYCPGGELFDYII
||....||.| |..|.|..|. |   |. .|||..|  |.. ..|     ....||| .|.   . |..| ..| . |. |.. .|.|.. |||||| |.
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

SQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLF---DEYHKLK--LIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQG---KSYLGSEAD
  .  .|.. | . .||.||| | ||.| .||||||||||.   ||..|.|  ..|||| .|  ....  ..|.||.. | ||| . .   | | . . |
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGL-SKIFDHDENLMKTACGTPGYVAPEVLECKKDKPY-DKACD

VWSMGILLYVLMCGFLPFDDDN-VMALYKKIMRGKY--DVPKWLSPSSI---LLLQQMLQVDPKKRISMKNLLNHPWI
.|| |. .|.| ||. || |.|  . |..||....|  . | | . |.     .. .|| ||||||.. .  ||||||
MWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase MELK.AA Pkinase 11-263 32 3.9e-96 330.49 Pfam 1-293 (293) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-293/293
Sequence Identity: 32% (96 aa)

YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKT---EIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGG----ELFDYII--SQ
|.....|| |.|..|....|. ||..||.||..| .  |. .....   ||. .|.|.| .|..||.. |. ..| ||.|||.||    .|||||   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DRL--SEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFD-EYHK---LKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSM
 ..  ||.| . ...||.....| ||.|  ||||||||.|.| ..|    .|..||||... .  ..  ..| ||.. |.|||.|.| .| |...|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILLYVLMCGFLPFDDD------NVMALYKKIMRGKYDVPKWLS---------------------PSSILLLQQMLQVDPKKRISMKNLLNHPWI
|..|| ..|| .||...      . |.....||..... . . .                     .. . ..  .|..|||||.. . .|.|||.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MELK.AA RAD53 11-263 34 7.1e-96 286.05 In-house 1-305 (305) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-305/305
Sequence Identity: 34% (106 aa)

YELHETIGTGGFAKVKLACHILTGEMVAIKIMDK-------NTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETA-NKIFMVLEYCPGGELFDYIISQD
| . ...|.|.|..||||    |.. ||||| ||       ..  ..  .. .|.|.||.| |. | ..| . .|.    .||||.  |||||. |.|. 
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

R----LSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYH------------------KLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
|    ..| . .  |.|.. || | |..| .|||||||| |....                   ..|. |||| .|  |.. . ..| ||...| ||| |
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGL-SKFVGEGSF-MKTMCGTPQYVAPEVI

QGK---------------SYLGSEADVWSMGILLYVLMCGFLPFDDD-----NVMALYKKIMR-GKYDV--PKW--LSPSSILLLQQMLQVDPKKRISMK
 .|                | ... |.|||| .||.. ||..||.||       | |...| . ||| .  |.|   | .   | ..||.|||.||.. .
TSKGHNCYHENEERQVQVGY-TKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTID

NLLNHPWI
..|||||.
EALNHPWM
Kinase MELK.AA Ciliate-E2 11-263 24 9.8e-89 301.11 In-house 1-365 (365) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-365/365
Sequence Identity: 24% (94 aa)

YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNT--------------------LGSDLPRIKTEIEALKNLR----------------HQHICQLYH
|.... ||.|.|..|............|||| | .                       ...  || ||  .. ..                | .|...| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

VLE--TANKIFMVLEYCPGGELFDYIISQD-----------RLSEEETRVVFRQIVS---------------AVAYVHSQG-YAHRDLKPENLLFDEYHK
. .  . |.|..|.||| ||.|||||....           ...|.| . ...||..               |. | ||..   |||.||||.||     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LKLIDFGLCAKPKGNKDYHL------------------------------QTCCGSLAYAAPELIQGKSYLG--------SEADVWSMGILLYVLMCGFL
.|.|||||. | . . ....                              .|.||.. | ||| ..||.| .         ..|.||.|..|| ...| .
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFDDDNVMALYKKIMRGKYDVP----------------KW--LSPSSILLLQQ----MLQVDPKKRIS-MKNLLNHPWI
||        ...|. .|.| |                .|  .|.. . |...    |||.||.|||. .. .|||||.
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MELK.AA Ciliate-E2-Unclassified 11-263 26 2.6e-84 286.42 In-house 1-352 (352) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-352/352
Sequence Identity: 26% (92 aa)

YELHETIGTGGFAKVKLACHILTG------EMVAIKIMDKNTLGSDLPRIKTEIEALKNLR-------------------HQHICQLYHVLETANKIFMV
|.....||.|||.||... |. ..      .|  |.| ...   .   .|. |.....|.                    | .|  .... .. ..|..|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEYCPGGELFDYIISQDR-----------------LSEEETR-----VVFRQIVSAVAYVHSQG-YAHRDLKPENLLFDEYH---KLKLIDFGLCAKPKG
.|||.||.|..|| ..                   ..|....       |.||...  | |...   |||.||||.|||. .   ..|.||||.. |.. 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

N--------------KDYHLQTCCGSLAYA----APELIQGKSYLGS---EADVWSMGILLYVLMCGFLPFDDDN----------------VMALYKKIM
|              |. ...|.||.. |     |||..||. | .|   ..|.||.|..|| .. | .||.| |                 . ||..|.
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

RGKYDVPK--W------LSPSSILLLQ----QMLQVDPKKRISMKNLLNHPWI
 .....||  |      .||. . ...    .||...|.|||... .|||||.
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase MELK.AA Pkinase_Tyr 11-133 25 2.5e-17 59.3 Pfam 1-137 (270) Show / Hide 
Range on Protein: 11-133
Range on HMM: 1-137/270
Sequence Identity: 25% (35 aa)

YELHETIGTGGFAKVKLACHI----LTGEMVAIKIMDKNTLGSD---LPRIKTEIEALKNL-RHQHICQLYHVLE-TANK--IFMVLEYCPGGELFDYII
 .. ...| | | .|...        |.  ||.|.. |..  ..   .     |.. .|.| .|..| .|| |         |..|.||.|.| | ||  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

S----QDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDL
.    ...|. ..     .|| .. .| .|... ||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase MELK.AA TyrKc 11-263 20 1.1e-16 47.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-263
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNL--RHQHICQLYHVLETA-------NKIFMVLEYCPGGELFDYIISQ
 .| ...| | | .| ..  .   ..||.| . ...    .  .  |.. ...|  .|..| .|| |  .          ...|.||.|.| | ||. . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

DR-LSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGN-------KDYHLQT--CC---GSLAYAAPELIQGKSYLGS
 . |. ..      || .  .| ||... ||||   | | .| |  |  ||||. . .         . |. ..  ..     .   ||| |. . .  .
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF-TT

EADVWSMGILLY-VLMCGFLPFDD-----DNVMALYKKIMRGKYDVPKWL---------SPSSILLLQQMLQVDPKKRISMKNLLNHPWI
. |||| |.... ..  |  |  .      .   .......|..  .            ..    . .|  . ||..| .....  |  .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MELK.AA Pkinase_Tyr 176-224 28 2.875698 1.53 Pfam 182-232 (270) Show / Hide 
Range on Protein: 176-224
Range on HMM: 182-232/270
Sequence Identity: 28% (15 aa)

APELIQGKSYLGSEADVWSMGILLYVLMC-GFLP-FDDDNVMALYKKI-MRG
||| |. .    .. |||| |.|.. ..  |  | . .     .|..|  .|
APECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG
UBA_CAMKL MELK.AA UBA_CAMKL 283-321 30 4.2e-07 23.82 In-house 1-41 (41) Show / Hide 
Range on Protein: 283-321
Range on HMM: 1-41/41
Sequence Identity: 30% (13 aa)

DDDCVTELSVH--HRNNRQTMEDLISLWQY-DHLTATYLLLL
|.... |.  .    .  ...| | . . | .|.||||.|||
DEEIIQEMCKMWHGFDREEIIESLRN-NKYHNHITATYYLLL
KA1 MELK.AA KA1 605-651 27 3.7e-21 74.14 Pfam 1-48 (48) Show / Hide 
Range on Protein: 605-651
Range on HMM: 1-48/48
Sequence Identity: 27% (13 aa)

GKVTMQFELEVCQLQ-KPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
.. ...||..||... .....|....|..|..|.|| |...||.....
EPEVVKFEIQVCKVPGRLGLYGVDFKRVSGNQWQYKDLCTKILKEMRL