Gene MAST1 (Human)

MAST1

Species: Human
Alias: SAST170, MAST1, SAST, KIAA0973
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 19p13.2,

Classification

Group: AGC
Family: MAST
Subfamily: MAST

Sequence

Name Sequence Type Origin Length Description Download
MAST1.NA RNA Sugen Kinome 4933 None Fasta, JSON
MAST1.AA Protein Sugen Kinome 1570 None Fasta, JSON
MAST1.kin_dom Protein Kinase Domain Sugen Kinome 274 None Fasta, JSON

Protein domain

Protein domains of MAST1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF1908 MAST1.AA DUF1908 142-338 66 4.1e-135 459.96 Pfam 167-369 (369) Show / Hide 
Range on Protein: 142-338
Range on HMM: 167-369/369
Sequence Identity: 66% (136 aa)

SITDED---GGRRSPAVRPRSRSL-SPGRSPSSYDNEIVMMNHVYKERFPKATAQMEEKLRDFTRAYE--PDSVLPLADGVLSFIHHQIIELARDCLTKS
|..|||    |.||| .||||||| ||.||....|||||||||||||||||||.||||.| .|  ..   |.. |.|||.|. |||||..|.||||| ||
SCQDEDNNFCGCRSPHHRPRSRSLSSPSRSCITFDNEIVMMNHVYKERFPKATQQMEERLQHFIHHFKNIPCDSLRLADPVVRFIHHQVVEMARDCLHKS

RDGLITTVYFYELQENLEKLLQDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKTDIPRYIIRQLGLTRDPF
...|||  ||||.||.||.||..|.||||| ||.|.|...||||||||||||||||||| |||||||||||||.||... .|||||||||.||||.|||.
HAKLITSRYFYEMQEKLERLLHEAHERSESEEVPFITHVIKKLLIIISRPARLLECLEFDPEEFYHLLEAAEGQAKVMQGIKTDIPRYIIHQLGLNRDPI

PDV
 ..
EEM
DUF1908 MAST1.AA DUF1908 61-141 66 1e-46 166.33 Pfam 1-92 (369) Show / Hide 
Range on Protein: 61-141
Range on HMM: 1-92/369
Sequence Identity: 66% (61 aa)

PLDSPRNFSPNTPAHFSFASSR-------RADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERL----HQLPYQPTVDELHFLSKHFGSTE
|.||||||| .....| |.  |       ||||||||.|||||||||||.|||.|||.|||||||    ||||.||| |.|||||||| .||
PIDSPRNFSTSSMMNFPFVPIRRITNCRDRADGRRWSVASLPSSGYGTNPPSSNVSSQCSSQERLNQLPHQLPFQPTQDDLHFLSKHFCCTE
Kinase MAST1.AA MAST 374-647 55 4.8e-229 707.9 In-house 1-337 (337) Show / Hide 
Range on Protein: 374-647
Range on HMM: 1-337/337
Sequence Identity: 55% (187 aa)

FDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFET--RRHLCMVMEYVEGGDCATLLKNIG-ALP
|..||.||.|||||||||.|..|..|||||.||.|..|..||..|.||||.|||...||||| ||.||.|  ...|||||||.||||||.||...| ..|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

VEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEG---------------HIEKDAREFL------------
..||.||.|||||.|||||.||||||||||||.||.|.||||||||||||.|.|..|||.|||               ||.|....|             
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNKN

------------------------DKQVCGTPEYIAPEVILRQG-YGKPVDWWAMGIILYEFLVGCVPFFGDTPEE-LFGQVIS--DDILWPEG-----D
                        .||.||||.||||||||.|| ||||||||.||||.|||||||.||.|||||| .|...|.  ..| |||.     |
QIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDD

EALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFF
.... ||| ||. ||| ||..||||.|| |.||| ||
DCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase MAST1.AA MAST 374-647 52 2.2e-210 684.91 In-house 1-334 (334) Show / Hide 
Range on Protein: 374-647
Range on HMM: 1-334/334
Sequence Identity: 52% (175 aa)

FDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEM
|..||.||.||||.||||.|..|..|||||.|.|...|..|...| .|||.||....||||| ||.||.|...|||||||.||||||.||...|.....|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

ARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEG---------------HIEKDAREFL---------------
|.||.|||||.|||||..|||||||||||.||.|.||||||||||||.|.|......|||               ....|...|                
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

--------------------DKQVCGTPEYIAPEVILRQG-YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDD---ILWPEG-----DEALP
                    .||.||||.||||||||.|| .|||||||.||||.|||||||.||..|||||.|.......   | ||||     |||..
QQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMS

TEAQLLISSLLQTNPLVRLGAG-GAFEVKQHSFF
 ||| ||. ||| .|..||||. || ||||| ||
PEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase MAST1.AA AGC 374-647 29 3.2e-168 439.1 In-house 1-395 (395) Show / Hide 
Range on Protein: 374-647
Range on HMM: 1-395/395
Sequence Identity: 29% (118 aa)

FDTIKLISNGAYGAVYLVRHR------DTRQRFAMKKINKQN-LILRN--QIQQAFVE------------RDILTFAE----------NPFVVG-MFCSF
|. .|.|. |..| |||||..      || . .|||...|.   ....  ..... .|            |.||. .           .||.|  ...||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETRRH--LCMVMEYVE--------GGDCATLLKNIG-----ALPVEMARMYFAE-------TVLALEYLHN-YGIVHRD-LKPDNLLITSMGHIKLTDFG
.. .|  |..||||..        ||.| ..| . |      .. |.|| |.||       .||||||||.  ||.||| |||.|.|... |||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKMGLMS-----------LTTNLYEG---------------HIEKDA----------REFLDKQVCG--TPEYIAPEVILRQGYGKPVDWWA--MGIIL
|.|.| ..           .... ...               .. ...           ... .  ||  ||||.|||..    |||..|||.  .|...
LCKEGMNDGEKGQQSQSNMKFHW-HNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

YEFLVGCVPFFGDTPE----------ELFGQVI------SDDILWP-------EGDEALPTEAQLLISSLLQTNPLVRLGAG-------GAFEVKQHSFF
||.|.|. ||.||.|.          |.| ...      .... .|       ..|. .  ||. ||. ||. .|  |||.|       || |.|.| .|
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MAST1.AA S_TKc 374-647 32 1.7e-99 337.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 374-647
Range on HMM: 1-231/231
Sequence Identity: 32% (94 aa)

FDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEG--GDCATLLKNIGA---
.. ...|  ||.| ||..||..| ...|.|.|.          ...  |..||     |..| .. .|..  ||.|||||..|  ||  ...|. |    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYG
   .|  .|| |......||||.|. ||.||||||.|.|...  |||..||||..                        . .||||.|.||||.   |||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------TTFCGTPWYMAPEVL---GYG

K-PVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFE----VKQHSFF
| ..|||. |.||||.|.|. ||   .....| ..              . ||  .|. .|| .|  |..|  |..    .|.| .|
KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAST1.AA RSK-Unclassified 374-647 37 1.3e-91 288.03 In-house 1-283 (283) Show / Hide 
Range on Protein: 374-647
Range on HMM: 1-283/283
Sequence Identity: 37% (108 aa)

FDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLK--NIGALPV
|  ..||  |  | ||||| .|| | .|||  .|. .| .| |. .  |..|.   . ||.| .. || |.  | ..|||  |||    |       .  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

EMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMG------LMS--LTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQG
. .|.| .|...||||||  ... ||||||| .    ||..||||.||. .       |       . .  |  .   |  .  ||| ||.|||.| | |
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHG--FRTNSFCGTEEYLAPEMIRRCG

YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAG-G-AFEVKQHSFF
 .| |||| .||..|| |.|| |. |.  .|.|  .   ..  |. |. .  ... ||  ||| ||  |||.. | | ..|.| ||
HTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPH-DSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase MAST1.AA AktR 374-647 37 3.1e-88 299.43 In-house 1-268 (268) Show / Hide 
Range on Protein: 374-647
Range on HMM: 1-268/268
Sequence Identity: 37% (106 aa)

FDTIKLISNGAYGAVYLVRHR-DTRQRFAMKKINKQNLILRNQIQQAFVERDILT-FAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPV
|. .|.. .||.| ||||... |. . .||| | |...| |||....  ||.|.   . .|| | .. .|.|...|  .|||..||.  . ||... .  
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EMARMYFAETVLALEYLHNY-GIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDA-REFLDKQVCGTPEYIAPEVILR-QGYGKPV
|.|| |||. .|||||||.   |. |||||.|.|. . ||.|.|||||||              ....  .. . . .||||||.|||.|.. .|..|.|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSV

DWWAMGIILYEFLVGCVPFFG-DTPEELFGQVISDDILWPEGDEALPTEAQLLIS-SLLQTNPLVRLG--AGGAFEVKQHSFF
|||| || .|| ..|| ||.  .. .... . |.. .. ..  . .  ... ||   ||. ||  |||  . |. |.| | .|
DWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase MAST1.AA RSK 377-647 34 2.7e-81 276.37 In-house 1-278 (278) Show / Hide 
Range on Protein: 377-647
Range on HMM: 1-278/278
Sequence Identity: 34% (101 aa)

IKLISNGAYGAVYLVRHR---DTRQRFAMKKINKQNLILRNQ-IQQAFVERDILTFAE-NPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGA---
.|.   |.||.|.|.|     ||.| .||| ..|  .. |.  .  .. ||.||   .  ||.|  . .|.|  .| ..|||..||.  | |.. .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITS---MGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAR-EFLDKQVCGTPEYIAPEVIL----
.  . |..|.|| |||.|.||  ||.||||||.| | ..    |||||||||..| .               ... ... .  |.| ||.|||..     
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF---------------RCDHNQWTMTFCYTIEYMAPEMLKRANQ

RQGYGKPVDWWAMGIILYEFLVGCVPFFG---DTPEELFGQVISDDILWPEGD--EALPTEAQLLISSLLQTNPLVRLGAG--GAFEVKQHSFF
. |..| .|||  |...|| |.||.|| |   ....|.. .. . . . ....  . | .||. ||. .|. .|  |||.|  .| |.|||..|
QGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGK-FSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MAST1.AA NDR 374-523 45 1e-78 242.23 In-house 1-155 (350) Show / Hide 
Range on Protein: 374-523
Range on HMM: 1-155/350
Sequence Identity: 45% (71 aa)

FDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAE--NPFVVGMFCSFETRRHLCMVMEYVEGGDCAT---LLKNIGA
|. ||.|. ||.| |.|||..||.. .|||...|.  . .||. .   ||||.. |   ||.|| ...||    .|. ||||. |||  |   ||.. . 
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGL
.. ..|| | ||.|.|.|..|..|..|||.||||.|| . ||||||||||...|.
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGM
Kinase MAST1.AA Pkinase 374-647 28 1.1e-78 272.55 Pfam 1-293 (293) Show / Hide 
Range on Protein: 374-647
Range on HMM: 1-293/293
Sequence Identity: 28% (89 aa)

FDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFV--ERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGG----DCATLLK--N
. ... |  |..| ||. .|..|....|.|.|.|.  .  .. |...   |  |.     |..| ....||...|..|||||.|||    | .....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

IGAL--PVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHI----KLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVI
 |..  . . ...|. ... .|||.|. ||.||||||.|.|| . |||    |..||||.|               .   . .  . .||||.|.|||||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------------Y-NNS-M--TTFCGTPWYMAPEVI

L-RQGYGKPVDWWAMGIILYEFLVGCVPFFGD------TPEELFGQVISDDILWPEGDE------------------ALPTEAQLLISSLLQTNPLVRLG
. .|.||..||.|..|.||||.| |  || |.      .. ... .. . .. ...  .                  ... |.. .|...|. .|  |..
RGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT

AGGAFEVKQHSFF
   | ...|| .|
---AEQILQHPWF
Kinase MAST1.AA Akt 374-525 40 3.3e-55 174.9 In-house 1-154 (264) Show / Hide 
Range on Protein: 374-525
Range on HMM: 1-154/264
Sequence Identity: 40% (62 aa)

FDTIKLISNGAYGAVYLVRHRDTRQRF-AMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVE
|| .|..  |..| |.||.  || . . ||| . |. .| .||..... || ||    .||.|..  || |  .|..||.|. ||.  ..|.  .  . .
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

MARMYFAETVLALEYLHNYGIVHRD-LKPDNLLITSMGHIKLTDFGLSKMGLMS
 || | || .||.|.||. .|. || ||| |.|. . |||.||||||.|.....
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIK
Kinase MAST1.AA PKA 374-520 42 5.8e-53 182.28 In-house 1-149 (263) Show / Hide 
Range on Protein: 374-520
Range on HMM: 1-149/263
Sequence Identity: 42% (63 aa)

FDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVG-MFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVE
|..|... .| .| |.|.||... . .||| ..||  . ..|..    |. ||.  ..||.|  |  .| ..|.| ||||||.||.  . | . | ..  
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

MARMYFA-ETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSK
.|. | | . ||||||||.  |..||||| |.|| . ||||.|||| .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase MAST1.AA SGK 374-522 37 2.8e-51 156.36 In-house 1-175 (283) Show / Hide 
Range on Protein: 374-522
Range on HMM: 1-175/283
Sequence Identity: 37% (65 aa)

FDTIKLISNGAYGAVYLVRHRDT------------------RQRFAMKKINKQNLI-------LRNQIQQAFVER-DILTFAENPFVVGMFCSFETRRHL
|| .|.|  | .| ||.|.| |.                   . .||| ..||  |        ...      || .||     || |.   .| |   |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMG
 .||.||.||.    |.  . .|   || | || |.||||||   |..|||||.|.|  ..||..||||||.| |
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEG
Kinase MAST1.AA Akt 547-647 36 5.2e-39 122.28 In-house 162-264 (264) Show / Hide 
Range on Protein: 547-647
Range on HMM: 162-264/264
Sequence Identity: 36% (38 aa)

VCGTPEYIAPEVILRQGYGKPVDWWA-MGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLG--AGGAFEVKQ
.||||||.|||... .|..|.||||.  |...||.. |  ||. .  ...| .  . ..  |.  ...  |.. |||.||. .|  |||   ..| |.|.
FCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDK-DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKR

HSFF
| .|
HPWF
Kinase MAST1.AA SGK 548-647 38 3.9e-37 111.9 In-house 186-283 (283) Show / Hide 
Range on Protein: 548-647
Range on HMM: 186-283/283
Sequence Identity: 38% (39 aa)

CGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAG-GAFEVKQHSF
|||||| ||||.. |.... |||| .|..|||...|  ||.    .... . |. ..  | .      .|  ||  ||| .|  |||.  .. |.|.| |
CGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ---MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPF

F
|
F
Kinase MAST1.AA NDR 549-647 41 4.1e-37 111.56 In-house 243-350 (350) Show / Hide 
Range on Protein: 549-647
Range on HMM: 243-350/350
Sequence Identity: 41% (45 aa)

GTPEYIAPEVILR-QGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILW-----PEGDEA-LPTEAQLLISSLLQTNPLVRLGAGG--AF
|||.|.||||... .||.. .|||  | |.||.|||  ||..|||.| .  ...  . |       . || |  ||. ||  |.  .|  |||..|  . 
GTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVD

EVKQHSFF
|.|.|.||
EIKSHPFF
Kinase MAST1.AA PKA 547-647 37 6e-31 109.15 In-house 158-263 (263) Show / Hide 
Range on Protein: 547-647
Range on HMM: 158-263/263
Sequence Identity: 37% (41 aa)

VCGTPEYIAPEVILRQ-GYGKPVDWWAMGIILYEFLVGCVPFFGD--TPEELFGQVISDDILWPEGDEALPTEA---QLLISSLLQTNPLVRLG--AGGA
.||||||.|||.|..  |.||.||||| ||. ||.|.|  ||. .  .| ...   .. .| .|. .      |     ||..|||...  |.|   .|.
LCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDS---DANYFKDLIKKLLQVDLTKRYGNMKNGV

FEVKQHSFF
  .| | .|
NDIKNHKWF
Kinase MAST1.AA TyrKc 374-647 18 3.6e-11 -42.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 374-647
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

FDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFA--ENPFVVGMFCSFETR-------RHLCMVMEYVEGGDCATLLK
   .| . .||.| ||. . .   .  | |....        ..    |  |..    ..| .| ..    .          |..||||...||.   |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NIGA-LPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMS----LTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVI
. .  |...    .        ||||  ...||||   | |... ...| .|||||. .         .  |    .|...  |           |||.|
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML------PIRWMAPECI

LRQGYGKPVDWWAMGIILYEFLVGCVPFFGD------TPEELFGQVISDDILWPEGD--EAL-----PTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSF
    .    | |. |. ..| .  . .   .      ...|.. .| . . . .  .  . .     |.|   ....  . .|  |           |..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HEC

F
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F
Kinase MAST1.AA Pkinase_Tyr 446-520 29 1.9e-07 25.88 Pfam 81-159 (270) Show / Hide 
Range on Protein: 446-520
Range on HMM: 81-159/270
Sequence Identity: 29% (23 aa)

HLCMVMEYVEGGDCATLLKN----IGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSK
....||||...||  . |..     ..|....   . ..   ..|||.. ...||||   | |.|. ...| .||||..
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase MAST1.AA Pkinase_C 665-710 21 2e-06 25.97 Pfam 1-46 (46) Show / Hide 
Range on Protein: 665-710
Range on HMM: 1-46/46
Sequence Identity: 21% (10 aa)

HLESEDDTSYFDTRSDRYHHVNS-YDEDDTTEEEPVEIRQFSSCSPR
...|..|||.||.  .. ... .  |..  ....  . |.|. ..| 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase MAST1.AA S_TK_X 648-708 23 0.00023 13.56 SMART 1-79 (79) Show / Hide 
Range on Protein: 648-708
Range on HMM: 1-79/79
Sequence Identity: 23% (20 aa)

RDLDWTGLLR----QKAEFIPHLE----SEDDTSYFD---TRSDRYHHVNSYDEDDT------------TEEEPVEIRQFSSCS
|..|| .|..     .. |.| .     |. |||.||   |. .       .. ||.            || .| . |.|.   
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-----LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
PDZ MAST1.AA PDZ 975-1055 26 2.3e-16 61.62 SMART 1-80 (80) Show / Hide 
Range on Protein: 975-1055
Range on HMM: 1-80/80
Sequence Identity: 26% (25 aa)

KKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPAQEAG------LCAGDLITHVNG-EPVHGMVHPEVVELILKSGN-----KVAVTTTPFE
. .||...              .... .|..||||  ||      |..|| |. ||| .|| .| | ..|... ..|.     || .|  . .
GGLGFSIVG-------------GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
PDZ MAST1.AA PDZ 1002-1052 31 9.8e-10 35.9 Pfam 33-86 (86) Show / Hide 
Range on Protein: 1002-1052
Range on HMM: 33-86/86
Sequence Identity: 31% (17 aa)

HVEEG-GPAQEAG-LCAGDLITHVNGEPVHGMVHPEVVELILKSGN-KVAVTTT
.| .| |.|. .| ...|| |. .||... .| | ..|..| .|.. .|..|  
EVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ