Gene MARK4 (Human)

MARK4

Species: Human
Alias: MARK4, MARKL1, KIAA1860, Nbla00650, FLJ90097
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 19q13.2-q13.33,

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
MARK4.NA RNA Sugen Kinome 3249 None Fasta, JSON
MARK4.AA Protein Sugen Kinome 752 None Fasta, JSON
MARK4.kin_dom Protein Kinase Domain Sugen Kinome 252 None Fasta, JSON

Protein domain

Protein domains of MARK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MARK4.AA MARK 59-310 56 8.70000000001e-178 585.51 In-house 1-262 (262) Show / Hide 
Range on Protein: 59-310
Range on HMM: 1-262/262
Sequence Identity: 56% (149 aa)

YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNP-SSLQKLFREVRIMKGLNHPNIVKLFEVIE--TEKT-LYLVMEYASAGEVFDYLVSH--GR
|..|.|||.|..||||||.|..|||.|||||..|..||.  ......||..||| |.||||.|||.|||  ||.. .||.||||| ||..||...|  ||
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

MKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEA--NIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLV
..|.|||. ||||||||.|||.|||||||.|.||.|.|..   ||||.|||||.... |.||.||||.|||.|||.|..|.||||.||||||||.||..|
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

SGSLPFDGHN--LKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI
.|..|||| .  .|||....|||||..|...|..|.....|.|..|| .| |.|.|||..|.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase MARK4.AA CAMKL 59-310 49 1.6e-168 542.02 In-house 1-297 (297) Show / Hide 
Range on Protein: 59-310
Range on HMM: 1-297/297
Sequence Identity: 49% (147 aa)

YRLLRTIGKGNFAKVKLARH-ILTGREVAIKIID--KTQLNPSSLQK-----------LFREVRIMKGLN---HPNIVKLFEVIETEKT------LYLVM
||...|.|||.|.|||||.| ..||..|||||||  |....| ....           ..||..||| ||   ||||.||.|||||...      .||||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYASAGE--VFDYLVSH----GRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEA--NIKIADFGFSNEFT-L----GSKLDTFCGSPPYA
||.| ||   |||.|.|    |||.|.|||  ||||||||.|||...|||||.|.||.|||     ||||.||||||...      | ||.||||||||.
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APELFQG--KKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLK---------ELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI
|||.|||  |.||||.|||||.|||||..| | ||||. ...         ....... .........| ||....|. |. || || |..|||...| 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase MARK4.AA QIK 59-310 59 5.2e-167 561.13 In-house 1-272 (272) Show / Hide 
Range on Protein: 59-310
Range on HMM: 1-272/272
Sequence Identity: 59% (162 aa)

YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGR------
| . ||||||||| ||||||. |  .||||||||.||. . |||..||| ||| |.||.|.||..|.||.. .|.|.||.| || ||||..|||      
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------MKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVD
              |.|.||| .| ||.|||||||..|||||||||||.|||.. ||||||||||| |. |  | |.||||||||||.|.||.||||.||
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVD

IWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI
|||.||.|| ||.|.||||| .|..||.||| ||.|.||.||.|||.. |. ||..|..| | .||.. .|.
IWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase MARK4.AA NuaK 59-310 49 6.5e-145 384.18 In-house 1-252 (252) Show / Hide 
Range on Protein: 59-310
Range on HMM: 1-252/252
Sequence Identity: 49% (126 aa)

YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKE
|....| ||| . |||||. . |||||||| | |     .  . .  ||..||  ||||.|.. .|| |    . .|||||| || .||. . ... |.|
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

ARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFD
||  ||||||||||||. .|.||||| || |||.. |.|||||| || .  .  | |||||| || ||   |. | ||||| |||||.|||.| |..|||
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFD

GHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI
||. |.|   . .|.|. |   |. |.   |  |  || .| |...| .  |.
GHDFKHLVKQISQGAYYEPCKPSDACM-LIRWMLMVNPRRRATIYDICHHWWV
Kinase MARK4.AA AMPK 59-310 49 1.5e-143 428.98 In-house 1-254 (254) Show / Hide 
Range on Protein: 59-310
Range on HMM: 1-254/254
Sequence Identity: 49% (126 aa)

YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ-KLFREVRIMKGLNHPNIVKLFEVI-ETEKTLYLVMEYASAGEVFDYLVSHGRMKEK
| .  |||.| | |||.. ||||| .|||||..|. .  .. . .. ||..|.| ..||.|..|.||| ||.. ...||||.| || ||| |.|||..|.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

EARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPF
||.  | ||.|.| |||. .||||||| ||||||.. ||||.||| ||  . | .| | |||| |||||. .||.| |||||||| ||||| .. | |||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

DGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI
|  |  .|  ... |.| .| ..|......... |  .| || | ..|....| 
DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase MARK4.AA CAMK 64-310 31 1.9e-143 465.45 In-house 1-425 (425) Show / Hide 
Range on Protein: 64-310
Range on HMM: 1-425/425
Sequence Identity: 31% (136 aa)

TIGKGNFAKVKLARHILTG------------REVAIKIIDKTQLN--------------------------PSSLQKLFREVRIMKG-------LNHPNI
|.|.|.|.||||..|..|.            ..||||||||..|                           |.......||..|||        |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLFEVIE------------TEKT--------LYLVM---EYASAG----EVFDYLVSH---------------GRMKEKEARAKFRQIVSAVHYCHQKN
.||.||.|            | ..        .|.||   ||.| |    ..|||.|.|               ||..|.|||  ||||.|||||||..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKAENLLLDAE-----------------ANIKIADFGFSNEFTL------------------------GSKLDTFCGSPPYAA-PELFQG-----
||||||| ||.|||                   .||||.||||.|.|.                         | |. ||||.|.|.| ||...|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------KKYDGPEVDIWSLGVILYTLVSGSLPFDGH-------------NLKELRERVLRGKYR-VPFYMST-----------------------DCE
        |.|.||..|.||.|||||....| .||.|              |..|| |....|||.  |.|.|.                       .| 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

SILRRFLVLNPAKRCTLEQIMKDKWI
. .|. |. .| || |.||.....|.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MARK4.AA NIM1 59-310 43 2.5e-120 355.17 In-house 1-258 (258) Show / Hide 
Range on Protein: 59-310
Range on HMM: 1-258/258
Sequence Identity: 43% (113 aa)

YRLLRTIGKGNFAKVKLARHILTGREVAIKIID--KTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEK
||.   || ||| ||||. | ||   |||||.|  || .    .  | ||.  |  ..|||||.|.||.||   ..||||||. || . .    | . | 
YRFCGEIGRGNFSKVKLGVHQLTKEKVAIKIMDLDKTKMDQKTQRMLSREIQCMECMHHPNIVRLYEVVETLTRVHLVMEYARGGELYTHIHQEGKLREI

EARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTL----GSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSG
..   | ||||||   | .||||||.|||| .. ..  .|..|||||         . .|.|||||||||||||||   | |. ||.| ||..||  . |
HCKPIFAQIVSAVKHMHSRNIVHRDIKAENVMYTSNNCVKVGDFGFSCYCKMGTGANQMLNTFCGSPPYAAPELFQDEHYIGEYVDVWALGILLYFMMTG

SLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI
  ||      ..   .| |.| .| | |  |    |. |   |. | | .|.|.. |.
VMPFRAETVPKMKKCILKGQYQIPDYVSLPCHRLIRGMLKHIPTQRYTIDQMMNHQWM
Kinase MARK4.AA S_TKc 59-310 37 8.4e-112 378.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 59-310
Range on HMM: 1-231/231
Sequence Identity: 37% (99 aa)

YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASA--GEVFDYLVSHGR----
|..||.|||| |.||...||. |||.||||||.         ... ||..|.|  .|||||||..|... . ||.||||..   |..|||....||    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLV
  . | .||  ..||..|. |||...|.||||| ||.|||   .|||.|||.. ..      .||||.| | |||..   .|.....|.||.|.||| ..
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

SGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMK-------DKWI
.|  ||.  ..... ....          | .. ...|. |. .|.|| |  ....       . |.
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MARK4.AA BRSK 59-310 51 7.1e-111 374.65 In-house 1-254 (254) Show / Hide 
Range on Protein: 59-310
Range on HMM: 1-254/254
Sequence Identity: 51% (130 aa)

YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN--PSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEK
||| .| |||   .|||  |  ||. |||||| |  |   .| |.|  ||. |||  .||.. |...| |. | |||..|. | || |||||  ||.. |
YRLEKTLGKGQTGLVKLGVHCVTGKKVAIKIINKEKLSNKESMLMKVEREIAIMKLIDHPHVMKMYDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPK

EARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPF
|||  ||||.||. .|| .|| ||||| |||||| . ||||||||       .. |.| |||| || ||  .| ||||   |.|| ||||| |  | |||
EARKFFRQIISALDFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQVKDMMLHTSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPF

DGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI
|  || .| |.| || . .| .   || . ||  .  .|.|| .|..| |  | 
DDDNLRQLLEKVKRGVFHMPHFIHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY
Kinase MARK4.AA TSSK 59-310 36 3.8e-105 346.04 In-house 1-289 (289) Show / Hide 
Range on Protein: 59-310
Range on HMM: 1-289/289
Sequence Identity: 36% (106 aa)

YRLLRTIGKGNFAKVKLARHILTGRE----------------VAIKIIDKTQLNPSSLQK-LFREVRIMKG-LNHPNIVKLFEVIETEK-TLYLVMEYAS
| . ..||.|..|||..|..  . ..                |||||||..   .  |.| | ||  ||.. |.||||....| .||.    |.|||||.
YNVGKKIGHGSYAKVYCAYSKKHKCKHNPRLRDDLRIKRHTHVAIKIIDRKKAPTDYLNKFLPREIQIMRKTLKHPNIIQFYEMFETCQGKIYMVMEYAE

AGEVFDYLVSH------GRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGS------KLDTFCGSPPYAAPELF
 | ...|   .      |...|..||. |||.|||| ||| .|.|||||| ||.|||   |||..||||..... ..      .. |||||  ||||| .
HGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKHWNIKLTDFGFARYWPRDDPGRCCHLSKTFCGSYAYAAPEIL

QGKKYDGPEVDIWSLGVILYTLVSGSLPFDG--HNLKELRERVL-RG-KYRV--PFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI
.|..||.  .|.||.|||||..| |..|||   .|.. . ...  .. ...       |..| ...|. | ..| .| ....|... |.
RGIPYDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM
Kinase MARK4.AA Pkinase 59-310 35 6.2e-105 359.7 Pfam 1-293 (293) Show / Hide 
Range on Protein: 59-310
Range on HMM: 1-293/293
Sequence Identity: 35% (104 aa)

YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFR--EVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAG----EVFDYLV--SH
|...|.||.|.|..|....|. ||..||.|||.|   ... .| ..|  |..||| |||||||.|... |... .|.||||.  |    . |||.   .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRM--KEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANI----KIADFGFSNE--FTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSL
|..   |.|..  ..||.... |||...|.||||| ||.|.| . .|    ||.|||..       .| ..||||.|.|.|||. .| .|.||.||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVILYTLVSGSLPFDGH------NLKELRERVLRGKYRVPFY---------------------MSTDCESILRRFLVLNPAKRCTLEQIMKDKWI
|.||| ...| .||.||      . ... .|....... ...                     .| .| ..... | ..|.||.| |||....|.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MARK4.AA SNRK 59-310 48 7.29999999999e-103 337.7 In-house 1-254 (254) Show / Hide 
Range on Protein: 59-310
Range on HMM: 1-254/254
Sequence Identity: 48% (122 aa)

YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGR-MKEKE
| | .|.|.| || ||||||. ||  ||.|.||||..   |  .||.||| ||   |||||.|.|||.|   |||..|    ....||.. | . ..|. 
YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDL

ARAKFRQIVSAVHYCHQKNIVHRDLKAENLL-LDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPF
||  |.||. |. ||||. .|||||| || .  .    .|. ||||||.|  | ||.|.|||  |.|||.  | .|| | ||||||||||| || | .||
ARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPF

DGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI
.  |  |   ...  || ||  .|..|  .. . || .| || .||.|    |.
QEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase MARK4.AA Pkinase_Tyr 59-201 31 3e-27 92.91 Pfam 1-156 (270) Show / Hide 
Range on Protein: 59-201
Range on HMM: 1-156/270
Sequence Identity: 31% (50 aa)

YRLLRTIGKGNFAKVKLARHI----LTGREVAIKIIDKTQLNPSS--LQKLFREVRIMKGL-NHPNIVKLFEVIE-TEKT--LYLVMEYASAGEVFDYLV
 ......|.|.| .|....       |. .||.|.. | .  ..   .....||..||| | .|||||.|  |.   ..   .|.||||.  |   ||| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SH----GRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFG
.|    .. . |.     .|| ..  | ..||..|||| | | |.. .  .||.|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase MARK4.AA TyrKc 59-309 25 1.4e-26 95.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 59-309
Range on HMM: 1-280/280
Sequence Identity: 25% (75 aa)

YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGL--NHPNIVKLFEVIETE-------KTLYLVMEYASAGEVFDYLVS
 .|....| |.| .| ... .   ..||.| . .       .. . || |||. |  .|||||.|. |. ..       . |..||||.. |   ||| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HGR-MKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLG------SKLDTF----CGS--PPYA--APELFQGKKYDG
|..  . |.      || .   | |.||..|||| | | |....  .||.||| | . . .      ..  .     .|    |.   ||| .. .|.  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-

PEVDIWSLGVILYTLVS-GSLPFDG-----HNLKELRERVLRG-KYRVPFY--------MSTDCESILRRFLVLNPAKRCTLEQIMKDKW
.. |.|| || .. . . |  |  |      . .|..|.| .|   . | .        ....  .| ..    .|..|.| ..| ....
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase MARK4.AA Pkinase_Tyr 238-276 31 0.554931 3.95 Pfam 196-236 (270) Show / Hide 
Range on Protein: 238-276
Range on HMM: 196-236/270
Sequence Identity: 31% (13 aa)

DIWSLGVILYTLVS-GSLP-FDGHNLKELRERVLRGKYRVP
|.|| || .. ... |  | . |    |. |.. .  || |
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMP
UBA_CAMKL MARK4.AA UBA_CAMKL 331-368 51 3.9e-17 59.48 In-house 1-41 (41) Show / Hide 
Range on Protein: 331-368
Range on HMM: 1-41/41
Sequence Identity: 51% (21 aa)

DTKRIEVMVGM--GYTREEIKESLTSQKY-NEVTATYLLLG
| ..|. |. |  |..||||.||| ..|| |..||||.||.
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL
UBA MARK4.AA UBA 331-368 26 2.9e-09 38.02 SMART 1-38 (38) Show / Hide 
Range on Protein: 331-368
Range on HMM: 1-38/38
Sequence Identity: 26% (10 aa)

DTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLG
. ..|. ...||..|||....| ....|. .|...|. 
YEEKIDQLMEMGFDREECVQALRACNWNVEMAMNWLFS
UBA MARK4.AA UBA 330-366 21 2e-06 27.15 Pfam 1-38 (38) Show / Hide 
Range on Protein: 330-366
Range on HMM: 1-38/38
Sequence Identity: 21% (8 aa)

GDTKRIEVMVGM-GYTREEIKESLTSQKYNEVTATYLL
 | . .. .. | |..... |. | . ..|. .|.. |
IDEEMVKQLMEMTGFSMMQCKKALRACNNNVERAVEWL
KA1 MARK4.AA KA1 706-752 37 1.2e-19 69.06 Pfam 1-48 (48) Show / Hide 
Range on Protein: 706-752
Range on HMM: 1-48/48
Sequence Identity: 37% (18 aa)

PEPLSHFEVEVCQLP-RPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
...  .||..||..| |.||.|| |.||.| ......|.|.|.....|
EPEVVKFEIQVCKVPGRLGLYGVDFKRVSGNQWQYKDLCTKILKEMRL