Gene MARK2 (Human)

MARK2

Species: Human
Alias: EMK1, MGC99619, PAR-1, MARK2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 11q12-11q13 ,

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
MARK2.NA RNA Sugen Kinome 4748 None Fasta, JSON
MARK2.AA Protein Sugen Kinome 788 None Fasta, JSON
MARK2.kin_dom Protein Kinase Domain Sugen Kinome 252 None Fasta, JSON

Protein domain

Protein domains of MARK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MARK2.AA MARK 53-304 57 1.7e-180 594.51 In-house 1-262 (262) Show / Hide 
Range on Protein: 53-304
Range on HMM: 1-262/262
Sequence Identity: 57% (151 aa)

YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS-SSLQKLFREVRIMKVLNHPNIVKLFEVIE--TEKT-LYLVMEYASGGEVFDYLVAH--GR
|..|||||.|..||||||.|..||..||.||..|..||   ......||..||| |.||||.|||.|||  ||.. .||.||||||||..||..||  ||
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

MKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADM--NIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLV
..|.|||. ||||||||.|||.| |||||.|.||.|.|...  ||||.|||||.... |.||.||||.|||.|||.|..|.||||.||.|||||.||..|
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

SGSLPFDGQN--LKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM
.|..||||..  .|||....|||||.||...|..|.||....| .||..| |.|.|||..||
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase MARK2.AA CAMKL 53-304 49 2.3e-171 551.25 In-house 1-297 (297) Show / Hide 
Range on Protein: 53-304
Range on HMM: 1-297/297
Sequence Identity: 49% (149 aa)

YRLLKTIGKGNFAKVKLARH-ILTGKEVAVKIID--KTQLNSSSLQK-----------LFREVRIMKVLN---HPNIVKLFEVIETEKT------LYLVM
||..||.|||.|.|||||.| ..||..||.||||  |....  ....           ..||..||| ||   ||||.||.|||||...      .||||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYASGGE--VFDYLVAH----GRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADM--NIKIADFGFSNEFT-F----GNKLDTFCGSPPYA
||.||||   |||.|.|    |||.|.|||  ||||||||.|||.. |||||.|.||.||| ..  ||||.||||||...      |.||.||||||||.
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APELFQG--KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLK---------ELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM
|||.|||  |.||||.||.||.|||||..| | ||||.....         ....... ....|....| ||..|..| |  ||.|| |..|||...||
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase MARK2.AA QIK 53-304 58 4e-169 568.16 In-house 1-272 (272) Show / Hide 
Range on Protein: 53-304
Range on HMM: 1-272/272
Sequence Identity: 58% (160 aa)

YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR------
| . .|||||||| ||||||. | ..||.|||||.||... |||..||| |||.|.||.|.||..|.||.. .|.|.||.|.|| ||||..|||      
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------MKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVD
              |.|.||| .| ||.|||.|||.. ||||||||||.|||..|||||||||||| |. |  | |.||||||||||.|.||.||||.||
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVD

VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM
.||.||.|| ||.|.|||||..|..||.||| ||.||||.||.||| | .. |...|..| | .||.. |||
IWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase MARK2.AA AMPK 53-304 50 4.4e-148 442.67 In-house 1-254 (254) Show / Hide 
Range on Protein: 53-304
Range on HMM: 1-254/254
Sequence Identity: 50% (129 aa)

YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLNHPNIVKLFEVI-ETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
| . ||||.| | |||.. |||||..||.||..|. . ... . .. ||..|.|...||.|..|.||| ||.. ...||||.|||| ||| | |||..|.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF
||.  | ||.|.| |||.  ||||||| ||||||...||||.||| ||  . |..| | |||| |||||. .||.| |||||.|| ||||| .. | |||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

DGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM
| .|  .|  ... |.| || ..|.....|.|. |  .| || | ..|... | 
DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase MARK2.AA CAMK 58-304 31 6.8e-145 470.23 In-house 1-425 (425) Show / Hide 
Range on Protein: 58-304
Range on HMM: 1-425/425
Sequence Identity: 31% (135 aa)

TIGKGNFAKVKLARHILTG------------KEVAVKIIDKTQLN--------------------------SSSLQKLFREVRIMKV-------LNHPNI
|.|.|.|.||||..|..|.            ..||.|||||..|                            .......||..|||        |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLFEVIE------------TEKT--------LYLVM---EYASGG----EVFDYLVAH---------------GRMKEKEARAKFRQIVSAVQYCHQKF
.||.||.|            | ..        .|.||   ||.|||    ..|||.|.|               ||..|.|||  ||||.|||.|||.. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKAENLLLDADM-----------------NIKIADFGFSNEFTF------------------------GNKLDTFCGSPPYAA-PELFQG-----
||||||| ||.||| ..                 ||||.||||.|.|.                         | |. ||||.|.|.| ||...|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------KKYDGPEVDVWSLGVILYTLVSGSLPFDGQ-------------NLKELRERVLRGKYR-IPFYMST-----------------------DCE
        |.|.||..|.||.|||||....| .||.|              |..|| |....|||. .|.|.|.                       .| 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NLLKKFLILNPSKRGTLEQIMKDRWM
.|..| |  .|.|| |.||.... ||
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MARK2.AA NuaK 53-304 49 3.8e-143 379.44 In-house 1-252 (252) Show / Hide 
Range on Protein: 53-304
Range on HMM: 1-252/252
Sequence Identity: 49% (124 aa)

YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS-LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKE
|...|| ||| . |||||. . ||.|||.| | |    .   . .  ||..||  ||||.|.. .|| |    . .||||||||| .||.   ... |.|
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

ARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD
||  |||||||| |||.  |.||||| || |||.. |.|||||| || .  .. | |||||| || ||   |. | ||||| |||||.|||.| |..|||
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFD

GQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM
|.. |.|   . .|.|. |   |. |. |  . |  || .| |...| .  |.
GHDFKHLVKQISQGAYYEPCKPSDACM-LIRWMLMVNPRRRATIYDICHHWWV
Kinase MARK2.AA NIM1 53-304 44 7.89999999999e-124 365.62 In-house 1-258 (258) Show / Hide 
Range on Protein: 53-304
Range on HMM: 1-258/258
Sequence Identity: 44% (115 aa)

YRLLKTIGKGNFAKVKLARHILTGKEVAVKIID--KTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
||. . || ||| ||||. | || . ||.||.|  || .    .  | ||.  |  ..|||||.|.||.||   ..||||||.||| . .    | . | 
YRFCGEIGRGNFSKVKLGVHQLTKEKVAIKIMDLDKTKMDQKTQRMLSREIQCMECMHHPNIVRLYEVVETLTRVHLVMEYARGGELYTHIHQEGKLREI

EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTF----GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSG
..   | ||||||.  | . |||||.|||| .. .   .|..|||||         . .|.|||||||||||||||   | |. |||| ||..||  . |
HCKPIFAQIVSAVKHMHSRNIVHRDIKAENVMYTSNNCVKVGDFGFSCYCKMGTGANQMLNTFCGSPPYAAPELFQDEHYIGEYVDVWALGILLYFMMTG

SLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM
  ||      ..   .| |.| || | |  |  | .  |.  |  | | .|.|.. ||
VMPFRAETVPKMKKCILKGQYQIPDYVSLPCHRLIRGMLKHIPTQRYTIDQMMNHQWM
Kinase MARK2.AA BRSK 53-304 51 2.5e-112 379.49 In-house 1-254 (254) Show / Hide 
Range on Protein: 53-304
Range on HMM: 1-254/254
Sequence Identity: 51% (132 aa)

YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLN--SSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
||| || |||   .|||  |  ||| ||.||| |  |    | |.|  ||. |||  .||.. |...| |. | |||..|. |||| |||||  ||.. |
YRLEKTLGKGQTGLVKLGVHCVTGKKVAIKIINKEKLSNKESMLMKVEREIAIMKLIDHPHVMKMYDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPK

EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF
|||  ||||.||. .|| . | ||||| |||||| . ||||||||       .  |.| |||| || ||  .| ||||   |||| ||||| |  | |||
EARKFFRQIISALDFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQVKDMMLHTSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPF

DGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM
|  || .| |.| || . .| .   || .||.. .  .|.|| .|..| |  | 
DDDNLRQLLEKVKRGVFHMPHFIHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY
Kinase MARK2.AA S_TKc 53-304 36 9.69999999999e-111 375.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 53-304
Range on HMM: 1-231/231
Sequence Identity: 36% (97 aa)

YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASG--GEVFDYLVAHGR----
|..|..|||| |.||...||. ||..||.|||.         ... ||..|.|  .|||||||..|... . ||.||||..|  |..|||.. .||    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLV
  . | .||  ..||..|..|||.. |.||||| ||.|||   .|||.|||.. ..      .||||.| | |||..   .|.....|.||.|.||| ..
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

SGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK-------DRWM
.|  ||.  ..... ....          | .. ....| |  .|.|| |  ....       . |.
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MARK2.AA TSSK 53-304 37 1.3e-106 350.95 In-house 1-289 (289) Show / Hide 
Range on Protein: 53-304
Range on HMM: 1-289/289
Sequence Identity: 37% (107 aa)

YRLLKTIGKGNFAKVKLARHILTGKE----------------VAVKIIDKTQLNSSSLQK-LFREVRIMKV-LNHPNIVKLFEVIETEK-TLYLVMEYAS
| . |.||.|..|||..|..  . ..                ||.||||..   .  |.| | ||  ||.. |.||||....| .||.    |.|||||.
YNVGKKIGHGSYAKVYCAYSKKHKCKHNPRLRDDLRIKRHTHVAIKIIDRKKAPTDYLNKFLPREIQIMRKTLKHPNIIQFYEMFETCQGKIYMVMEYAE

GGEVFDYLVAH------GRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGN------KLDTFCGSPPYAAPELF
.| ...|  ..      |...|..||. |||.||||.||| . .|||||| ||.||| . |||..||||..... .       .. |||||  ||||| .
HGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKHWNIKLTDFGFARYWPRDDPGRCCHLSKTFCGSYAYAAPEIL

QGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--QNLKELRERVL-RG-KYRI--PFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM
.|..||.  .||||.|||||..| |..|||   .|.. . ...  .. ....      |..| .|... | ..|..| ....|... ||
RGIPYDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM
Kinase MARK2.AA SNRK 53-304 48 5.5e-106 348.08 In-house 1-254 (254) Show / Hide 
Range on Protein: 53-304
Range on HMM: 1-254/254
Sequence Identity: 48% (123 aa)

YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKE
| | ||.|.| || ||||||. ||. ||||.||||..   |  .||.||| ||.  |||||.|.|||.|   |||..|   |....||.. | . ..|. 
YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDL

ARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMN-IKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF
||  |.||. |..||||. .|||||| || .    .  .|. ||||||.|  |.||.|.|||  |.|||.  | .|| | ||.|||||||| || | .||
ARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPF

DGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM
.  |  |   ...  || .|  .|..| .|... |. .| || .||.|    |.
QEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase MARK2.AA Pkinase 53-304 35 9.60000000001e-106 362.4 Pfam 1-293 (293) Show / Hide 
Range on Protein: 53-304
Range on HMM: 1-293/293
Sequence Identity: 35% (106 aa)

YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFR--EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGG----EVFDYLV--AH
|.....||.|.|..|....|. |||.||||||.|   .|. .| ..|  |..||| |||||||.|... |... .|.||||. ||    . |||.   .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRM--KEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNI----KIADFGFSNE--FTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL
|..   |.|..  ..||.....|||.. |.||||| ||.|.| ...|    ||.|||..       .  ..||||.|.|.|||. .| .|.||.||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVILYTLVSGSLPFDGQ------NLKELRERVLRGKYRIPFY---------------------MSTDCENLLKKFLILNPSKRGTLEQIMKDRWM
|.||| ...| .||.|.      . ... .|....... ...                     .| .|  ..|. | ..|.|| | |||... |.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MARK2.AA TyrKc 53-303 26 3.6e-28 100.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 53-303
Range on HMM: 1-280/280
Sequence Identity: 26% (77 aa)

YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVL--NHPNIVKLFEVIETE-------KTLYLVMEYASGGEVFDYLVA
 .|.|..| |.| .| ... .    .|||| . .       .. . || |||. |  .|||||.|. |. ..       . |..||||...|   ||| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HGR-MKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFG------NKLDTF----CGS--PPYA--APELFQGKKYDG
|..  . |.      || .  .| |.| ..|||| | | |....  .||.||| | . . .       .  .     .|    |.   ||| .. .|.  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-

PEVDVWSLGVILYTLVS-GSLPFDG-----QNLKELRERVLRG-KYRIPFY--------MSTDCENLLKKFLILNPSKRGTLEQIMKDRW
.. |||| || .. . . |  |  |      . .|..|.| .|   ..| .        ....  .. |.    .|..| | ..| ....
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase MARK2.AA Pkinase_Tyr 53-195 32 8e-28 94.85 Pfam 1-156 (270) Show / Hide 
Range on Protein: 53-195
Range on HMM: 1-156/270
Sequence Identity: 32% (51 aa)

YRLLKTIGKGNFAKVKLARHI----LTGKEVAVKIIDKTQLNSSS--LQKLFREVRIMKVL-NHPNIVKLFEVIE-TEKT--LYLVMEYASGGEVFDYLV
 ...|..|.|.| .|....       |. .||||.. | .  ..   .....||..||| | .|||||.|  |.   ..   .|.||||. .|   ||| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AH----GRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFG
.|    .. . |.     .|| .. .| ..| ..|||| | | |.. .. .||.|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase MARK2.AA Pkinase_Tyr 232-270 34 0.032582 8.12 Pfam 196-236 (270) Show / Hide 
Range on Protein: 232-270
Range on HMM: 196-236/270
Sequence Identity: 34% (14 aa)

DVWSLGVILYTLVS-GSLP-FDGQNLKELRERVLRGKYRIP
|||| || .. ... |  | . |    |. |.. .  || |
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMP
UBA_CAMKL MARK2.AA UBA_CAMKL 325-362 41 3.1e-16 56.28 In-house 1-41 (41) Show / Hide 
Range on Protein: 325-362
Range on HMM: 1-41/41
Sequence Identity: 41% (17 aa)

DPRRTELMVSM--GYTREEIQDSLVGQRY-NEVMATYLLLG
|... ..|..|  |..|||| .||  ..| |...|||.||.
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL
UBA MARK2.AA UBA 325-362 26 4.7e-09 37.33 SMART 1-38 (38) Show / Hide 
Range on Protein: 325-362
Range on HMM: 1-38/38
Sequence Identity: 26% (10 aa)

DPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLG
.  . . ...||..|||....|  . .|. ||...|. 
YEEKIDQLMEMGFDREECVQALRACNWNVEMAMNWLFS
UBA MARK2.AA UBA 324-360 18 6.5e-05 21.56 Pfam 1-38 (38) Show / Hide 
Range on Protein: 324-360
Range on HMM: 1-38/38
Sequence Identity: 18% (7 aa)

KDPRRTELMVSM-GYTREEIQDSLVGQRYNEVMATYLL
 |.   . ...| |..... .. |    .|. .|.. |
IDEEMVKQLMEMTGFSMMQCKKALRACNNNVERAVEWL
KA1 MARK2.AA KA1 742-788 43 1.1e-22 79.31 Pfam 1-48 (48) Show / Hide 
Range on Protein: 742-788
Range on HMM: 1-48/48
Sequence Identity: 43% (21 aa)

HEDFVQWEMEVCKLP-RLSLNGVRFKRISGTSMAFKNIASKIANELKL
 .  |..|..|||.| ||.|.||.|||.|| ....|....|| .|..|
EPEVVKFEIQVCKVPGRLGLYGVDFKRVSGNQWQYKDLCTKILKEMRL