Gene MAP2K6 (Human)

MAP2K6

Species: Human
Alias: MAP2K6, PRKMK6, SAPKK3, MAPKK6, MEK6, MKK6
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 17q24.3-25,

Classification

Group: STE
Family: STE7
Subfamily: MEK3

Sequence

Name Sequence Type Origin Length Description Download
MAP2K6.NA RNA Sugen Kinome 2873 None Fasta, JSON
MAP2K6.AA Protein Sugen Kinome 334 None Fasta, JSON
MAP2K6.kin_dom Protein Kinase Domain Sugen Kinome 262 None Fasta, JSON

Protein domain

Protein domains of MAP2K6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAP2K6.AA MEK3 53-314 76 2.4e-236 791.46 In-house 1-264 (264) Show / Hide 
Range on Protein: 53-314
Range on HMM: 1-264/264
Sequence Identity: 76% (201 aa)

LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVID-KGQTIP
...|.||||||||.|.||||..||.||||||||.|||||||||.|||.||.||..|||.||.||||.|||||||||||.|||.|||||..|.. .|..||
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHIP

EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELA
||||||||.|||.||...|..|.||||||||||||||. |||||||||||||||||.|||||||||||||||||.||.|||||.||||.|||||||||.|
EDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMA

ILRFPYDSWGTPFQQLKQVVEEPSPQLPADK-FSAEFVDFTSQCLKKNSKERPTYPELMQHPFF
|.|.|||.|.|||||||||||||.||||..| ||....||..||||||..|||.|||||.|||.
IGRYPYDNWHTPFQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase MAP2K6.AA STE7 53-314 55 8.60000000001e-184 616.88 In-house 1-288 (288) Show / Hide 
Range on Protein: 53-314
Range on HMM: 1-288/288
Sequence Identity: 55% (161 aa)

LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS-QEQKRLLMDLDISMRTVDCPFTVTFYGALFREGD--VWICMELMD-TSLDKFYKQVID---
|| | |||.|.||||.||||.|||.||||||||.|.|. .|||..||.||. ... |||..|.||||...|||  .|||||.|| ..|||||| | .   
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

--KGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV-AKTIDAGCKPYMAPERINPELNQKGYSVKSDIWS
  |. .|||.|||||||...|.|..||.|...|||||||||.|.|  ||||.|||||.|.||||. |.| ..||.||||||||..  |...|.|.||.||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG--NKQHYDVRSDVWS

LGITM-IELAILRFPYDSWGT-----------------PFQQLKQVVEE-PSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ-HPFF
||||| ||.|..|.||..| |                 .|.||...|.| |.|.||  |||.||.|| ..||.|. .|||.|..||. |||.
LGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP--KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase MAP2K6.AA MEK4 53-314 52 3.8e-151 496.72 In-house 1-275 (275) Show / Hide 
Range on Protein: 53-314
Range on HMM: 1-275/275
Sequence Identity: 52% (143 aa)

LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVN-----SQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDK
|. . |.|.||.|.| ||.| .||.||||||||  .|        |||||||..|  |.  .||  | ||||.|.||| ||||||||.|.||||| | ..
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV

GQT-IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGI
 .. |||.|.|.|.| .|.||..|  .. .|||||||||.|... | || |||||.|.||||.||| ||||.|||||||| || |. || ..||.|||||
QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGI

TMIELAILRFPYDSWG--TPFQQLKQVVEEPSPQLPADKF----SAEFVDFTSQCLKKNSKERPTYPELMQHPFF
||.|.|  .|||. |     | |...||.  .|.|  |..    | ....|   || |. ..|| | .| ..||.
TMYEVATGKFPYRKWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase MAP2K6.AA MEK7 53-314 46 1.6e-117 396.72 In-house 1-269 (269) Show / Hide 
Range on Protein: 53-314
Range on HMM: 1-269/269
Sequence Identity: 46% (125 aa)

LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDK-GQTIP
|. | ..| |  | | ||||  || |||||  | | |. | || |||||.     |||. |. .|.. .. |||||||.| | .||  | .       ||
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFIP

EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP-ELNQKGYSVKSDIWSLGITMIEL
| |.||. |.|..||. |  | ...||||||||.|.   |..| ||||||| .||| |.|  ||| .||||||| | . |.  | . .|.||||||..||
EQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVEL

AILRFPYDSWGTPFQQLKQVVEE--PSPQLPADK---FSAEFVDFTSQCLKKNSKERPTYPELMQHPFF
|  ..||    . |  .  . ..  ..| ||  .   || .| .|  .||.|. ..|| |..|||||| 
ATGQYPYPGCDMEFEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase MAP2K6.AA STE 53-314 30 2.3e-109 369.61 In-house 1-359 (359) Show / Hide 
Range on Protein: 53-314
Range on HMM: 1-359/359
Sequence Identity: 30% (112 aa)

LEPIMELGRGAYG-VVEKMRHVPS--------------GQIMAVKRIR----------------ATVNSQEQKRLLMDLDISMRTVD-CPFTVTFYGALF
.| | ..|.||.| |. .|.| ..              |.|||.|...                 ..|..|....|....| ..  . .|. |..||. |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

REG-------DVWICMELMD-TSLDKFYKQVIDKGQT----------IPEDILGKIAVSIVKA-LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS
.||       ..|||||.||  |||...|..  .|..          .||.....|...|.|. |..|||.  .||||.||.|.|.     || ||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

GYLVDSVA----------------KT-IDAGCKPYMAPERINPELNQ--KGYSVKSDIWSLGITMIELAILRFPY-------DSWGTP--------FQQL
| |.||.|                |.  ..|.  .||||.|... .   |||..|.||||||.|.||.|  . |.         . .|        |.||
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

KQVVEEPSPQLPAD------------------KFSAEFVDFTSQCLKKNSKERPTYPELMQ--HPFF
 ..|..|.|.|| .                  |.| || || ..||.|. ..|||. .|..  |||.
-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP2K6.AA STE7-Unclassified 53-314 38 4.2e-103 348.85 In-house 1-301 (301) Show / Hide 
Range on Protein: 53-314
Range on HMM: 1-301/301
Sequence Identity: 38% (117 aa)

LEPIMELGRGAYGVVEKMRHVP------SGQIMAVKRIRATVN-SQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGD---VWICMELMDT-SLD---K
|| . .||.|..|.|.| .|..      .| ||| | |.   | .  .| .|. | .   .  .|. |..||| . |.    . ||||.||  |||   .
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

FYKQVID----KGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV--AKTIDAGCKPYMAPERINPE-LNQ
 ||..      .| .||| .||||| .. ..|..|| |. .||||.||.|.|.|. |||| ||||..| |....  |||  .||  ||.||||. .  . 
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKT-WVGCQMYMSPERIQGQMPHR

KGYSVKSDIWSLGITMIELAILRFPYD------SWGTP--------FQQLKQVVEEPSPQLPADK----FSAEFVDFTSQCLKKNSKERPTYPELMQ-HP
 .|||||||||||.| .|.|....||.                   .. |  .|..|.|.|| |.    .|.|| || |.|.||...|||.. .|   ||
PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHP

FF
. 
WI
Kinase MAP2K6.AA MEK5 53-314 44 1e-82 281.11 In-house 1-254 (254) Show / Hide 
Range on Protein: 53-314
Range on HMM: 1-254/254
Sequence Identity: 44% (119 aa)

LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPE
.     || |  | | |  |||||.|.||| |   .  . ||... .|.| .   | |. . |||| | |  . || | ||      |..       |||
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-LYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYRC-------IPE

DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI
 |||...|.||| |. | . | ..||||||||.|.|  ||.|.||||.|  ||.|...|   |   |||||||  .     | . ||.||||| ..|.|.
HILGRMTVAIVKGLNYLWN-LKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERISGDQ----YGIHSDVWSLGIFFMEMAT

LRFPY-----DS-WGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF
 ||||     |     | | |. .|.| .| || ||||. ||.|  ||..|  |.||   .|||||| 
GRFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase MAP2K6.AA S_TKc 53-314 28 1.7e-76 261.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 53-314
Range on HMM: 1-231/231
Sequence Identity: 28% (78 aa)

LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDT---SLDKFYKQVIDKG--
 | . ..|.||.|.| | ||. .|.|.|.|.|.        ....  ..| ..  ..|. |..|..    ......||..|.   .| .. |.   .|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSV-KSDIWSLGIT
. .||    ...  |..|||..||.  .||||.||.|.|..   ..| ||||..  |      |   |   ||||| .       ||.  |.|.||.|..
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCI

MIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ-------HPFF
..|..  . |..   .... .|...            | |. || ..||.|. ..|||  |..|       ||.|
LYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAP2K6.AA MEK1 53-256 43 1.4e-64 219.49 In-house 1-195 (297) Show / Hide 
Range on Protein: 53-256
Range on HMM: 1-195/297
Sequence Identity: 43% (89 aa)

LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIP
.| | ||| |  ||| |.|| ..| ||| | |.  .    .. .. .| . .     |. | |||| . .|.. |||| ||  |||   |..    . ||
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA----GRIP

EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELA
|.||||..| ... |  |. |  ..||||||||.|.|. | .|.||||.|| |.||.|     | . ||.|||    |    |.|.|||||.|. ..|.|
EKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPER----LQGTHYTVQSDIWSMGLSLVEMA

ILRFP
| |.|
IGRYP
Kinase MAP2K6.AA STE20 53-314 31 6.3e-58 198.77 In-house 1-288 (288) Show / Hide 
Range on Protein: 53-314
Range on HMM: 1-288/288
Sequence Identity: 31% (91 aa)

LEPIMELGRGAYGVVEKMRHVPSGQI----MAVKRIRATVNS---QEQKRLLMDLDISMRTVDCPFTVTFYGALFRE----GDVWICMELMDT-SLDKFY
 | . ..|.|.||.| | .|.|.|..     |.|..     .   .|.. ..   .| |.  ..|  |..||. ...     . ||.||...  ||   .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISI-MKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

KQVIDKGQ-----TIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD-------SVAKTIDAGCKPYMAPERINPE
|... .|.     .. |.    |   ....|..|||.  .||||.|  |.|..  |.|| .||| .. | .       .  .|.  |   .|||| |. .
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTF-VGTPYWMAPEVIQCM

LN-QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV--EEPSPQLP---ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF
 .  |||  |.|||||||| ||.|  . || .   |.. . ..    .|.| |     .|.| || || ..|| |. ..|||  .|..|||.
EGPDKGYDYKCDIWSLGITAIEMAEGEPPY-FDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP2K6.AA Pkinase 53-314 26 2.1e-55 195.18 Pfam 1-293 (293) Show / Hide 
Range on Protein: 53-314
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLL---MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDT-----SLDKFYKQVI
.. .  .|.|..|.| | .|. .|.| |||.|.   .. .... .   . . | |. ...|. |..|..  ........||...      .|      .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQI-MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF----DYI

D--KGQTI--PEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQV----KMCDFGISG---YLVDSVAKTIDAGCKPYMAPERINPELNQKG
   .. ..  .|. . ...  |...||..||  ..||||.||.|.||.  |..    | ||||..    |  .| ..|. .|  .||||| |.    ...
STWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF-CGTPWYMAPEVIR---GGQY

YSVKSDIWSLGITMIELAILRFPYDSWG----TPFQQLKQVVEEPSPQLPADKF----------------------SAEFVDFTSQCLKKNSKERPTYPE
|. |.|.||.|....|..  |.|..       .   |.. ...  .|.|. | .                      | |. || . ||.|. |.||| ..
YGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LMQHPFF
..|||.|
ILQHPWF
Kinase MAP2K6.AA TKL 59-312 16 1.5e-42 147.72 In-house 1-364 (364) Show / Hide 
Range on Protein: 59-312
Range on HMM: 1-364/364
Sequence Identity: 16% (61 aa)

LGRGAYGVVEKMRHVP--------SGQIMAVKRIRATVNSQEQKRL---------------------LMDLDI----SMRTVDCPFTVTFYGALFREGD-
.|.|..|.| | ..          .|. .|||... . .. . | .                     ...  .    .|.  ..|  | |.|. ..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------VWICMELM-DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS-------KLSVIHRDVKPSNVLINALGQ------------
             .| ||..   ||  ..            . . ..| .| .....|||       |  .|||| |..|.|..  ..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--VKMCDFGISGYL--------------------VDSVAKTIDAGCKPYMAPERINPELN------------QKGYSVKSDIWSLGITMIELAILRFPYD
  .| ||||.|  .                    . . ..    | . .|||| .. ..|            .. || |.|..| || . |..  . ||.
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

SWGTPFQQ---------LKQVVEEPSPQLP-----------ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHP
  . . ..          . ...   | .|            . .  .. .   .| . . ..||.  |.... 
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MAP2K6.AA TyrKc 53-314 24 1.7e-15 27.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 53-314
Range on HMM: 1-280/280
Sequence Identity: 24% (73 aa)

LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTV--DCPFTVTFYGALFRE-------GDVWICMELMDT-SLDKFYKQ
.. . .||.||.|.| | .     .  ||| ...      .. ..  . | |. .  . |  | .||.   .       . ..| ||.|.  .|... . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARI-MCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

VIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS-------VAKTIDA--GCKP-----YMAPERINPE
  .|   .. . | .... | .  |.||||  .||||    |.|... ..|| .||| | .. |          ..     |.|       |||| |   
HRPK---LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

LNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWG-----TPFQQLKQVVEEP-SPQLPAD-------KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF
 | . .. |||.|| |..| |.  .   ||  .|      . |.. . |..   .  |..         ..|  .  .|| . . ..|||  |.  | .|
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPY--PGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MAP2K6.AA MEK1 264-314 47 2.4e-14 44.95 In-house 247-297 (297) Show / Hide 
Range on Protein: 264-314
Range on HMM: 247-297/297
Sequence Identity: 47% (24 aa)

FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF
|  |  .|.|| |.||   || ||.|| ..||.|| .|| .  .||.|.|.
FEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase MAP2K6.AA Pkinase_Tyr 53-250 27 1.3e-11 39.98 Pfam 1-207 (270) Show / Hide 
Range on Protein: 53-250
Range on HMM: 1-207/270
Sequence Identity: 27% (58 aa)

LEPIMELGRGAYGVVEKMRHV----PSGQIMAVKRIRATVNSQE--QKRLLMDLDISMRTV-DCPFTVTFYGALF-REGD--VWICMELMDT-SLDKFYK
.. . .||.||.|.| | .        ..  ||| .. .  ...  .. ..  . | |..  ..|  | .||.   ...   ..| ||.|   .|... .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKI-MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

QV-IDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDS---VAKTIDAGCKPYMAPERINPELNQKGYSV
.   ||..  ..| | .... | |..|.|.||   ||||.   |.|..  ..|| |||| . ..  |.   ....      . |||| ||       ...
KHREDKQPLTMKD-LLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK----FTT

KSDIWSLGITMIEL
|||.|| |..| |.
KSDVWSFGVLMWEI