Gene MAP2K3 (Human)

MAP2K3

Species: Human
Alias: MAP2K3, MEK3, PRKMK3, MKK3, MAPKK3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 17p11.1-p11.2,

Classification

Group: STE
Family: STE7
Subfamily: MEK3

Sequence

Name Sequence Type Origin Length Description Download
MAP2K3.NA RNA Sugen Kinome 2319 None Fasta, JSON
MAP2K3.AA Protein Sugen Kinome 347 None Fasta, JSON
MAP2K3.kin_dom Protein Kinase Domain Sugen Kinome 262 None Fasta, JSON

Protein domain

Protein domains of MAP2K3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAP2K3.AA MEK3 64-325 76 5.2e-237 793.67 In-house 1-264 (264) Show / Hide 
Range on Protein: 64-325
Range on HMM: 1-264/264
Sequence Identity: 76% (201 aa)

LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLD-KNMTIP
.|.|.||||||||.|.|.||.||||||||||||.|||||||||.|||.||.||..||.|||.||||.|||||||||||.|||.||||||.|.. ..|.||
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHIP

EDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMA
|||||.||.|||.||...|..|.||||||||||||||..|.|||||||||||||||.|||.|||||||||||||.||.|||||.||||||||||||||||
EDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMA

ILRFPYESWGTPFQQLKQVVEEPSPQLPADR-FSPEFVDFTAQCLRKNPAERMSYLELMEHPFF
|.|.||..|.|||||||||||||.||||... |||...||..|||.||..||.||.|||||||.
IGRYPYDNWHTPFQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase MAP2K3.AA STE7 64-325 53 2.5e-180 605.37 In-house 1-288 (288) Show / Hide 
Range on Protein: 64-325
Range on HMM: 1-288/288
Sequence Identity: 53% (156 aa)

LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNS-QEQKRLLMDLDINMRTVDCFYTVTFYGALFREGD--VWICMELMD-TSLDKFYRKVLD---
|..|.|||.|.||||.|.|| .||.||||||||.|.|. .|||..||.||..... || |.|.||||...|||  .|||||.|| ..|||||..|..   
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

--KNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSV-AKTMDAGCKPYMAPERINPELNQKGYNVKSDVWS
  |. .|||.||| |||.....|..||.|...|||||||||.|.|..|.||.|||||.|.||||. |.|...||.||||||||..  |...| |.|||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG--NKQHYDVRSDVWS

LGITM-IEMAILRFPYESWGT-----------------PFQQLKQVVEE-PSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELME-HPFF
||||| ||||..|.||..| |                 .|.||...|.| |.|.||   |||||.|| ..||.|.| || .| .||. |||.
LGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP--KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase MAP2K3.AA MEK4 64-325 51 8.3e-150 492.27 In-house 1-275 (275) Show / Hide 
Range on Protein: 64-325
Range on HMM: 1-275/275
Sequence Identity: 51% (141 aa)

LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIR-ATVN-----SQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLD-
|  ..|.|.||.|.| | .| .|| ||||||||  .|        |||||||..|  |.  .| | | ||||.|.||| ||||||||.|.||||. | . 
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV

KNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGI
..  |||.|.| |.| .|.||..|  .. .|||||||||.|.. .| || |||||.|.||||.|||.||||.|||||||| || |. || ..||||||||
QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGI

TMIEMAILRFPYESWG--TPFQQLKQVVEEPSPQLPADRF----SPEFVDFTAQCLRKNPAERMSYLELMEHPFF
||.| |  .|||. |     | |...||.  .|.|  | .    |.....| . ||.|.  .| .| .| ..||.
TMYEVATGKFPYRKWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase MAP2K3.AA MEK7 64-325 44 3e-113 382.52 In-house 1-269 (269) Show / Hide 
Range on Protein: 64-325
Range on HMM: 1-269/269
Sequence Identity: 44% (121 aa)

LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDK-NMTIP
|  |...| |  | | |.|| .||.|||||  | | |. | || |||||.     || | |. .|.. .. |||||||.| | .||  ...       ||
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFIP

EDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINP-ELNQKGYNVKSDVWSLGITMIEM
| |.| . |.|. ||. |  | ...||||||||.|.   | .| ||||||| .||| |.|  ||| .||||||| | . |.  | . .||||||||..|.
EQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVEL

AILRFPYESWGTPFQQLKQVVEE--PSPQLPADR---FSPEFVDFTAQCLRKNPAERMSYLELMEHPFF
|  ..||.   . |  .  . ..  ..| ||      |||.| .|  .||.|.. .|  | .||.||| 
ATGQYPYPGCDMEFEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase MAP2K3.AA STE 64-325 29 2.8e-106 359.4 In-house 1-359 (359) Show / Hide 
Range on Protein: 64-325
Range on HMM: 1-359/359
Sequence Identity: 29% (108 aa)

LVTISELGRGAYG-VVEKVRHAQS--------------GTIMAVKRIR----------------ATVNSQEQKRLLMDLDINMRTVD-CFYTVTFYGALF
.  |...|.||.| |. ...| ..              |.|||.|...                 ..|..|....|....| ..  . . . |..||. |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

REG-------DVWICMELMD-TSLDKFYR------KVLDKN----MTIPEDILGEIAVSIVRA-LEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGIS
.||       ..|||||.||  |||....      | |..|     ..||.... |...|... |..|||.  .||||.||.|.|.     || ||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

GYLVDSVA----------------KT-MDAGCKPYMAPERINPELNQ--KGYNVKSDVWSLGITMIEMAILRFPY-------ESWGTP--------FQQL
| |.||.|                |.  ..|.  .||||.|... .   |||..|.|.||||.|.||||  . |.         . .|        |.||
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

KQVVEEPSPQLPAD------------------RFSPEFVDFTAQCLRKNPAERMSYLELME--HPFF
 ..|..|.|.|| .                  ..|||| || ..||.|.| .| .. .|..  |||.
-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP2K3.AA STE7-Unclassified 64-325 36 1.3e-97 330.62 In-house 1-301 (301) Show / Hide 
Range on Protein: 64-325
Range on HMM: 1-301/301
Sequence Identity: 36% (110 aa)

LVTISELGRGAYGVVEKVRHAQ------SGTIMAVKRIRATVN-SQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGD---VWICMELMDT-SLD---K
|.....||.|..|.|.|..|        .|.||| | |.   | .  .| .|. | ..  .  . | |..||| . |.    . ||||.||  |||   .
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

FYRKVLD----KNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSV--AKTMDAGCKPYMAPERINPE-LNQ
 | |..     .  .||| .|| || .. ..|..|| |. .||||.||.|.|.|..| || ||||..| |....  |||. .||  ||.||||. .  . 
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTW-VGCQMYMSPERIQGQMPHR

KGYNVKSDVWSLGITMIEMAILRFPYE------SWGTP--------FQQLKQVVEEPSPQLPADR----FSPEFVDFTAQCLRKNPAERMSYLELME-HP
 .| ||||.||||.| .|.|....|||                   .. |  .|..|.|.|| |.    .|.|| || ..|. |.| || .. .| . ||
PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHP

FF
. 
WI
Kinase MAP2K3.AA MEK5 64-325 42 8.3e-78 264.8 In-house 1-254 (254) Show / Hide 
Range on Protein: 64-325
Range on HMM: 1-254/254
Sequence Identity: 42% (114 aa)

LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPE
.     || |  | | |  |  || |.||| |   .  . ||... .|.| .   |  | . |||| | |  . || | ||      ||.       |||
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-LYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYRC-------IPE

DILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAI
 ||| ..|.||. |. | . | ..||||||||.|.| .|..|.||||.|  ||.|...|   |   |||||||  .     | . |||||||| ..|||.
HILGRMTVAIVKGLNYLWN-LKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERISGDQ----YGIHSDVWSLGIFFMEMAT

LRFPYESWG------TPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFF
 ||||           | | |. .|.| .| || |.||  ||.|  ||..| | .|    .||.||| 
GRFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase MAP2K3.AA S_TKc 64-325 27 6.6e-75 256.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 64-325
Range on HMM: 1-231/231
Sequence Identity: 27% (76 aa)

LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT---SLDKFYRKVLD--KN
   . ..|.||.|.| |.||  .| |.|.|.|.        ....  ..| ..  .. . |..|..    ......||..|.   .| .. .|     ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

MTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNV-KSDVWSLGIT
  .||     ..  |..|||..||.  .||||.||.|.|...  |.| ||||..  |      |   |   ||||| .       ||.  |.|.||.|..
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCI

MIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELME-------HPFF
..||.  . |..   .... .|...            |||. ||  .||.|.|..|..  |...       ||.|
LYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAP2K3.AA MEK1 64-267 42 4.9e-62 210.68 In-house 1-195 (297) Show / Hide 
Range on Protein: 64-267
Range on HMM: 1-195/297
Sequence Identity: 42% (88 aa)

LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMD-TSLDKFYRKVLDKNMTIP
. .|.||| |  ||| |.|| ..| ||| | |.  .    .. .. .| . .      | | |||| . .|.. |||| ||  |||   .|.      ||
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA----GRIP

EDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMA
|.||| ..| ..| |  |. |  ..||||||||.|.| .| .|.||||.|| |.||.|     | . ||.|||    |    | |.||.||.|. ..|||
EKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPER----LQGTHYTVQSDIWSMGLSLVEMA

ILRFP
| |.|
IGRYP
Kinase MAP2K3.AA STE20 64-325 29 1.2e-59 204.51 In-house 1-288 (288) Show / Hide 
Range on Protein: 64-325
Range on HMM: 1-288/288
Sequence Identity: 29% (85 aa)

LVTISELGRGAYGVVEKVRHAQSGTI----MAVKRIRATVNS---QEQKRLLMDLDINMRTVDCFYTVTFYGALFRE----GDVWICMELMDT-SLDKFY
   . ..|.|.||.| |..| ..| .     |.|..     .   .|.. ..   .| |.  .. . |..||. ...     . ||.||...  ||   .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISI-MKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

RKVLDKNM-----TIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVD-------SVAKTMDAGCKPYMAPERINPE
.... ..      .. |.    |   ....|..|||.  .||||.|  |.|....| || .||| .. | .       .  .|.  |   .|||| |. .
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTF-VGTPYWMAPEVIQCM

LN-QKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVV--EEPSPQLP---ADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFF
 .  |||. |.|.|||||| ||||  . ||     |.. . ..    .|.| |     ...|||| || ..|| |.|..| .  .|..|||.
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDM-HPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP2K3.AA Pkinase 64-325 24 1.5e-51 182.42 Pfam 1-293 (293) Show / Hide 
Range on Protein: 64-325
Range on HMM: 1-293/293
Sequence Identity: 24% (76 aa)

LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLL---MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-----SLDKFYRKVL
..... .|.|..|.| | .|  .| | |||.|.   .. .... .   . . | |. ... . |..|..  ........||...      .|    . . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQI-MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF---DYIS

-DKNMTI--PEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHV----KMCDFGISGY--LVDSVAKTMDAGCKPYMAPERINPELNQKGYN
 ... ..  .|. .  ..  |.|.||..||  ..||||.||.|.||...||.    | ||||..    .  ..  |  .|  .||||| |.    ...| 
TWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYG

VKSDVWSLGITMIEMAILRFPYESWG----TPFQQLKQVVEEPSPQLPADRF----------------------SPEFVDFTAQCLRKNPAERMSYLELM
 |.|.||.|....||.  |.|.        .   |.. ...  .|.|. |..                      |.|. ||   ||.|.|..| .  ...
PKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

EHPFF
.||.|
QHPWF
Kinase MAP2K3.AA SLK 66-325 31 2.8e-42 140.38 In-house 3-259 (259) Show / Hide 
Range on Protein: 66-325
Range on HMM: 3-259/259
Sequence Identity: 31% (83 aa)

TISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMD-TSLDKFYRKVLDKNMTIPED
 | ||| ||.| |.| .| . . . | | |  . .  | .  ....|| . ...  . |  |.| . ....|. .|  |   .|     ... . .. ||
IIGELGDGAFGKVYKAQHKEQKVFAAAKMI-EIKDEEELEDYMVEIDI-LSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNI---MVELEHPLTED

ILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPY-MAPERINPE-LNQKGYNVKSDVWSLGITMIEMA
 .  ..  .. ||..|||.  |||||.|  |.|.  .|.|.. |||.|  .   . |       || |||| .  | .  . |  |.|.||||||.||||
QIQYVCKHMCEALNWLHSN-KVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMA

ILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFF
 .  |..        ||    ||   .   ..| || ||  .|| |.|  | .  .||.|...
QMEPPHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase MAP2K3.AA TyrKc 64-325 23 6.6e-16 34.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 64-325
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTV--DCFYTVTFYGALFRE-------GDVWICMELMDT-SLDKFYRK
.. . .||.||.|.| | .     .  ||| ...      .. ..  . | |. .  .    | .||.   .       . ..| ||.|.  .|... ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARI-MCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

VLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDS-------VAKTMDA--GCKP-----YMAPERINPE
  .|   .. . | .... | .  |.||||  .||||    |.|......|| .||| | .. |          ...    |.|       |||| |   
HRPK---LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

LNQKGYNVKSDVWSLGITMIEMAILRFPYESWG----TPFQQLKQVVEEP-SPQLPAD-------RFSPEFVDFTAQCLRKNPAERMSYLELMEHPFF
 | . .. |||||| |..| |.  .  .  .       . |.. . |..   .  |..       . ..|  .   || . .|..| .  |.  | .|
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MAP2K3.AA MEK1 275-325 49 4e-15 47.66 In-house 247-297 (297) Show / Hide 
Range on Protein: 275-325
Range on HMM: 247-297/297
Sequence Identity: 49% (25 aa)

FQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFF
|  |  .|.|| |.||   || ||.||  .||.|||.||    .|| |.|.
FEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase MAP2K3.AA Pkinase_Tyr 64-261 26 5e-15 51.53 Pfam 1-207 (270) Show / Hide 
Range on Protein: 64-261
Range on HMM: 1-207/270
Sequence Identity: 26% (57 aa)

LVTISELGRGAYGVVEKVRHA----QSGTIMAVKRIRATVNSQE--QKRLLMDLDINMRTV-DCFYTVTFYGALF-REGD--VWICMELMDT-SLDKFYR
.. . .||.||.|.| | .      . ..  ||| .. .  ...  .. ..  . | |..  ..   | .||.   ...   ..| ||.|   .|... |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKI-MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KV--LDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYL-VDS---VAKTMDAGCKPYMAPERINPELNQKGYN
|    ... |...  | .... | ...|.|.||   ||||.   |.|......|| |||| . ..  |.   ....      . |||| ||       ..
KHREDKQPLTMKD--LLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK----FT

VKSDVWSLGITMIEM
.|||||| |..| |.
TKSDVWSFGVLMWEI