Gene LOK (Human)

LOK

Species: Human
Alias: LOK, STK10, PRO2729
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 5q35.3,

Classification

Group: STE
Family: STE20
Subfamily: SLK

Sequence

Name Sequence Type Origin Length Description Download
LOK.NA RNA Sugen Kinome 6039 None Fasta, JSON
LOK.AA Protein Sugen Kinome 968 None Fasta, JSON
LOK.kin_dom Protein Kinase Domain Sugen Kinome 259 None Fasta, JSON

Protein domain

Protein domains of LOK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LOK.AA SLK 36-294 73 1.4e-184 619.45 In-house 1-259 (259) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-259/259
Sequence Identity: 73% (191 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQ
|||.||||||||||||||..||....||||.||.|.|||||||.|||.||..|.||.||||..|||.|.|||.|||||.|||||.||.||...|||.|||
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

VVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEP
.||..|.||||.|||...|||||||||.|||..||.||||||||||| .|.||||.|||||||||||||||||.||.||||||||||||||||||||.||
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFV
||||.|||||||||.||.||||..||.||.||.||||..|.|.|..|...|||..|..|
PHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase LOK.AA STE20 36-294 45 1.2e-147 496.75 In-house 1-288 (288) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-288/288
Sequence Identity: 45% (132 aa)

WEIVGELGDGAFGKVYKAKNKETGAL----AAAKVIETKSE----EELEDYIVEIEILATCDHPYIVKLLGAYYHD----GKLWIMIEFCPGGAVDAIML
.|.. ..| |..|||||| .|.|| .    .| |... ...    .|.|| . || |.. |.||.||| .|.|. |     .||| .|.| || .  || 
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---ELDR-----GLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLK----TLQ-KRDSFIGTPYWMAPEVVMCETMK
   ....      ..|.|| ..||..|..|..|||..|||||.||.|.|.| .|.. ||||||.|.  |    | | ||..|.||||||||||..|....
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIA--KSDPPTLLT--PSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFV
| .||||.||||||||.||||  |||.....|||....|.  . .||||    |.||| ||.||..  |.|.|| ||.| |||.|||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase LOK.AA STE 36-294 33 1.5e-124 420.11 In-house 1-359 (359) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-359/359
Sequence Identity: 33% (122 aa)

WEIVGELGDGAFGKVYKAKNK------ETGAL---------AAAKVIETKSE-----------------EELEDYIVEIEILATCD--HPYIVKLLGAYY
||.....| ||||.||||.|.      .|| .          | |... ...                 ||..... ||.|.  |.  ||.||| .|.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HDG-------KLWIMIEFCPGGAVDAIML---ELDRGLT----------EPQIQVVCRQMLEA-LNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSA
..|       .|||  |...|| .| |.    .  ..|.          |.|| ..||| |.. |..|||..|||||.|..|.|.     . |.||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KNLK---------------TLQ-KRDSFIGTPYWMAPEVVMCETMK-DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKS-----------
.  .               | | ||..|.||| ||||||..... . | .||.|.||||||.|.||||  .||.|...|||... |...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----DPPTLLT-----------------PSKWSVEFRDFLKIALDKNPETRPSAAQLLE--HPFV
    .||.| .                 |.||| ||.||..  |.|.|. ||.| |||.  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase LOK.AA MST 36-294 47 9.20000000001e-114 363.0 In-house 1-254 (254) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-254/254
Sequence Identity: 47% (123 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYY--HDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQ
 .||. || |..|.|||| .|.|| . | |.. .  .| |.. | || |.  |. .||||. | |.   .  .|| .|.| .| |  ||   .| |.| |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

IQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQI
| ..... |  |  ||. ..||||.|||| |.  ||   |||||||.    |  ||...||||||||||| .    |   ||.|||||||||| ||||  
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQ--EIK---YDCKADIWSLGITAIEMAEG

EPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFV
.|| ... |||.. .| .. |||.  |..|| || ||..  | |||| |..| |||.|||.
MPPYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase LOK.AA YSK 36-294 45 7.79999999999e-111 335.01 In-house 1-257 (257) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-257/257
Sequence Identity: 45% (118 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIE-TKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLE-LDRGLTEPQ
. .    | | || |||. .. |.   | |.|.  ..|.| ||   || .|. || ||| | .|.|  | ||||  |.| || .   |      .. |..
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQI
| .. |  | .| .||| | |||| || |||.. .||. |.||||...   | .||. |.||||||||||...|    . ||.|||||||||| .|||  
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEV---SYYDFKADIWSLGITAYEMAKG

EPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFV
|||. .. ||||.  | |. ||.|   ...|  | .|  . |.|.|| |||| .|| | |.
EPPYCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase LOK.AA KHS 36-294 45 2.6e-96 324.46 In-house 1-258 (258) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-258/258
Sequence Identity: 45% (120 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQ
.|..  .| | .| ||||...... ||| |||    .....    || .. .| || ||   |.| .  ||||..|.| ||..  |  ..   |.| || 
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIY-HVTGPLSELQIA

VVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEP
 |||. |..|..|||.  .|||.|  |.|.| .||..||||||||.   |. || |||||||||||||   |  .   |.   |||..||| ||.| . |
YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE--RKGGYNQLCDIWAVGITAIELAELQP

PHHELNPMRVLLKIAKSD--PPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFV
|  .| |||.|. ..||.  ||.|   .|||  | .|.|.|| |||  ||.| .||.||||
PMFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase LOK.AA S_TKc 36-294 32 7.2e-95 322.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPG--GAVDAIMLELDRG-----
.||. ..| ||||||||...|.|| . | |.|        |. . ||.||   .||.||||...... ..|..  |.|.|  | .  .. .  |.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDY-KADIWSLGITL
..| ... ...|...||...||..|||||||  |.|..    | ..|||....        ..|.|||..|||||.        .|.. |.|.||.|..|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCIL

IEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLE-------HPFV
.||.  .|| .    | ...|. .            | |..||..  |.|.|| ||.| ..|.       ||..
YEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LOK.AA PAKL 36-294 42 1.8e-88 300.22 In-house 1-256 (256) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-256/256
Sequence Identity: 42% (111 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHD-GKLWIMIEFCPGGAVDAIMLELDRGLTEPQI
 |.   ||.|..| ||||  |.|.   | |||| |   | .|   ||.||  |  |.||   |       ..||  ..|  | .  .|      |.| ||
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

QVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQ-KRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQI
 |. .| |  |  |||| ||||| || |.|..  ... .|||||| .   ..     . ||||||||||.     .. ..|..|.||||||||.||||  
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEI-----INKQNYNNKCDIWSLGITAIEMADG

EPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFV
.||| ...||| .. |    |||.  | .|| .| |||   . | || |.|. .|| ||| 
FPPHYDMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase LOK.AA NinaC 36-294 41 5.8e-87 295.22 In-house 1-267 (267) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-267/267
Sequence Identity: 41% (112 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSE--EELEDYIVEIEILAT-CDHPYIVKLLGAYYHD-----GKLWIMIEFCPGGAVDAI---MLE
|||. . | | .|||.|.|||. | .|| |. .  ..  || |.   |  || . |||| .|.  | ||       ..||. .|.| || |  .   .| 
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHDEEIEA---EYNILRDYCDHPNVVRFYGMYYKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLK

LDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLG
..| . |. |  . .  . .|  ||. ..|||| |  |.|.| || ..| ||||||    |. .|   .|||.||||||. |.   |. ||  .|.||||
CGRRMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLG

ITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFV
|| ||..  .||  .. ||| . ||    ||||. | .|. || ||    | |. | ||.  ..|||||.
ITAIELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase LOK.AA Pkinase 36-294 29 1.7e-84 291.84 Pfam 1-293 (293) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-293/293
Sequence Identity: 29% (89 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV----EIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGG----AVDAIML-ELD
..|.. .| |.||.|||...| || . | |.|. ..|.. .|..     ||.|.. ..||.||.|..... ......  |.|.||       ...  . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RGL--TEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDI----RLADFGVSAKN-LKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKAD
...  .| ... ...|.|..|...||..|||||||  |.|.  .|.|    ...|||....  .   .  ..| |||..|||||..    ....|..|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVD

IWSLGITLIEMAQIEPPHHEL------NPMRVLLKIAK----SDPPTLLTPS--------------KWSVEFRDFLKIALDKNPETRPSAAQLLEHPFV
.||.|..|.||.  .||  .       ..| .. .| .    .| |.. ..|              .|| |..||.|  |.|.|. ||.|.|.|.||..
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LOK.AA PAKA 36-294 39 2.7e-83 283.02 In-house 1-260 (260) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-260/260
Sequence Identity: 39% (104 aa)

WEIVGELGDGAFGKVYKAKNKETGAL--AAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDR----GL
 . . ..| || |.||.|.|..|.     | |... | .   |  | || .. .| |. ||. . .|  | .||. .|.  ||    .  . ..     .
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

TEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIE
.| ||  |||. | .|.|.||| .||||.|  |.|.  .|.. ..|||  |   .  |||..  ||||||||||.   . |.  ||.| ||||||| .||
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVI---RRKQ--YDEKVDIWSLGIMAIE

MAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFV
|.  |||. . .| | .  ||.   | .. | ||| ||.|||.  |..... |.|| .||.||| 
MIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase LOK.AA Ste20-DD1 36-294 45 5.8e-82 278.6 In-house 1-268 (268) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-268/268
Sequence Identity: 45% (123 aa)

WEIVGELGDGAFGKVYKA-------KNKETGALAAAKVIETKS---EEELEDYIVEIEIL-ATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLE
  ||   | | || |           |     . | | .|      || .     ||.||  | | |||||  | |  .  | |  |.| || .  ||  
FQIVEVIGQGSFGVVCTCRWMKKKDRNTNNNRVIACKFVEMNADDVEENSN-LKKEIDILKNTMDCPYIVKYHGCYIKENMLMIVMEYCDGGSILDIMQM

LDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLG
    |.| ||  .| |  . | .|||.||.||| ||||||.  ||  .|||||||.    . .|    || ||||.||..|     .  || ||||||||
CSKRLIEEQIAAICYQIVKGLVYLHSNRITHRDIKAGNVLVNKEGQPKLADFGVSTIAVNQGFKMNTVIGSPYWMSPEIIMPPKGSQG-YDQKADIWSLG

ITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFV
|| ||||   ||  ..|| ||   |    ||||  || || || || |  | .||. |||| ||| |||.
ITAIEMAESKPPRFNVNPVRVIFVIPHQQPPTLKIPSNWSPEFNDFIKQCLNMNPDKRPSAQQLLNHPFI
Kinase LOK.AA Pkinase_Tyr 36-179 30 3.7e-24 82.44 Pfam 1-158 (270) Show / Hide 
Range on Protein: 36-179
Range on HMM: 1-158/270
Sequence Identity: 30% (48 aa)

WEIVGELGDGAFGKVYKAKNK----ETGALAAAKVI-ETKSEEE--LEDYIVEIEILATC-DHPYIVKLLGAYY-HDGK--LWIMIEFCPGGAVDAIMLE
 ..  .|| ||||.|||.. |    .|.   | |.. |. ..|.  .|| . |..|. .  .|| ||.|.|. . ...   ..|  |..|.|  .    .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

L---DRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVS
    .. || ...   |.|  .....|.||..||||| | |.| | .. .. .||| .
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase LOK.AA TyrKc 36-297 22 9.1e-20 72.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 36-297
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATC--DHPYIVKLLGAYYHD-------GKLWIMIEFCPGGAVDAIMLELD
 .   .|| ||||.|||.. |      | |..   .   .|| . |..|.     .|| ||.|.|.  ..       . |.|  |..|.|. .    .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

RGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKT-------LQKRDSF-IGTP-----YWMAPEVVMCETMKDTP
. |. ..    | |  .  ..||||..||||| | |.| . .. .. .||| | .             .| .   |.       |||||.      ..  
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----NYGK

YDYKADIWSLGITLIEMA-QIEPPHHE-----LNPMRVLLKIAKSDPPTLLTPSK--------WSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSI
.  | |.|| |... |.    ..|. .     ... .|. .. . .   .  |           . |  .  |   . .|| ||. ...     .. .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY--RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase LOK.AA Pkinase_Tyr 198-291 25 0.000193 15.66 Pfam 180-269 (270) Show / Hide 
Range on Protein: 198-291
Range on HMM: 180-269/270
Sequence Identity: 25% (24 aa)

WMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQ-IEPP-HHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEH
|||||. .        .  | |.|| |... |.    | |   .. . .|. .|...    .  | . . |  | .|   ...|| ||. ....|.
WMAPECINYGK-----FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR-MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQ
PKK LOK.AA PKK 586-725 45 8.4e-54 189.85 Pfam 1-144 (144) Show / Hide 
Range on Protein: 586-725
Range on HMM: 1-144/144
Sequence Identity: 45% (65 aa)

KHELQLEQMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKK--EVKNEVEKLP--RQQRKESMK
||.||.|||...|.|. ....|....|.|..|||||||.|||||.....||....||| ||....  |.|.|| .||  |.| ||||.|  |.|||. ||
KHQLQKEQMKDQFFQQRHQMLKRHEKEMEQMERQQKQQIEKMEQRQTQERRRLPKRIRAEQEKRMKMFKESLKIEKKNMEPKQEVEKMPQFREQRKDRMK

QKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKE
|.|||. ||.|   ..|||...|..|..|....  .|.... .|
QEMEEMEQKHQEQEQEFVAQCEENHEEMMQQMQNEHRHMLMEHE
PKK LOK.AA PKK 754-895 47 7.4e-67 233.22 Pfam 1-144 (144) Show / Hide 
Range on Protein: 754-895
Range on HMM: 1-144/144
Sequence Identity: 47% (68 aa)

RHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGG-SAAEQREKIKQFSQQEEKRQK
.|||.|.|.|||.|.|||..|..|||| |||.|.....||... ||.||. ||||..|.| ..||.|.|.||.|.  . ......||..||..|...|.|
KHQLQKEQMKDQFFQQRHQMLKRHEKEMEQMERQQKQQIEKMEQRQTQERRRLPKRIRAEQEKRMKMFKESLKIEKKNMEPKQEVEKMPQFREQRKDRMK

SERLQQQQKHENQMRDMLAQCESNMSE-LQQLQNEKCHLLVEHE
 |.....|||..|.....||||.|..| .||.|||..|.|.|||
QEMEEMEQKHQEQEQEFVAQCEENHEEMMQQMQNEHRHMLMEHE