Gene LATS2 (Human)

LATS2

Species: Human
Alias: LATS2, KPM, FLJ13161
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards ,
Annotation: Consensus chromosomal location: 13q11-13q12.1,

Classification

Group: AGC
Family: NDR
Subfamily: LATS

Sequence

Name Sequence Type Origin Length Description Download
LATS2.NA RNA Sugen Kinome 5558 None Fasta, JSON
LATS2.AA Protein Sugen Kinome 1088 None Fasta, JSON
LATS2.kin_dom Protein Kinase Domain Sugen Kinome 306 None Fasta, JSON

Protein domain

Protein domains of LATS2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
UBA LATS2.AA UBA 99-136 20 1.2e-05 24.15 Pfam 1-38 (38) Show / Hide 
Range on Protein: 99-136
Range on HMM: 1-38/38
Sequence Identity: 20% (8 aa)

VNRQMLQELVNA-GCDQEMAGRALKQTGSRSIEAALEYI
.. .|...|.   | . . . .||....  ..|.|.|..
IDEEMVKQLMEMTGFSMMQCKKALRACNN-NVERAVEWL
Kinase LATS2.AA NDR 668-973 54 4.8e-235 733.44 In-house 1-350 (350) Show / Hide 
Range on Protein: 668-973
Range on HMM: 1-350/350
Sequence Identity: 54% (191 aa)

FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEAD--NEWVVKLYYSFQDKDSLYFVMDYIPGGDMMS---LLIRMEV
|..||..|.||||||.|..| ||...||||..||......||||||.|||||.||||  |.||||||||||||..||.||.|.||||||.   ||..|..
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

FPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTG---------------------FRWTHNSKYYQ-KGSHVRQDSMEPSD
|.|..|||||||...|||||||||.|||||||||.||| ||||||||||||||                     |.|||||.||| .. | .||.|....
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPMTTYSTFHWTHNSWYYQNMKEHRPQDFMDNWN

LWDDVSNCRCGD-----R---LKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLR-KGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENT
 ......|.|.      .   .|.|..|..||..||||.|.||||.|.||||... .||.|.|||||.|.|..|||||.|||.. ||.||. |..||..|
SNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQT

L-----HIPAQVKLSPEARDLITKLCC-SADHRLGRNG--ADDLKAHPFF
.     |.|....||||| |||..|||  .|||||..|  .|. |.||||
WDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase LATS2.AA AGC 668-973 32 8.70000000001e-185 482.93 In-house 1-395 (395) Show / Hide 
Range on Protein: 668-973
Range on HMM: 1-395/395
Sequence Identity: 32% (139 aa)

FVKIKTLGIGAFGEVCLACKV------DTHALYAMKTLRKKD---VLNRNQVAHVKAE------------RDILAEAD----------NEWVVK-LYYSF
|  .|..| |.||.|.|. |.      ||  .|||| |.||.    ...|.|.|...|            |.||....          . ..|| |.|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDKDS--LYFVMDYIP--------GGDMMSLLIRME-----VFPEHLARFYIAE-------LTLAIESVHK-MGFIHRD-IKPDNILIDLDGHIKLTDFG
||||   |||||.|.|        ||.....|. ..     .|.|  ||||.||       ..||.|. |. ||.|||| .||.|||.| ||||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCTG----------------FRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQ-----------RCLAHSLVG--TPNYIAP
||.                 |.| ||.|| ||.      .|.      . .        | ....  ....           | ......|  ||.|.||
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-QKS------NMD------T-N--------K-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAP

EVLLRKGYTQLCDWWS--VGVILFEMLVGQPPFLAPTPT----------ETQLKVI------NWENTL------HIPAQVKLSPEARDLITKLCC-SADH
|.|    |.. |||||  .|....|||.|.||| . .|           |.  |..      ||. ..      ..|.....||||.|||.||.|   ..
EIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEK

RLGRN-------GADDLKAHPFF
||| .       ||...|.||.|
RLGCGGNDFGDKGAEEIKNHPWF
Kinase LATS2.AA DMPK 668-813 49 2.6e-105 261.13 In-house 1-147 (270) Show / Hide 
Range on Protein: 668-813
Range on HMM: 1-147/270
Sequence Identity: 49% (73 aa)

FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRME-VFPEH
|  .|  | |.||||..     |   |||| . |.. | | ..| .. ||||.. .. .|...|.| |||.. ||.||.| ||||. .|. | | ..|| 
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

LARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLC
.||||.||..||| |.|.||..||||||||.|.|  ||||| ||| |
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSC
Kinase LATS2.AA S_TKc 668-973 30 2.1e-98 334.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 668-973
Range on HMM: 1-231/231
Sequence Identity: 30% (98 aa)

FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPG--GDMMSLLIRMEV---
. .....| ||||.|... ...|. ..|.| ..           |.. |..|| . . ...||||..||| |.||.||.|..|  ||..... ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQ
   |||  ||||.... .|.|  |..|.||||.||.|||.|   |||..||||.. .                                           
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

RARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQ-LCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCC-SADH
           ....|||.|.|||||   ||.   |||||.|.||.|||.|.|||      .. .|.|              ||||.|.| |...   ..
-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEK

RLGRNGADD----LKAHPFF
|..   |       |.||.|
RPTA-EALQDEWDIKCHPWF
Kinase LATS2.AA RSK 671-973 33 6.5e-96 324.95 In-house 1-278 (278) Show / Hide 
Range on Protein: 671-973
Range on HMM: 1-278/278
Sequence Identity: 33% (108 aa)

IKTLGIGAFGEVCLACKV---DTHALYAMKTLRKKDVLNRNQ-VAHVKAERDILAEAD-NEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEV---
.| || |..|.| |  |.   ||  .|||| |.|. . .|.  ..|...||.||..      .|.|.|.||... || .|.|..||..   | . .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDL---DGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQ
| |. |.||.||..||.|  |. |.||||.||.||| |    .|||||||||.|  |                                           
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-------------------------------------------

RARKQHQRCLAHSLVGTPNYIAPEVLL----RKGYTQLCDWWSVGVILFEMLVGQPPFLA---PTPTETQLKVINWENTLHIPAQVKLSPEARDLITK-L
   . ..  .... ..| .|.|||.|     ..|... ||||| ||...|||.|.||| .    .. |.  .. . . .| .|.  .||.||.|||.| |
---RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKML

CCSADHRLG--RNGADDLKAHPFF
.     |||  ...|...|.||.|
HRDPHKRLGCGPQDAEEIKQHPWF
Kinase LATS2.AA AktR 668-973 34 3.8e-92 312.43 In-house 1-268 (268) Show / Hide 
Range on Protein: 668-973
Range on HMM: 1-268/268
Sequence Identity: 34% (109 aa)

FVKIKTLGIGAFGEVCLACKV-DTHALYAMKTLRKKDVLNRNQVAHVKAERDILA-EADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPE
|. .| || ||||.| |. |  |.  .|||| ..||.  .|||  |.  ||.|.. ....   |||.|.||.|. |.|.|.|.|||.. . | . . | |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

HLARFYIAELTLAIESVHKM-GFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQ
  ||||.|.  ||.|  |.    | ||.||.|||.|.|||.|.|||||                                                   |
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK------------------------------------------------LQ

HQ---RCLAHSLVGTPNYIAPEVLLR-KGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLIT-KLCCSADH-R
 .   . .|.|..||| |.|||.... ||..  .|||..|. ..||..|.||| .   ..  .| .. .  . .|  ...|....|||. || |     |
FMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKR

LG--RNGADDLKAHPFF
||  .||....| ||.|
LGYYCNGWEEIKSHPWF
Kinase LATS2.AA MAST 668-812 47 2.7e-80 244.87 In-house 1-148 (337) Show / Hide 
Range on Protein: 668-812
Range on HMM: 1-148/337
Sequence Identity: 47% (71 aa)

FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQD--KDSLYFVMDYIPGGDMMSLLIRME-VFP
|  || .. ||.| |.|. . .|  ..|||.... | . .||| .|..||.||....|..|||..||||   |. |..||.|  |||  |||  .   .|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGL
|..|..||||. |..|  |..| .|||.||||.||| .||||||||||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGL
Kinase LATS2.AA MAST 668-812 50 6.7e-78 250.65 In-house 1-145 (334) Show / Hide 
Range on Protein: 668-812
Range on HMM: 1-145/334
Sequence Identity: 50% (73 aa)

FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHL
|  || .. ||.| |.|. . .|  ..|||...| | .|.|.| .|..||.|||...|..|||..|||| |. |..||.|  |||  |||  .  |.|..
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

ARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGL
|..||||. |..|  |..| .|||.||||.||| .||||||||||
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGL
Kinase LATS2.AA Akt 668-813 52 9.2e-71 225.4 In-house 1-148 (264) Show / Hide 
Range on Protein: 668-813
Range on HMM: 1-148/264
Sequence Identity: 52% (78 aa)

FVKIKTLGIGAFGEVCLACKVDTHALY-AMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEH
|  .| || |.|| | |. | ||  .| ||| |.|.  ...|||.|.|.|| ||   ..  .|.|.||||..| |||||||..||.  ..| | ..|.| 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

LARFYIAELTLAIESVHKMGFIHRD-IKPDNILIDLDGHIKLTDFGLC
 ||||.||. ||||  |... | ||  || |||.| ||||.|||||||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLC
Kinase LATS2.AA GEK 668-813 50 9.8e-61 202.46 In-house 1-147 (269) Show / Hide 
Range on Protein: 668-813
Range on HMM: 1-147/269
Sequence Identity: 50% (74 aa)

FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRME-VFPEH
|  .| .| ||||||.     .|  .|||| | | ..| |  .|  . |||.| . |. |. .| | ||| . ||.||||  |||.. || . |   || 
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

LARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLC
.|||||||. .||.|||.....||||||||.|.|  |||.| ||| |
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSC
Kinase LATS2.AA ROCK 668-813 52 1e-60 205.42 In-house 1-145 (263) Show / Hide 
Range on Protein: 668-813
Range on HMM: 1-145/263
Sequence Identity: 52% (76 aa)

FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHL
|  || .| |||||| |  .  ..  |||| | | ... |   |    ||||.| |  ||.|.|.| |||.  || ||||.||||...|.   .| ||  
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDV-PEKW

ARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLC
|||| .|. ||....| |||||||.||||.|.|  ||.|| ||| |
ARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTC
Kinase LATS2.AA DMPK 874-973 49 4.8e-59 144.09 In-house 162-270 (270) Show / Hide 
Range on Protein: 874-973
Range on HMM: 162-270/270
Sequence Identity: 49% (54 aa)

VGTPNYIAPEVL--LRKG----YTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINW-ENTLHIPAQVK--LSPEARDLITKLCCSADHRLGRNGA
|||| ||.||||  .  .    |   ||||||||...|||.|. || | .  ||  |  |  .| |  |...|  .|.||.||| .| |....||||||.
VGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEMLYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGY

DDLKAHPFF
.|.|.||||
EDFKCHPFF
Kinase LATS2.AA Pkinase 668-813 33 3e-42 150.45 Pfam 1-159 (293) Show / Hide 
Range on Protein: 668-813
Range on HMM: 1-159/293
Sequence Identity: 33% (54 aa)

FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVK-AERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGG----DMMSLLI--RM
.......| |.||.|.......|  ..|.|...|..     ...|.. .|  |... . . .|.||..|.|||..|.||.| .||    | ....   | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

EVF--PEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHI----KLTDFGLC
 .|  .|. ..||. ..  ..|  |.||.||||.||.||||| .|||    |..||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase LATS2.AA MAST 874-973 47 5.9e-41 122.43 In-house 229-337 (337) Show / Hide 
Range on Protein: 874-973
Range on HMM: 229-337/337
Sequence Identity: 47% (52 aa)

VGTPNYIAPEVLLRKG-YTQLCDWWSVGVILFEMLVGQPPFLAPTPTE-TQLKVINWENTLHIPAQ------VKLSPEARDLITK-LCCSADHRLGRNGA
.||| ||||||.|..| | .  ||||.|.|..| ||| ||| . || | .  ..|| .. .  |         ..||||.||| | |      ||| |||
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGA

DDLKAHPFF
|. | ||||
DEIKQHPFF
Kinase LATS2.AA MAST 872-973 45 1.9e-38 121.36 In-house 223-334 (334) Show / Hide 
Range on Protein: 872-973
Range on HMM: 223-334/334
Sequence Identity: 45% (51 aa)

SLVGTPNYIAPEVLLRKG-YTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWE-NTLHIPAQ------VKLSPEARDLITKLCCS-ADHRLGRN
...||| ||||||.|..| . .  ||||.|.|..| ||| |||   ||.|.  ...| . |   .|         ..||||.||| ||       ||| |
QCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGAN

-GADDLKAHPFF
 |||. | ||||
NGADEVKQHPFF
Kinase LATS2.AA GEK 874-973 49 4.9e-37 121.59 In-house 162-269 (269) Show / Hide 
Range on Protein: 874-973
Range on HMM: 162-269/269
Sequence Identity: 49% (53 aa)

VGTPNYIAPEVL--LRKG---YTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVK---LSPEARDLITKLCCSADHRLGRNGAD
|||| ||.||.|  .  |   | . |||||.||...||| |. || |    ||  |..|... ...|.|..   .| ||.||| .| ||..|||||||..
VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQ

DLKAHPFF
| | ||||
DFKKHPFF
Kinase LATS2.AA ROCK 874-973 50 2.9e-35 117.35 In-house 160-263 (263) Show / Hide 
Range on Protein: 874-973
Range on HMM: 160-263/263
Sequence Identity: 50% (52 aa)

VGTPNYIAPEVLLRKG----YTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLKA
|||| ||.||||  .|    | . |||||||| ..|||||. || | .   |  |...  | |. | .|..| .|.||| |    ...|||||| ||.|.
VGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQ

HPFF
|.||
HKFF
Kinase LATS2.AA Pkinase 870-973 25 1.8e-23 84.07 Pfam 168-293 (293) Show / Hide 
Range on Protein: 870-973
Range on HMM: 168-293/293
Sequence Identity: 25% (33 aa)

AHSLVGTPNYIAPEVLL-RKGYTQLCDWWSVGVILFEMLVGQPPFLAP---TPTETQLKVINWENTLHIPAQVKLS---------------------PEA
.....|||.|.||||.. ...|.. .|.||.|.||.||| |.|||       .  .|...|.      .. .   .                     .|.
MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

RDLITKLCC-SADHRLGRNGADDLKAHPFF
.|.|....|     |..   |.... ||.|
KDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase LATS2.AA Akt 870-913 44 7.4e-23 69.82 In-house 159-203 (264) Show / Hide 
Range on Protein: 870-913
Range on HMM: 159-203/264
Sequence Identity: 44% (20 aa)

AHSLVGTPNYIAPEVLLRKGYTQLCDWWS-VGVILFEMLVGQPPF
. .. ||| |.|||.|. .|.|. .|||. .|....||. |.|||
TKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF
Kinase LATS2.AA TyrKc 668-959 18 2.3e-11 -38.89 SMART 1-280 (280) Show / Hide 
Range on Protein: 668-959
Range on HMM: 1-280/280
Sequence Identity: 18% (62 aa)

FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEA--DNEWVVKLYYSFQDK-------DSLYFVMDYIPGGDMMSLLI
 ...|.|| ||||||...         | |.|..        ..    |  |. .   ... .|.||    ..       . |. || | |.||  . | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RMEV-FPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNC-RCGDRLKT
. .  ..      .        |  |....||||.   |.|.. ....| .||||.                              |. .  ..|     
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS-----------------------------RDIYDDDQQG-----

LEQRARKQHQRC----LAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEML-VGQPPFLAP----TPTETQLKVINWENTLHIPAQ------VKLS
    ..|.  |      .....      |||..  . .|   | || || ..|..  ||.|   .     . .  .. .   . . .|.       |  .
----ESKDYYRKKEHKGGKTMLPI-RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCP

PEARDLITKLCCSAD-----------HRL
.|  . | | |. .|           ...
DEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase LATS2.AA Akt 932-973 37 2.2e-09 26.09 In-house 220-264 (264) Show / Hide 
Range on Protein: 932-973
Range on HMM: 220-264/264
Sequence Identity: 37% (17 aa)

LHIPAQVKLSPEARDLITKLCC-SADHRLG--RNGADDLKAHPFF
. .|   ..|||..|||..|.    ..|||   |.|...|.||.|
VKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase LATS2.AA Pkinase_C 992-1046 27 5.1e-09 35.03 Pfam 1-46 (46) Show / Hide 
Range on Protein: 992-1046
Range on HMM: 1-46/46
Sequence Identity: 27% (15 aa)

TISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHPEHAFYEFTFRRFF
....| ||||||| ... | .| .      |. ..|...     .|  ||.....
QVKSPTDTSNFDPEFTDEPPMDTP----PDWR-MSSGDQE----PFRGFTYVNPD
Kinase LATS2.AA S_TK_X 974-1044 22 1.9e-05 23.64 SMART 1-79 (79) Show / Hide 
Range on Protein: 974-1044
Range on HMM: 1-79/79
Sequence Identity: 22% (20 aa)

SAIDFSSDIR----KQPAPYVPTIS----HPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHPEHA--------FYEFTFRR
. ||.  ...    . ..|..|.|.    .| |||||||  .| ..        .  |.  |...  .| .        | .||...
RGIDW-DKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM------LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF
Kinase LATS2.AA Pkinase_Tyr 783-813 35 0.000214 15.51 Pfam 128-158 (270) Show / Hide 
Range on Protein: 783-813
Range on HMM: 128-158/270
Sequence Identity: 35% (11 aa)

HKMGFIHRDIKPDNILIDLDGHIKLTDFGLC
. ...||||.   |.|.. ....| .||||.
ESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase LATS2.AA Pkinase_Tyr 668-753 28 0.001334 12.82 Pfam 1-94 (270) Show / Hide 
Range on Protein: 668-753
Range on HMM: 1-94/270
Sequence Identity: 28% (27 aa)

FVKIKTLGIGAFGEVCLACKV----DTHALYAMKTLRKKDVLNRNQ--VAHVKAERDILAEA-DNEWVVKLYYSFQ-DKDS--LYFVMDYIPGGDM
 ...|.|| ||||||...       .|.   | |.|  |.     |   .   .|  |. .  ... .|.||     ....  .| || | |.||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase LATS2.AA Pkinase_Tyr 881-913 34 5.338159 0.62 Pfam 182-216 (270) Show / Hide 
Range on Protein: 881-913
Range on HMM: 182-216/270
Sequence Identity: 34% (12 aa)

APEVLLRKGYTQLCDWWSVGVILFEMLV-GQPP-F
|||..  . .|   | || || ..|..  |. | .
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY