Gene KIS (Human)

KIS

Species: Human
Alias: KIS, Kist, UHMK1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 11q21-q23.3,

Classification

Group: Other
Family: KIS

Sequence

Name Sequence Type Origin Length Description Download
KIS.NA RNA Sugen Kinome 2922 None Fasta, JSON
KIS.AA Protein Sugen Kinome 419 None Fasta, JSON
KIS.kin_dom Protein Kinase Domain Sugen Kinome 282 None Fasta, JSON

Protein domain

Protein domains of KIS.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase KIS.AA KIS 40-304 48 1.5e-212 675.05 In-house 116-473 (473) Show / Hide 
Range on Protein: 40-304
Range on HMM: 116-473/473
Sequence Identity: 48% (172 aa)

VRCCGN---------------PGSPPGALKQFLPPGTTGAAASAAEYG---------FRKERAALEQLQGHRN------------------IVTLYGVFT
||||.|               .|.|.|..|||..||.|.|....|...         ..|.||...|.|||||                  |||.||.||
VRCCNNNNDITSGTANHKDHKKGKPQGKEKQFAQPGRTHARVRTADHTEGSGRCGTRMQKRRATAQQAQGHRNKGKDSDHGSTRAPDSSTAIVTNYGRFT

IHFSPNVP-SRCLLLELLDVSVSELLLYS---------------------SHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKL
.|.||||. .||...|..||.|..|....                     ||.|||||||||||||..|.|.|.||.|.||||||||||||||.|||.|.
RHHSPNVKNTRCDNAEEDDVEVDDLADHQEGNQGASEEDVEEEDDDDEDASHYGCSMWMIQHCARDIAECLEFVHHCGWVHADLKPRNILWSAQNECWKI

IDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAG------------LQSDTECTSAVDLWSLGIILLEMFSGMKLKHT------------VRSQEWK
||||.||.|||||.||||||.|.||||...||..|||            .|||||||.|||.||||.|...|..||||.|.            .|.|.||
IDFGHSFQEGNQDFKYIQTDCYQAPEAKVWNCFVQAGGNQKVVHKMSAVDQSDTECTHAVDIWSLGCIIVRMYTGMKLYHQDDVLPGACLQCRIRCQNWK

ANSSAIIDHIFASKAVVNAAIP-----AYHLRDLIKSMLHDDPSRRIPAEMALCSPFF
.|...||||||..|.|.|.|||     ..|||||||||||.|..|||||||.||.|||
CNCEPIIDHIFKPKMVNNKAIPIRQAAVHHLRDLIKSMLHCDIARRIPAEMILCHPFF
S_TKc KIS.AA S_TKc 23-304 22 1.1e-37 132.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-304
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

WQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELL
...   .|.|. ..||..|  .       |.|.                 .|.|.. |..  .| |||.||.||         . .. .|..| .. .|.
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLF

LYSSHQGC-------SMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQS
 |  ..|.       .  .... .. ...||...|  | .| |||| ||| .    . |..||||. .       .. |  |.|||              
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL------------

DTECTS-AVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALC-------SPFF
    .  ..| ||.|.|| ||..|  . .         .  .....|               ..|.|. .|. ||..|. |  ||         |.|
--GYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase KIS.AA Pkinase 74-238 25 7e-26 92.6 Pfam 46-208 (293) Show / Hide 
Range on Protein: 74-238
Range on HMM: 46-208/293
Sequence Identity: 25% (47 aa)

RK--ERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYS------SHQGC--SMWMIQHCARDVLEALAFLHHEGYVHADLKPRN
|.  | . .  | .| |||.||..|.       .. .. .|...  .. ..  .      .| .   |.| ...... .|..|...| .| .| |||| |
RRLSEIQIMKRL-NHPNIVRLYDWFED-----KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPEN

ILWSAENEC---FKLIDFGLSFK--EGNQDVKYIQ--TDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSG
|| . ....   .|..||||. .  . |.   .    | .|.|||           ...... ...|| ||.|.|| ||..|
ILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV----------IRGGQYYGPKVDMWSCGCILYEMLCG
Kinase KIS.AA CMGC 80-238 19 7.6e-24 74.43 In-house 75-331 (513) Show / Hide 
Range on Protein: 80-238
Range on HMM: 75-331/513
Sequence Identity: 19% (51 aa)

LEQLQ----------------GHRNIVTLYGVFTIH-FSPNVP-----------SRCLLLELLDVSVSELLLYSS--HQG-----CSMWM----------
|..|.                 | |||.|| .|. .   .| .           . .|  |..| .  ...   .  .||      |             
LKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPP

--IQHCA------RDVLEALA--FLHHEG--YVHADLKPRNILWSAENECF-------------------KLIDFGLSFKEGNQ----------------
  |..        . .|..|.  ..|  .   .| |||| ||| . ..|..                   |..||||. ....                 
HNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVN

--------DVKYIQTDGYRAPEAELQNCLAQAGLQS----DTECTSAVDLWSLGIILLEMFSG
           |..|  |||||      |  ..  .     .. |...| ||.| |. ||. |
KDDKPNRPYTHYVVTRWYRAPE-----ILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTG
Kinase KIS.AA DYRK2 108-238 36 1.3e-22 70.02 In-house 77-198 (318) Show / Hide 
Range on Protein: 108-238
Range on HMM: 77-198/318
Sequence Identity: 36% (48 aa)

CLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENEC-FKLIDFGLSFKEGN-QDVKYIQTDGYRAPEAELQ
|. .|||.... |..   . || |.  .   |. .|..| ||| .  .|.|||| |||   .|    |.||||.|  |   ..  |||.  |||||. | 
CITFELLSMNLYEYIKKNHFQGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVIL-

NCLAQAGLQSDTECTSAVDLWSLGIILLEMFSG
      |.. ..    |.|.||.| |. |...|
------GGKYGM----AIDMWSFGCIMAELYTG
Kinase KIS.AA Ciliate-E2 139-304 22 9.6e-22 71.4 In-house 166-365 (365) Show / Hide 
Range on Protein: 139-304
Range on HMM: 166-365/365
Sequence Identity: 22% (52 aa)

ARDVLEALAFLHHEG-YVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQ----------------------------------TDGYRAPEAE
.. ...|| .|| ..  .| |.|| |||        |.|||||| |  ..  ....                                  | || |||  
IACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEIL

L------QNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLR-------------------
       |        |  .. . ..|.||||.|| || .|                       .  .   .  .| .. .                   
NGKKYDNQ--------QKQKGYDYKCDIWSLGVILYEMLFGKPPF-------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQE

--DLIKS----MLHDDPSRRIP-AEMALCSPFF
  ||||     ||  ||. ||  .| .|  |.|
CKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase KIS.AA TKL 29-292 16 1.3e-18 63.59 In-house 1-354 (364) Show / Hide 
Range on Protein: 29-292
Range on HMM: 1-354/364
Sequence Identity: 16% (59 aa)

LGSGSSASVYRVRCCGNPG------SPPGALKQFLPPGTTG-------------------AAASAAEYGFRKERAALEQL-QGHRNIVTLYGVFT-----
.|||... ||. .. |..|      . . | |.|                           .  |  . |..|. ..  .   | ||| ..|. .     
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-IHFSP--NVPSRCLLLELLDVSV-SELLLYSSHQGCSMWMI-QHCARDVLEALAFLHHEG--------YVHADLKPRNILWSAENE-------------
 .  .|  . .  |.  |. .     ..|.         |    . |.|.  ....|| ..         .| |||..|||    ..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

CFKLIDFGLSF-KEGNQDVKYIQ---------------------TDGYRAPEA---ELQNCLA---QAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKH
| |. |||||  ...... . ..                     | .. |||.   ..... .       .   | . ..| .| ||.| |.... .  .
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

TVRSQEWKANSSAIIDHIFASKA--VVNAAIP------------AYH---LRDLIKSMLHDDPSRR
   . .....    .. .|.  .       ||             .    ...|..   . ||. |
DYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKR
Kinase KIS.AA DYRK1 108-238 36 3.7e-16 52.78 In-house 77-199 (321) Show / Hide 
Range on Protein: 108-238
Range on HMM: 77-199/321
Sequence Identity: 36% (49 aa)

CLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGY--VHADLKPRNI-LWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAEL
|| .|||   . .||   . .| |. ...  |. .. || |.       .| |||| || |  .     |.|||| | . |.   .|||   ||.||  |
CLVFELLSYNLYDLLRNTHFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLL

QNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSG
       |.. |.    |.|.|||| || ||  |
-------GIEYDM----AIDMWSLGCILVEMHTG
Kinase KIS.AA DYRK 108-201 37 4.7e-16 56.72 In-house 77-174 (320) Show / Hide 
Range on Protein: 108-201
Range on HMM: 77-174/320
Sequence Identity: 37% (37 aa)

CLLLELLDVSVSELLLYSSHQGC-SMWMIQHCARDVLEALAFLHHE-GYVHADLKPRNILWSA--ENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPE
|.  |||. .  |.|   . ||  |.  ..  |. .|..| ||| .  ..|.|||| ||.      .   |.||||.|  |. .  .|||   |||||
CIVFELLSMNLYEFLKNNHFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPE
Kinase KIS.AA CAMK 28-186 17 3e-15 44.9 In-house 1-250 (425) Show / Hide 
Range on Protein: 28-186
Range on HMM: 1-250/425
Sequence Identity: 17% (43 aa)

RLGSGSSASVYRVRCCGNPGS----------PPGALKQFLPPGTTGAA----------------------ASAAEYGFRKERAALEQLQG------HRNI
 ||.|| . |....   ..|              | |       ..                            .  .|.| . . .|||      |.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VTLYGVFT-----------------------IHFS----PNVPSRCLLLELLDVSVSE---------LLLYSSHQGCSMWMIQHCARDVLEALAFLHHEG
. || |.                        ...       ..  .|. .|.|  |.          ...  ..   . .  ... | ...|....|  .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

YVHADLKPRNILWSAEN----------------ECFKLIDFGLS--FKEGN
 || |||| ||| .  |                   |.||||..  |..|.
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGE
Kinase KIS.AA Ciliate-E2-Unclassified 142-238 28 1.3e-13 43.61 In-house 152-266 (352) Show / Hide 
Range on Protein: 142-238
Range on HMM: 152-266/352
Sequence Identity: 28% (35 aa)

VLEALAFLHHEG-YVHADLKPRNILWSAENE--CFKLIDFGLSFKEGNQDVKY------------------IQTDGYR----APEAELQNCLA--QAGLQ
.|..| .|||..  .| |.|| ||| . ...  . |.||||.| | .... ..                  ..| .|     |||   ..      |   
ILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA---

SDTECTSAVDLWSLGIILLEMFSG
       ..| ||||.|| ||  |
------YKCDIWSLGVILYEMLFG
Kinase KIS.AA TyrKc 23-304 18 6.4e-09 -78.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 23-304
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

WQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQL-QGHRNIVTLYGVFTIH---FSPNVPSRCLLLELLDV-S
 .    ||.|    ||. .        . | |   .           .  |..|   . .|   | ||| |||| | .   |   ..  ....|. .  .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNF-MYIEPLMIVMEYMPHGD

VSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQ-------DVKYIQT-DGYR--------APE
  . | .. ..  .|    . . .. .  ..||. ...| ||  ||.| .... . |  ||||| . ..        |..  .. .| .        |||
LKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

AELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAI--------PAYHLRDLIKSMLHDDPSRRI
.             . ..|.. | || |. . |.|.  .  .    |. . . . .| .. . .     .             . ...|.  | ||. | 
CI-----------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR-

PAEMALCSPFF
   .. .  .|
-PTFSEIHECF
Kinase KIS.AA CMGC 277-304 53 3.2e-08 22.14 In-house 486-513 (513) Show / Hide 
Range on Protein: 277-304
Range on HMM: 486-513/513
Sequence Identity: 53% (15 aa)

LRDLIKSMLHDDPSRRIPAEMALCSPFF
..||.| ||. ||..|| || ||  |.|
AIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase KIS.AA RSK 145-181 43 1.9e-07 23.66 In-house 116-154 (278) Show / Hide 
Range on Protein: 145-181
Range on HMM: 116-154/278
Sequence Identity: 43% (17 aa)

ALAFLHHEGYVHADLKPRNILWSA--ENECFKLIDFGLS
|. .||  | .| |||| |||     ...  ||.|||..
AVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFC
Kinase KIS.AA CAMK 278-304 40 2.5e-07 18.88 In-house 399-425 (425) Show / Hide 
Range on Protein: 278-304
Range on HMM: 399-425/425
Sequence Identity: 40% (11 aa)

RDLIKSMLHDDPSRRIPAEMALCSPFF
.|||..||  ||..|. .| .|  |..
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase KIS.AA Pkinase 277-304 42 7.7e-07 25.26 Pfam 266-293 (293) Show / Hide 
Range on Protein: 277-304
Range on HMM: 266-293/293
Sequence Identity: 42% (12 aa)

LRDLIKSMLHDDPSRRIPAEMALCSPFF
..|.||..|. ||..|. || .|..|.|
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase KIS.AA KIS 23-39 39 2e-06 14.65 In-house 1-33 (473) Show / Hide 
Range on Protein: 23-39
Range on HMM: 1-33/473
Sequence Identity: 39% (13 aa)

WQVQSRLGSG----------------SSASVYR
||||.|||.|                ||..|||
WQVQRRLGMGRCAKVYHMSTDQDSFQSSVKVYR
Kinase KIS.AA DYRK 277-304 42 5.8e-05 14.81 In-house 293-320 (320) Show / Hide 
Range on Protein: 277-304
Range on HMM: 293-320/320
Sequence Identity: 42% (12 aa)

LRDLIKSMLHDDPSRRIPAEMALCSPFF
. |.|| .|  ||..|| .. ||  |.|
FKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase KIS.AA RSK 278-304 40 8.1e-05 13.97 In-house 247-278 (278) Show / Hide 
Range on Protein: 278-304
Range on HMM: 247-278/278
Sequence Identity: 40% (13 aa)

RDLIKSMLHDDPSRRIP-----AEMALCSPFF
.|||. ||| ||..|.      ||  . .|.|
KDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase KIS.AA RSK 220-238 47 0.000234 12.26 In-house 190-208 (278) Show / Hide 
Range on Protein: 220-238
Range on HMM: 190-208/278
Sequence Identity: 47% (9 aa)

TSAVDLWSLGIILLEMFSG
. |.|.||||... ||..|
DKACDWWSLGVLMYEMLTG
Kinase KIS.AA DYRK1 278-304 51 0.000241 10.61 In-house 295-321 (321) Show / Hide 
Range on Protein: 278-304
Range on HMM: 295-321/321
Sequence Identity: 51% (14 aa)

RDLIKSMLHDDPSRRIPAEMALCSPFF
.|||| ||. || .||    ||  .||
KDLIKRMLQYDPKQRITPYYALQHSFF
Kinase KIS.AA RSK 74-96 47 0.000351 11.61 In-house 48-70 (278) Show / Hide 
Range on Protein: 74-96
Range on HMM: 48-70/278
Sequence Identity: 47% (11 aa)

RKERAALEQLQGHRNIVTLYGVF
..||  ||  |.| .||||. .|
MTERNILERCQQHPFIVTLHYAF
Kinase KIS.AA Ciliate-E2-Unclassified 277-304 39 0.000416 10.17 In-house 325-352 (352) Show / Hide 
Range on Protein: 277-304
Range on HMM: 325-352/352
Sequence Identity: 39% (11 aa)

LRDLIKSMLHDDPSRRIPAEMALCSPFF
..||...||  .|. || .| .|. |.|
INDLLQKMLKKNPNKRITFEQILNHPWF
Kinase KIS.AA DYRK 222-238 64 0.008964 6.53 In-house 184-200 (320) Show / Hide 
Range on Protein: 222-238
Range on HMM: 184-200/320
Sequence Identity: 64% (11 aa)

AVDLWSLGIILLEMFSG
|.| |||| || |.| |
AIDMWSLGCILAELFTG
Kinase KIS.AA Pkinase 23-41 31 0.030096 9.03 Pfam 1-19 (293) Show / Hide 
Range on Protein: 23-41
Range on HMM: 1-19/293
Sequence Identity: 31% (6 aa)

WQVQSRLGSGSSASVYRVR
... ...||||...||. .
YHIGRKIGSGSFGCVYKCH
Kinase KIS.AA CAMK 222-238 47 0.039567 1.85 In-house 314-330 (425) Show / Hide 
Range on Protein: 222-238
Range on HMM: 314-330/425
Sequence Identity: 47% (8 aa)

AVDLWSLGIILLEMFSG
..| ||.|.||  | .|
KCDMWSCGVILYIMLCG
Kinase KIS.AA DYRK2 288-304 41 0.135956 0.57 In-house 302-318 (318) Show / Hide 
Range on Protein: 288-304
Range on HMM: 302-318/318
Sequence Identity: 41% (7 aa)

DPSRRIPAEMALCSPFF
||| |. .. ||  |..
DPSERMTPSQALKHPWI
Kinase KIS.AA Ciliate-E2-Unclassified 23-42 20 0.145425 1.22 In-house 1-20 (352) Show / Hide 
Range on Protein: 23-42
Range on HMM: 1-20/352
Sequence Identity: 20% (4 aa)

WQVQSRLGSGSSASVYRVRC
  ..  .|.|. ..||....
YKIIKQIGQGGFGKVYKCQH
RRM_1 KIS.AA RRM_1 345-400 26 7.5e-09 33.48 Pfam 13-73 (73) Show / Hide 
Range on Protein: 345-400
Range on HMM: 13-73/73
Sequence Identity: 26% (16 aa)

EDVKEECQKYGPVVSLLVPKE-----NPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVV
||...  .|.||..|  ...      .  ||  |||...  | ..| . . |..|.|. . 
EDLRDLFSKFGPIESIRIMRDNTRETGRSRGFAFVEFEDHEDAEKAIQAMNGKEFNGREIR
RRM KIS.AA RRM 320-402 16 9e-08 33.06 SMART 1-121 (121) Show / Hide 
Range on Protein: 320-402
Range on HMM: 1-121/121
Sequence Identity: 16% (21 aa)

TPVLRLLNVLDDDYLENEEEYEDVVEDVKEE--------CQKYGPVVSLLVPKENP------------------------GRGQVFVEYANAGDSKAA--
|   . ||   |..  .||. ...  .....        |...||.|.  ....                           ||  |||.... | ..|  
TIFVGNLN---DPWDVTEEDLREFF-KDMHSVHIHQCNCCSQFGPIVDCRIMRDKDNIHYYRCSRFCQMHQLGKNSNTGRSRGFAFVEFEDEEDAEKAMV

QKLLT---GRMF--DGKF---VVAT
....    |..|  ||.    .   
IEMMNASKGHEFRDDGRPTGHIRVK
RRM_1 KIS.AA RRM_1 327-402 20 0.000101 22.93 SMART 1-91 (91) Show / Hide 
Range on Protein: 327-402
Range on HMM: 1-91/91
Sequence Identity: 20% (19 aa)

NVLDDDYLENEEEYEDVVEDVK-EECQKYGPVVSL---LVPK--------ENPGRGQ--VFVEY-ANAGDSKAAQKLLTGRMFDGKFVVAT
 |.. .  . || |... |... |.| ..| ...     ...        .|  ||   |....  .  | ..|   . || |||. . ..
VVYVWNMVSPEEHYDEDFERFFKEMCEYFGQYGKINKIYWNNKTCHLNHYHNHKRGNGGVYIQFFQREEDAYRACVQYNGRWFDGRTHKCE