Gene JNK2 (Human)

JNK2

Species: Human
Alias: JNK2BETA, PRKM9, p54aSAPK, JNK2, JNK2ALPHA, JNK2A, JNK2B, JNK-55, MAPK9
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 5q35.3,

Classification

Group: CMGC
Family: MAPK
Subfamily: JNK

Sequence

Name Sequence Type Origin Length Description Download
JNK2.NA RNA Sugen Kinome 4336 None Fasta, JSON
JNK2.AA Protein Sugen Kinome 424 None Fasta, JSON
JNK2.kin_dom Protein Kinase Domain Sugen Kinome 296 None Fasta, JSON

Protein domain

Protein domains of JNK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase JNK2.AA JNK 26-321 68 1.7e-242 811.89 In-house 1-309 (309) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-309/309
Sequence Identity: 68% (212 aa)

YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP--FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH---
||.||.||.|||||||.|||.|.. .||.||..||  |||..|.||||||....||.||||||...|.||||.|||||||||.|||.||.|||||||   
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTF

MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMG--YKENVDIWSVGCIMGEL
|||||||||||.|||.||||||||.||||||||||||||..||||||.|||.|||....||||||||||||||||||.||.  ||||||||||||||.|.
MELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEM

VKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENR---PKYPGIKFEELFPDWIFP--SESERD-KIKTSQARDLLSKMLVIDPDKRISV
....|.|.|.||||||||.||.||||...||...||.||||||||   |.|....|.|.|||..||  ..||.. ......|||||..||||.||.||||
IRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQMQPHVRNYVENRNMDPYYQPYNFHEHFPDTLFPDVMQSEPKDHLTCHMARDLLFRMLVINPDDRISV

DEALRHPYI
|.||.||||
DDALQHPYI
Kinase JNK2.AA MAPK 26-321 47 9.20000000001e-193 646.68 In-house 1-328 (328) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-328/328
Sequence Identity: 47% (160 aa)

YQQLKPIGSGAQGIVCAAFDTVLGIN------VAVKKLSRPFQNQTHAKRAYRELVLLKCV-NHKNIISLLNVFTP-----QKTLEEFQDVYLVMELMDA
|| |||||.||.|.||.|.|. .. .      ||.||.||||||.||.||.|||. ||..  .|.|||.||..|||     |..||||.|.|.|||||..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLCQVIH-ME-LDHERMSYLLYQMLCG--IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN---------------FMMTPYVVTRYYRAP
.|.|.|. .  |......|..||.|.|  .|..|||..||||||||||.| ..|.|||.||||||.....               ..||.||.||.||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EVILG---MGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQ-P-TVRNYVENR---PKYPGIKFEELFPDWIFPSESE
|..|.   |.|...||.||||||..|... . ..|.|.|.|||||...|.||||| ||..... .  .|||....   ||||.. .|..||.. |     
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF-----

RDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI
   ....||.|||.||||.||||||.|.|||.|||.
---NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase JNK2.AA p38 26-321 50 9.80000000001e-142 477.17 In-house 1-289 (289) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-289/289
Sequence Identity: 50% (153 aa)

YQQLKPIGSGAQGIVCAAFDTVLGIN---VAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTP-QKTLEEFQDVYLVMELMDANLCQVIHM
||.|.|.|||| | ||.|.|.  |     ||.|||.||||   ||||.|||| |||. .| |.|.||.||||  . ...|||||.|...|.| | ... .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

E-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGELV
. |  ..  .|.||.| | |  ||||||||||||||| |  || |.||||||||   .   || ||.|| |||||..|  | | . |||||||||| ||.
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR--HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELI

KGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTV-RNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRH
 | . | |.||||| ..... .|||..||..|.|    |||....|..|   |...|.              . || ||| |||..||||||.. ||..|
TGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGA------------NPQAIDLLEKMLELDPDKRITAEEAMQH

PYI
||.
PYF
Kinase JNK2.AA CMGC 26-321 25 6.9e-135 446.1 In-house 1-513 (513) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-513/513
Sequence Identity: 25% (134 aa)

YQQLKPIGSGAQGIVCAAFDTVLGIN--------------VAVKKLSRPFQNQTHAK----------RAYRELVLLKCVN-----------------HKN
|. .|.||.|. |.|. ..|.  . .              ||.||...|| ....||          ||.||. .||..|                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IISLLNVFTPQ---KTLEE--------FQDVYLVMELMDANLCQVIHM-----------ELDHER------------MSYLL------YQMLCGIK--HL
|..|...|..    ....|        |...|||.|.|| .|.|.|..           .|..                |..      ||.|.|.|  ..
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAG--IIHRDLKPSNIVVKSDCTL--------------------KILDFGLARTACTN----------------------FMMTPYVVTRYYRAPEVIL
||..  ||||||||.|| . ..|.|                    || ||||||   ..                       ..|.|||||.|||||..|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

G----------MGYKENVDIWSVGCIMGELVKG--------CVIFQ-----------GTDHIDQWNKVIEQLGTP----------------SAEFMKKLQ
|          |.| . .|.||||||..|.. |          .|.           |..||||..| .. ||||                . |......
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

---------------------PTVRNYVEN---RPKYPGIKFEELFPD-------------------WIFPSESE-----RDKIKTSQARDLLSKMLVID
                     . .|||...    |..|......|||.                   . |.|.        .|  ..||.|||.|||..|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSH-KFNHQFKRKCCDPQAIDLLKKMLQYD

PDKRISVDEALRHPYI
|||||....||.|||.
PDKRITAEQALQHPYF
Kinase JNK2.AA ERK 26-321 41 2e-115 389.75 In-house 1-307 (307) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-307/307
Sequence Identity: 41% (132 aa)

YQQLKPIGSGAQGIVCAAFDTV-----LGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVN-HKNIISLLNVFTP-QKTLEEFQDVYLVMELMDANLCQV
|| .|.|| || |.||.|.|.       |  ||.|| ...| .   .||..||. ||.  . |.|||.|.... | ...  .. |.|.| |||.  | |.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE--QYNDIYCVEELMETDLHQI

IHME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR---------TACTNFMMTPYVVTRYYRAPEVILGM-GYKENV
|. .  |  .   |..||.|||.|..|||..|||||||||| | |.|.||| ||||||         . |.. .|| ||.||.|||||..|    | . .
INSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAM

DIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTP-SAEFMKKL-QPTVRNYVENRPK--YPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKML
||||.|||. |....  .|.| |...| | ... .||| | | ...   . ...|. | |.  .|.. .|..||.              .|| |||.|||
DIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNAN----------CNPQAIDLLEKML

VIDPDKRISVDEALRHPYI
|.||||||.|.|.|.||| 
VFDPDKRITVEECLEHPYF
Kinase JNK2.AA S_TKc 26-321 27 2.4e-89 304.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-231/231
Sequence Identity: 27% (86 aa)

YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA---NLCQVIHME
|. |..||.|| | |. . ..  |  ||.|...         ....||. .||  .|.||. |. ||         ...|.|||..|    .| ..|.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

--------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKE-NVDIWSVGC
        ..  .  ...||..|.....|| |||||||||.|| . .  ..|| ||||||        | ...|..|.||||.   ||    .|.||.||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

IMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVD
|. |.. |.  |.      | .......|                                                ...|.|...|.|. ||.||... 
ILYEMLCGYPPFP------QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-

EALR-------HPYI
|||.       ||..
EALQDEWDIKCHPWF
Kinase JNK2.AA nmo 27-321 41 5.9e-89 273.64 In-house 2-292 (292) Show / Hide 
Range on Protein: 27-321
Range on HMM: 2-292/292
Sequence Identity: 41% (125 aa)

QQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--HMELD
|  .||| || |.| .  |   |  ||.||.   |||   .|| .||| .|   .| |..|.|..  | . .. ||..| | ||| . | ..|    .| 
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH-KDFFQEIYVVTELMQSDLHKIIVSPQHLS

HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART--ACTNFMMTPYVVTRYYRAPEVILGM-GYKENVDIWSVGCIMGELVKG
 . .   |||.| |.| ||||.|.|||.|| |..| |.| ||| ||||||.    .   ||  ||| ||||||...|   | . ||||||||| .||.. 
SDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGR

CVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI
 ..||    |.| . ... ||||| | ||      .. .  .|. |  ... |.      |  .    .|  | .||..||. |||||||. .|| |||.
RILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKP-PCLQVLY---TLSSPDH----ATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase JNK2.AA ERK5 26-321 39 1.8e-88 300.24 In-house 1-295 (295) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-295/295
Sequence Identity: 39% (121 aa)

YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME--L
|. .  || || |.||.|     |  ||.||.   |   | ||| .||| .|.   | ||| . ..  |.. . |..||| |..||.. | |.|| .  .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACT------NFMMTPYVVTRYYRAPEVILGM-GYKENVDIWSVGCIMG
  | . | |||.| |.| .||| .|||||||||..|   | ||| |||.||  ||       . || || ||.|||||... .  |   .|.||||||.|
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

ELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQP-TVRNYVEN--RPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVD
|..    .| |   |.| . ... ||.|..  ..      |.||.     .. |   .|...|        . |.    || |||..||. .| .||.| 
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQP-KDWEKVYP--------KADR----QALDLLARMLRFEPSERITVN

EALRHPYI
.||.||..
KALQHPFL
Kinase JNK2.AA ERK7 26-321 37 2.9e-81 276.3 In-house 1-292 (292) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-292/292
Sequence Identity: 37% (115 aa)

YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH--ME
|. .| .| || |||  |.|   .  ||.||    |.||| | | .|| ..|.  . | |||.|.||.      .  .|.||| | |.. |  ||     
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVI----RADNDRDIYLVFEFMETDLHAVIRKGNI

LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF-------MMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCI
|      | .||.|  ||..||. .|||||||||| . |.|..|. ||||||.            |.| || || |||||. ||   |   || ||.|||
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

MGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYV-ENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVD
.||...|  .|.||  ..| .|..| .. |..| .. ... ..  . |. .. .  ......|.               .| ||| ..||  |.||....
LGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQ------------CCDDAIDLLKRLLVFNPKKRLTAE

EALRHPYI
.||.|||.
QALQHPYV
Kinase JNK2.AA ERK1 26-321 42 8.5e-81 274.74 In-house 1-289 (289) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-289/289
Sequence Identity: 42% (128 aa)

YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHM-ELD
| .|. || || |.||.| ||| .  ||.||.| ||  ||. .|  ||. .|.  .| ||| . ..    .|.|...|||.| .||.  | ...   .| 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIR-ADTIEQMRDVYIVQCLMETDLYKLLKTQHLS

HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELV
 . . | |||.| |.| .||| ..||||||||...   | ||| |||||| |  .      .| || ||.|||||..|   ||   .||||||||. |..
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

KGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKK-LQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRH
    || |   .|| |...  || || . ..  .    |||..  |  | . ...|||.              |.| ||| |||   |.||| |.||| |
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPK------------ADSKALDLLDKMLTFNPHKRITVEEALAH

PYI
||.
PYL
Kinase JNK2.AA Pkinase 26-321 27 3.5e-75 260.86 Pfam 1-293 (293) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-293/293
Sequence Identity: 27% (88 aa)

YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYR--ELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQV
|. ...||||. | |. . .   |. ||||..... ..    ... |  |. ..| .||.||. |. .|.        ...|.|||...       |. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

IH-------MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL----KILDFGLART--ACTNFMMTPYVVTRYYRAPEVIL-GMGYKE
|.       . .. .     .||.|.|....|| |||||||||.|| .......    || |||||.      |  || ...|..|.|||||. | .|  
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

NVDIWSVGCIMGELVKGCVIFQGT----DHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
 ||.||.|||. |.. |  .|.|     . .|| ...|.. . |  .|      .....  .. . .             . .... .  .. ..|....
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQ-MQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H-------------F-HWTF-HNWSEECKDFIKW

MLVIDPDKRISVDEALRHPYI
.|  || ||.. ...| ||..
CLCKDPKKRPTAEQILQHPWF
Kinase JNK2.AA MAPK-Unclassified 26-174 43 1.7e-57 197.37 In-house 1-157 (575) Show / Hide 
Range on Protein: 26-174
Range on HMM: 1-157/575
Sequence Identity: 43% (68 aa)

YQQLKPIGSGAQGIVCAAFDTVL-GINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLE-EFQDVYLVMELMDA---NLCQVIH
|   | ||||| |.|| | |. . .  || ||. . |.|.| .||. ||. .|   || ||| . ..|..   .  ||.|.|.||..|     .| |.|.
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

MEL---DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR
  .    |.   |..|| | |.| ||||.||||||||||. .  ||...| |||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase JNK2.AA MAPK-Unclassified 182-321 31 2.7e-35 123.59 In-house 405-575 (575) Show / Hide 
Range on Protein: 182-321
Range on HMM: 405-575/575
Sequence Identity: 31% (55 aa)

MTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGELVKG-----------CVIFQGTD--------------------HIDQWNKVIEQLGTPSAEFM
|| |||||.||||| .| |. |   |||||.||| .|..               .| |.|                    |.|| .  .. ||.|  | .
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

KKLQ-PTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTS--QARDLLSKMLVIDPDKRISVDEALRHPYI
   . . .| |..   . . ..| .|    .|.  .  |.|     ...|...|||...| |||. |.|| |||.
NFITCDSARKYIQSFKCKTPVHFTDL----MFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase JNK2.AA TyrKc 26-321 20 9.4e-13 -16.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-280/280
Sequence Identity: 20% (67 aa)

YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCV--NHKNIISLLNVFTPQKTLEEF---QDVYLVMELMDA-NLCQVI
 . .| .|.|| |.|. .  .   |.||||.|          .  .||. ... .  .|.||. |. | | |.    |   . ...|||.|.  .| . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYL

---HMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA--C--------TNFM----MTPYVVTRYYRAPEVILGMGY
   . .| .. . .  .|  ||  .||| ..|||||   |. |... | || ||||.|             .  .     . ...     |||.|    .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

KENVDIWSVGCIMGELVKGCVIFQGTDHI--DQWNKVIEQLGTPSAEFMKKL----QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARD
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TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------F---VCCPDEMYQ

LLSKMLVIDPDKRISVDEALRHPYI
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IMKQCWHEDPEDRPTFSEI--HECF
Kinase JNK2.AA Pkinase_Tyr 26-175 28 1.8e-07 25.94 Pfam 1-160 (270) Show / Hide 
Range on Protein: 26-175
Range on HMM: 1-160/270
Sequence Identity: 28% (47 aa)

YQQLKPIGSGAQGIVCAAFDT----VLGINVAVKKLSRPFQNQTH--AKRAYRELVLLKCV-NHKNIISLLNVFTPQKTLEEFQD--VYLVMELMDA-NL
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ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT-----DQGEPNQIYIVMEYMPHGDL

CQVIHME------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART
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LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD