Gene JAK1 (Human)

JAK1

Species: Human
Alias: JAK1A, JAK1B, JAK1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1p31.3, Secondary Group: TK, Secondary Family: JakB,

Classification

Group: TK
Family: Jak

Sequence

Name Sequence Type Origin Length Description Download
JAK1.NA RNA Sugen Kinome 5053 None Fasta, JSON
JAK1.AA Protein Sugen Kinome 1154 None Fasta, JSON
JAK1.kin_dom Protein Kinase Domain Sugen Kinome 278 None Fasta, JSON
JAK1.kin_dom2 Protein Kinase Domain Sugen Kinome 265 None Fasta, JSON

Protein domain

Protein domains of JAK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B41 JAK1.AA B41 32-286 20 1.2e-60 208.7 SMART 1-232 (232) Show / Hide 
Range on Protein: 32-286
Range on HMM: 1-232/232
Sequence Identity: 20% (58 aa)

PEPGVEVIFYLSDREPLRLGSG-EYTAEELCIRAAQACRISPLCHNLFALYDENT---KLWYAPNRTITVDDKM-----SLRLHYRMRFYFTNWHGTNDN
... ... .|. |...| . .. ..|...||  ... | |||..|..|.|. |..   . |. ...||.  |.      ...||.|..||...|||    
SPKPRFCRVYFMDGTTLEFEVDSSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHEDRHWLDHWKTIMKQDVKWHKSEPWTLHFRVKFYPPDWHG----

EQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQ-------LPELPKDI
                     .. .. .|. ...|...| ..|...  .| .          .|.|||..|.|.. . .  .. .       . ...|..
---------------------FPNQLQEDPTRYNYFYLQCRHDILQGRHPCP----------HEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYK

SYKRYIPETLNKSIRQR-------NLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIF
||||..|. ...||.|.       .  .| || ...|..           .. .....|.|||........ ||.| |
SYKRFLPKQWIDSIKQSFMHYQMHHKEWRKRIMEWHKNH-----------CGMTPEEAKLKYLQICQRWPPMYGVEHF
Kinase JAK1.AA SH2 437-532 24 1.1e-17 66.02 SMART 1-87 (87) Show / Hide 
Range on Protein: 437-532
Range on HMM: 1-87/87
Sequence Identity: 24% (24 aa)

QNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQK-GRYSLHG-SDRSFPSLGDLMSHLKKQILR
|. .||.|  | | ..|...| ..| ...|.| .  ..   ..... |        ...|...|. .. |.|.. . ..|.|||| .|  | ..  |.
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES--NPGDYVLSVRWK--------GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase JAK1.AA Jak 374-446 15 0.001774 8.36 In-house 70-146 (299) Show / Hide 
Range on Protein: 374-446
Range on HMM: 70-146/299
Sequence Identity: 15% (12 aa)

HIVIKESVVSINKQDNKKMELKLSSHEEALSFVS----LVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICT
|||. . |.   .||...|.  .... .......    . ... ..|.|...... ......   .... .||..|.
HIVKYHGVCCHWCQDEYCMVMEYWCYGPLDDYLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCA
Kinase JAK1.AA Jak 583-847 38 9.69999999999e-144 483.82 In-house 1-299 (299) Show / Hide 
Range on Protein: 583-847
Range on HMM: 1-299/299
Sequence Identity: 38% (115 aa)

LVQGEHLGRGTRTHIYSGTLMDYK---DDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVC--VRDVENIMVEEFVEGGPLDL
| . ||||.|.....|........   |||.  .|.|..|..||..|.|...|..|....|.|.|.||||||...|||  ... |..|| |... ||||.
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

FMH----RKSDVLTT--PWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGID-SECGPFIKLSDPGIPITVLSRQEC--IERIPWIAPECVED-S
..|    |... ...  .||...|||......|||||...||.||..|.|..|||.. . . ||.||.||........|...   |||||.||||... .
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK

KNLSVAADKWSFG-TTLWEIC----------------YNGEIPLKDKTLIEKERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRAIMRDINK
..|..|.|||||| .||||||                ..|..|........|..|||...|...|.  ..|...||..|..|||||||.||.|.||.|.
FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ
Kinase JAK1.AA Pkinase_Tyr 583-845 28 2.5e-80 272.65 Pfam 1-270 (270) Show / Hide 
Range on Protein: 583-845
Range on HMM: 1-270/270
Sequence Identity: 28% (80 aa)

LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL--DPSHRD-ISLAFFEAASMMRQV-SHKHIVYLYGVCV-RDVE--NIMVEEFVEGGPL
.. |. ||.|   ..| ||. .        ...||.|  |.|  . .|.. .. .|.. |..|.|  .|..|| |||||. ..     ..| |....| |
ITFGKKLGEGAFGEVYKGTWKG------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL

DLFMHRK---SDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITV-------LSRQECIERIPWIAPECVE
. . ...    . ||.... . . | |....|||.| ..|  ....| |...       . ..| .| |   ..        .|...   |.| ||||  
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECIN

DSKNLSVAADKWSFGTTLWEICYNGEIP-LKDKTLIE-KERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRAIMRDI
..|  ... | |||| ..|||.  ||.|  .. .  | .|..||...|   |   ..|. |||..|..|||..|| |..| ...
YGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase JAK1.AA TK 583-845 15 1.7e-58 194.38 In-house 1-486 (486) Show / Hide 
Range on Protein: 583-845
Range on HMM: 1-486/486
Sequence Identity: 15% (77 aa)

LVQGEHLGRGTRT---HIYSGTLMDYKDDEGT---------------SEEKKIKVILKVLDPSHRDISLAFFE--------------AASMMRQVS----
.. |. ||.|       .| |.. . ....|.               .|..|..|  |.| . . . . .||.               |..| . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKHIVYLYGVCVRDVE------------NIMVEEFVEGGP----LDLFMHRKSDV--------------------------------------------
 |..|| |||||.....             ..|.|....|     |. . .....                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTTPWKFKVAKQLASALSYLEDK------DLVHGNVCTKNLLLAREGID----SECGPFIKLSDPG---
                               ||....   . |.|....||..|       .||..... | |.......    ..|||..|..| |   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----------------------------------IPITVLSRQECIERIPWIAPECVEDSK--------NLSVAADKWSFGTTLWEICYNGEIPLKD--
                                       ..... .   | | ||||..| .          . . | |||| ..|||. .|. |     
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

-----------KTLIEKERF---------------YESRCRPVTPSC------------KELADLMTRCMNYDPNQRPFFRAIMRDI
           . ..|. |                ..  . |  |..            .|..|||..| .|||..|| |... . .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase JAK1.AA TKL 625-845 16 1.2e-22 78.44 In-house 62-364 (364) Show / Hide 
Range on Protein: 625-845
Range on HMM: 62-364/364
Sequence Identity: 16% (52 aa)

DPSHRDISLAFFEAASMMRQVSHKHIVYLYG---------VCVR----DVENIMVEEFVEGGP-LDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKD-
||  . .   . | . ||.. .| .|| ..|         ||..    . .  .| |...||  |...          . ... |.. |....||  .. 
DPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNP

-------LVHGNVCTKNLLLAREGI-------DSECGPFIKLSDPGIPITVLSRQE-----------------------CIERIPWIAPECVEDSKNLSV
       ..| .  .||.|. . .        .     ..|..| |.  ..  ...                       ..  . | |||. ... |.. 
KWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTE

AA---------------DKWSFGTTLWEICYNGEIPLKDKTL---------IEKERFYESRCRPVTP--------------SCKELADLMTRCMNYDPNQ
..               | .|||  ||||.   .   ...           .. .  .. ..||  |                .....||..|...||..
KVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEK

RPFFRAIMRDI
|| |  |.  .
RPSFQEILKRL
Kinase JAK1.AA TK-Unique 583-793 22 2.3e-20 67.01 In-house 1-239 (294) Show / Hide 
Range on Protein: 583-793
Range on HMM: 1-239/294
Sequence Identity: 22% (57 aa)

LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDIS-LAFFEAASMMRQVS-HKHIVYLYGVCVRDV-ENIMVEEFVEGGPLDLFM
|. |. .|.|   ... |..   .    ....|...|..| |  ...| .  .|.  ..||...  |..|| ..|.|...     .. |....| |. . 
LEVGDVIGEGAFGQVWRGEVWGIW----KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYL

H---------------------RKSDVLTTPWK----FKVAKQLASALSYLED--KDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPI-----TVL
.                     ......|.| .    .  |.|.|....||.   |  ||...|..| ||..       .  .|..| |.       .|.
RTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE-------DKVCKICDFGMARDVYTNGVY

SRQECIERIP--WIAPECVE-DSKNL-SVAADKWSFGTTLWEICYNGEIP
|...  .|||  | |||    . ..  .   | |||| ..|||. .|. |
SMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACP
Kinase JAK1.AA Frk 635-849 25 2.2e-18 60.0 In-house 41-260 (260) Show / Hide 
Range on Protein: 635-849
Range on HMM: 41-260/260
Sequence Identity: 25% (57 aa)

FFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMH---RKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSEC
|   | .|... |  .. || || ..   ... | .. | |  ..    .|   .  .    .| |.|. . |||..  .|  .  .|.|.  . |    
FLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNI----

GPFIKLSDPGIPITVLSRQE------CIERIP--WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCR-PVTPSC-KELA
   .|. | |.   ..  .|         |.|  | ||| .. .|  .. .| ||||  | ||   | .|    |  |     .   | |  | | ..| 
---CKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNK-FTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLY

DLMTRCMNYDPNQRPFFRAIMRDINKLE
..|  | . ||..|| |  .   ...  
EIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase JAK1.AA TyrKc 583-845 22 1.7e-16 44.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 583-845
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQV--SHKHIVYLYGVCVRD-------VENIMVEEFVEGG
.. |. ||.|    .| ||.              |.|  |.| ...     .| . |..|...  .|..|| |||||. .           .| |....|
ITLGKKLGEGAFGEVYKGTWK-------------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

PLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSR-------QECI------ER--IP-
 |. . ... . |... . . . | |.  .||..| ..|    . | |.....        .| || |    . .        .         ..  .| 
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

-WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIP--------LKDKTLIEKERFYESRCRPVTP-------SCKELADLMTRCMNYDPNQRPFFRAI
 | ||||  . .  . . | |||| ..|||. .|. |        .... .||. .  . . .|  .         .|. ..|..| ..||..|| |..|
RWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

MRDI
 ...
HECF
Kinase JAK1.AA S_TKc 583-847 16 9.8e-15 39.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 583-847
Range on HMM: 1-231/231
Sequence Identity: 16% (47 aa)

LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEG--GPLDLFMH
   ....|.|.    | ..  .           . .| .|...         .    .....  |..|| ||.|..   .  || |...|  | |  ...
YEILRKIGKGAFGKVYKCRHKK----------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIK

RKSDV-----LTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSV-AA
..        ..  .  ....|...|| |. ..  .|  .   |.|| .          ||..| |.   .     ..    ..||| .      .  ..
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL---TTFCGTPWYMAPEVL----GYGKCKC

DKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMR-------DINK
| ||.| .|.| .. |. |       . .. ..  .       .|. |.. .|...||..||    ...       .   
DWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase JAK1.AA UTK 635-739 25 9.8e-13 39.89 In-house 53-168 (296) Show / Hide 
Range on Protein: 635-739
Range on HMM: 53-168/296
Sequence Identity: 25% (30 aa)

FFEAAS---MMRQVS-HKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSD-------VLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLA
| | |    || |.. | ... |.|||...   ..| |. |.| |. .. | ..        ||   . . | . |....||. . .||.... .| |..
FMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVH

REGIDSECGPFIKLSD
. . .  |. ..|..|
MHRMMWHCMMVCKIAD
Kinase JAK1.AA Syk 583-712 29 1.3e-10 32.79 In-house 1-129 (257) Show / Hide 
Range on Protein: 583-712
Range on HMM: 1-129/257
Sequence Identity: 29% (40 aa)

LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRD--ISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIM-VEEFVEGGPLDLFM
|||.. .| |    . .|..|      |  |.. ||| .|.|   | .      |   |. | |  |..|| . |.|    |  | | | .|.||.  ..
LVQDNEIGCGNFGSVHKGWYMMK---SGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGIC--HAEMMMMVMEMAELGPMHKYL

HRKSDVLTTPWKFKVAK-QLASALSYLEDKDLVH
  . .  |.    ..   | |.   ||| |  ||
QQHRHEITANNVLELWHTQVAMGMCYLEEKHFVH
Kinase JAK1.AA Ack 639-724 29 1.5e-10 31.83 In-house 53-140 (266) Show / Hide 
Range on Protein: 639-724
Range on HMM: 53-140/266
Sequence Identity: 29% (27 aa)

ASMMRQVSHKHIVYLYGVCVRDVEN-IMVEEFVEGGPLDLFMHRKSD----VLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAR
.. | .  | |.| |||| |.|.    || |. ..| |   ..         ..| . |  . |.|....||| | ..|  . . |.||..
VAIMHSLDHPHLVRLYGV-VLDQPMLMMVTELAPCGSLLDCLRKHCRTAFFLIHTLCDF--CMQIAMGMRYLEMKRCIHRDLAARNILLFS
Kinase JAK1.AA EGFR 616-722 26 1.3e-09 27.91 In-house 28-134 (258) Show / Hide 
Range on Protein: 616-722
Range on HMM: 28-134/258
Sequence Identity: 26% (29 aa)

KIKVILKVL-DPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGN
|| |  ||| . . .  . .. . | .|  | |.|.| | |||. .    .|  .   | |  ...   | .        . | |. ..|||.. .|| .
KIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQHKDNIGSQHLLNWCVQIAKGMQYLEEHRMVHRD

VCTKNLLL
  . | |.
LAARNVLV
Kinase JAK1.AA Pkinase 756-845 16 2.8e-08 30.37 Pfam 175-293 (293) Show / Hide 
Range on Protein: 756-845
Range on HMM: 175-293/293
Sequence Identity: 16% (20 aa)

IPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDK----TLIEKERFYESRCRPVTPSC------------------------KELADLMTRC
....||| . ...  . ..| ||.| .|.| .  |. | ...    .. ....... ...|.  ..                        .|. |....|
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

MNYDPNQRPFFRAIMRD--I
 ..||..|| .. |. .  .
LCKDPKKRPTAEQILQHPWF
Kinase JAK1.AA Pkinase 583-705 17 5.2e-08 29.41 Pfam 1-124 (293) Show / Hide 
Range on Protein: 583-705
Range on HMM: 1-124/293
Sequence Identity: 17% (24 aa)

LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISL---AFF--EAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGG----
.. |. .|.|.    | ..  .. .          .| .|... .|.. .    ..   |.. .|. ..|..|| ||... .. .  || |..|||    
YHIGRKIGSGSFGCVYKCHHKGTGK----------IVAVKIIKKRHEKSWKDQTHRRLSEIQ-IMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVM

PLDLFMH-RKSDVL--TTPWKFKVAKQLASALSYL
 |  ... ... ..  .     ....|....| |.
DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYC
Kinase JAK1.AA Src 634-712 28 1.3e-05 14.95 In-house 40-120 (255) Show / Hide 
Range on Protein: 634-712
Range on HMM: 40-120/255
Sequence Identity: 28% (23 aa)

AFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMH--RKSDVLTTPWKFKVAKQLASALSYLEDKDLVH
|| . |  | ...|...| || || ..     | |. . | |  . .  ..   |  |     | | |.  .||| . ..|
AFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIH
Kinase JAK1.AA UTK 758-793 38 2e-05 14.56 In-house 205-240 (296) Show / Hide 
Range on Protein: 758-793
Range on HMM: 205-240/296
Sequence Identity: 38% (14 aa)

WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIP
| |||.. .    . . | |||| ..|||. .|  |
WMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLP
Kinase JAK1.AA Ack 756-785 50 3.4e-05 13.48 In-house 175-203 (266) Show / Hide 
Range on Protein: 756-785
Range on HMM: 175-203/266
Sequence Identity: 50% (15 aa)

IPWIAPECVEDSKNLSVAADKWSFGTTLWE
..| ||||    .  | | | |.|| ||||
FAWCAPECLR-HRQFSHASDVWMFGVTLWE
Kinase JAK1.AA UTK 819-845 37 8.2e-05 12.4 In-house 270-296 (296) Show / Hide 
Range on Protein: 819-845
Range on HMM: 270-296/296
Sequence Identity: 37% (10 aa)

ELADLMTRCMNYDPNQRPFFRAIMRDI
.. .||.||..|||  || |. .   .
PVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase JAK1.AA EGFR 756-846 27 0.00025 10.08 In-house 167-258 (258) Show / Hide 
Range on Protein: 756-846
Range on HMM: 167-258/258
Sequence Identity: 27% (26 aa)

IPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCR-PVTPSC-KELADLMTRCMNYDPNQRPFFRAIMRDIN
| |.| ||..  .    . | ||.| |.||.   |. | .   . |   . |   | |  | |   .  .| .|   |.. || |. ..   .
IKWMALECIHHRC-YTHQSDVWSYGVTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase JAK1.AA TK-Unique 815-845 33 0.000743 9.32 In-house 262-294 (294) Show / Hide 
Range on Protein: 815-845
Range on HMM: 262-294/294
Sequence Identity: 33% (11 aa)

PSC--KELADLMTRCMNYDPNQRPFFRAIMRDI
..|  .|.  || .| ...| .|| ||.|   .
EHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase JAK1.AA Syk 758-785 53 0.001411 8.16 In-house 175-201 (257) Show / Hide 
Range on Protein: 758-785
Range on HMM: 175-201/257
Sequence Identity: 53% (15 aa)

WIAPECVEDSKNLSVAADKWSFGTTLWE
| ||||.   |  | . | |||| |.||
WYAPECIYYYK-FSHKSDVWSFGVTMWE
Kinase JAK1.AA Src 758-793 38 0.007137 5.54 In-house 166-200 (255) Show / Hide 
Range on Protein: 758-793
Range on HMM: 166-200/255
Sequence Identity: 38% (14 aa)

WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIP
| |||.. .  . .. .| ||||  |.||   | .|
WTAPEAI-NYGRFTIKSDVWSFGILLTEIVTYGRVP
Kinase JAK1.AA Src 822-845 33 0.021195 3.91 In-house 232-255 (255) Show / Hide 
Range on Protein: 822-845
Range on HMM: 232-255/255
Sequence Identity: 33% (8 aa)

DLMTRCMNYDPNQRPFFRAIMRDI
..|..| . || ||| |  .    
QIMLQCWHKDPEQRPTFEYLQWFL
Kinase JAK1.AA Syk 822-839 38 0.031908 3.43 In-house 240-257 (257) Show / Hide 
Range on Protein: 822-839
Range on HMM: 240-257/257
Sequence Identity: 38% (7 aa)

DLMTRCMNYDPNQRPFFR
.|| .|  |..  || | 
QLMNKCWIYKWCDRPTFV
Kinase JAK1.AA Ack 822-845 33 0.264727 0.16 In-house 243-266 (266) Show / Hide 
Range on Protein: 822-845
Range on HMM: 243-266/266
Sequence Identity: 33% (8 aa)

DLMTRCMNYDPNQRPFFRAIMRDI
..| .|   .|  || | ||  . 
QMMMQCWQHHPADRPTFSAIRDQL
Kinase JAK1.AA Jak 875-1151 41 2e-156 525.93 In-house 1-299 (299) Show / Hide 
Range on Protein: 875-1151
Range on HMM: 1-299/299
Sequence Identity: 41% (123 aa)

LKRIRDLGEGHFGKVELCRYDPEG------DNTGE--QVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKE
||....|||||||.|..||||...      |...|  ||.|| .. ... .|. |...||.|.....|..||||.|.|...........||....|.|..
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

YLP----KNKNKINL--KQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQ---VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSK
||.    ..|...|.  ......| |||.||.||....|.|.|..|||.||..|..   |||..|.|.... .|||||....|||....|||||||...|
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK

FYI--ASDVWSFG-VTLHELL-TYCDSDSSPMALFLKMIG-PTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEA
||   |.|.|||| |||.|.. .|||.. ||.|.||.||| ....||...|..|....|.|||.|..|.||.|.||..||...|..|.||...|. ...
FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ
Kinase JAK1.AA Pkinase_Tyr 875-1149 38 6.8e-131 443.93 Pfam 1-270 (270) Show / Hide 
Range on Protein: 875-1149
Range on HMM: 1-270/270
Sequence Identity: 38% (108 aa)

LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNH--IADLKKEIEILRNL-YHENIVKYKGICTEDGGN-GIKLIMEFLPSGSLKEYLPK
.. .. ||||.||.| ........|||. .||||.||. .   .  ..|. .|..|...| .|.|||.. |.||..|.   | ..||. | |.|..|| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---KNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYY-TVKDDRDSPVFWYAPECLMQSKFYIASDVWS
.   |.....|. |....||.|||.|| |....||||||||.||.....|||.||||...| ....|| ..... . |..|.||||.. .|| ..|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTL-KEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGF
|||.. |..||...              |   |. ..... . ..| |.|||.|||||.|.||..||...|..| .|. ..| .
FGVLMWEIFTYGEQP-------------TYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase JAK1.AA TyrKc 875-1149 37 3.3e-125 423.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 875-1149
Range on HMM: 1-280/280
Sequence Identity: 37% (111 aa)

LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL--YHENIVKYKGICTEDGG-----NGIKLIMEFLPSGSLKEY
.. .. ||||.||.| .....       .|||||.||...    ..|. .|..|...|   |.|||.  |.||..|.       . ..||. | |.||.|
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETD------KEYYTVKD--DRD--SPVFWYAPECLMQSK
| |...|...|. |....||..||.|| |....||||||||.|| ..|.|||.||||...|. |      |.||..|   ...   |. |.||||.. .|
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPN--------CPDEVYQLMRKCWEFQPSNRTSFQNLIEGF
| ..||||||||.. |..||...  . |..           |. ..... .|.|.|.|.|||        ||||.||.|..||...|..| .|....| |
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---------MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase JAK1.AA TK 875-1149 20 2.4e-95 320.09 In-house 1-486 (486) Show / Hide 
Range on Protein: 875-1149
Range on HMM: 1-486/486
Sequence Identity: 20% (100 aa)

LKRIRDLGEGHFG---KVELCRYDPE---------------------GDNTGEQVAVKSLKPESGGNHIADLK----------------KEIEILRN--L
.. .. ||||.||   .| .... ..                     .... ..|||| ||.... .  . .                  |......  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

YHENIVKYKGICTEDGG----------NGIKLIMEFLPSGS----LKEYLPKNKNK--------------------------------------------
 |.|||.  |.||....            . ..||. | |.    |..|| |...|                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------INLKQQLKYAVQICKGMDYLGSR------QYVHRDLAARNVLVESEHQ-----------VKIGDFG---
                               ....|.| ...||..|| || |.      ..|||||||||.|| ....           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LTKAIETDKEYYTVKD-----------------------DRDSPVFWYAPECLM---------QSKFYIASDVWSFGVTLHELLTYCDSDSSP-M
     |...|. |..||....                       ..  |. |.|||||.           || ..||||||||...|..||..    . |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

AL-----FLKMIGPTHGQMTVTRLVNTLKEG--------------KRLPCPPNCP--------------DEVYQLMRKCWEFQPSNRTSFQNLIEGF
       .           ... ... |..|               |.|.||.||              .|.|.||..||...|. | .|. | | .
SNQDVWKD---------G-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase JAK1.AA Frk 875-1153 36 6.5e-62 212.0 In-house 1-260 (260) Show / Hide 
Range on Protein: 875-1153
Range on HMM: 1-260/260
Sequence Identity: 36% (103 aa)

LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLP---KN
.. || || | ||.|   ..     |    |||| |||  |     |. .|  |...| |  ...   .|| .  . | .| | .  |||.|||    ..
IQLIRRLGSGQFGEVWEGLW-----NNTTPVAVKTLKP--GTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVE--EPIYIITELMRHGSLQEYLQAINDK

KNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKE-YYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVT
 ......|..  | |.  || || |. |.|||||||||||. .  .|| |||| . .  |.|  |  . .   |. | |||    .|| | |||||||. 
GRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGIL

LHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL
| |..||            .|  |  | ||    .. ...| |.|.||||| ..|..| .||. .| .|  |  |   .|  .
LTEIITYG-----------RM--PYPG-MTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase JAK1.AA UTK 875-1077 29 8.6e-61 206.69 In-house 1-236 (296) Show / Hide 
Range on Protein: 875-1077
Range on HMM: 1-236/296
Sequence Identity: 29% (70 aa)

LKRIRDLGEGHFGKVELCRYDPEGDNTGE-QVAVKSLKPESGGNHIAD----LKKEIE---ILRNLY-HENIVKYKGICTEDGGNGIKLIMEFLPSGSLK
... |.||.|.|| | ..|.... .  .| .|||| ..... ...  .    . .|     .. ... |.|...  |.|| ...  . ...|. . |.| 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLR

EYLPKNKNKIN-------LKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEH-------QVKIGDFG---LTKAIET--------DKEYYTVKDD
 || ... . .       | |.|..|..|  || || |...|||||||||.|| . .       ..||.|||   ..... |        . .||.  ..
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

RDSPVFWYAPECLMQS-KFYIASDVWSFGVTLHELLTY
.  |. |.|||.| .  .| ..||||||||...|..|.
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW
Kinase JAK1.AA Src 875-1077 38 3.7e-59 199.6 In-house 1-196 (255) Show / Hide 
Range on Protein: 875-1077
Range on HMM: 1-196/255
Sequence Identity: 38% (78 aa)

LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLP--KNK
.|..| ||.|.|| |    ..   .||  .||||.||| .   . ... .|..|. .| ||..|.   .|...    |  . |.   ||| .||   .  
IKLCRKLGQGQFGEVWMGYWN---GNT--KVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE--PIYIVTEYMSHGSLLDYLKKDGEG

NKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLH
 ...|.|..  | |. .||.||.|..|.|||||||||||  .  .|..|||| . |. |.. |. . .   |. | |||..   .| | |||||||. |.
RHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLT

ELLTY
|. ||
EIVTY
Kinase JAK1.AA S_TKc 875-1153 23 9.9e-59 202.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 875-1153
Range on HMM: 1-231/231
Sequence Identity: 23% (69 aa)

LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS--GSLKEYLPKNK
 . .| .|.| |||| .||       ||..||.| .|         ....||.||..  |.||||..... .   . . ..||...   |.|..|. |..
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRG

NK-----INLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYI-ASDVWS
 .     ..  .  .|. |||....|. |.. .||||   |.|. .  ..||.|||| . .          .      .. ||| |   ..   ..|.||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWS

FGVTLHELLT----YCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGF-----EALL
.|..| |.|.    ..      |.. .|.||                           ..|. ...|||... |..| .   . ..         .
CGCILYEMLCGYPPFP-----QMQMMFKKIG---------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase JAK1.AA EGFR 875-1077 38 5.6e-58 191.03 In-house 1-199 (258) Show / Hide 
Range on Protein: 875-1077
Range on HMM: 1-199/258
Sequence Identity: 38% (78 aa)

LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNK
||... || | ||.|    . |||.|    ||.| |. ..| .   ..  |  ..  . |...|.  |.| ..    ..|.  ..| |.| .|. ..|..
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ---MQLVTQYMPYGCLLDYVRQHKDN

INLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHEL
|  ...| ..||| ||| ||  .. |||||||||||| |  .||| |||| |  | |.. |.... .  |. | | ||. . ..  .|||||.|||. ||
IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGK-MPIKWMALECIHHRCYTHQSDVWSYGVTCWEL

LTY
.|.
MTF
Kinase JAK1.AA TKL 881-1149 20 3.8e-56 192.84 In-house 1-364 (364) Show / Hide 
Range on Protein: 881-1149
Range on HMM: 1-364/364
Sequence Identity: 20% (81 aa)

LGEGHFGKVELCRYD------PEGDNTGEQVAVKSLKPESGGN--------------------------HIADLKKEIEILRNLYHENIVKYKGICTEDG
.|.|.||.|   ..       | . .||. |||| .| ..  .                              ...|| ....| |.|||...|.|.. .
IGSGGFGEVYKGKWRGWGGKCP-S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP

GNG-----------IKLIMEFLPSGS-LKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQ--------YVHRDLAARNVLVESEHQ------------
...           . ..||. | || |  ..        . | .. | .|..||.|| |..         .||||  .|.|| .  .            
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--VKIGDFGLTKAIETDKEYYTVKDD-------------RDSPV---FWYAPECLMQS----------------KFYIASDVWSFGVTLHELLTYCDSDS
  .||.|||| . ......    . .             . ...    | |||.|...                ..  ..||.|||. | |.|| |    
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

SPMALFLKMIGPTHGQMTVTRL---------VNTLKEGKRLPCP------------PNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGF
           | ....  ...         .   ..|.|.|.|            |.||... .|| .||.  |..| ||| ... .
-----------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase JAK1.AA Ack 875-1077 35 9.8e-54 179.64 In-house 1-207 (266) Show / Hide 
Range on Protein: 875-1077
Range on HMM: 1-207/266
Sequence Identity: 35% (74 aa)

LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPE--SGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK
...   ||.| || |     .    ..  |||||.|...  . .| . |. .|  |. .| |...|.  |.        .....|. | ||| . | | .
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPM--LMMVTELAPCGSLLDCLRKHC

N--KINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESE-HQVKIGDFGLTKAIETDKEYYTVKDDR--DSPVFWYAPECLMQSKFYIASDVWSF
   .  .   . ...||..|| ||...  .||||||||.|. |    |||.||||  |    . ||. .  |    |  | ||||| . .|  |||||.|
RTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMF

GVTLHELLTY
|||| |  .|
GVTLWEMFSY
Kinase JAK1.AA TK-Unique 875-1077 32 1.3e-53 183.28 In-house 1-235 (294) Show / Hide 
Range on Protein: 875-1077
Range on HMM: 1-235/294
Sequence Identity: 32% (76 aa)

LKRIRDLGEGHFGKVELCRYDP--EGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLY-HENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKN
|.  . .||| || |  . . .  ....   .|||| || .. .   .|..|||.....|  |.|||.  |.||... .   .|||..| |.|  || ..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC

KNK-------------------------INLKQQLKYAVQICKGMDYLGS--RQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSP
. .                         |..|. . .|.||..|| || |  .. |||||.|||||. . ...||.|||... ..|...| . .     |
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

VFWYAPECLM--QSKF-YIASDVWSFGVTLHELLTY
. | ||| |   .  . .. ||||||||.. |..|.
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTL
Kinase JAK1.AA Syk 875-1077 36 4.4e-48 163.6 In-house 1-205 (257) Show / Hide 
Range on Protein: 875-1077
Range on HMM: 1-205/257
Sequence Identity: 36% (76 aa)

LKRIRDLGEGHFGKVELCRYDPE---GDNTGEQVAVKSLKPESGG-NHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPK
| . . .| | || |    |      |.    .||.| || . .  .    .  | ..   | |  ||.  |||    .    ..||  . |..  || .
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICH---AEMMMMVMEMAELGPMHKYLQQ

NKNKINLKQQLKYAV-QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGV
... |  .  |.    |.  || || ... ||||||||||| . .|. || |||. ||   | .||. .     || ||||||    ||  .||||||||
HRHEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGV

TLHELLTY
|. | . |
TMWEMFSY
Kinase JAK1.AA Pkinase 875-1149 21 1e-39 141.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 875-1149
Range on HMM: 1-293/293
Sequence Identity: 21% (67 aa)

LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKK-----EIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSG----SLK
....| .|.| ||.| .|.   .|.    .|||| .| .  ...   ..      ||.|...| |.|||........  .. | ..||... |    .|.
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLF

EYLP-KNKNKI--NLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQV----KIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLM-QSK
.|.  ......    ..  .|. ||..|..|. |.  .||||   |.|. .. ..    ||.|||| | ..     ..  ...    .. ||| .. ...
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQY

FYIASDVWSFGVTLHELLTYCDSDSSPMALFLKM----IGPTHGQMTVTRLVNTLKEGKRLPCP---------------PNCPDEVYQLMRKCWEFQPSN
   ..|.||.|..|.|.|.          .|          .. || . ..   |..    .|.               .| ..|  .....|... |. 
YGPKVDMWSCGCILYEMLCGR-------PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKK

RTSFQNLIEG--F
| ... . .   |
RPTAEQILQHPWF
Kinase JAK1.AA Syk 1108-1143 44 1.1e-15 50.41 In-house 222-257 (257) Show / Hide 
Range on Protein: 1108-1143
Range on HMM: 222-257/257
Sequence Identity: 44% (16 aa)

LKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQ
.. |.|..||. ||.|.||||.|||  .. .|  | 
IENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase JAK1.AA UTK 1110-1149 40 2e-14 45.79 In-house 255-296 (296) Show / Hide 
Range on Protein: 1110-1149
Range on HMM: 255-296/296
Sequence Identity: 40% (17 aa)

EG--KRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGF
.|   |.|||. ||..||.||..||.  |..| .|. | . .
NGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase JAK1.AA Ack 1109-1149 41 5e-14 43.72 In-house 226-266 (266) Show / Hide 
Range on Protein: 1109-1149
Range on HMM: 226-266/266
Sequence Identity: 41% (17 aa)

KEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGF
||| ||| |. || ..||.| .||...|  | .| .. . .
KEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase JAK1.AA Src 1099-1149 38 9.6e-14 43.02 In-house 204-255 (255) Show / Hide 
Range on Protein: 1099-1149
Range on HMM: 204-255/255
Sequence Identity: 38% (20 aa)

MTVTRLVNTLKEGKRLPCPPNCPDEVYQ-LMRKCWEFQPSNRTSFQNLIEGF
||    .  .. | |.|||.|||||.|. .|..||. .|  |  |  | . .
MTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase JAK1.AA TK-Unique 1097-1149 29 3.4e-12 38.45 In-house 241-294 (294) Show / Hide 
Range on Protein: 1097-1149
Range on HMM: 241-294/294
Sequence Identity: 29% (16 aa)

GQMTVTRLVNTLKEGKRLPCPPNC-PDEVYQLMRKCWEFQPSNRTSFQNLIEGF
..|  ..... ...|.|.| |..| ..|.|.||. ||   |. | ||  ..  .
PGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase JAK1.AA EGFR 1108-1150 44 3.4e-12 36.63 In-house 216-258 (258) Show / Hide 
Range on Protein: 1108-1150
Range on HMM: 216-258/258
Sequence Identity: 44% (19 aa)

LKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFE
|..|.||| ||.|   ||..| |||   .  |  |. |.| |.
LEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK