Gene IKKe (Human)
IKKe
Sequence
Protein domains of IKKe.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | IKKe.AA | IKK | 9-293 | 55 | 2.5e-187 | 628.62 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 9-293 Range on HMM: 1-297/297 Sequence Identity: 55% (164 aa) WHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQ-------NIVKLFAVEET---GGSRQKVLVMEYCSSGSLLSVL |...|.|||||...||..|.||.|. ||||..|..|..|.|.|..||||....|||| ||..|...||. ..|.|.|||||..|.|...| WEMCDRLGQGAFGNVYHWRHKKTGRKVAVKHCNHMSWMRCRWVWCREFEWMKRLNHQRQFVWFPNIWCLCDIEEDMQWQICKQPVIVMEYCTGGDLYKYL ESPENAFGLPE-DEFLVVLRCVVAGMNHLR-ENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQK .||.|..||.| .|||.|.|...|||.||. .||||||||||||||...||.|..|||.||||.|||.||||.|.|.||||||||||||||||||||.|| NSPWNCCGLKEGHEFLQVCRDCCAGMHHLHSQNGIVHRDIKPGNIMCQKGEDGKTIYKITDFGYAREWDDDEMFMSFYGTEEYLHPDMYERAVLRKPHQK AFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCW ....|||.||.|||.||.|||.|||.|...|||..|.|..||||||.|...|.|...|||.|||..||..|.|. ....|..|.....||..|..|| PYCATVDYWSFGVTFYHCATGELPFMPHWQPRRWHEKMKHITTEKPSGVCIGVQEEMNGPVEWSSHLPQYCHLCQIIHEQMEPWCIMMLEWHQDQCW |
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| Kinase | IKKe.AA | S_TKc | 9-311 | 22 | 2e-50 | 174.73 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 9-311 Range on HMM: 1-231/231 Sequence Identity: 22% (70 aa) WHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQNIVKLFAVEETGGSRQKVLVMEYCSS--GSLLSVLESPENA-- .. ...|.|| ..|||.|.||.|..||.|. . | || ..|.| .| |||||. | .. .|||||. |.|...... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL -FGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGV-TV |..|| . ... .. ..... ..||.|||.|| ||. |..||| ||.| .. || .|. | . .| . RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL-----------GYGKCKC DLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFAET | ||.|..|| ..| || . . |... ... .. ..|... .| .. . ... DWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE SDILQRVVV .|| . . WDIKCHPWF |
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| Kinase | IKKe.AA | CAMK | 14-221 | 19 | 5.3e-47 | 149.08 | In-house | 1-334 (425) | Show / Hide |
Range on Protein: 14-221
Range on HMM: 1-334/425
Sequence Identity: 19% (66 aa)
LLGQGATASVYKARNKKSG------------ELVAVKVFNTTSYL-------------------------RPREVQ--VREFEVLRK-------LNHQNI
||.|. . |.....|... . ||.|. ... ||. . || |...| |.| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VKLFAVEETGG---------SRQK---------VLVM---EYCSSG----SLLSVLESPEN------------AFGLPEDEFLVVLRCVVAGMNHLRENG
.||. | |.. . .| ..|| |||| | |.. . . .. . ..|.| . | .. ..... ...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
IVHRDIKPGNIMRLVGEEGQ-------------SIYKLTDFGAARELDD------------------------DEKFVSVYGTEEYLH-PDMYER-----
|||||.|| ||. .... |..||| |...|. ..|. . || || | . ..
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
----AVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPF
... | .| ||.|| || .| .||
MQNAT---DEEKPYYGPKCDMWSCGVILYIMLCGYPPF
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| Kinase | IKKe.AA | Pkinase | 9-221 | 29 | 1.1e-45 | 162.59 | Pfam | 1-212 (293) | Show / Hide |
Range on Protein: 9-221 Range on HMM: 1-212/293 Sequence Identity: 29% (65 aa) WHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVR---EFEVLRKLNHQNIVKLFAVEETGGSRQKVLVMEYCSSG----SLLSVLE-S .|. .|.|. ..|||...|..|..||||... . ... | | .....||| |||.|. . |. .. .||||| | .| .... . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW PENAFGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRL-VGEEGQSIYKLTDFGAARE--LDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKA ...| ..|.| ... .. |.... ..||.|||.|| ||. |. . . |..||| |. . .. . .. || .|. | | .| .. RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAP---EV--IR--GGQY FGVTVDLWSIGVTLYHAATGSLPF | || ||.|..|| ..| .|| YGPKVDMWSCGCILYEMLCGRPPF |
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| Kinase | IKKe.AA | ULK | 9-221 | 27 | 2.3e-42 | 145.7 | In-house | 1-256 (329) | Show / Hide |
Range on Protein: 9-221 Range on HMM: 1-256/329 Sequence Identity: 27% (71 aa) WHTDDLLGQGATASVYKARNKKS----GELVAVKV-----FNTTSYLRP----REVQVREFEVLRKLN--------HQNIVKLFAVEETGGSRQKVLVME .. .. ||.|. . |||.||||. .|.||.|. .| ..... . .| ....||. |.|||||. . || . ..|| YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME YCSSGSLLSVLE----SPENA---FGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEG--------QSIYKLTDFGAARELDDD----E || | | . .. .||. |.|.| . ... ..|. .|....|.|||||| ||. | .. . ..|..||| |. .|.| . YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ KFVSVY------GTEEYLHPDMYERAVLRKPQ--QKAFG-VTVDLWSIGVTLYHAATGSLPF ... || | | .. | || .. ..|.||.|. .| .| || MMMTCVNEKRLCGTPLYMAPQILQG------QGEQKPYYDYKCDIWSLGCIFYEMLYGKPPF |
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| Kinase | IKKe.AA | ULK | 9-221 | 26 | 1.2e-40 | 141.38 | In-house | 1-252 (324) | Show / Hide |
Range on Protein: 9-221 Range on HMM: 1-252/324 Sequence Identity: 26% (68 aa) WHTDDLLGQGATA-SVYKARNKKS---GELVAVKVFN-----TTSYLRP----REVQVREFEVLRKLN---HQN--IVKLFAVEETGGSRQKVLVMEYCS . .. ||.|. . |||.||||. ...||.|. . ..... . . .| ....||. |.| ||||. . || . ..|||| YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN SGSLLSVLE----SPENA---FGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEG--------QSIYKLTDFGAARELDDD----EKFV | | . .. .|| |.|.| . ... ..|. .|....|.|||||| ||. | .. . ..|..||| |. .|.. .. GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ SVY------GTEEYLHPDMYERAVLRKPQ--QKAFG-VTVDLWSIGVTLYHAATGSLPF . || | | .. | || .. .|.||.|. .| .|. || TCVNEKRIKGTPLYMAPQILQG------QGEQKPYYDYKCDIWSLGCIFYEMLYGKYPF |
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| Kinase | IKKe.AA | STE | 9-221 | 22 | 3.9e-40 | 139.43 | In-house | 1-268 (359) | Show / Hide |
Range on Protein: 9-221 Range on HMM: 1-268/359 Sequence Identity: 22% (65 aa) WHTDDLLGQGATASVYKARNKK---------------SGELVAVKVFNTTSYL----------------RPREVQVREFEVLRKLN--HQNIVKLFAVEE | . .|.||. .||||.|.| .||..|.|. | . .. .| ....|.| |.|||| . .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF TGGSR-----QKVLVMEYCSSGSLLSVLE---SPENA--------FGLPEDEFLVVLRCVVAG-MNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDF .| . ..|||.. ||| .... .. . . .||.. ...| .. | ...| ...|.||||||.||. ||.|| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDF GAARELDD-----------------DEKFVSVYGTEEYLHPDMYER---AVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPF | . |.| ..| .. || . | . .. . | .. .| ||.| |. . ||| |. GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R----DKGYDTKCDIWSLGCTIIEMATGKPPW |
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| Kinase | IKKe.AA | CAMKL | 9-179 | 28 | 2.3e-33 | 103.7 | In-house | 1-199 (297) | Show / Hide |
Range on Protein: 9-179 Range on HMM: 1-199/297 Sequence Identity: 28% (58 aa) WHTDDLLGQGATASVYKARN-KKSGELVAVKVFNTTSYLRPREVQ--------------VREFEVLRKLN---HQNIVKLFAVEETGGS----RQKVLVM . . ||.|. . | |.. . || ||.|. . .. || . ...|| |.||.||. | || . .||| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM EYCSSGS--LLSVLESPENAF-GLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDD-----DEKFVSVYGTEE ||||.|. |. ... .. .||.| | .|...|.. ..||||||||| || |. | | . |..||| . . .. ..|. |. . EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENI--LLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP Y | Y |
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| Kinase | IKKe.AA | Ciliate-E2 | 9-234 | 19 | 6.3e-29 | 96.43 | In-house | 1-301 (365) | Show / Hide |
Range on Protein: 9-234
Range on HMM: 1-301/365
Sequence Identity: 19% (63 aa)
WHTDDLLGQGATASVYKARNKKSGE-----------------------LVAVKVFNTT--SYLRPREVQVREFE----------VLRKLNHQNIVKLFAV
..|||. .||||....| .. ..|.|... .. . . || . .|..||| ||.|.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
EETGGSRQKVLVMEYCSSGSLLSVLE--------------SPENAFGLPEDEFLVV---------LRCVVAGMNHLRENG-IVHRDIKPGNIMRLVGEEG
.. ||||||. |.|.. .. .. . . .. ..|.. ....| ... |.|||||| ||.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------
QSIYKLTDFGAARELDDD--------------------------------EKFVSVYGTEEYLHPDMYE-RAVLRKPQQKAFGVTVDLWSIGVTLYHAAT
|..||| ....||| . | ...|| .|. | ... .|| . .|.||.||.|| .
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF
GSLPFIPFGGPRRNKEIM
| .|| ..|.
GKPPF--------QQQIK
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| Kinase | IKKe.AA | TKL | 15-221 | 18 | 1.5e-27 | 96.27 | In-house | 1-289 (364) | Show / Hide |
Range on Protein: 15-221
Range on HMM: 1-289/364
Sequence Identity: 18% (56 aa)
LGQGATASVYKARNKK--------SGELVAVKVFNTTS--------------------------YLRPREVQVREFEVLRKLNHQNIVKLFAVEETGGSR
.|.|. . |||.. . .|. ||||.|.... . . |. ..| ....|.|.|||.. .. ....
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
Q-----------KVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENG--------IVHRDIKPGNIMRLVGEEGQ-----------
. .|||||. ||||..| . .. . . |||.| .. |.|||.|. || || | ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNI--LVDENWTNVSNYMYNPNA
-SIYKLTDFGAARELDDDE--------------------KFVSVYGTEEYLHPDMYERAVLRKP--------QQKAFGVTVDLWSIGVTLYHAATGSLPF
|..||| .|... .. . .. || .. | . . . . ... . .| .| |. |. .|. .|.
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY
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| Kinase | IKKe.AA | MARK | 15-159 | 38 | 1.8e-26 | 83.71 | In-house | 7-151 (262) | Show / Hide |
Range on Protein: 15-159 Range on HMM: 7-151/262 Sequence Identity: 38% (57 aa) LGQGATASVYKARNKKSGELVAVKVFNTTSYLRPRE--VQVREFEVLRKLNHQNIVKLFAVEETGGSRQK--VLVMEYCSSGSLLSVLESPENAFGLPED .|.|. | |..|..|..|. ||.|. . .. .| . || |...||.| ||.||| | | .|. .|.|||.|.|.|.. ... .| |.|. IGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIE-QDTEQHQIYLIMEYASGGELYDYIKAHPNGR-LHEE EFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEG-QSIYKLTDFG | . | .| ..| . ...|||||||| || |. |.| . | |..||| EARRIFRQIVSAVNYCHSKNIVHRDIKPENI--LIDENGNHNI-KIIDFG |
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| Kinase | IKKe.AA | STE20 | 9-176 | 29 | 8.4e-25 | 87.77 | In-house | 1-185 (288) | Show / Hide |
Range on Protein: 9-176 Range on HMM: 1-185/288 Sequence Identity: 29% (58 aa) WHTDDLLGQGATASVYKARNKKSGEL----VAVKVFNTTSYLRP---REVQVREFEVLRKLNHQNIVKLFAVEETGGSRQKV--------LVMEYCSSGS . . .|||.. .||||..|..||. ||.|. | . . .| . | ......|.|||| . || .| .|||||. || YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYY------GSYLKDDTCDDELWIVMEYCGGGS LLSVLES--PENA----FGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDD-----DE-KFVSVYGT |. ... . . . . |.. ...| |. | ..| .|.|.||||| .|| |..|.|. ||.||| . |.. . | .. || LTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNI--LLTEDGEV--KLADFGVCAQLTKHGRDTMQFKRNTFVGT |
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| Kinase | IKKe.AA | Pkinase_Tyr | 9-136 | 30 | 4e-14 | 48.46 | Pfam | 1-137 (270) | Show / Hide |
Range on Protein: 9-136 Range on HMM: 1-137/270 Sequence Identity: 30% (42 aa) WHTDDLLGQGATASVYKARNK----KSGELVAVKVFNTTSYLRP--REVQVREFEVLRKL-NHQNIVKLFAVEE-TGG-SRQKVLVMEYCSSGSLLSVLE . . ||.|| .|||.. | . . ||||. . .. . || || .....| .|.|||.| .| |. . | .||||. |.||. | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLR SP-ENAFGLPEDEFLVVLRCVVAGMNHLRENGIVHRDI .. |. |. . | . . .||..| .....|||. KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL |
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| Kinase | IKKe.AA | TyrKc | 9-325 | 19 | 2.4e-13 | -7.04 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 9-325
Range on HMM: 1-280/280
Sequence Identity: 19% (70 aa)
WHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKL--NHQNIVKLFAVEETGGS-----RQKVLVMEYCSSGSLLSVLESP
. .. || || |||.. | . ||||. . . || || ....|| .|.|||.|..| ..| . .||||.. |.|.. | ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH
ENAFGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDD-EKFVSVYGTEEYLHPDMYERAV--LRK------
.. |. ...| . .||..| .....|||. |. ||||.. . | .||| .|...|| .. |.| . .|
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNC--LVGENH--TVKISDFGLSRDIYDDDQQG---------ESKDYYRKKEHKGGKTMLPIR
------PQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGP----RRNKEIMYRITTE----KPAG----AIAGAQRRENGPLEWSYTLPITCQLSLGLQ
. . | | || ||... | . | |. |.|.. .. . .|. .
WMAPECINYGKFTTKSDVWSFGVCMWEIFT--YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------------
SQLVPILANILEVEQAKCWGFDQFFAETSDILQRVVVHVFSL------SQAVLHHIY
| . .| . .. . . .|..
-----------------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | IKKe.AA | CAMKL | 202-221 | 60 | 4.7e-05 | 11.92 | In-house | 217-236 (297) | Show / Hide |
Range on Protein: 202-221 Range on HMM: 217-236/297 Sequence Identity: 60% (12 aa) VDLWSIGVTLYHAATGSLPF || ||.||.|| .| ||| VDIWSCGVILYAMVCGYLPF |
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| Kinase | IKKe.AA | MARK | 202-221 | 55 | 0.001042 | 8.19 | In-house | 187-206 (262) | Show / Hide |
Range on Protein: 202-221 Range on HMM: 187-206/262 Sequence Identity: 55% (11 aa) VDLWSIGVTLYHAATGSLPF || || || || .|..|| VDIWSLGVVLYFMVCGYFPF |
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