Gene IGF1R (Human)

IGF1R

Species: Human
Alias: MGC142172, IGF1R, MGC142170, IGFIR, CD221, MGC18216, JTK13
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 15q26 ,

Classification

Group: TK
Family: InsR

Sequence

Name Sequence Type Origin Length Description Download
IGF1R.NA RNA Sugen Kinome 11242 None Fasta, JSON
IGF1R.AA Protein Sugen Kinome 1367 None Fasta, JSON
IGF1R.kin_dom Protein Kinase Domain Sugen Kinome 270 None Fasta, JSON

Protein domain

Protein domains of IGF1R.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain IGF1R.AA Recep_L_domain 51-161 38 6.2e-47 159.53 Pfam 1-121 (121) Show / Hide 
Range on Protein: 51-161
Range on HMM: 1-121/121
Sequence Identity: 38% (47 aa)

NCTVIEGYLHILLISKAEDYRSY---RFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFY--NYALVIFEMTN--LKDIGLYNLRNITR--GAI
|||||.|.|.|..... .. ...    ||....||.|||..|. ..... ..||||..||| .||.  ||||.|... |  |......||.||||  | .
NCTVIYGNLEITWRDEHNE-LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKNGGV

RIEKNA--DLCYLST-VDWSLIL
.|..|   .|||. | ..|..|.
YIHNNPHPKLCYTHTEIMWWMIY
Furin-like IGF1R.AA Furin-like 175-333 48 6.8e-87 285.54 Pfam 1-182 (182) Show / Hide 
Range on Protein: 175-333
Range on HMM: 1-182/182
Sequence Identity: 48% (90 aa)

PKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTN--RCQ----KMCPSTCGKRACT--ENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPP
..||.|.||||.| .. |.|||||..|.||||..|   ||    |.||. |..|.||   ..||||..|||.|..|.|||.||||||.|. |.||..|||
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKHRRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQCPP

----------------NTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNG-SQSMYCIPCEGPCPKVCE
                .||.|||||||....|...   ...| . .|||.|||| |||||...|  ...| | ||||||||||.
MMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKL--SHNPDCNYYVIHNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
FU IGF1R.AA FU 227-270 40 6.7e-15 56.75 SMART 1-48 (48) Show / Hide 
Range on Protein: 227-270
Range on HMM: 1-48/48
Sequence Identity: 40% (20 aa)

NNEC--CHPECLGSCSAPDNDTACVACRHYYYA---GVCVPACPPNTYR
...|  |||||.. |. |. ...|..|.|.||    |.||. |||..|.
DGVCKPCHPECATGCWGPG-PDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain IGF1R.AA Recep_L_domain 352-467 38 1.9e-47 161.26 Pfam 1-121 (121) Show / Hide 
Range on Protein: 352-467
Range on HMM: 1-121/121
Sequence Identity: 38% (46 aa)

GCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEG-NYSFYVLDNQN--LQQLWDWDHRNLTIKAGKMYF
.||...||| |..|...|. .|...| ..|...|||..|.....|..|||..||| | |..  .. ||..|..||.|  ||.||.| ..|.|.|.|..|.
NCTVIYGNLEITWRDEHNELEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKNGGVYI

AFNP--KLCVSEIYRMEEVTG
 .||  ||| .... |.....
HNNPHPKLCYTHTEIMWWMIY
FN3 IGF1R.AA FN3 489-592 12 4.4e-05 24.13 SMART 1-69 (69) Show / Hide 
Range on Protein: 489-592
Range on HMM: 1-69/69
Sequence Identity: 12% (15 aa)

ESDVLH---FTSTTTSKN------RIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPW----T
 . . .   .. | ....       . ..|    ||        .|.|.                                       ..||||.    |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK---PP--------IVGYR-------------------------------------YTVTGLKPGQYPWT

QYAVYVKAVTLTMVEND
.| . |.||. ...   
EYEFRVRAVNGNDAGEG
FN3 IGF1R.AA FN3 611-814 6 1e-06 29.12 SMART 1-69 (69) Show / Hide 
Range on Protein: 611-814
Range on HMM: 1-69/69
Sequence Identity: 6% (14 aa)

PSIPLD---VLSASNSSS------QLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCA
|. | .   .   . .|.      .. ..|.||          ||...                                                    
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----------IVGYR----------------------------------------------------

CPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPF----T
                                                                                       ....|.|     |
--------------------------------------------------------------------------------------YTVTGLKPGQYPWT

LYRIDIHSCNHEAEKLG
 |.. .   |. .   |
EYEFRVRAVNGNDAGEG
FN3 IGF1R.AA FN3 832-914 15 4e-07 30.93 SMART 1-69 (69) Show / Hide 
Range on Protein: 832-914
Range on HMM: 1-69/69
Sequence Identity: 15% (15 aa)

DDIPGP---VTWEPRPEN------SIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPG-----NYTARIQATSL--SGNG
 . |.    .....  ..      |. |.| .|      |. |.                        ...  | ||     .|. |..| .    | |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase IGF1R.AA InsR 999-1268 73 2.5e-231 774.76 In-house 1-278 (278) Show / Hide 
Range on Protein: 999-1268
Range on HMM: 1-278/278
Sequence Identity: 73% (205 aa)

ITMSRELGQGSFGMVYEGVAKGVVKDEPET--RVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP
|.. ||.|||||||||||.|||.|.||...  |.|||||||.||||||||||||||||||||||||||||||.|.|||..|.||.||.|||||||||.||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

EME-NNPVLA----PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTT
|.| |||..     .|.|..|.|||.||.||||||.|.||||||||.|||||..|||||||||||||||||.|||||||||.||||||.|||||||||||
EEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFTT

YSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV-MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE
.||||||||||||..||.|||||||||||||... |.|..|..|.|||....|||.|||||.|||||.||.||.....
HSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase IGF1R.AA Pkinase_Tyr 999-1266 45 2.8e-154 523.11 Pfam 1-270 (270) Show / Hide 
Range on Protein: 999-1266
Range on HMM: 1-270/270
Sequence Identity: 45% (127 aa)

ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRE--RIEFLNEASVMKEF-NCHHVVRLLGVVS-QGQP--TLVIMELMTRGDLKSYLR
||. ..||.|.||.||.|..||  .|.... ||.|...| |. ..  | .|..||..||.. .....|||.||.. ||.|   ...||.|  |||..|||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYY-RKGGKGLLPVRWMSPESLKDGVFTT
. |      .   |.... ..||. .||.||.|| .....|||||||||.|.|...|||.|||..||||..||| ||.|.| ||..||.||....|.|||
KHR------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

YSDVWSFGVVLWEIATLAEQP-YQGLSNEQVLRFV-MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI
 ||||||||..||| |. ||| |.|.|||.|....  .|. ...|.|||| . .||..||.|.|..||.| ||.. .
KSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase IGF1R.AA TyrKc 999-1266 40 9.40000000001e-144 484.79 SMART 1-280 (280) Show / Hide 
Range on Protein: 999-1266
Range on HMM: 1-280/280
Sequence Identity: 40% (122 aa)

ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEF--NCHHVVRLLGVVSQG-------QPTLVIMELMTRGDLKS
||. ..|| | || ||.|..|        . ||.|...| |    | .|..||..|...  .  ..|||.||..|.       .| ...||.|  ||||.
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYET-------DYYRK----GGKGLLPVRW
|||. ||.          .........  ||.||.||  ....|||||||||.|.|..||||.|||..||||.        |||||    |||..||.||
YLRKHRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG-----LSNEQVLRFVMEGGLLDKPDN--------CPDMLFELMRMCWQYNPKMRPSFLEIISS
|.||....|.||| ||||||||..||| |. .||| |     .||..|...|..|. ...|.|        ||| ....|..||...|..||.| ||.. 
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

I
.
F
Kinase IGF1R.AA TK 999-1266 25 1.2e-120 406.37 In-house 1-486 (486) Show / Hide 
Range on Protein: 999-1266
Range on HMM: 1-486/486
Sequence Identity: 25% (123 aa)

ITMSRELGQGSFG---MVYEGVAKGVV--------------------KDEPETRVAIKTVNE--AASMRERIE-----------FLNEASVMKEFN----
||. ..||.| ||   .||.| ..|                      |.. .|.||.|.. |  |.|..|...           ||.||..|| ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-CHHVVRLLGVVSQG------------QPTLVIMELMTRGD----LKSYLRSLRPEMENNPVLAP-----------------------------------
 . ..|||.||..||            .| ...||.|  ||    |..|||. ||.. ...   .                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------PSLSKMIQMAGEIADGMAYLNAN------KFVHRDLAARNCMVAEDFT-----------VKIGDFGMT-
                               ...  .. |.  ||.||.|| ..      .|||||||||||.|.|. .           .||.|||.. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RDIYETDYYRKGG------------------------KGLLPVRWMSPESLKDGV---------FTTYSDVWSFGVVLWEIATLAEQPYQG-L
       ||||. |.|.. .                        .| ||.|||.||.|.|.|         ||| ||||||||..||| |....|| | .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------EQVLRFVMEGGLL--------------DKPDNCP--------------DMLFELMRMCWQYNPKMRPSFLEIISSI
||         ..|.... .|| |               .|..||              .....||..||.|.|. ||.| .. . .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IGF1R.AA UTK 999-1266 38 7.89999999999e-110 371.18 In-house 1-296 (296) Show / Hide 
Range on Protein: 999-1266
Range on HMM: 1-296/296
Sequence Identity: 38% (115 aa)

ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EAASMRERI---EFLNEAS---VMKEFN-CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSY
.  .|.|||| ||.|... .. .   ..| .||.|. . .|.. .|.    .|..||    .|| |. . .|.||.||..|..|.....|.| .||| ||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRSLRPEMENNPVLAPPSLS--KMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED-------FTVKIGDFG---MTRDIY---------ETDYYRKG
||. ||. .     .| .|.  ....||  ||.||.||   .||||||||||| |...        ..||.|||   |.|...         |..||.. 
LRRHRPTPP----ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQ

GKGLLPVRWMSPESLKDG-VFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGG--LLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI
. . .|.|||.||.| ..  ||| |||||||||.||| | . .|| |.||.||. .|..||  .. .|. ||. ...||. ||.|.| .||.| .. . .
HQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase IGF1R.AA Sev 999-1266 48 3.6e-105 351.37 In-house 1-277 (277) Show / Hide 
Range on Protein: 999-1266
Range on HMM: 1-277/277
Sequence Identity: 48% (133 aa)

ITMSRELGQGSFGMVYEGVAKGVV-KDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPE
 .. | || | || |||| || .    | | ||||||    .   | .||| || .|  |.   .| ..||   . |  .|||.|  ||| .|||  |  
LKLRRFLGSGAFGEVYEGQAKDIDGVGEEEQRVAIKTLRKGSTDQEKQEFLKEAHLMSKFKHPNIVCQMGVCLDNEPQYIIMEHMEGGDLLCYLRAARMT

MENNPV-LAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE-------DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVF
   ||   |  .|. .. |   |. |  ||    |||||||.||| | .         .|||||||  ||||  ||||| | ||||||||.|||| ||.|
TFQNPQPTAGLTLMDLVEMCIDISKGCEYLEDMHFVHRDLACRNCLVSVKDYTTHRRRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLMDGYF

TTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI
|| ||||.||.  ||| ||  |||   ||  ||..| .|| |. |..||| |. .|| ||.  |  ||||  .   .
TTQSDVWAFGILCWEIMTLGHQPYPAHSNFEVLNHVQAGGRLQQPRMCPDDLWMMMRQCWRQDPWQRPSFHMCQNML
Kinase IGF1R.AA ALK 999-1268 43 7e-102 344.77 In-house 1-273 (273) Show / Hide 
Range on Protein: 999-1268
Range on HMM: 1-273/273
Sequence Identity: 43% (121 aa)

ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEM
||  | ||.| || ||.|  ..   |  .  ||.||  | .|  .   |..|| .|  ||   |||..|.  | || ... |.|  ||.||.||  ||. 
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP

E--NNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFT---VKIGDFGMTRDI-YETDYYRKGGKGLLPVRWMSPESLKDGVFTTY
|  .   |.    .  .| .  .| |  ||  |.|.||| |||||          .||.|||| ||| | .|||||||. ..|| || || . ||.||. 
ESLQPSQLT---MKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSK

SDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE
.||||||| .|||  |   || | .|..|. || ||| .| | |||   . .|. |||  |  ||.|  |. .|..
TDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase IGF1R.AA Trk 999-1266 39 3.2e-98 332.63 In-house 1-275 (275) Show / Hide 
Range on Protein: 999-1266
Range on HMM: 1-275/275
Sequence Identity: 39% (109 aa)

ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPE-
| . .||| | || |. .  .  . ..  . ||.||  .|.    | .|  || .. .   .|.|.. ||   ..| | . | |  |||. |||.  |  
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASE-NARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

---MENNP--VLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYE-TDYYRKGGKGLLPVRWMSPESLKDGVFTT
   ....|   . |  ...|   | .|| || |.    |||||.|.|||.|...  |||||||| ||.|. ||||| |... ||.||| |||     ||.
MCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTY

YSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGL-LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI
 |||||||||.||. |   ||. .|||  |  ....| . |..|  ||  ....|. |||  |..| .  .|   |
ESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase IGF1R.AA Musk 999-1266 41 5.7e-98 324.35 In-house 1-282 (282) Show / Hide 
Range on Protein: 999-1266
Range on HMM: 1-282/282
Sequence Identity: 41% (117 aa)

ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEM
|   |..|.| || |.   | | | .|.|| ||.|   . ||      |  ||  | ||    .|.||||   |.|    .| |  |||  .|.|  |  
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

ENNPVLAPPS------------LSKM--IQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESL
 .      ..            |. .   .|| .|| |||||.  .||||||| |||.. |   ||| |||. | ||  |||.  .    |.||| |||.
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

KDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI
 .  ||. ||||..||.||||   |.||| |.. | |. .. .|  |  |.|||  ...||| ||| ||  ||.| .|  .|
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase IGF1R.AA TK-Unique 999-1266 36 4.8e-96 325.39 In-house 1-294 (294) Show / Hide 
Range on Protein: 999-1266
Range on HMM: 1-294/294
Sequence Identity: 36% (107 aa)

ITMSRELGQGSFGMVYEGVAKGVVKDEPET-RVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQ-PTLVIMELMTRGDLKSYLRSLR
... ...|.|.|| |. | ..|. |.. .. .||.|.... |.  .. .||.|...|||  .| ..|..||.    . |.. ||| . .|.| .|||. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PEM-------------ENNPVLAPPS-LS--KMIQMAGEIADGMAYLNA--NKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY-ETDYYRKGGKGLLPV
|.|             ...|   ... .|   ... | .|| ||.||     |.|||||.|||....||...||.||||.||.| ...| .....| .|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMSPESLK--DGVF-TTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNC-PDMLFELMRMCWQYNPKMRPSFLEIISSI
|||.|||||  .|.. || ||||||||..|||.|| ..|| |........ . .|  ...|..| .. ...||. |||..|..|||| .|.. .
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase IGF1R.AA CTKB 999-1268 41 1.5e-88 300.49 In-house 1-269 (269) Show / Hide 
Range on Protein: 999-1268
Range on HMM: 1-269/269
Sequence Identity: 41% (114 aa)

ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNC-HHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPE
| .   || | ||.|| | || .. |   | |||| . ...|     .|. |  .|.       .|||||.     | |...||| .||||  ||  || 
IVLKQKLGEGHFGVVYAGEAKKIMPDQAVTPVAIKMLQDSSSEATN-DFMKEVKIMQTIDGDQKIVRLLGICTRETPFLMVLELMAKGDLKTLLRNSRPK

MENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWS
      |.|    ..  ||  .||||||.   . ||||||||||.| ... | |||||. ||.|   ||   .   ||.|||||||. |||.|| |||||
TSKPSALSP---RRLALMAADVADGMAYIASKRIVHRDLAARNCLVHQNWRVCIGDFGISRDVYMREYYKMQASNPLPIRWMSPESINDGVYTTQSDVWS

FGVVLWEIATLAEQPYQG-LSNEQVLRFVMEG-GLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE
.|.|.||| | |  || . ..|  |   .  .   . .|  ||| ...||  ||   |  |.|| |   ..  
YGIVIWEIMTFAKMPYPEYETNMEVVERICDEDYRMWQPKECPDEFYDLMMQCWDEEPDDRISFKELHEKTLL
Kinase IGF1R.AA FGFR 999-1266 35 6e-84 285.19 In-house 1-293 (293) Show / Hide 
Range on Protein: 999-1266
Range on HMM: 1-293/293
Sequence Identity: 35% (105 aa)

ITMSRELGQGSFGMVYEGVAKGVVKD--EPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHH-VVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLR
 |.   || | || |  . |||...|  | |. ||.| . . .. .. .    |  .||    |  ...|||. .|. |  || |.  .| |. .||. |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PEM-ENNPVLA--------PPSLS------------KMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLL
|   .  .           .|.              . ...|  .| || ||   | .||||||||  | .|.  || |||  ||| ..||||| . | |
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLS-NEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI
|. || ||.| | |.|. |||||.|| |||| |. .||| .    |.   . .||  ..|| ||.  .. .|. ||  .|. ||.| ... ..
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase IGF1R.AA S_TKc 999-1267 19 5.7e-40 140.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 999-1267
Range on HMM: 1-231/231
Sequence Identity: 19% (55 aa)

ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTR--GDLKSYLRSLRP
 .. |..|.|.|| || .. |.        .|||| ..        . ...| ...|. .. ..|.|..|    .   ..||..    |||..|... ..
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

E-----MENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTT
.     .         .      .. .|.....|.  ....||||   | .. |  ..||.|||. | .                 .|.|| |    ...
HGLRFPF---------PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGK

-YSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS--------SIK
  .|.||.|..|.| ..  . |..    ..... ..           .. . ...| |.|..|. ||.  |.             
CKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IGF1R.AA Pkinase 999-1266 19 5.5e-37 131.86 Pfam 1-293 (293) Show / Hide 
Range on Protein: 999-1266
Range on HMM: 1-293/293
Sequence Identity: 19% (61 aa)

ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EAASMRERIEFLN--EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRG----DLKSYL
..  | .|.|||| ||... ||  |     .||.|... . ... .... ..  |...||..|. ..|||....  ..   ..||..  |    ||..|.
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTV----KIGDFGMTRDI-YETDYYRKGGKGLLPVRWMSPESLK-
.      ... ..   |    . .. .|. |..|. .....||||   |... .. ..    ||.|||  . . |  .   ..  | .  ..|.|| .. 
ST-----WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP--WYMAPEVIRG

DGVFTTYSDVWSFGVVLWEIATLAEQPYQGL----SNEQVLRFVMEGGLLDKPDNCP-----------------------DMLFELMRMCWQYNPKMRPS
.   .. .|.||.|..|.| ..  . |..|     .    .  . . .  . . ..|                       . . .... |....|| ||.
GQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT

FLEIISS--I
. .|  .  .
AEQILQHPWF