Gene HRI (Human)

HRI

Species: Human
Alias: EIF2AK1, HRI, KIAA1369
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 7p22.1,

Classification

Group: Other
Family: PEK
Subfamily: HRI

Sequence

Name Sequence Type Origin Length Description Download
HRI.NA RNA Sugen Kinome 4465 None Fasta, JSON
HRI.AA Protein Sugen Kinome 630 None Fasta, JSON
HRI.kin_dom Protein Kinase Domain Sugen Kinome 417 None Fasta, JSON

Protein domain

Protein domains of HRI.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase HRI.AA HRI 274-583 68 2.8e-248 831.08 In-house 271-613 (613) Show / Hide 
Range on Protein: 274-583
Range on HMM: 271-613/613
Sequence Identity: 68% (234 aa)

SSSSSIIFAEPTPEKEKRFGESDTEN-----------QNNKSVKYTTNLVIRESGELESTLELQENGLAGLS---ASSIVEQQLPLRRNSHLEESFTSTE
..||.|||...|..|||.|||||..|           .|||.||||||.|||.|.|||||.|||||||....   ...|...|.|.|.|.|....|..|.
QNSSEIIFVRQTQRKEKHFGESDKKNSYEKIKITATTKNNKIVKYTTNPVIRNSAELESTIELQENGLTRIHNRIRTAIFHHQQPIRHNKHRRSIFWDTQ

ESS---EENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMAN--VATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPD
|||   |.|....||||..||.|||||||||||||||||.|||||.||||||..|||||||  |..||||..|||.||||||.|||||.||||||||.||
ESSPEVESNYWPRGQTEFKYHYMLHIQMQLCELSLWDWISERNKRSREYVDETECPYVMANEKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPD

Q---QVKIGDFGLACTDILQKN-----------TDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL
|   |||||||||||.||||..           .||||||...|.|||||||||.|||||||.||.||.||||||.||.|.||||||||||||||||||.
QGHPQVKIGDFGLACEDILQEPKTPMRFRRDQDFDWTNRNPCVTQTHTSRVGTCTYASPEQLDGSQYDNKSDMYSMGVILFELFQPFGTEMERAEVLTGV

RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELF
||||.||||||||||||||||||||||.|||||||||||||||
RTGQIPESLRKRCPVQAKYIQHLTRRNASQRPSAIQLLQSELF
Kinase HRI.AA PEK 167-583 26 7e-191 640.43 In-house 1-655 (655) Show / Hide 
Range on Protein: 167-583
Range on HMM: 1-655/655
Sequence Identity: 26% (175 aa)

FEELAILGKGGY-GRVYKVRNKLDGQYYAIKKILIKGAT---------------KTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVIQPRADRAAIE
|||...|||||. |.||||.|||||.|||||.| .. ..               |..|.|||||||.|| |.|||||.||.||||........ ... ..
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

LPS------------------------------LEVLSDQEEDREQCGVKNDES----SSSSIIFAEPTPEKEKRFGESD--------------TENQNN
|.|                              ..|.|. .|||||.|.|...|    .||.... | ..........|.              |||.|.
LDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSE-CEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENENE

KSVKYTTNLVIRESGE----------------------------------------LESTLELQENGLAGLSASSIVEQQLPLRRNSHLEE---------
....|....|...| .                                        ..........|  . . ..  ..| ... ... .          
SHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQS

-------------------------SFTSTEESSEENVNFLGQTEAQYH-------LMLHIQMQLCELSLWDWIVERN----------------------
                         |.....|..|.| |.. ....|.|       ..|.|||..|| ...... ..|                      
HKKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYI

------------KRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQ----QVKIGDFGLACTDI--------------
            .. |.. ||..|........ .||....||..|||..|..||||||.||||.  .|    ||||||||||....              
MNQCCFQSTWSMNM-RQW-DENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQ

------LQKNTDWTNRNGKRTPT-------------------------HTSRVGTCLYASPEQLEGS-----EYDAKSDMYSLGVVLLELFQPFGTEM-E
      ...|..|.|.|.. .||                         ||..||||||.|||||.|.      |. |.||||||....|...|| |.| |
SYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMME

RAEVLTGLRT------GQLP-ESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELF
|...|| ||.      |..| .......|.||..||... .. .||||| |.||.|.|
RVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase HRI.AA HRI 167-273 60 2.2e-78 266.74 In-house 1-127 (613) Show / Hide 
Range on Protein: 167-273
Range on HMM: 1-127/613
Sequence Identity: 60% (77 aa)

FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVIQPR--------------------ADR
||...|.||||||||||||.|||.|.||||||.||..||..|||..|||||||.|||.|||.||.|||||||.|||.                    .||
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIEHVHQIQPQQRLMLGLGSFTDMGNGFEGEEDR

AAIELPSLEVLSDQEEDREQCGVKNDE
..||.|..||...|||||||||||.||
EEIEEPEEEVEEEQEEDREQCGVKKDE
Kinase HRI.AA GCN2 421-583 34 1.5e-50 174.26 In-house 312-511 (511) Show / Hide 
Range on Protein: 421-583
Range on HMM: 312-511/511
Sequence Identity: 34% (69 aa)

KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACT--------------------------DILQKNTDWTNRNGK-RTP------TH
..| ...||. |||..|..|||||| ||||   ...||||||||| .                          .| |...    ....  .       .|
RYFRQILEGLNYIHSQGMIHRDLKPSNIFLDC-CGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHH

TSRVGTCLYASPEQLEGSEYDAKSDMYSL-GVVLLELFQP-FGTEMERAEVLTGLRTGQLPESLRK----RCPVQAKYIQHLTRRNSSQRPSAIQLLQSE
|..||| .| .|||.  | |. | ||||| |....|...| | |.|||...|. ||  ..|. . |    . . |.. |. .. .....|||| ||||.|
TGKVGTPFYMCPEQQ-KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLRSCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHE

LF
. 
FL
Kinase HRI.AA S_TKc 167-583 17 8.3e-41 142.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 167-583
Range on HMM: 1-231/231
Sequence Identity: 17% (74 aa)

FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVIQPRADRAAIELPSLEVLSDQEEDREQ
.| | ..|||..|.|||.|.| .|...|||.|                                                                    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

CGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQNNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENV
                                                                                ..   | .  .     .  |
--------------------------------------------------------------------------------EHIRREIQILKK--HHPNIV

NFLGQTEAQYHLMLHIQMQLCEL---SLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFG
....  .      |.. | .|.    .| | |..|...|. .       .    .| .......... |.|..||.|||||| ||.|     ..||.|||
KLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF-------PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFG

LACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDA-KSDMYSLGVVLLELFQ---PFGTEMERAEVLTGLRTGQLPESLRKRCPVQAK-
||.                     |. .||  | .|| |    |.  |.|..|.|..| |..    ||  .|..   . |              . .|| 
LARQL-------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------------SPEAKD

YIQHLTRRNSSQRPSAIQLLQ-------SELF
 |... ... ..||.| ..||        . |
FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HRI.AA PEK 486-583 34 6.4e-35 113.2 In-house 644-758 (758) Show / Hide 
Range on Protein: 486-583
Range on HMM: 644-758/758
Sequence Identity: 34% (40 aa)

THTSRVGTCLYASPEQLEGS----------------EYDAKSDMYSLGVVLLELFQP-FGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNS
.|| .||| ||.||||. .                  |. | | |||| .. ||. | | |.|||. ... || ||.| .. .  | ... || ..  | 
RHTVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLRNGQWPKWFTQKYPQEYEFIQQMMSMNP

SQRPSAIQLLQSELF
..||.|.|.. . .|
DERPTADQISMHDFF
Kinase HRI.AA Pkinase 421-583 24 5.1e-32 114.3 Pfam 112-293 (293) Show / Hide 
Range on Protein: 421-583
Range on HMM: 112-293/293
Sequence Identity: 24% (49 aa)

KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQV----KIGDFGLACT-DILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLE-GSEYDAKSDMY
... ....|. |.|.|||.|||||| ||...  . ..    ||.|||||.  |              . .  |...||  |..|| .  |..|. |.||.
FYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGVVLLELFQ---PFGTE-----MERAEVLTGLRTGQLPESLRKRCPVQ--------------------AKYIQHLTRRNSSQRPSAIQLLQSELF
|.|..| |..    ||  .     ..  ...   . ..|...  . |..                      . |  . ... ..||.| |.||.. |
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase HRI.AA PEK 167-235 42 6.5e-29 92.75 In-house 1-76 (758) Show / Hide 
Range on Protein: 167-235
Range on HMM: 1-76/758
Sequence Identity: 42% (32 aa)

FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKG-------ATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIE
||.   ||.||.| |... ||.|. .||||.|  .         ...   ||.|||. || | |.||| |. || |
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLE
Kinase HRI.AA CAMK 388-520 25 1.4e-27 85.37 In-house 146-324 (425) Show / Hide 
Range on Protein: 388-520
Range on HMM: 146-324/425
Sequence Identity: 25% (47 aa)

EL--SLWDWIVERNKRGREYVDESA------CPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPD----------------QQVKIGDFG
||   | |.|||. ..| |     .      . ..    | ..|. ....| |.|...|||||||| || |   .                 ..|| |||
ELFDDLFDYIVEHGCYGEEF----DQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFG

LA--CTD---------ILQKNTDWTN--RNGKRTPTHTSRVGTCLYAS-PEQLEG--------------SEYDAKSDMYSLGVVL
.|  ...         . ...    |    .. ..  . ..||  |.. || |.|                |. |.|| |.||.|
FANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase HRI.AA GCN2 167-235 54 1.8e-27 93.02 In-house 1-72 (511) Show / Hide 
Range on Protein: 167-235
Range on HMM: 1-72/511
Sequence Identity: 54% (39 aa)

FEELAILGKGGYGRVYK-VRNKLDGQYYAIKKILIK-GATKTVC-MKVLREVKVLAGLQHPNIVGYHTAWIE
|||...||||| |.|.| |||..||.||||||. |.    |  |  | .|||| |. |.|...| |..||||
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIE
Kinase HRI.AA STE-Unique 419-583 25 6.6e-26 88.64 In-house 405-616 (616) Show / Hide 
Range on Protein: 419-583
Range on HMM: 405-616/616
Sequence Identity: 25% (55 aa)

ATKIFQELVEGVFYIHNMG--IVHRDLKPRNIFLHGPD----QQVKIGDFGLACTDILQ-----------------KNTDWTNRNGKRTP---------T
. ..  ...||  |.|  .  |.||||||.|||.   .      |||.|||.| . ..                   |   ||   . ||         |
VIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYT

HTSRVGTCLYASPEQLEGS-----EYDAKSDMYSLGVVLLEL---FQPFGTEMERAE--VLTGLRTGQLP-----ESLRKRCPVQAKYIQHLTRRNSSQR
 .. .||  | .|| ...      .||.|.|..||| .....   ..|..    .     .  . . |.|     .   |  | |.  |. . .|| ..|
MKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHR

PSAIQLLQSELF
||| |||.... 
PSAHQLLHHFWL
Kinase HRI.AA PKR 422-545 40 3.6e-23 79.75 In-house 128-238 (272) Show / Hide 
Range on Protein: 422-545
Range on HMM: 128-238/272
Sequence Identity: 40% (51 aa)

IFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGK-RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVL
..  .|.|| |||  ...|||||| ||||   ....|||||||.        |   |  || |    | | ||  | ||||.   .|    |.| ||..|
LYEQIVKGVDYIHSKKLIHRDLKPSNIFLVD-ERHIKIGDFGLV--------TALKN-DGKSR----TRRKGTLQYMSPEQIFSQHYGKEVDIYALGLIL

LELFQPFGTEMERAEVLTGLRTGQL
 ||     ||.|.    . || | .
AELLHVCFTEFEKIKFFEDLRDGDF
Kinase HRI.AA NEK 167-235 37 2.5e-21 72.16 In-house 1-75 (286) Show / Hide 
Range on Protein: 167-235
Range on HMM: 1-75/286
Sequence Identity: 37% (28 aa)

FEELAILGKGGYGRVYKVRNKLDGQY-----YAIKKILIKGATKTVCMKVL-REVKVLAGLQHPNIVGYHTAWIE
.|..  .|.| .|.||||| | ||.      |..||| ... .     . .  ||..|. |.|||||.|. ..||
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIE
Kinase HRI.AA STE 421-523 28 2.6e-21 72.07 In-house 155-261 (359) Show / Hide 
Range on Protein: 421-523
Range on HMM: 155-261/359
Sequence Identity: 28% (34 aa)

KIFQELVEG-VFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLAC--TDILQKNTDWTNRNG------KRTPTHTSRVGTCLYASPEQLEG------S
.| .....|   |.|...|.|||.|| ||.|      ||. |||..   ||.. ..   .  |.       .    .. |||  . .|| ...      .
YICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVCGQLTDSMANI-Q-S--NNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDK

EYDAKSDMYSLGVVLLEL
.||.|.|..||| ...|.
GYDTKCDIWSLGCTIIEM
Kinase HRI.AA Pkinase 167-239 26 1.4e-19 70.36 Pfam 1-75 (293) Show / Hide 
Range on Protein: 167-239
Range on HMM: 1-75/293
Sequence Identity: 26% (20 aa)

FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLR--EVKVLAGLQHPNIVGYHTAWIEHVHV
.. . ..|.|..|.||| ..| .|. .|.|.|  ... . ...  .|  |..... |.||||| .. .. .. |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHI
Kinase HRI.AA PEK-Unclassified 167-235 32 9.6e-19 61.48 In-house 1-74 (835) Show / Hide 
Range on Protein: 167-235
Range on HMM: 1-74/835
Sequence Identity: 32% (24 aa)

FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIK-----GATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIE
| ..  .|.||.. ||.. .|.|   ||.|.| ..             | ..||  .| . ||||. |   |||
FNQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIKEDLQKHYEKEIMEVRYMAQVNHPNIIRYYHSWIE
Kinase HRI.AA PEK 380-465 32 1.3e-18 57.63 In-house 414-513 (758) Show / Hide 
Range on Protein: 380-465
Range on HMM: 414-513/758
Sequence Identity: 32% (36 aa)

LHIQMQLCEL-SLWDWIVER-NKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQ----------------------
. ||||||.  .| ||.  | . . |.           ...   .|  ..||| |||..|. ||||||.|||.   .|                      
MYIQMQLCRKETLKDWMRNRCTMESRP-----------WMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGH

-QVKIGDFGLA
  .|||||||.
QIIKIGDFGLV
Kinase HRI.AA PEK-Unclassified 488-581 25 6.5e-18 58.49 In-house 731-835 (835) Show / Hide 
Range on Protein: 488-581
Range on HMM: 731-835/835
Sequence Identity: 25% (27 aa)

TSRVGTCLYASPEQL-----------EGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQ
|| .|| .|.|.||.            .  |. . |.||.|......| .. | |||   .  .. | ||     . |  |  |.        .||   .
TSTCGTYTYSSNEQESQKKVRIKAHFQADFYNHRTDIYSVGIIFFQMFHQMNTTMERVKTIQNCKKGELPKHFCAKFPRLAEIIKDSLSNDPQKRPLLSK

LLQSE
. |  
IEQTL
Kinase HRI.AA STE 167-240 19 5e-17 56.75 In-house 1-115 (359) Show / Hide 
Range on Protein: 167-240
Range on HMM: 1-115/359
Sequence Identity: 19% (22 aa)

FEELAILGKGGYGRVYKVRNKL---------------DGQYYAIKKILIKGATK---------------TVCMKVLREVKVLAGLQ--HPNIVGYHTAWI
.| . ..|||..| ||| .|.                 |...|||.. ..  ..               .   ..|.|.|..  ..  ||||| |. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

---------EHVHVI
         ......
KEGHNHKNDDELWIC
Kinase HRI.AA CAMK 172-227 20 3.4e-16 47.99 In-house 1-101 (425) Show / Hide 
Range on Protein: 172-227
Range on HMM: 1-101/425
Sequence Identity: 20% (21 aa)

ILGKGGYGRVYKVRNKLDG------------QYYAIKKILIKGATKT--------------------------VCMKVLREVKVLAGLQ-------HPNI
.||.|..| |.....|...            | .||| |  | ...                            . .|.||....  ||       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

V
.
I
Kinase HRI.AA NEK 421-465 37 8.4e-16 52.48 In-house 118-170 (286) Show / Hide 
Range on Protein: 421-465
Range on HMM: 118-170/286
Sequence Identity: 37% (20 aa)

KIFQELVEGVFYIHNM-----GIVHRDLKPRNIFLHGPDQQ---VKIGDFGLA
..|. .. .. |.|..      |.|||.|| ||||   . .   |||||||..
DWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGIS
Kinase HRI.AA STE-Unique 168-235 27 4.4e-15 49.49 In-house 1-72 (616) Show / Hide 
Range on Protein: 168-235
Range on HMM: 1-72/616
Sequence Identity: 27% (20 aa)

EELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGAT----KTVCMKVLREVKVLAGLQHPNIVGYHTAWIE
..  ..|.|. | |.. .|| |. ..|||.| .|. .         . ..|.  ...| |.||| |  .|..
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLW
Kinase HRI.AA PEK-Unclassified 419-467 40 5.6e-15 47.95 In-house 615-664 (835) Show / Hide 
Range on Protein: 419-467
Range on HMM: 615-664/835
Sequence Identity: 40% (20 aa)

ATKIFQELVEGVFYIHNMG-IVHRDLKPRNIFLHGPDQQVKIGDFGLACT
.  | .. . .  .||  . .||||.|| |||.     |.|||||||. .
CREITRQIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLVKK
Kinase HRI.AA PKR 167-233 38 1.5e-14 48.43 In-house 1-61 (272) Show / Hide 
Range on Protein: 167-233
Range on HMM: 1-61/272
Sequence Identity: 38% (26 aa)

FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAW
|...  .| ||.| |.| . ..||. |.||..      |    |  .||. || |.| ||| ||  |
FKDIEEIGSGGFGQVFKAKHRIDGKRYVIKRV------KYNNEKAEHEVQALAKLDHVNIVHYHSCW
Kinase HRI.AA TyrKc 167-583 13 1.8e-11 -37.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 167-583
Range on HMM: 1-280/280
Sequence Identity: 13% (62 aa)

FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGL--QHPNIVGYHTAWI---------EHVHVIQPRADRAAIELPSLE
 . . .|| | .|.||| . |         .  .|   .   .  .|| ...  |  .|||||  . . .         | . ..   ..     |  ..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDL--KD

VLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQNNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESF
 | . ...                                                                                            
YLRKHRPK--------------------------------------------------------------------------------------------

TSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVATKIFQELV----EGVFYIHNMGIVHRDLKPRNIFLH
                                                              . .| . .      .|  |.| ....||||  ||. ..
--------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVG

GPDQQVKIGDFGLACTDILQK-----NTDWTNRN---GKR--TPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF----QPFGTE----MER
 .  .|||.||||.  ||  .     ..|        |..   |            .|| .  ...  ||| .| ||.. |.|    ||   .    |. 
ENH-TVKISDFGLSR-DIYDDDQQGESKDYYRKKEHKGGKTMLPIR--------WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSN

AEVLTGLRTGQLPESLRK---------RCPVQAKYIQHLTRRNSSQRPSAIQLLQSELF
.||.  ...|  ..                .    ..   ... ..||.  ..   |.|
QEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase HRI.AA NEK 488-523 45 1.9e-09 29.8 In-house 181-217 (286) Show / Hide 
Range on Protein: 488-523
Range on HMM: 181-217/286
Sequence Identity: 45% (17 aa)

TS-RVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLEL
..  |||  |.|||....  |. |||. |||.|| |.
YTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEM
Kinase HRI.AA Pkinase_Tyr 432-465 44 8.3e-07 23.68 Pfam 126-158 (270) Show / Hide 
Range on Protein: 432-465
Range on HMM: 126-158/270
Sequence Identity: 44% (15 aa)

YIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLA
| ......||||  ||. .. .  .|||.|||||
YLESKNCIHRDLAARNCLVTENN-VVKICDFGLA
Kinase HRI.AA STE 560-583 26 0.001879 8.2 In-house 334-359 (359) Show / Hide 
Range on Protein: 560-583
Range on HMM: 334-359/359
Sequence Identity: 26% (7 aa)

IQHLTRRNSSQRPSAIQLLQ--SELF
|..  ... ..||.| |||.   . .
INKCLQKDPNKRPTASQLLKSEHPFI
Kinase HRI.AA Pkinase_Tyr 167-227 28 0.006729 10.44 Pfam 1-67 (270) Show / Hide 
Range on Protein: 167-227
Range on HMM: 1-67/270
Sequence Identity: 28% (21 aa)

FEELAILGKGGYGRVYKVRNKLDGQYY----------AIKKILIKGATKTV--CMKVLREVKVLAGL-QHPNIV
 . .  ||.| .|.|||      | ..          |.|..   ||..      . .||.|..  | .|||||
ITFGKKLGEGAFGEVYK------GTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIV
Kinase HRI.AA CAMK 560-583 16 0.04098 1.8 In-house 402-425 (425) Show / Hide 
Range on Protein: 560-583
Range on HMM: 402-425/425
Sequence Identity: 16% (4 aa)

IQHLTRRNSSQRPSAIQLLQSELF
|... ... ..|... | |. . .
IRKMLQVDPEKRMTIEQCLNHPWM
Kinase HRI.AA NEK 565-583 31 0.062813 3.05 In-house 268-286 (286) Show / Hide 
Range on Protein: 565-583
Range on HMM: 268-286/286
Sequence Identity: 31% (6 aa)

RRNSSQRPSAIQLLQSELF
... .||||. |.|.  . 
QKDPEQRPSCNQILEMPFI
Kinase HRI.AA PEK-Unclassified 378-401 37 0.109402 0.19 In-house 500-523 (835) Show / Hide 
Range on Protein: 378-401
Range on HMM: 500-523/835
Sequence Identity: 37% (9 aa)

LMLHIQMQLCELSLWDWIVERNKR
. . ||| ||  ..   |. |||.
FIFYIQMELCHYTTARYIINRNKK
Kinase HRI.AA Pkinase_Tyr 498-524 37 2.527253 1.72 Pfam 182-208 (270) Show / Hide 
Range on Protein: 498-524
Range on HMM: 182-208/270
Sequence Identity: 37% (10 aa)

SPEQLEGSEYDAKSDMYSLGVVLLELF
.|| .  ...  ||| .| ||.. |.|
APECINYGKFTTKSDVWSFGVLMWEIF