Gene HIPK2 (Human)

HIPK2

Species: Human
Alias: HIPK2, PRO0593
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 7q34-q36,

Classification

Group: CMGC
Family: DYRK
Subfamily: HIPK

Sequence

Name Sequence Type Origin Length Description Download
HIPK2.NA RNA Sugen Kinome 15245 None Fasta, JSON
HIPK2.AA Protein Sugen Kinome 1198 None Fasta, JSON
HIPK2.kin_dom Protein Kinase Domain Sugen Kinome 329 None Fasta, JSON

Protein domain

Protein domains of HIPK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase HIPK2.AA HIPK 199-527 80 3.4e-260 829.16 In-house 1-329 (329) Show / Hide 
Range on Protein: 199-527
Range on HMM: 1-329/329
Sequence Identity: 80% (265 aa)

YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPL
|||||||||||||||||||||||||.||||||||||.||||||||||||..||.|.||.|.||||||||.|||||||||||||||||||.|||||.||||
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLPL

KYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGW
|.|||.||||.|||||||.||||||||||||||||||.|.|||||||||||||||||.||.|||||||||||||||||||||..||||||||||||||||
KHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGW

PLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRR
||||||.||||||||.|||.||.|.||.|..|..|||.||..| ...||||....||..|..||||||||||||||||..|||..|.|..|..|||.|||
PLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRPWRLKHIEEHEQQTSVKSKEARKYIFNCLDDMPEVNMLVDPERQDYRVEKIDRR

EFIDLLKKMLTIDADKRITPIETLNHPFV
||...||||.|.||.|||||.|.||||||
EFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase HIPK2.AA DYRK 199-527 42 6.5e-184 617.28 In-house 1-320 (320) Show / Hide 
Range on Protein: 199-527
Range on HMM: 1-320/320
Sequence Identity: 42% (141 aa)

YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE-SADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPL-
||.||..|.|.||||||||...|||.|||||..|.....||.|||..|| .|... . | |..|..|..|.|.||.|.|||.|..|||.|||.|.| .. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

PLKYIRPVLQQVATALMKLKSL-GLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELF
.|...|...||. |.| .|...  .||.|||||||||..| |.....|||||||...... ...||.|||.|||||.|||.|.|.|||||||||..||||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQP-RNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELF

LGWPLYPGASEYDQIRYISQTQGLPAEYLLSAG--TKTTRFFNRDTDSPYPLWRLKTPDDHEAETG-IKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLV
.||||.||..||||...| ...|.| . ....|  .....||..           .... .. .|. .|........... ..  ..... . .  |.. 
TGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC-----------FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRH

EKADRREFIDLLKKMLTIDADKRITPIETLNHPFV
. .|...|.|..||.|..| .||||| . |.||..
Q-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase HIPK2.AA CMGC 199-527 23 9.5e-111 365.31 In-house 1-513 (513) Show / Hide 
Range on Protein: 199-527
Range on HMM: 1-513/513
Sequence Identity: 23% (121 aa)

YEVLEFLGRGTFGQVVKCWK--------------RGTNEIVAIKILKNHPSYARQGQ-------------IEVSILARLS------------TESADDYN
||... .|.||.|.|.||.               . ||||||||..|| . | .|..              |..|| .|.            ... .. |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

FVRAYECFQHKN-----------------HTCLVFEMLEQNLYDFLKQNK--------------------------FSPLPLKYIRPVLQQVATALM--K
 |. |..|.|||                 | .|||| ....||...|.|.                             ... .||   .|. ..|    
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LKSLG--LIHADLKPENIMLVDPSRQP----------------YRVKVIDFGSASHVSKA-----------------------VCSTYLQSRYYRAPEII
. | .   || |||||||.. .  . .                .|.|..|||.| ....                          ..| ..|.||||||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LGLP----------FCEAIDMWSLGCVIAELFLG--------WPLYPGASE-----------YDQIRYISQTQGLPAEYLLSAGT-------KTTRFFNR
|| .          ....|||||.||..||...|        .|| || ||           .||.  | .. | |  .....|.       ..  ..|.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

DTDSPYPL------WRLKTPDDHEAETGIKSKEARKYIFN-CLDDMAQVNMTTDLEGSDML----------------------------VEKADRREFID
     |..      |    .    ..|...|. ||.||.. .   . . .  ..|.  .                               .| .  ..||
IKLPWYNKFPKKWNW----Q----TMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAID

LLKKMLTIDADKRITPIETLNHPFV
||||||..| |||||. . |.||. 
LLKKMLQYDPDKRITAEQALQHPYF
Kinase HIPK2.AA YAK 199-527 39 4.3e-107 362.09 In-house 1-347 (347) Show / Hide 
Range on Protein: 199-527
Range on HMM: 1-347/347
Sequence Identity: 39% (138 aa)

YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARL-STESADDYN----FVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF
| ||  ||.||||||||| . .|||..|.|..|| . |  |.  |. ||  |   .  .. |    ..| |  | |||| |||||||. |||..||||||
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAE
  .    ||  . |.  ..  |..  .|| |||||||||  | . |  .|.|||||.    | |  || |.|.||.||||.. ..| .||||||||..||
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNK-P-EIKIIDFGSSCQEKKMVY-TYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAE

LFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTD---------------SPYPLWRLKTPDDHEAETGIKSKEARKYI-FNCLDDMA
|||| |..||.|||.||  |  . | |   ..  |   ...| .                   ||    .|| .| . . .|. || ..|  . || |. 
LFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYFHCHDGSNSDDNNNNNNNNNGKPY-YYIFKTKQDYQIDEKIQLKESKTYFQYKCLNDIK

QVNMTTD--LEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFV
. .|         |   ..  |  |||..  .|  .  .| .|     |||.
N-YMYFKQFMRNQDDTKNNRHRDCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase HIPK2.AA DYRK2 199-437 40 8.5e-84 272.34 In-house 1-243 (318) Show / Hide 
Range on Protein: 199-437
Range on HMM: 1-243/318
Sequence Identity: 40% (98 aa)

YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP
||.||..|.| |||||||    |.. ||||.. |   ...| ..|. || ....   |  .| |.  . |   ||.|..|| |  |||...|.|.|  . 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLG
|. .|.  ... ..|  |.   .||.|||||||.|  . |    .|||||||   .      || |||.|||||.|||...  ||||||.||..|||. |
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRS--GIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTG

WPLYPGASEYDQIRYISQTQGLPAEYLLSAG-----TKTTRFFNR
 || ||  | ||. ..    |.| . ...       ...  |||.
YPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNS
Kinase HIPK2.AA S_TKc 199-527 23 6.1e-82 279.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 199-527
Range on HMM: 1-231/231
Sequence Identity: 23% (82 aa)

YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQ---NLYDFLKQNKF--
||.|. .|.|.||.| ||....|..||||||.|      .. . |..|| .      .  | |. |..||. .| ..|.|....   .|.|..|...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCE-AIDMWSLGCV
  .|.|   .| ...|.. ||  . |.| || |||||||.| .      ..|..|||.| ..     .|.  ...|.|||..   ..   ..|.||.||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

IAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDM
..|.. | |..|   ..  .. |                                                                             
LYEMLCGYPPFP--QMQMMFKKIG----------------------------------------------------------------------------

LVEKADRREFIDLLKKMLTIDADKRITPIETLN-------HPFV
       .|..|...|.|. | .||.|  | |.       ||..
------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HIPK2.AA DYRK1 199-449 39 8.6e-75 254.78 In-house 1-251 (321) Show / Hide 
Range on Protein: 199-449
Range on HMM: 1-251/321
Sequence Identity: 39% (100 aa)

YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP
||.   .|.| |||||| . . . | |||||.||  ..  | |||. .|  .  . ... |. |.  . | ..|| |||||.|  |||| |.  .|    
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LKYIRPVLQQVATALMKLKS--LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELF
|  .|   ||..|||. . .  | .|| |||||||.|. | |    .|.|||||. .. . .   |.|||.||.||..||...  |||||||||.. |. 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRS--AIKIIDFGSSCQLGQRIY-QYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMH

LGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLK
 | ||. |..| ||.  |    |.| ....  . |. ..|..|.|  . . . .
TGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTR
Kinase HIPK2.AA PRP4 199-403 42 4.8e-55 189.18 In-house 1-207 (320) Show / Hide 
Range on Protein: 199-403
Range on HMM: 1-207/320
Sequence Identity: 42% (89 aa)

YEVLEFLGRGTFGQVVKCW-KRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE---SADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQN-KF
|.|  . | | |. |..|  .  .|| |||||. | ..  . |  |. || .|.     . | .  || .. |.|..| ||||| .  || . ||.  | 
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAE
  | || .|   ||   ||  || .. .|||.|| || ||  |..    | .|||||||..      ||.||.|||||||.| |.  .||||| || ..|
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNI-LVNESKN--TLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYE

LFLGWPLYPG
|. |  ..||
LYTGKIMFPG
Kinase HIPK2.AA Pkinase 199-423 30 1.2e-50 179.36 Pfam 1-237 (293) Show / Hide 
Range on Protein: 199-423
Range on HMM: 1-237/293
Sequence Identity: 30% (76 aa)

YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI-----EVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQ-----NLYDFL
|.... .|.|.||.| || ..||..|||.||.| .     . |.     |..|..||.       | || |..|. |.| ..|.| .|       |.|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

K---QNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSAS---HVSKAVCSTYLQSRYYRAPEIIL-GLPFCEA
.   ...|. .. . .. .. |.. .|  . | | || |||||||....    . .||..|||.|    . ..  ..|.  ...|.|||.|. | .   .
STWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDMWSLGCVIAELFLGWPLYPGA----SEYDQIRYISQTQGLPAEY
.||||.||...|...| |..||.    . .||.  | .. | | ..
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHF
Kinase HIPK2.AA CLK 199-335 32 2.3e-48 142.67 In-house 1-150 (350) Show / Hide 
Range on Protein: 199-335
Range on HMM: 1-150/350
Sequence Identity: 32% (49 aa)

YEVLEFLGRGTFGQVVKCWKRGT-NEIVAIKILKNHPSYARQGQIEVS-ILARLSTE-SADDYNF---VRAYECFQH-KNHTCLVFEMLEQNLYDFLKQN
||..  || |||| ||.|| .   .  ||.|| .|.  |  . ..|.. |.  . .  ...  .    .. ...| . ..| |.|||..  ..|||.| |
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

K------FSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDP
.      . |.|.  ||    |  .|. .| ...|.| ||||||| .||.
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDS
Kinase HIPK2.AA DyrkP 199-397 38 1.4e-46 151.05 In-house 1-201 (323) Show / Hide 
Range on Protein: 199-397
Range on HMM: 1-201/323
Sequence Identity: 38% (79 aa)

YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTES-ADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNK----F
| ..|.||   | . ..|  . || .. .||. |   |  |   |. .|  .      |. | .| |. | || |  .. |.|..|||.| | |.     
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAE
    .  .  . ||.  ||  . || ||| |||||||..   |.   .||.|||||.  .   . | | ||| |||||.|.|  .   ||||||||..||
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMK--SYPKCQVKIIDFGSSCFIHDHLSS-YVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAE

LFLG
|. |
LWTG
Kinase HIPK2.AA RCK 264-410 32 5.1e-32 98.65 In-house 64-223 (298) Show / Hide 
Range on Protein: 264-410
Range on HMM: 64-223/298
Sequence Identity: 32% (52 aa)

YECFQHKN--HTCLVFEMLEQNLYDFLKQ--NKFSPLPLKY--IRPVLQQVATALMKLKSLGLIHADLKPENIMLVD-----PSRQPYRVKVIDFGSA-S
.| .....  .  .||| ...||| ..|    .  .|| .   |.  . |.. .|  . . |  | ||||||||. .       . ....|..|||.. .
KEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCRE

HVSKAVCSTYLQSRYYRAPEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQI
  ||     |  .|.|||||..|      . .|.|..||...||   .||.||.|| |||
IRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQI
Kinase HIPK2.AA CLK 342-403 43 2.2e-21 60.23 In-house 186-249 (350) Show / Hide 
Range on Protein: 342-403
Range on HMM: 186-249/350
Sequence Identity: 43% (28 aa)

VKVIDFGSAS--HVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPG
..|||||||      .   ||  ..| |||||.||||.. .  | || ||.. || .|  |...
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQT
Kinase HIPK2.AA RCK 199-233 45 1.8e-11 32.34 In-house 1-35 (298) Show / Hide 
Range on Protein: 199-233
Range on HMM: 1-35/298
Sequence Identity: 45% (16 aa)

YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNH
| ... ||.||.| |.|  .  |.|||||| .|..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQK
Kinase HIPK2.AA RCK 499-527 44 1.1e-09 26.55 In-house 270-298 (298) Show / Hide 
Range on Protein: 499-527
Range on HMM: 270-298/298
Sequence Identity: 44% (13 aa)

EFIDLLKKMLTIDADKRITPIETLNHPFV
. |.|..|||..| .||||. . |.||. 
DCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase HIPK2.AA CLK 490-527 42 1.3e-09 24.22 In-house 313-350 (350) Show / Hide 
Range on Protein: 490-527
Range on HMM: 313-350/350
Sequence Identity: 42% (16 aa)

MLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFV
|. .. . |...||..||| .|  ||||  . | ||| 
MDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase HIPK2.AA TyrKc 199-485 19 1.6e-08 -84.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 199-485
Range on HMM: 1-280/280
Sequence Identity: 19% (64 aa)

YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARL--STESADDYNFVRAYECFQHK-------NHTCLVFEMLEQ-NLYDFL
 . .. ||.| ||.|.|.  .   . ||.| ||..    .    | .|. .|  . .     | || | .  ..          ..|.|  .  .| |.|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP-----NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKA-VC----STYL-----QSR-----YYRAPEII
. ..   |..|       |.|     | | ..|| ||   |... ..     .||. ||| .  .     .    ..|      ...        ||| |
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

LGLPFCEAIDMWSLGCVIAELF-LGWPLYPG-----ASEYDQIRYISQTQGLPAEYL---LSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKE
    | .. | || | .. |.| .| . |||      | .. |.|. |   .|       .|                                 . ..|
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------FVCCPDE

ARKYIFNCLDD-------MAQVNMTTDL
  . .  | .        ....    ..
MYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase HIPK2.AA DYRK1 495-527 45 2e-08 25.16 In-house 289-321 (321) Show / Hide 
Range on Protein: 495-527
Range on HMM: 289-321/321
Sequence Identity: 45% (15 aa)

ADRREFIDLLKKMLTIDADKRITPIETLNHPFV
.|   | ||.|.||  |  .|||| . | |.|.
EDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase HIPK2.AA PRP4 502-527 57 4.1e-08 25.87 In-house 295-320 (320) Show / Hide 
Range on Protein: 502-527
Range on HMM: 295-320/320
Sequence Identity: 57% (15 aa)

DLLKKMLTIDADKRITPIETLNHPFV
||| |.|  |  ||||. | | |||.
DLLDKCLMLDPKKRITCNEALKHPFI
Kinase HIPK2.AA DYRK2 500-527 39 9.1e-07 17.68 In-house 291-318 (318) Show / Hide 
Range on Protein: 500-527
Range on HMM: 291-318/318
Sequence Identity: 39% (11 aa)

FIDLLKKMLTIDADKRITPIETLNHPFV
||| .|. .. |...|.|| . |.||. 
FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase HIPK2.AA Pkinase 498-527 36 2e-06 23.56 Pfam 264-293 (293) Show / Hide 
Range on Protein: 498-527
Range on HMM: 264-293/293
Sequence Identity: 36% (11 aa)

REFIDLLKKMLTIDADKRITPIETLNHPFV
.|..|..|..|. |  ||.|. . |.||..
EECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase HIPK2.AA Pkinase_Tyr 199-233 33 6e-06 20.82 Pfam 1-39 (270) Show / Hide 
Range on Protein: 199-233
Range on HMM: 1-39/270
Sequence Identity: 33% (13 aa)

YEVLEFLGRGTFGQVVKCWKR----GTNEIVAIKILKNH
 . .. ||.| ||.|.|.  .    .|.  ||.|.||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase HIPK2.AA DyrkP 494-527 38 1.7e-05 13.28 In-house 290-323 (323) Show / Hide 
Range on Protein: 494-527
Range on HMM: 290-323/323
Sequence Identity: 38% (13 aa)

KADRREFIDLLKKMLTIDADKRITPIETLNHPFV
. |   |||  ...| ||  .| |  | |.||..
RTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF