Gene HIPK1 (Human)

HIPK1

Species: Human
Alias: MGC33548, MGC33446, KIAA0630, MGC26642, HIPK1, Nbak2, Myak
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 1p11-p12,

Classification

Group: CMGC
Family: DYRK
Subfamily: HIPK

Sequence

Name Sequence Type Origin Length Description Download
HIPK1.NA RNA Sugen Kinome 8212 None Fasta, JSON
HIPK1.AA Protein Sugen Kinome 1210 None Fasta, JSON
HIPK1.kin_dom Protein Kinase Domain Sugen Kinome 329 None Fasta, JSON

Protein domain

Protein domains of HIPK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase HIPK1.AA HIPK 190-518 79 4.3e-258 822.4 In-house 1-329 (329) Show / Hide 
Range on Protein: 190-518
Range on HMM: 1-329/329
Sequence Identity: 79% (261 aa)

YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPL
|||||||||||||||.|||||.|.|.||||||||||.||||||||||||..||.||||||.|||.||||.|||||||||||||||||||.|||||.||||
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLPL

KYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGW
|.||||||||.|||||||.||||||||||||||||||.|.|||||||||||||||||.||.|||||||||||||||||||||..||||||||||||||||
KHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGW

PLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRR
||||||.||||||||.|||.||.|.||.|..|..|||.|| ......||||..|||| .|..||||||||||||||||..|||..|.|..|...||.|||
PLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRPWRLKHIEEHEQQTSVKSKEARKYIFNCLDDMPEVNMLVDPERQDYRVEKIDRR

EYIDLLKKMLTIDADKRITPLKTLNHQFV
|....||||.|.||.|||||...|||.||
EFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase HIPK1.AA DYRK 190-518 41 1.4e-180 606.24 In-house 1-320 (320) Show / Hide 
Range on Protein: 190-518
Range on HMM: 1-320/320
Sequence Identity: 41% (138 aa)

YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSE-NADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPL-
||.||..|.|.||||.|||.. |.|.|||||..|.....||.|||..||..|. . . |.|..|. |..|.|.||.|.|||.|..|||.|||.|.| .. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

PLKYIRPILQQVATALMKLKSL-GLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELF
.|...|...||. |.| .|...  .||.|||||||||..| |.....|||||||...... ...||.|||.|||||.|||.|.|.|||||||||..||||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQP-RNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELF

LGWPLYPGASEYDQIRYISQTQGLPAEYLLSAG--TKTTRFFNRDPNLGYPLWRLKTPEEHELETG-IKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLA
.||||.||..||||...| ...|.| . ....|  .....||..           ....|.. .|. .|........... ..  ..... . .  |.. 
TGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC-----------FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRH

EKADRREYIDLLKKMLTIDADKRITPLKTLNHQFV
. .|.....|..||.|..| .|||||   |.| ..
Q-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase HIPK1.AA CMGC 190-518 22 2.2e-109 360.72 In-house 1-513 (513) Show / Hide 
Range on Protein: 190-518
Range on HMM: 1-513/513
Sequence Identity: 22% (120 aa)

YEVLEFLGRGTFGQVAKCWK--------------RSTKEIVAIKILKNHPSYARQGQ-------------IEVSILSRLS------------SENADEYN
||... .|.||.|.| ||.               . |.||||||..|| . | .|..              |..|| .|.            ..| .. |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

FVRSYECFQHKN-----------------HTCLVFEMLEQNLYDFLKQNK--------------------------FSPLPLKYIRPILQQVATALM--K
 |. |..|.|||                 | .|||| ....||...|.|.                             ... .|| . .|. ..|    
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LKSLG--LIHADLKPENIMLVDPVRQP----------------YRVKVIDFGSASHVSKA-----------------------VCSTYLQSRYYRAPEII
. | .   || |||||||.. .  . .                .|.|..|||.| ....                          ..| ..|.||||||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LGLP----------FCEAIDMWSLGCVIAELFLG--------WPLYPGASE-----------YDQIRYISQTQGLPAEYLLSAGT-------KTTRFFNR
|| .          ....|||||.||..||...|        .|| || ||           .||.  | .. | |  .....|.       ..  ..|.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

DPNLGYPL------WRLKTPEEHELETGIKSKEARKYIFN-CLDDMAQVNMSTDLEGTDML----------------------------AEKADRREYID
 ....|..      |      .   .|...|. ||.||.. .   . . .  ..|.  .                              ..| .  . ||
IKLPWYNKFPKKWNW------Q--TMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAID

LLKKMLTIDADKRITPLKTLNHQFV
||||||..| |||||.   |.| . 
LLKKMLQYDPDKRITAEQALQHPYF
Kinase HIPK1.AA YAK 190-518 37 4.2e-103 348.85 In-house 1-347 (347) Show / Hide 
Range on Protein: 190-518
Range on HMM: 1-347/347
Sequence Identity: 37% (131 aa)

YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRL--SSENADEY---NFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKF
| ||  ||.||||||.|| .  |.|..|.|..|| . |  |.  |. ||  |    .  ..     ..| |  | |||| |||||||. |||..||||||
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

SPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAE
  .    ||  . |.  ..  |..  .|| |||||||||   . .|  .|.|||||.    | |  || |.|.||.||||.. ..| .||||||||..||
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCK-PNKP-EIKIIDFGSSCQEKKMVY-TYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAE

LFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLG-----------------YPLWRLKTPEEHELETGIKSKEARKYI-FNCLDD
|||| |..||.|||.||  |  . | |   ..  |   ...| .   .|                 |    .|| .. . . .|. || ..|  . || |
LFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYFHC--HDGSNSDDNNNNNNNNNGKPY-YYIFKTKQDYQIDEKIQLKESKTYFQYKCLND

MAQVNM--STDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFV
. . .|  .      |   ..  |   ||..  .|  .  .| .|     | |.
IKN-YMYFKQFMRNQDDTKNNRHRDCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase HIPK1.AA DYRK2 190-428 40 1.9e-84 274.53 In-house 1-243 (318) Show / Hide 
Range on Protein: 190-428
Range on HMM: 1-243/318
Sequence Identity: 40% (98 aa)

YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP
||.||..|.| ||||.||    ||. ||||.. |   ...| ..|. ||..... . |. .| |.  . |   ||.|..|| |  |||...|.|.|  . 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLG
|. .|.  ... ..|  |.   .||.|||||||.|  . |    .|||||||   .      || |||.|||||.|||...  ||||||.||..|||. |
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRS--GIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTG

WPLYPGASEYDQIRYISQTQGLPAEYLLSAG-----TKTTRFFNR
 || ||  | ||. ..    |.| . ...       ...  |||.
YPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNS
Kinase HIPK1.AA S_TKc 190-518 23 2.1e-78 267.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 190-518
Range on HMM: 1-231/231
Sequence Identity: 23% (80 aa)

YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQ---NLYDFLKQNKF--
||.|. .|.|.||.| ||....|..||||||.|      .. . |..||..      .  | |. |..||. .| ..|.|....   .|.|..|...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--SPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCE-AIDMWSLGCV
  .|.|   .| ...|.. ||  . |.| || |||||||.| .      ..|..|||.| ..     .|.  ...|.|||..   ..   ..|.||.||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

IAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDM
..|.. | |..|   ..  .. |                                                                             
LYEMLCGYPPFP--QMQMMFKKIG----------------------------------------------------------------------------

LAEKADRREYIDLLKKMLTIDADKRITPLKTLN-------HQFV
       .| .|...|.|. | .||.|  . |.       |...
------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HIPK1.AA DYRK1 190-452 37 3.1e-75 256.25 In-house 1-263 (321) Show / Hide 
Range on Protein: 190-452
Range on HMM: 1-263/321
Sequence Identity: 37% (101 aa)

YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP
||.   .|.| ||||.| . . ..| |||||.||  ..  | |||. .|  .  . ... |. |.  . | ..|| |||||.|  |||| |.  .|    
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LKYIRPILQQVATALMKLKS--LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELF
|  .| . ||..|||. . .  | .|| |||||||.|. | |    .|.|||||. .. . .   |.|||.||.||..||...  |||||||||.. |. 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRS--AIKIIDFGSSCQLGQRIY-QYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMH

LGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIK
 | ||. |..| ||.  |    |.| ....  . |. ..|..||. .. . . .  . |  | . .
TGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTR
Kinase HIPK1.AA PRP4 190-394 40 8.5e-53 181.72 In-house 1-207 (320) Show / Hide 
Range on Protein: 190-394
Range on HMM: 1-207/320
Sequence Identity: 40% (85 aa)

YEVLEFLGRGTFGQVAKCW-KRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSE---NADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQN-KF
|.|  . | | |. | .|  .  ..| |||||. | ..  . |  |. || .|.       | .  || .. |.|..| ||||| .  || . ||.  | 
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

SPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAE
  | || .|   ||   ||  || .. .|||.|| ||.           | .|||||||..      ||.||.|||||||.| |.  .||||| || ..|
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNE---SKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYE

LFLGWPLYPG
|. |  ..||
LYTGKIMFPG
Kinase HIPK1.AA Pkinase 190-465 27 3.3e-51 181.22 Pfam 1-275 (293) Show / Hide 
Range on Protein: 190-465
Range on HMM: 1-275/293
Sequence Identity: 27% (83 aa)

YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQI-----EVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQ-----NLYDFL
|.... .|.|.||.| || ...| .|||.||.| .     . |.     |..|. ||...|      || |..|. |.| ..|.| .|       |.|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN-----IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

K---QNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLV-DPVRQPYRVKVIDFGSAS---HVSKAVCSTYLQSRYYRAPEIIL-GLPFCE
.   ...|. .. . .. .. |.. .|  . | | || |||||||... ...  . .||..|||.|    . ..  ..|.  ...|.|||.|. | .   
STWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

AIDMWSLGCVIAELFLGWPLYPGA----SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLD
..||||.||...|...| |..||.    . .||.  | .. | | ..  .      .|| . .            . |..     |.|... | .||.
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------F-HWTF-HNWSEECKDFIKWCLC
Kinase HIPK1.AA CLK 190-326 32 2e-48 142.9 In-house 1-150 (350) Show / Hide 
Range on Protein: 190-326
Range on HMM: 1-150/350
Sequence Identity: 32% (49 aa)

YEVLEFLGRGTFGQVAKCWKRST-KEIVAIKILKNHPSYARQGQIEVS-ILSRLSSE-NADEYNF---VRSYECFQH-KNHTCLVFEMLEQNLYDFLKQN
||..  || |||| | .|| ..  |  ||.|| .|.  |  . ..|.. |.  .    ...  .    .. ...| . ..| |.|||..  ..|||.| |
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

K------FSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDP
.      . |.|.  || .  |  .|. .| ...|.| ||||||| .||.
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDS
Kinase HIPK1.AA DyrkP 190-388 38 8.8e-46 148.36 In-house 1-201 (323) Show / Hide 
Range on Protein: 190-388
Range on HMM: 1-201/323
Sequence Identity: 38% (79 aa)

YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSE-NADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNK----F
| ..|.||   | .  .|  . |  .. .||. |   |  |   |. .|  .      || | .| |. | || |  .. |.|..|||.| | |.     
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

SPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAE
    .  .  | ||.  ||  . || ||| |||||||..    .   .||.|||||.  .   . | | ||| |||||.|.|  .   ||||||||..||
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKC--QVKIIDFGSSCFIHDHLSS-YVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAE

LFLG
|. |
LWTG
Kinase HIPK1.AA RCK 255-401 33 3.4e-33 102.46 In-house 64-223 (298) Show / Hide 
Range on Protein: 255-401
Range on HMM: 64-223/298
Sequence Identity: 33% (53 aa)

YECFQHKN--HTCLVFEMLEQNLYDFLKQ--NKFSPLPLKY--IRPILQQVATALMKLKSLGLIHADLKPENIMLVD-----PVRQPYRVKVIDFGSA-S
.| .....  .  .||| ...||| ..|    .  .|| .   |. |. |.. .|  . . |  | ||||||||. .       . ....|..|||.. .
KEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCRE

HVSKAVCSTYLQSRYYRAPEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQI
  ||     |  .|.|||||..|      . .|.|..||...||   .||.||.|| |||
IRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQI
Kinase HIPK1.AA CLK 333-394 43 2.2e-21 60.23 In-house 186-249 (350) Show / Hide 
Range on Protein: 333-394
Range on HMM: 186-249/350
Sequence Identity: 43% (28 aa)

VKVIDFGSAS--HVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPG
..|||||||      .   ||  ..| |||||.||||.. .  | || ||.. || .|  |...
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQT
Kinase HIPK1.AA RCK 190-224 45 4.2e-11 31.17 In-house 1-35 (298) Show / Hide 
Range on Protein: 190-224
Range on HMM: 1-35/298
Sequence Identity: 45% (16 aa)

YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNH
| ... ||.||.| | |  .  |.|||||| .|..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQK
Kinase HIPK1.AA RCK 490-518 41 3.2e-09 25.1 In-house 270-298 (298) Show / Hide 
Range on Protein: 490-518
Range on HMM: 270-298/298
Sequence Identity: 41% (12 aa)

EYIDLLKKMLTIDADKRITPLKTLNHQFV
. |.|..|||..| .||||. . |.|.. 
DCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase HIPK1.AA TyrKc 190-447 21 1.4e-08 -84.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 190-447
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRL--SSENADEYNFVRSYECFQHK-------NHTCLVFEMLEQ-NLYDFL
 . .. ||.| ||.| |.  .   . ||.| ||..    .    | .|...|  . .     | || | .  ..          ..|.|  .  .| |.|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP-----NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKA-VC----STYL-----QSR-----YYRAPEII
. ..   |..|    .  |.|     | | ..|| ||   |... ..     .||. ||| .  .     .    ..|      ...        ||| |
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

LGLPFCEAIDMWSLGCVIAELF-LGWPLYPG-----ASEYDQIRYISQTQGLPAEYL--------LSAGTKT--TRFFNRDPNLGYPLWRLKTPEEHEL
    | .. | || | .. |.| .| . |||      | .. |.|. |   .|             ..   .  ..  ..||.     . .     ...
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI----HECF
Kinase HIPK1.AA DYRK1 486-518 42 1e-07 22.66 In-house 289-321 (321) Show / Hide 
Range on Protein: 486-518
Range on HMM: 289-321/321
Sequence Identity: 42% (14 aa)

ADRREYIDLLKKMLTIDADKRITPLKTLNHQFV
.|   . ||.|.||  |  .||||.. | |.|.
EDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase HIPK1.AA CLK 481-518 39 5e-06 13.17 In-house 313-350 (350) Show / Hide 
Range on Protein: 481-518
Range on HMM: 313-350/350
Sequence Identity: 39% (15 aa)

MLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFV
|. .. . |. .||..||| .|  ||||    | | | 
MDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase HIPK1.AA PRP4 493-518 50 5e-06 18.05 In-house 295-320 (320) Show / Hide 
Range on Protein: 493-518
Range on HMM: 295-320/320
Sequence Identity: 50% (13 aa)

DLLKKMLTIDADKRITPLKTLNHQFV
||| |.|  |  ||||.   | | |.
DLLDKCLMLDPKKRITCNEALKHPFI
Kinase HIPK1.AA Pkinase_Tyr 190-224 35 0.000115 16.42 Pfam 1-39 (270) Show / Hide 
Range on Protein: 190-224
Range on HMM: 1-39/270
Sequence Identity: 35% (14 aa)

YEVLEFLGRGTFGQVAKCWKR----STKEIVAIKILKNH
 . .. ||.| ||.| |.  .    .||  ||.|.||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase HIPK1.AA Pkinase 492-518 33 0.00022 16.58 Pfam 267-293 (293) Show / Hide 
Range on Protein: 492-518
Range on HMM: 267-293/293
Sequence Identity: 33% (9 aa)

IDLLKKMLTIDADKRITPLKTLNHQFV
.|..|..|. |  ||.|.   |.| ..
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase HIPK1.AA DYRK2 491-518 32 0.000358 9.1 In-house 291-318 (318) Show / Hide 
Range on Protein: 491-518
Range on HMM: 291-318/318
Sequence Identity: 32% (9 aa)

YIDLLKKMLTIDADKRITPLKTLNHQFV
.|| .|. .. |...|.||   |.| . 
FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase HIPK1.AA DyrkP 485-518 29 0.034096 2.25 In-house 290-323 (323) Show / Hide 
Range on Protein: 485-518
Range on HMM: 290-323/323
Sequence Identity: 29% (10 aa)

KADRREYIDLLKKMLTIDADKRITPLKTLNHQFV
. |   .||  ...| ||  .| |    |.| ..
RTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF