Gene Haspin (Human)

Haspin

Species: Human
Alias: GSG2, Haspin
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 17p13.2,

Classification

Group: Other
Family: Haspin

Sequence

Name Sequence Type Origin Length Description Download
Haspin.NA RNA Sugen Kinome 2842 None Fasta, JSON
Haspin.AA Protein Sugen Kinome 798 None Fasta, JSON
Haspin.kin_dom Protein Kinase Domain Sugen Kinome 314 None Fasta, JSON

Protein domain

Protein domains of Haspin.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Haspin.AA Haspin 486-742 41 8.49999999999e-127 427.54 In-house 1-264 (264) Show / Hide 
Range on Protein: 486-742
Range on HMM: 1-264/264
Sequence Identity: 41% (110 aa)

RCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDL-----VNGSHQKTFEEILPEIIISKELSLLSG-EVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDH
.|.|||||..||||... ....|..||| |....      ..|.||.|..|.|.|||| |... ||  ..|.....|.|...|..|.|.....|.|.|||
NCKKIGEGCYGEVFSVTWNGKEVVMKIIPIHWSCCKYYGEYCGEHQQTNDEALNEIIIMKKMGKLSHRNMCPNFPNFCGMCVVTQVPGKCCKKLNKMWDH

YNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLK-KTSLKKLHYTLNGKSSTIPS
|. |..|.||||||||..||.|....|.||..|...|.|.... . .||..||. |...|.... |.|.||||||||.| ||..|.||||..||. .|.|
YCYTHHSENDRPDFFKKNQLHIHWIMEYGGRPLDNFRWKFNTCNQCISIMCQLVMSMYIAKDEMQFWHNDLHWGNVLIKRKTKKKWLHYTMDGKTIKIKS

CGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNV
.|..| |||...||...|......|...||..|.. .|||||.|| |.|.... |...|.....
HGVMVTIIDFCKSRCGKDNKKIYWDWKNDETMFEQFWDYQFDVYRDMRKNCQHFWFVHHAKNWK
Kinase Haspin.AA DUF3635 708-798 40 5.1e-55 191.29 Pfam 1-121 (121) Show / Hide 
Range on Protein: 708-798
Range on HMM: 1-121/121
Sequence Identity: 40% (49 aa)

EDLFTGDG---------DYQFDIYRLMKKENNN--RWGEYHPYSNVLWLHYLTDKMLKQMTFKTKC--NTPAMKQIKRKI-----------QEFHRTMLN
.|.|.|.|         ||||||||.|.|...|  .|...||..||||||||..|.|..|.||..|  ||.||.....||           ..||.....
HDFFQGKGKSKINEYQYDYQFDIYRMMRKMLKNPICWSQFHPMTNVLWLHYLIHKLLHKMKFKSICTENTAAMRMYMKKIINHHLMDPARHKHFHQIFMS

FSSATDLLCQHSLF------K
|.||....|||.||      |
FESASIRHCQHYLFNWVRQMK
Kinase Haspin.AA Src 484-513 38 8.9e-09 25.9 In-house 1-31 (255) Show / Hide 
Range on Protein: 484-513
Range on HMM: 1-31/255
Sequence Identity: 38% (12 aa)

LQRCEKIGEGVFGEVFQ-TIADHTPVAIKII
...|.|.|.| ||||.. .  ..|.||.| .
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTL
Kinase Haspin.AA Ciliate-A9 484-514 31 4.5e-08 14.4 In-house 1-35 (392) Show / Hide 
Range on Protein: 484-514
Range on HMM: 1-35/392
Sequence Identity: 31% (11 aa)

LQRCEKIGEGVFGEVFQTIADH----TPVAIKIIA
.   ..|||| || |.| .       . .|.|.|.
FEPIKIIGEGAFGCVIQCRDIQQEDKQEYAVKVIQ
Kinase Haspin.AA YSK 485-516 50 6.1e-08 19.61 In-house 2-35 (257) Show / Hide 
Range on Protein: 485-516
Range on HMM: 2-35/257
Sequence Identity: 50% (17 aa)

QRCEKIGEGVFGEVFQTIADHTP--VAIKIIAIE
 . |.|| | ||||.  |  .|   ||||||  |
TKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLE
Kinase Haspin.AA MOS 484-513 36 1.2e-07 21.21 In-house 1-30 (299) Show / Hide 
Range on Protein: 484-513
Range on HMM: 1-30/299
Sequence Identity: 36% (11 aa)

LQRCEKIGEGVFGEVFQTIADHTPVAIKII
 ..|. || | ||.|.  .   .|||.|..
VCLCQMIGRGGFGSVWKAQYCGRPVAVKQV
Kinase Haspin.AA STE 484-543 20 1.5e-07 22.89 In-house 1-86 (359) Show / Hide 
Range on Protein: 484-543
Range on HMM: 1-86/359
Sequence Identity: 20% (18 aa)

LQRCEKIGEGVFGEVFQTIADHTP-----------------VAIKIIAIEGPDL---------VNGSHQKTFEEILPEIIISKELS
... ||||.| ||.|.. .  ...                 .|||.. .|  .          .. .... ...|| || | |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCN
Kinase Haspin.AA Pkinase_Tyr 484-513 33 6.6e-07 24.01 Pfam 1-36 (270) Show / Hide 
Range on Protein: 484-513
Range on HMM: 1-36/270
Sequence Identity: 33% (12 aa)

LQRCEKIGEGVFGEVFQTIAD------HTPVAIKII
..  .|.||| ||||.. ...      ..|||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML
Kinase Haspin.AA CMGC 484-513 26 2e-06 16.08 In-house 1-46 (513) Show / Hide 
Range on Protein: 484-513
Range on HMM: 1-46/513
Sequence Identity: 26% (12 aa)

LQRCEKIGEGVFGEVFQTIA----------------DHTPVAIKII
 .  .||||| .|.|.. .                 .   ||||.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKI
Kinase Haspin.AA SRM 487-513 50 4e-06 16.31 In-house 4-31 (253) Show / Hide 
Range on Protein: 487-513
Range on HMM: 4-31/253
Sequence Identity: 50% (14 aa)

CEKIGEGVFGEVFQTI-ADHTPVAIKII
| | ||| ||||.     .  .||||.|
CRKLGEGYFGEVWEGLWKGQVHVAIKVI
Kinase Haspin.AA STE20 484-538 32 6e-06 18.19 In-house 1-57 (288) Show / Hide 
Range on Protein: 484-538
Range on HMM: 1-57/288
Sequence Identity: 32% (20 aa)

LQRCEKIGEGVFGEVFQTIADHTP------VAIKIIAIEGPDLVNGSHQKTFEEILPEIII
 .  ||||.| .|.|.  .  .|       ||||.. .| .|      |. .|.|. || |
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNE----QDEWEDIQKEISI
Kinase Haspin.AA TK 484-513 21 7e-06 14.87 In-house 1-60 (486) Show / Hide 
Range on Protein: 484-513
Range on HMM: 1-60/486
Sequence Identity: 21% (13 aa)

LQRCEKIGEGVFG---EVFQTIADH---------------------------TPVAIKII
..  .|.||| ||   ||.. ..                             ||||.|..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKML
Kinase Haspin.AA S_TKc 484-797 14 1.9e-05 -96.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 484-797
Range on HMM: 1-231/231
Sequence Identity: 14% (52 aa)

LQRCEKIGEGVFGEVFQTIADH--TPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYN
 .  .|||.| ||.|.. .  .    ||||||                                      | |  |  .          | . |  |.. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------------------------EHIRREIQILKK--------HHPNIVKLYDVFQ

STKGSANDRPDFFKDDQLFIVLEFEFGGI---DLEQMRTKLS--------SLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLN
.              | |..|  .|. .    || ..  |          .  .|.....|.   |.      .. ||||   |.|| .           
D--------------DHLYMV--MEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-----------

GKSSTIPSCGLQVSIIDYTLSRLERDGIV---------VFCDVSMDE-------------DLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYL
           .. |.|  |.|.  . ..         |.   . .               ...|   .. ......||                     
-----------HIKICDFGLARQL-TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-------------------

TDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLC------QHSLF
               .| .|.. ||. ..  .     .| ..|       .|  |
---------------SPEAKDFIRKCLQKDPEKR--PTA-EALQDEWDIKCHPWF
Kinase Haspin.AA Pkinase 484-519 34 4.8e-05 18.92 Pfam 1-38 (293) Show / Hide 
Range on Protein: 484-519
Range on HMM: 1-38/293
Sequence Identity: 34% (13 aa)

LQRCEKIGEGVFGEVFQTIADHTP--VAIKIIAIEGPD
... .|||.| ||.|.. .   |.  ||.|||  .. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEK