Gene GSK3B (Human)

GSK3B

Species: Human
Alias: GSK3B
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 3q13.33,

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
GSK3B.NA RNA Sugen Kinome 7134 None Fasta, JSON
GSK3B.AA Protein Sugen Kinome 433 None Fasta, JSON
GSK3B.kin_dom Protein Kinase Domain Sugen Kinome 298 None Fasta, JSON

Protein domain

Protein domains of GSK3B.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GSK3B.AA GSK 56-353 61 1.1e-232 718.98 In-house 1-328 (328) Show / Hide 
Range on Protein: 56-353
Range on HMM: 1-328/328
Sequence Identity: 61% (202 aa)

YTDTKVIGNGSFGVVYQAKLC----DSGEL----VAIKKVLQDKRFK-NRELQIMRKL---DHCNIVRLRYFFYSSGEKKDE--VYLN-LVLDYVPETVY
|...||||.|||||||||...    ...|     ||||||.||||.| |||||||..|   ||.|||||.||||...|||||  ||.| ||..|.|.|.|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

RVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR--GEPNVSYICSRYYRAPELIFGATDYTSSI
.|.|||...||..|.|..||||||.||.|||.||.|||||||||||.|.||||.|||.|||||||||..  .|||.||||||||||||||||.|.||..|
QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQI

DVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP-----QIKAHPWTK--------DSSGTGHFTSGVRVFRP-RTPP
||||.|||.||.|.|||.|||||.|||||||||.|||||.|||..|||.|.|||||     |||.|||.|          .     .  | .|.  .|..
DVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQT-YYHKKYR-TVYMFKWCHTDM

E-AIALCSRLLEYTPTARLTPLEACAHSFF
. .| |.|..|.|.|..||.||||||| ||
QDWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase GSK3B.AA CMGC 56-353 21 3.4e-125 413.66 In-house 1-513 (513) Show / Hide 
Range on Protein: 56-353
Range on HMM: 1-513/513
Sequence Identity: 21% (113 aa)

YTDTKVIGNGSFGVVYQAKL--------------CDSGELVAIKKVLQDKRFKN----------------RELQIMRKL-----------------DHCN
|.  |.|| |..||||...               ....|.|||||. ... ...                ||..|...|                 .| |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVRLRYFFYSSGEKKDE-----------VYLNLVLDYVPETVYRVARHYS------------------------RAKQTLPVIYVKLYMYQLFRSLA--Y
||.|...||.......|           ..|.|| .|.. . |.. ....                        . .. ... ... ||||..|.|.  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IHSFG--ICHRDIKPQNLLLDPDTAV-------------------LKLCDFGSAKQLVRG----------------------EPNVSYICSRYYRAPELI
.|| .  |.|||.||.|.|..... .                   ||.||||.|...                         .|. .|...|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FGA---------TDYTSSIDVWSAGCVLAELLLG--------QPIFPGDSG-----------VDQLVEIIKVLGTPT---------------REQIREMN
.|.         ..||..||.||.||..||...|        .|.|||.|.           .||| .|.|||||||                |.. .|.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

PNYTEFK---------------------------FPQIKAHPWTK-------DSSGTGHFTSGVRVFRPR-------------------TPPEAIALCSR
.... .|                           ||... .||..        .  .  ..    ||  .                    .|.|| | ..
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKK--AMVF-NWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKK

LLEYTPTARLTPLEACAHSFF
.|.| |. |.|. .|..| .|
MLQYDPDKRITAEQALQHPYF
Kinase GSK3B.AA Pkinase 56-353 29 5.1e-102 350.02 Pfam 1-293 (293) Show / Hide 
Range on Protein: 56-353
Range on HMM: 1-293/293
Sequence Identity: 29% (96 aa)

YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR--------ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHY-
|.  ..|| ||||.||...  ..|..||.|..  ... ..         |.|||..|.|.|||||...|..    ||..|  .|..|.. ..| |.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIY--MVMEYCEGGLY-VMDLFD

---SRAKQTL--PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAV---LKLCDFGSAKQ--LVRGEPNVSYICSRYYRAPELIFGATDYTS
    ... ..  .   .| ||||..| |.|.|| ||.|||.||.|.|.| .  .   .|.||||.|||  . ... . .. ....|.|||.| |...|..
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

SIDVWSAGCVLAELLLGQPIFPGD----SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSR
..|.||.||.|.|.|.|.|.|||.    . .||.. | ...|.|..... . ......| |.. . |                ..| .....|.. ....
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------------F-HWTF-HNWSEECKDFIKW

LLEYTPTARLTPLEACAHSFF
.|.. |. |.|. ... | .|
CLCKDPKKRPTAEQILQHPWF
Kinase GSK3B.AA S_TKc 56-353 27 1.1e-88 301.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 56-353
Range on HMM: 1-231/231
Sequence Identity: 27% (87 aa)

YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE---TVYRVARHYSRAK--
|.  ..|| |.||.||...  ..|..||||..    .   ||.||..| .| |||.| ..|..        .| .|..|..    ..... ... | .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

QTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTS-SIDVWSAGCVLAE
. .|   .. ||||... |.|.|| ||.|||.||.|.|||    ..|.||||.|.||       ... ...|.|||..     |.  ..|.|| ||.|.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA
.| |.| ||      |. ...|..|                                                .|||. . ...|.. |. |.|  || .
MLCGYPPFP------QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQ

-------HSFF
       | .|
DEWDIKCHPWF
Kinase GSK3B.AA CDK 56-353 27 1.4e-74 237.99 In-house 1-284 (284) Show / Hide 
Range on Protein: 56-353
Range on HMM: 1-284/284
Sequence Identity: 27% (93 aa)

YTDTKVIGNGSFGVVYQAKLCDSG-----ELVAIKKVL--------QDKRFKN---RELQIMRKLDHCNIVRLRYFFYSS-----GEKKD-EVYLNLVLD
|   . || |..|||| |.  ..|     ..||.||.          .  |     ||  ....| | |||.|.  ....     . |   |  | .| .
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

YVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTA----VLKLCDFGSAKQLV-------RGEPNVSYICSRYY
|..   . . .             .| ||.|| | |.|.|| .| |||.||||.|.. .      .||. ||| |.             .  . .  . |
YMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPELIFGATDYT--SSIDVWSAGCVLAELLL---GQPIFPGDSGVDQLVEIIKVLGTPTREQ---IREMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSG
||||| .|...|.   .||.||.||..||...   ..|.|||||  |||  |....|||| ..   . .. |.|                          
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKL-PDY--------------------------

VRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
              | ...| | |. |..  .|  | .|
-------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase GSK3B.AA RCK 56-353 29 3.3e-74 234.8 In-house 1-298 (298) Show / Hide 
Range on Protein: 56-353
Range on HMM: 1-298/298
Sequence Identity: 29% (94 aa)

YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIMRKLD-HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYS
|. .| .| |..|.|  |.  ..||.|||||    ..|..       ||.. .|||  | ||. |.  ..     .|.  | .|. |. . .|   ... 
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIR----DNDTYQLYFVFEYMDMNLYQMMKDFK

RAKQT-LPVIY--VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPD--------TAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTS
  ... || .   .| .|||.. .||..|. |. |||.|| |... ..        . ..|..|||...      |.  |. .|.|||||..  .| |.|
E-RRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNS

SIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN--PNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLL
 .|.|. ||. .||   .| ||| | .||. .|.||.|||. .   .     . ..|.||| |               ..  .  |. ....| |.  .|
PMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCK--------------GMPLKQLIPNCSQDCIELMEKML

EYTPTARLTPLEACAHSFF
 . |  | |. .|. | .|
QWDPQKRITAQQALQHPYF
Kinase GSK3B.AA CDC2 56-353 28 2.7e-66 202.54 In-house 1-301 (301) Show / Hide 
Range on Protein: 56-353
Range on HMM: 1-301/301
Sequence Identity: 28% (93 aa)

YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLD-HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHY
|.  . || |..||||..|  .....||.||.  .             ||. .. .|. | |||.|.  ...         | .| .|.     .  . .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-------NKLYMVFEYLDMDLKKYMDMS

SRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICS-----RYYRAPELIFGATDYTSSIDVW
   .. .|...|| ||||. . ... |. .| |||.||||.|.| .....|. ||| |.    | |   |        . |||||. .|. .|. ..|.|
IPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAF--GIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMW

SAGCVLAEL---LLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFK--FPQIKA----HPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSR
| ||..||.       |.|.|||  |||  | ..||||. .   ..  .....|  ||. |.    .   .  ..        . .   ..||.| | ..
SIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVT-QLPDYKNTFPRWKPQDLSKICPNNQKK--------KNQ-SCLDPEGIDLLMQ

LLEYTPTARLTPLEACAHSFF
.| | |  |..  || .| .|
MLQYDPQKRISAKEALQHPYF
Kinase GSK3B.AA CDKL 56-353 32 4e-59 200.79 In-house 1-286 (286) Show / Hide 
Range on Protein: 56-353
Range on HMM: 1-286/286
Sequence Identity: 32% (101 aa)

YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ---DKRFK---NRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRA
|    ..| || |||.  .  ..|..||||| .    |.  |    ||. . . | | ||| |.  |     .| . .  ||  |.  ||  .  .    
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVF----RRKRKLH--LVFEYCDHTVLHELEE---Y

KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV-RGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLA
 . ..   |. ||.|. ..... |.  . |||||| |.|. |   ..|||||| |..|   ||    |   | ||||||  | |.| ...|.|..|||.|
PNGVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMA

ELLLGQPIFPGDSGVDQLVEIIKVLG--TPTREQIREMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLE
|.. |||..||.| .|||  |.|.||  .|  ..|  .|| .   |||.|.            |. .  . ..    ..|. .   .|.  |. |.|  .
EMIDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIE------------HMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQ

ACAHSFF
.  |..|
LMHHPYF
Kinase GSK3B.AA MAPK 56-353 28 4.6e-58 199.21 In-house 1-328 (328) Show / Hide 
Range on Protein: 56-353
Range on HMM: 1-328/328
Sequence Identity: 28% (99 aa)

YTDTKVIGNGSFGVVYQAKLCD------SGELVAIKKV---LQDKRFKN---RELQIMRKL-DHCNIVRLRYFFYSS-----GEKK--DEVYLNLVLDYV
|.. | || |..|||  |.         .|. |||||.    |.. .     ||. ..| . .| ||..|.  |. .     ...   ...|  .| .. 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIY--IVMELM

PETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS--LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV-------------------
    ... .       .|  . ..  |||. |   | |||| .. |||.|| |.|.. .  . |.||||    | |.. .                    
ETDLHQIIKSQQ----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDL-KICDFG----LARSIDPEYHHHHQQDDPHCFQKMHMT

SYICSRYYRAPELIFG--ATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN-P----NYTE-FK-FPQIKAHPWTKD
 |.  |.|||||....  ...|| ..|.||.|| .||.|  ..|.|||.. .||.  |..|||||..| |. .  .    || . .. .|. ...||.| 
EYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKM

SSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
 ...            .. |.|| | ...|.  |  |.|  || .| .|
FPNANF----------NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase GSK3B.AA CDK7 158-280 47 4.6e-57 150.29 In-house 104-226 (288) Show / Hide 
Range on Protein: 158-280
Range on HMM: 104-226/288
Sequence Identity: 47% (60 aa)

VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ
.| || .. . | | |   | |||.|| |||....  .||. ||| |..   | ||  |   .  |.|||||| |||  |....|.|| ||..|||.|  
IKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNEN-GQLKIADFGLARFY--GSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PIFPGDSGVDQLVEIIKVLGTPTREQ
|..|||| .|||. | . ||||| |.
PYLPGDSDIDQLTRIFQTLGTPTEEE
Kinase GSK3B.AA ERK7 56-353 31 1.3e-52 178.14 In-house 1-292 (292) Show / Hide 
Range on Protein: 56-353
Range on HMM: 1-292/292
Sequence Identity: 31% (97 aa)

YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKLD-HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSR
|   | .| | .|.|  |    ... ||.||.        |     ||  ... .. | ||.||   .  . ..   .|  || ..       | |.   
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDR--DIY--LVFEFMETDLHAVIRK---

AKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE------PNVS-YICSRYYRAPELIFGATDYTSSIDVW
  . |  | ..  ||||.| . |.||  . |||.|| |.||| .  | |.|||| |  .   |      | .  |.  | |||||   |.. ||  .| |
-GNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMV-KVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMW

SAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTAR
| ||.|.|.| |.|.||| | ..|.  |..... ||.| |  ....|      |..            . .     . | ....|| |  ||| . |  |
SIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMN-----------QQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKR

LTPLEACAHSFF
||  .| .| . 
LTAEQALQHPYV
Kinase GSK3B.AA ERK 162-353 32 5.2e-45 155.85 In-house 114-307 (307) Show / Hide 
Range on Protein: 162-353
Range on HMM: 114-307/307
Sequence Identity: 32% (68 aa)

MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK-QLVRGEPNV--------SYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL
|||. . | |||| .. |||.|| |.|.  .  .|| |||| |  . .  ..|.         |. .|.|||||..  ...||...|.||.|| .||.| 
MYQILCGLKYIHSANVIHRDLKPSNILVNSN-CDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLG

GQPIFPGDSGVDQLVEIIKVLGTP-TREQIREM-NPNYTEF--KFPQ--IKAHPWTKDSSGTGHFTSGVRVFRPRTP--PEAIALCSRLLEYTPTARLTP
..|.||| . |.|. .|....||| . |....  ..|. ..  ..|   ... || .             .| |...  |.|| | ...|.  |. |.| 
RKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWEN-------------IF-PNANCNPQAIDLLEKMLVFDPDKRITV

LEACAHSFF
 |. .| .|
EECLEHPYF
Kinase GSK3B.AA TyrKc 56-353 20 3.1e-13 -8.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 56-353
Range on HMM: 1-280/280
Sequence Identity: 20% (70 aa)

YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---RELQIMRKL--DHCNIVRLRYFFYSSGEKK---DEVYLNL-------VLDYVPETVY
 |  |..|.| ||.||....    . ||.|..  |.  .    ||..||.||  .| |||||     ..|..    . ... .        .||  ..  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

RVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG----EPNVSYI-----CSR-----YYRAPE
.           |..     ...|  .  .|.|| .. |||.   | |.. .  . | .||| .. .  .    |    |      ...        |||
K-----------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

LIFGATD-YTSSIDVWSAGCVLAELL-LGQPIFPG---DSGVDQLVEIIKVLGTPTREQIREM----NPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRV
 |   .  .|.  |||| | .. |.. .||.  ||      .    |.|. . .  |  . .                                      
CI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------

FRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
| .. |.|   . ..  .. |  | |  |   |..|
F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase GSK3B.AA CDK7 56-87 46 3.9e-11 25.46 In-house 1-32 (288) Show / Hide 
Range on Protein: 56-87
Range on HMM: 1-32/288
Sequence Identity: 46% (15 aa)

YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV
|.  | || | |..|| |    .|. |||||.
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKI
Kinase GSK3B.AA Pkinase_Tyr 56-112 31 7.5e-10 33.99 Pfam 1-69 (270) Show / Hide 
Range on Protein: 56-112
Range on HMM: 1-69/270
Sequence Identity: 31% (22 aa)

YTDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVLQDKRFKN-------RELQIMRKL-DHCNIVRL
 |  |..| |.||.||....     . .  ||.|.. ..   ..       ||..||..| .| |||||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase GSK3B.AA ERK 56-113 31 1e-06 21.03 In-house 1-70 (307) Show / Hide 
Range on Protein: 56-113
Range on HMM: 1-70/307
Sequence Identity: 31% (22 aa)

YTDTKVIGNGSFGVVYQAKLCD-----SGELVAIKKV---LQDKRFKN---RELQIMRKLD-HCNIVRLR
| ..| || |..|||  |.        .|. |||||.     .... .   ||. ..| .. | ||. |.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLF
Kinase GSK3B.AA CDK7 325-353 17 0.002479 4.25 In-house 260-288 (288) Show / Hide 
Range on Protein: 325-353
Range on HMM: 260-288/288
Sequence Identity: 17% (5 aa)

EAIALCSRLLEYTPTARLTPLEACAHSFF
... | ....   | .|.|  ..  . .|
DLLDLMCGMWTMNPCKRWTCTQCLKMPYF