Gene GPRK6 (Human)

GPRK6

Species: Human
Alias: GRK6, FLJ32135, GPRK6
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 5q35.2,

Classification

Group: AGC
Family: GRK
Subfamily: GRK

Sequence

Name Sequence Type Origin Length Description Download
GPRK6.NA RNA Sugen Kinome 2952 None Fasta, JSON
GPRK6.AA Protein Sugen Kinome 589 None Fasta, JSON
GPRK6.kin_dom Protein Kinase Domain Sugen Kinome 263 None Fasta, JSON

Protein domain

Protein domains of GPRK6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RGS GPRK6.AA RGS 52-170 25 2.8e-36 121.64 Pfam 1-124 (124) Show / Hide 
Range on Protein: 52-170
Range on HMM: 1-124/124
Sequence Identity: 25% (32 aa)

DYHSLCERQPIGRLLFREFCAT-RPELSRCVAFLDGVAEYEVT---PDDKRKAC-GRQLTQNFLSHTGPDLIPEVPRQLVTNCTQRLEQ-GPCKDLFQEL
..|.||. |||||.|||.|. .  .|. ... |.. . .....   .|.|.... .|.  .....   |  .. ........| ..|||  |..|.|.| 
SFHHLCNDQPIGRRLFRQFLESEFCEY-ENIEFWLACEDFKKMFSDSDEKMHQKDAREIYNKYIAPDSPCECHNIDHDTREHCQDNLEQAQPTPDCFDEA

TRLTHEYLSVAPFADYLDSIYFNRF
 | ......  ..  .|.| |..||
QRHIYTLMEKDSYPRFLKSDYYQRF
RGS GPRK6.AA RGS 52-171 25 4.5e-35 123.76 SMART 1-121 (121) Show / Hide 
Range on Protein: 52-171
Range on HMM: 1-121/121
Sequence Identity: 25% (31 aa)

DYHSLCERQPIGRLLFREFCATRPEL-SRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPD-LIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLT
..|.||...||||..||||. ..... .... |.. . |.....|..|....|.. . ..|  .|    ..........| |.|.. |..|.|.|  | .
SFHHLCDNDPIGRRYFREFLKQEFCEYKENLEFWLACEEFKKMEDEERRQKAREIYDKYISPNAPCEHCVNIDHHTREQCQQCLCN-PHPDCFDEAQRHV

HEYLSVAPFADYLDSIYFNRFL
.....  .....| | |. |.|
YQLMEKDSYPRFLRSDYYKRYL
Kinase GPRK6.AA GRK 186-448 74 1.5e-234 747.26 In-house 1-272 (272) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-272/272
Sequence Identity: 74% (202 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR---FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ--
||||||||||||||||||||||||||||||.|.||||||||||.||||||||||||.||   |.|..|||||||||||||.|.||||||..|||.||.  
FRQYRVLGKGGFGEVCACQVRATGKMYACKCLDKKRIKKRKGETMALNEKQILEKVHSRDCPFIVCMAYAYETKDALCLVMTIMNGGDLHYHIYNMGNNE

AGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ-TIKGRVGTVGYMAPEVVKNER-YTFSPDWWALGCLLYEM
.||.|.|..|||||||||||..||.|||||||||||||||||||.||||||||...|||| .|.|||||.|||||||..||| |.||||||.|||..|||
PGFDEERMRFYAAEICCGLEHMHRRRIVYRDLKPENILLDDHGHVRISDLGLACEIPEGQPMIHGRVGTHGYMAPEVLQNERAYDFSPDWWSLGCMIYEM

IAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGG--SAREVKEHPLF
|.|.|||.|.|.|.|||||.|.|||.|..|...||..|...|..||.|||..|||||||  .|.||||||.|
IEGHSPFRQHKEKVKREEVDRRVKEDPVKYPDKFSEEAKDICEMLLQKDPEQRLGCRGGTCGAQEVKEHPFF
Kinase GPRK6.AA GRK 186-448 81 3e-230 771.21 In-house 1-265 (265) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-265/265
Sequence Identity: 81% (217 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMG-QAGFP
|||||||||||||||||||||||||||||||||||||||||||.||||||||||||.||||||||||||||||||||.|.|||||||||||.|| ..||.
FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEQMALNEKQILEKVHSRFVVSLAYAYETKDALCLVMTIMNGGDLKFHIYNMGENPGFD

EARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSP
|.||.|||||||||||.||||||||||.||||||||||||||||||||||..||||.|.||||||||||||||||||||||||||.||||.||||.|.||
EERAIFYAAEICCGLEHLHRERIVYRDMKPENILLDDHGHIRISDLGLAVEIPEGQMIRGRVGTVGYMAPEVVKNERYTFSPDWWGLGCLIYEMIEGRSP

FQQRKKKIKREEVERLVKEVPEEYS-ERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF
|.|||.|.|||||.| ||| ||.|| |.|| .|...|..||.|||..|||||.....||..||.|
FRQRKEKVKREEVDRRVKEDPEKYSHEKFSEEAKDICRMLLHKDPEQRLGCREEGCDEVRQHPFF
Kinase GPRK6.AA AGC 186-448 28 5.6e-160 417.29 In-house 1-395 (395) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-395/395
Sequence Identity: 28% (114 aa)

FRQYRVLGKGGFGEVCACQVR------ATGKMYACKKLEKKR-IKKRK--GEAMALNE------------KQILEKVN----------SRFVVS-LAYAY
|. ..|.|||.||.|. .. .      .|||.||.|.|.||. |...|   ......|            ..||||.|          . |.|. | |..
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETKDA--LCLVLTLMN--------GGDLKFHIYHMG--QAG-FPEARAVFYAAE-------ICCGLEDLHR-ERIVYRD-LKPENILLDDHGHIRISDLG
..||   |..|. .|.        ||.. .... .|  . | |.| || |||||       |...|| ||.   |..|| |||||||||..|||...| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAVHVP---------------------------------------------------EGQTIKGRVG--TVGYMAPEVVKNERYTFSPDWWA--LGCLLY
|.  ..                                                   .... .  .|  |  |||||..    |... |||.  ||||.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMIAGQSPFQQ------------RKKKIKREEVERLVKEVPEEYS----------ERFSPQARSLCSQLLCKDPAERLGCRGGS-----AREVKEHPLF
||..|..||.             .... .. .  |.... ....           . |||.|..|...||||||..||||.|.      | |.|.|| |
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase GPRK6.AA BARK 186-448 50 6.6e-97 328.25 In-house 1-264 (264) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-264/264
Sequence Identity: 50% (136 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR----FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA
|   |..|.||||||  |    |||||| | |.||||| ..|| .||||. .|. |       |.| ..||..| | || .| |||||||    ||. | 
FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFHTPDKLCFILDLMNGGDLH---YHLSQH

G-FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV-KNERYTFSPDWWALGCLLYEMI
| | |.   ||||||  ||| .|.  .||||||| |||||..||.||||||||    . .     ||| |||||||. |   |  | ||..|||.|| ..
GVFSEQEMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDENGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLYKLL

AGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF
 | ||| | | | | .|..|.   .  |  . ||.. |.|   || .| ..||||.|. |.|||||| |
RGHSPFRQHKTKDK-HEIDRMTLTMNVELPDSFSKEMRDLLEGLLQRDVSKRLGCMGRGAQEVKEHPFF
Kinase GPRK6.AA S_TKc 186-448 34 1.1e-92 315.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNG--GDLKFHIYHMGQAG-
..  |..|||.||.|. |. . ||. .|.|..            ....| |||.| .  ..| | ..... | |..|. ...|  |||. .| ..|  | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF-SPDWWALGCLLYEM
   ||| .| ||...|||.|| .|. .|..|||||||||||.  || |.| ||| ..      .  .||  ||||||.    |.. . |||..||.||||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

IAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSA--REVKEHPLF
..|. ||.        ... ....          ||.|... ...|.|||..|...    .  ...| || |
LCGYPPFP------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GPRK6.AA AktR 186-448 37 7e-83 281.65 In-house 1-268 (268) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-268/268
Sequence Identity: 37% (103 aa)

FRQYRVLGKGGFGEVCACQVR-ATGKMYACKKLEKKRIKKRKGEAMALNEKQILE-KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGF
|. |..||||.||.|  .| .  ..|.|| | . || |..|. .  ...|..|.| ..|  | | | |. .||. | ...  . ||.| .|. . ..  |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKK--F

PEARAVFYAAEICCGLEDLHRE-RIVYRDLKPENILLDDHGHIRISDLGLAV--HVP-EGQTIKGRVGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEM
 | .| ||.|.|. .|| || .  |.|||||||||||| .||..|.| ||.    .  . .. .  .||. |||||.... . ...| ||||.|...|||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

IAGQSPFQQ--RKKKIKREEVERLVKEVPEEYSERFSPQARSLCS-QLLCKDPAERLG--CRGGSAREVKEHPLF
..|. ||..  .. .....  ..  ...|  |.. ||.|...|.  .||||.| .|||  | |  . |.|.|| |
VTGCPPFYHKNQNQMFQKIKIKQ-QNKFP--YPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNG--WEEIKSHPWF
Kinase GPRK6.AA RSK 189-448 36 7.5e-83 281.55 In-house 1-278 (278) Show / Hide 
Range on Protein: 189-448
Range on HMM: 1-278/278
Sequence Identity: 36% (102 aa)

YRVLGKGGFGEVCACQVR---ATGKMYACKKLEKKRIKKR-KGEAMALNEKQILEKVN-SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG-
 .|||.||.|.|  |.     .||. || | |.|. |..| |  . .. | .||| .. . |.|.| ||..|.. | |.. ...||.|  |... .. | 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD---HGHIRISDLGLAVH-VPE-GQTIKGRVGTVGYMAPEVVK---NER-YTFSPDWWALGC
| | .| ||.||| . .| ||   |..|||||||||.||   .|||...| |..   ... .|  .  ..|. |||||..|    .. .. . ||| ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLYEMIAGQSPFQQRKKKIKREEVERLVKEVP--EEYS--ERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF
|.||| .|..|||.   .  |.|. . ...     .    .  |. |..| ...|..||. ||||  . | |.|.|| |
LMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase GPRK6.AA Pkinase 186-448 29 3.5e-80 277.5 Pfam 1-293 (293) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMAL-NEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGG----DLKFHIYHMGQ
..  |..|.|.||.|. |. . |||..|.|...|...|. | .. .. .| ||. ..|. ..| | ...|.|| ...|. ...||    ||. .|  . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

AGF--PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI----RISDLGLAVH--VPEGQTIKGRVGTVGYMAPEVVK-NERYTFSPDWWAL
 .|  .|  . ||. .|..||| .|...|..|||||||||.|..|||    .|.| ||| .     ..  ....|| .||||||.. .. |. . |.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCLLYEMIAGQSPFQQR----KKKIKREEVERLVK-EVPEEYSERFS-------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPL
||.||||. |. ||...    .   ... ..|  . ........  |                   . ...... .|||||..|..     |.....|| 
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW

F
|
F
Kinase GPRK6.AA Akt 186-448 39 1e-79 254.46 In-house 1-264 (264) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-264/264
Sequence Identity: 39% (109 aa)

FRQYRVLGKGGFGEVCACQVRATGKMY-ACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFP
|.  .||||| || |  ..  .|.|.| | | | |..| ...  . .. |. ||...|. |.|.| |.  |.| |..|.  .|||.| .|... .   |.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKR--RFS

EARAVFYAAEICCGLEDLHRERIVYRD-LKPENILLDDHGHIRISDLGLAV-H-VPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWA-LGCLLYEMIA
| || ||.||| ...| ||   |.||| |||||||.| .|||.. | ||.  . . .... |   ||  |.|||. ..  .| . |||. |||..|||. 
EDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMC

GQSPF--QQRK---KKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF
|. ||  |...   |||| ..|     . |.   ...||....| |.|| ||| .|||   . |.|.|.|| |
GRPPFYNQDHHQMFKKIKNQPV-----KFPDK--DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase GPRK6.AA SGK 186-448 36 3.8e-79 243.95 In-house 1-283 (283) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-283/283
Sequence Identity: 36% (106 aa)

FRQYRVLGKGGFGEVCACQVRAT------------------GKMYACKKLEKKRIK-------KRKGEAMALNEK-QILEKVNSRFVVSLAYAYETKDAL
|.   |.|||.||.|   .  ..                  .|.|| | | |. |        |.| .   . |.  || .... | |.| ||  ||. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAV-HVPEGQTIKGRVGTVGYMAPEVVK
 .|.  .|||.. .|.   .   ||| || |||||| | || ||   |.||||||||||||. ||... | ||.   . . .| .   ||. |.|||| .
YFVMDYVNGGEMFYHLQREKH--FPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLR

NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF
 . .  . ||| |||.||||. |  ||  | |..  .   .. ..        .|..|..|  .|| ||| .||| . . ..|.|.|| |
KQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYD--NIINQPL--QIPPQMSNDAWDLIQGLLQKDPKKRLGTKRD-FMEIKNHPFF
Kinase GPRK6.AA Ciliate-E2 186-448 21 7.3e-71 241.74 In-house 1-365 (365) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-365/365
Sequence Identity: 21% (82 aa)

FRQYRVLGKGGFGEVCACQVRATGKM-----------------------YACKKLEKKRIKKRKGEAMAL----------NEKQILEKVNSRFVVSLAYA
.   ...|.|.|| |. |.|. ..|.                       || | ..|. |.  | |   .          |||.|||..|. ... . ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--TKDALCLVLTLMNGGDLKFHIY----------------HMGQAGFPEARAV--------FYAAEICCGLEDLHRER-IVYRDLKPENILLDDHGHI
..  ... . ||. . .||||. .|.                 . ....  .  .        ||.|.|...|| || .  |..||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

RISDLGLAVHVPEG--------------------------------QTIKGRVGTVGYMAPEVVKNER---------YTFSPDWWALGCLLYEMIAGQSP
 |.|.||.  . .                                 ....  .|| ||||||.....          |... |.|.||..||||. |. |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQQRKKKIKREEVERLVKEVPEEYS------------------ERFSPQARSLCSQ----LLCKDPAERLGCRGGSAREVKEHPLF
|            ..  |. . ...                  .  |...  |...    .|.||| .|..    .. ....|| |
F------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase GPRK6.AA Ciliate-E2-Unclassified 186-448 24 1.4e-70 240.79 In-house 1-352 (352) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-352/352
Sequence Identity: 24% (88 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKK-RKGEAM--------ALNEKQ-------------ILEKVNSRFVVSLAYAYETKDALCLVL
..  ...|.||||.|. || . ... || | . |..|.| .. . .        ..|.|.             ||   .. |.| . |. ..|. ...|.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

TLMNGGDLKFHIYHMGQ---------------AGFPEARAV-----FYAAEICCGLEDLHRE-RIVYRDLKPENILLDDHG---HIRISDLGLA------
 ...||||...| ....                 |.|  |.     ||.|.|..||| ||..  |..||.||||||.|. |   .|.|.|.|..      
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

----------VHVPEGQTIKGRVGTVGYM----APEVVKNERYT----FSPDWWALGCLLYEMIAGQSPFQQRKKKI------------KREEVERLVKE
            ..  | .. ..|| .||    |||| ... |     .. |.|.||..||||. |. ||.......             |.....  |.
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

VPEEYSE--------RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF
 . ....        . ||.|  ....||.|..  ... |  .. ....||.|
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-TFEQILNHPWF
Kinase GPRK6.AA TyrKc 186-423 20 6e-15 19.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 186-423
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV--NSRFVVSLAYAYETK-------DALCLVLTLMNGGDLKFHI-
 .  ..|| | ||||. .. .    . | |.| .        ... ..| .|. |.  .   .| |  .  ..       . |..|. .| .|||| .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

YHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG-------QTIK------GR-VGTVGYMAPEVVKNER
.| ..  .. .  . ..  |.|| | ||. ... |||   |.|... ....||| ||.  . ..       ....      |. .  .  ||||. .  .
KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YTFSPDWWALGCLLYEMIA-GQSPFQQ---RKKKIKREEVERLVKEV-----PEE------------------------YSERFSPQARSLCSQL
.|.  | |. | ...|.   ||.|      .  ... .|| ..||.      |..                         ..|  |  . .....
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR--PTFSEIHECF
Kinase GPRK6.AA S_TK_X 449-528 20 1e-09 39.56 SMART 1-79 (79) Show / Hide 
Range on Protein: 449-528
Range on HMM: 1-79/79
Sequence Identity: 20% (18 aa)

KKLNFKRLGA--GMLEPPFKPDPQAIYCKDVLDIEQFS--TVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETE----CFQELNVFG
.......| .  ...||||||.....|  .  |...|     ...         .. . ...... |||| .|||    .| ... . 
RGIDWDKLYNQQKEIEPPFKPKIKEVYA-SPTDTSNFDPEFTEETPM-------LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF
Kinase GPRK6.AA Pkinase_Tyr 186-333 22 0.000709 13.75 Pfam 1-158 (270) Show / Hide 
Range on Protein: 186-333
Range on HMM: 1-158/270
Sequence Identity: 22% (36 aa)

FRQYRVLGKGGFGEVCACQVR----ATGKMYACKKLEKKRIKKRK--GEAMALNEKQILEKV-NSRFVVSLAYAYE-TKDA--LCLVLTLMNGGDLKFHI
 .  ..||.| ||||. .  .     |.   | |.| |    ..    |..   | .|. .  .   .|.|  .    ..   ...|. .| .|||. . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

YHM--GQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA
     ..  ..  . . ....|..|.| |.. ... |||   |.|... ....|.| |||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase GPRK6.AA Pkinase_Tyr 352-386 32 0.005023 10.87 Pfam 181-217 (270) Show / Hide 
Range on Protein: 352-386
Range on HMM: 181-217/270
Sequence Identity: 32% (12 aa)

MAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSP-FQ
||||. .. ..|   | |. | |..|..  |..| ..
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYP