Gene FYN (Human)

FYN

Species: Human
Alias: FYN, SYN, MGC45350, SLK
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 6q21-q22,

Classification

Group: TK
Family: Src
Subfamily: SrcA

Sequence

Name Sequence Type Origin Length Description Download
FYN.NA RNA Sugen Kinome 2650 None Fasta, JSON
FYN.AA Protein Sugen Kinome 537 None Fasta, JSON
FYN.kin_dom Protein Kinase Domain Sugen Kinome 250 None Fasta, JSON

Protein domain

Protein domains of FYN.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 FYN.AA SH3 85-142 43 1.7e-26 95.25 SMART 1-58 (58) Show / Hide 
Range on Protein: 85-142
Range on HMM: 1-58/58
Sequence Identity: 43% (25 aa)

TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVD
  ..|||||.|...|.|||.||.....|. ....||..|  .||..|..|||||...|
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 FYN.AA SH3_1 88-135 46 2.1e-26 91.86 Pfam 1-49 (49) Show / Hide 
Range on Protein: 88-135
Range on HMM: 1-49/49
Sequence Identity: 46% (23 aa)

VALYDYEARTEDDLSFHKGEKFQILNSSEG-DWWEARSLTTGETGYIPS
||||||.|...|.||| ||....... |.. |||..|...||..|..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 FYN.AA SH3_2 86-141 19 5.3e-15 55.42 Pfam 1-68 (68) Show / Hide 
Range on Protein: 86-141
Range on HMM: 1-68/68
Sequence Identity: 19% (13 aa)

LFVALYDYEA-RTEDD-----LSFHKGEKFQIL---NSSEGDWWEA-RSLTTGET--GYIPSNYVAPV
..... ||.. . ...     |.|.||... ..   . . ..||.. .....|..  |..||..|...
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 FYN.AA SH2 149-231 60 1.4e-52 156.21 Pfam 1-81 (81) Show / Hide 
Range on Protein: 149-231
Range on HMM: 1-81/81
Sequence Identity: 60% (50 aa)

WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHY
||.||. |..|||.|.. |||.||||.||||.|.| |.|| ||...  ||.||||.|...||||||||.| .|..||.||.||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP--GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 FYN.AA SH2 147-237 41 6.7e-36 126.5 SMART 1-87 (87) Show / Hide 
Range on Protein: 147-237
Range on HMM: 1-87/87
Sequence Identity: 41% (39 aa)

EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITT--RAQFETLQQLVQHYSERAAG
..||.|.. |..||. |.. |.| |.||.|.||...|.|.||.|.      ..||||.||..|.|.|||..  | .|..| .||.||.  . |
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase FYN.AA SrcA 271-520 90 8.60000000001e-226 721.19 In-house 1-250 (250) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-250/250
Sequence Identity: 90% (226 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDM
..|..|||.|.|||||||||||.||||||||||||||||.|||||||||||.|||||||||||||||||||||||.||||||||||.||..||||.||||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVDM

AAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM
|||||.||||.|||||||||||.||||||. |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM

NNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFL
|||||||||||||.||||||||.||||||..||.||||||||||||||||
NNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase FYN.AA Src 271-520 76 4.8e-205 687.47 In-house 1-255 (255) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-255/255
Sequence Identity: 76% (195 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLK-DGEGRALKLPNLV
..|...||.|||||||||.||||||||.||||||||||| ||.||||||||.|.||||||||.|.| |||||||||..|||||.|| |||||.|.||.|.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIE--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP
|||||||.||||.|.||||||||. .|.|||....||.|||||||||.  |.||.||.|||||||||||||..|||||||||||||||||||.||.||||
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPGMNNREVLEQVERGYRMPCPQDCPISLHE-LMIHCWKKDPEERPTFEYLQSFL
||||.|.|||.|||||||||||. || .|.| .| .||.||||.||||||||.||
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FYN.AA SFK-Src 271-524 61 1.3e-188 564.7 In-house 1-259 (259) Show / Hide 
Range on Protein: 271-524
Range on HMM: 1-259/259
Sequence Identity: 61% (158 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAV-VSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVD
 .| |.|| ||||.|| |.||. | ||.||||||.|| | ||.|||.||||.|..|.|||||    |||||.|| |  |||||.|.. .||.|..| |||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIE-DNE-YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPY
||||||.|||| |  |..||||   |.|||.  .||..|||..| .. |.| |||..|||||||||||||... || |||||||||||..|.|| ||.||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMNNREVLEQVER--GYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYF
||| | ||| ||.|  |||||||. ||  ....|. ||.. |..||||| |.  .||.|
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase FYN.AA SrcB 271-521 71 4.1e-170 571.44 In-house 1-251 (251) Show / Hide 
Range on Protein: 271-521
Range on HMM: 1-251/251
Sequence Identity: 71% (180 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDM
|.|.|.|| |||||||||..|...|||.||.|.|||||| ||.|| .||.|.||.||.|||||. |||||.||||.||.||||||  ||  |.|| |.||
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKEPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLIDM

AAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM
.||.| |||||||||||||||| ||||| . |.||||||||||.||||||||| |||||||||||||  .| ||||||||||||||.|.|| ||.|||||
SAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGM

NNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLE
 | ||....|||||||.|. ||  | ..|..|||. |||||||.|||| |.
TNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase FYN.AA Src-Unclassified 271-520 52 1.9e-154 519.39 In-house 1-284 (284) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-284/284
Sequence Identity: 52% (148 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPG---TMSPESFL--------EEAQIMKKLKHDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGE
..|.. || ||||||| | | |   ||.||..||   ||||| ||        .|||||||..| .||.|||| | |||.||.|||| .||||..|. | 
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GRALKLPNL------------VDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGL-----ICKIADFGLA--RLIEDNEYTARQGAKFPIKWTAPEAAL
|. | .. .            ||.||||| || | |   |.||||   |.|.|        . |..|||||  .|..| .| .|.||.||.||.|||...
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCP--QDCPISLHE-LMIHCWKKDPEERPTFEYLQSFL
|| |.|||||||.|||| |. |||..||||| ||||||.|||||||| |  . || .. | .|  || |||. ||||. |  ..
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase FYN.AA Pkinase_Tyr 271-520 48 1.3e-153 520.83 Pfam 1-270 (270) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-270/270
Sequence Identity: 48% (131 aa)

LQLIKRLGNGQFGEVWMGTWN-----GNTKVAIKTLKPGTMSP----ESFLEEAQIMKKL-KHDKLVQLYAVVS--EEP--IYIVTEYMNKGSLLDFLKD
....| || |.||||..|||.     ....||.|.||.|.|..    |.|..||.|||.| .|...|.||.|..  .||  ||||.||| .|.|||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

G--EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI-EDNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSF
   ....|... |..|..|.|.||.| |..|.|||||.  |.||......||.||||||.| .| .| ..|.|.|.||||.|||.  ||.||.|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLTELVTKGRVP-YPGMNNREVLEQV-ERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFL
|.|. |..| |. | |||| | ||.|.. |.|||||||..||  ...|| .||..|||.||||......|
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FYN.AA Frk 271-524 66 1.2e-149 503.49 In-house 1-260 (260) Show / Hide 
Range on Protein: 271-524
Range on HMM: 1-260/260
Sequence Identity: 66% (174 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLK--DGEGRALKLPNL
.|||.||| ||||||| | || .| ||.|||||||| |. || ||||||||.| ||.|||||   ||||||.|| | .|||...|.  ...|| .... |
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

VDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLAR-LIEDNE--YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGR
|||||||||||||.| .|||||||   |.|||...||||||||||| |. |||  | .|.||.||||||||||| | .||||||||||||||||..| ||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

VPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYF
.||||| |.|||..|..|||||.| .||  | |.|..||..||..||||| ||  |||||
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase FYN.AA Src-Echino1 271-520 61 2.6e-143 482.42 In-house 1-252 (252) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-252/252
Sequence Identity: 61% (154 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVD
|.. |..|.|..|||| | |||||.||.||||..||||  || || .|||..|. .||.||| |.. ||||||| |..|.|.|.||.|... .|.. |.|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

MAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPG
| |..|.|| |... |..||||   |.|||.| .||||||||||......| ..||||.|||||||||||||||||||||||||||.||.|| ||.||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

MNNREVLEQVERGYRMPCPQDCPISLHEL-MIHCWKKDPEERPTFEYLQSFL
| |||||.||.|||||| ...|| ||... |. || |||  |||||.| .|.
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase FYN.AA TyrKc 271-520 41 3.6e-136 459.6 SMART 1-280 (280) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-280/280
Sequence Identity: 41% (119 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKL--KHDKLVQLYAVVSE--------EPIYIVTEYMNKGSLLDFLKDGEGR
..|.| ||.|.||||. |||.  ..||.|.||...   | |..||.||.||  .|. .|.||.|...        ||..||.||| .|.|.|.|.. ...
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDN--------EYTARQ--GAK--FPIKWTAPEAALYGRFTIKSD
 |... |.... |.|.||.|....|.|||||   |.|||.....||.||||.| |.|          |....  |.|  .||.|.|||.  ||.||.|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILLTELVTKGRVPYPG-----MNNREVLEQVERGYRMPCPQD--------CPISLHELMIHCWKKDPEERPTFEYLQSFL
|||||... |. | |  ||||     |.|.||.|.|..|||||.|..        ||  ....|  ||. |||.||||. . ...
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FYN.AA SRM 271-521 51 1.8e-127 428.57 In-house 1-253 (253) Show / Hide 
Range on Protein: 271-521
Range on HMM: 1-253/253
Sequence Identity: 51% (131 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGT-MSPESFLEEAQIMKKLKHDKLVQLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLV
  | ..|| | ||||| | | |  .||||  |    |  . .  | | |||| | ... |.||.|  .|.||.|| | ||.|. .|.| ...||..|.|.
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

DMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYP
|.| ||| ||.| |  |||||||   |.|||....||..|||||||| |  |    . . |.|||||||| |. . .||||||||||| |. |.| .|||
DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLE
|| | | . |..||||||||  || . | ||. ||..|||.||.|  |   | 
GMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase FYN.AA TK 271-520 26 3.3e-122 411.75 In-house 1-486 (486) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-486/486
Sequence Identity: 26% (128 aa)

LQLIKRLGNGQFG---EVWMGTWNGN--------------------------TKVAIKTLKPG-TMSPES--------------FLEEAQIMKKLK----
..|.| || ||||   ||..|.|.|                           |.||.|.||.| .||.|               |||||..||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HDKLVQLYAVVSEE-------------PIYIVTEYMNKGS----LLDFLK--DGEGRA-----------------------------------------
 |. .|.||.|....             |..||.|||..|.    |.|.|.  .....                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LKLPNLVDMAAQVAAGMAYIERM------NYIHRDLRSANILVGNGLI-----------CKIADFG---
                               | .. |. |..|.|.||.|....      |..||||   |.|||....           |||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLI-EDNEYTARQ------------------------GAKFPIKWTAPEAAL---------YGRFTIKSDVWSFGILLTELVTKGRVPYPG-M
     ||| | .| .|....                        |.|.||.|.|||. .         ||.||.||||||||.|. |..| |..||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NN---------REVLEQVERG--------------YRMPCPQDCP--------------ISLHELMIHCWKKDPEERPTFEYLQSFL
.|         .||.|...||              .|||.|..||                ...||  ||..|||.||||. |...|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FYN.AA Tec 271-522 47 4e-114 385.45 In-house 1-254 (254) Show / Hide 
Range on Protein: 271-522
Range on HMM: 1-254/254
Sequence Identity: 47% (120 aa)

LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLP-NLV
| ..| ||.|||| | .| | .. .||||..| |.|| | |.|||..|.|| | |||||| | |.. ||||||||| .|.||..|.  ...  |    | 
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

DMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYP
.|  .|  |||| || ..|||||   | |||   . |..|||..| . | .||   |.|||.|| .||   | |.  |||||.||.|  |  . |..||.
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

GMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLED
 | | || |.| .|.|.  |. |. .. . | |||.  |||||||. | . ...
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase FYN.AA S_TKc 271-524 25 1.5e-57 198.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 271-524
Range on HMM: 1-231/231
Sequence Identity: 25% (69 aa)

LQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNK--GSLLDFLKDGEGRA----LK
 .... .| | ||.|. ..... . .|||| .|      |... | ||.|| .|. .|.|| |  .. .|.|.||..   |.|.|..|.  ..     . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI-KSDVWSFGILLTELVTK
      ...|.. ...|. ... |||||  .|||. .    ||.||||||..                . |||      ..  |.|.||.|..| |... 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-

GRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQS-----FLEDYF
|. |.|  .  ......            . .. ... .|..||||.|||   .        .  .|
GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FYN.AA Pkinase 271-520 25 1.2e-47 169.46 Pfam 1-293 (293) Show / Hide 
Range on Protein: 271-520
Range on HMM: 1-293/293
Sequence Identity: 25% (77 aa)

LQLIKRLGNGQFGEVWMGTWNGNTK-VAIKTLKPGTMSPESFLE-----EAQIMKKLKHDKLVQLYAVV-SEEPIYIVTEYMNKG----SLLDFLKDGEG
.......| | ||.|. ... |. | ||.|..|  . ...   .     |.||||.|.|.  |.|| .. ..  ||.|.||...|    .| |...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RAL--KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLIC----KIADFGLARL--IEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVW
...      . ... |.. |..|. .|. ||||| ..|||. |   .    ||.|||||..  .  |..| . |  .   . |||  . .   . |.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPW---YMAPEVIRGGQYYGPKVDMW

SFGILLTELVTKGRVPYPGM------NNREVLEQVER-GYRMPCPQDCP-------------------ISLHELMIHCWKKDPEERPTFEYLQSF--L
|.|..| |... || |.||       . ....... .  .. ..|..|.                    .. ...  |..|||..|||.| .     .
SCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF