Gene Fused (Human)

Fused

Species: Human
Alias: DKFZp434N0223, Fused, STK36, KIAA1278, FU
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 2q35,

Classification

Group: Other
Family: ULK
Subfamily: Fused

Sequence

Name Sequence Type Origin Length Description Download
Fused.NA RNA Sugen Kinome 4952 None Fasta, JSON
Fused.AA Protein Sugen Kinome 1315 None Fasta, JSON
Fused.kin_dom Protein Kinase Domain Sugen Kinome 251 None Fasta, JSON

Protein domain

Protein domains of Fused.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Fused.AA Fused 4-254 75 2.1e-225 755.13 In-house 1-251 (251) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-251/251
Sequence Identity: 75% (190 aa)

YHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQ
|||.||.|.||||.|||.||||...|||.|||||.|||.|||.||.||.||||...||.|.||.|||||||||||||||||.||.|.||.|||.||.||.
YHVSEMVGQGSFGCVYKARRKYDSKVVAIKFIPKRGRSDKELKNLRRECEIMRRMHHPHIIHMIDSFETDKEVVVVTDYAEMELHQYLEYDGKMPEEQVR

AIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYAT
.||..|||||||||||||||||||||||||.|...||||||||||.||.||.||||||||||||.||||||.||||.||.||.|||||||.||.|||.|.
RIACHLVSALYYLHSHRILHRDMKPQNILLDKNMHIKLCDFGFARNMSINTHVLTSIKGTPLYMAPELVEEQPYDHHADMWSLGCILYELMVGQPPFCAN

SIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFI
|||.|||.|..|.|.|||||..|..||||||||||||.|.|||.||.|||.
SIFHLVSMIKHDDVKWPSTITSCCRNFLQGLLTKDPRHRISWPQLLCHPFV
Kinase Fused.AA AGC 4-254 23 1.1e-111 289.53 In-house 1-395 (395) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-395/395
Sequence Identity: 23% (93 aa)

YHVLEMIGEGSFGRVYKGRRK------YSAQVVALKFIPKLG---RSEK-ELRNLQRE------------IEIMRGLR----------HPNIVH-MLDSF
...| .||.||||.||  |.|       . .. |.| . |     . .| .... ..|             .|.  ..          ||.||. .  ||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETDKE--VVVVTDYAE----------G-ELFQILE---DDGKLPEDQVQAIAAQ-------LVSALYYLHS-HRILHRD-MKPQNILLAKGGGIKLCDFG
....   .  | .|..          | |||..|    . |...|.... .||.       .|.|| |||| . | ||| .|| |||| . | |||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FARAMST--------------------------------------------------NTMVLTSIKG--TPLYMSPELVEERPYDHTADLWS--VGCILY
..  . .                                                  ..   ... |  || ||.|| .    |....| ||  .||..|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELAVGTPPFYATS----------IFQLVSLIL------KDPVRWP----------STISPCFKNFLQGLLTKDPRQRLS----------WPDLLYHPFI
|. .| ||||. .           ...  .|.      ...|..|          . .||  |.....||.|||..||             ..  ||. 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase Fused.AA ULK 4-254 30 5.5e-109 368.37 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-329/329
Sequence Identity: 30% (101 aa)

YHVLEMIGEGSFGRVYKGR---RKYSAQVVALKFIPKLGRSEKELRN-----------LQREIEIMRGLR--------HPNIVHMLDSFETDKE--VVVV
|.. ...|.||||.|||||   .| . .|. . .. .. ....   |           |..||.||. |         ||||| ..| |||...  .  .
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

TDYAEG-ELFQILEDDGKLPEDQ----------VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKG------------GGIKLCDFGFARAMSTN---
..| .|  |.|... ..|||||.          .. .  |..... .||.|.| |||.||||||. .|            | .|..|||||. .. .   
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

--TMVLTS----IKGTPLYMSPELVEER----PYD-HTADLWSVGCILYELAVGTPPFYATSIFQLV-----SL----------ILKDPVRWP-----ST
   |. ..    ..||||||.|......    ||. ...|.||.|||.||. .| |||||  .....     .|          | | | ..|      .
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

ISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFI
||| .|......|..|...| ||..|. ||..
ISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase Fused.AA S_TKc 4-254 35 7.2e-104 352.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-231/231
Sequence Identity: 35% (95 aa)

YHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEG---ELFQILEDDGK----
|..|. ||.|.||.|||.| | . ..||.| |.         ....|||.|..  .|||||...|.|.. ... .|..|..|   .||..... |.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDH-TADLWSVGCILYEL
  .|| ... ...|...|| |.|||.|.||| ||.|||| .   ||.||||.|| .       |.. ||| ||.||..   .|..  .| ||.||||||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

AVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLY-------HPFI
..| |||.   ....  .|.          || .|.|....|.|||..|..  ..|        ||..
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Fused.AA Pkinase 4-254 32 3.7e-103 353.81 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

YHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQR--EIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEG-----ELFQILE--DD
||... ||.||||.|||...| . ..||.| |.| .......... |  ||.||. |.||||| ..|.||..... .|..|.||     .|| ...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKL--PEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGI----KLCDFGFARAM-STNTMVLTSIKGTPLYMSPELVE-ERPYDHTADLWSV
|..  .|.... .. |....|.|.||..|.|||.||.|||. . | |    |.||||.|. .   |   .|.. ||| ||.||..   ..|.. .| ||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCILYELAVGTPPFYAT------SIFQLVSLILKDPVRWPSTIS---------------------PCFKNFLQGLLTKDPRQRLSWPDLLYHPFI
||||||.. | |||.        .  |.. .|.. |.....  .                     . .| |. ..|.||| .|......| ||..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Fused.AA ULK 4-254 30 2.2e-97 329.84 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-324/324
Sequence Identity: 30% (98 aa)

YHVLEMIGEGSFG-RVYKGRRKYS---AQVVALKFIPKLGRSEKELR--------NLQREIEIMRGLR---HPN--IVHMLDSFETD--KEVVVVTDYAE
| . ...|.||||  ||||| | .    |.|| | |.| . ..|...        .|..||.||. |    |||  || ..| |||.  . .  ...| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

G-ELFQILEDDGK---------LPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGG------------IKLCDFGFARAMSTNT---MVLTS
|  |.|... ..|         |.|.... .  |..... .||.| | |||.||||||. .| .            .|..|||||.    |.   .....
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

IK------GTPLYMSPELVEER----PYD-HTADLWSVGCILYELAVGTPPFYATSIFQLV----SL----------ILKDPVRWP-----STISPCFKN
..      ||||||.|......    ||. . .|.||.|||.||.  | .||..  . ...    .|          | . |...|       ||| .|.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FLQGLLTKDPRQRLSWPDLLYHPFI
.....|..|...| ||.... ||..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase Fused.AA CAMK 9-254 22 3e-90 290.95 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-254
Range on HMM: 1-425/425
Sequence Identity: 22% (97 aa)

MIGEGSFGRVYKGRRKYSA------------QVVALKFIPK--LGR------------------------SEKELRNLQREIEIMRG-------LRHPNI
 .|.|||| |.....| .             | || |.|.|  |                          ..| ..|..||||||.        |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VHMLDSFET-------------------DKEVVVVT---DYAEG-ELFQ--------------------ILEDDGKLPEDQVQAIAAQLVSALYYLHSHR
..... .|.                   ||... |.   .|..| |||.                    |. ..|...|.... .  |..||. |.||| 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDMKPQNILLAKGG----------------G-IKLCDFGFARAMSTN-----------------------TMVLTSIKGTPLYMS-PELVE------
| ||| || |||| . .                . ||..|||||. .  .                       .  ..   ||| ||. ||...      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------ERPYDHTADLWSVGCILYELAVGTPPFYAT-------------SIFQLVSLILKDPVRWPST----------------ISPC--------FK
        ...|.  .| ||.|.||| . .|.||||.              .. .|   |.|   ..|.                 ||           |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NFLQGLLTKDPRQRLSWPDLLYHPFI
......|..|| .|..  . | ||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Fused.AA STE 4-254 26 1.6e-80 273.84 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-359/359
Sequence Identity: 26% (95 aa)

YHVLEMIGEGSFGRVYKGRRKY---------------SAQVVALKFIPKLGRS---------------EKELRNLQREIEIMRGLR--HPNIVHMLDSFE
.  .|.||.|.|| |||....                . ...| | ...   .               ..|. ....||.||. ..  |||||. .....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TD-------KEVVVVTDYAE-GELFQILE---DDGK-----------LPEDQVQAIAAQLVSA-LYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFAR
 .        |. ..  | . | | .|..     ||           .||.|. .|. |.. . |||||||.| ||| ||.||||     .||||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

AMSTN--------------TMVLT--SIKGTPLYMSPELVEE------RPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLIL-------------
 .. .              ||.    .. ||| .|.|| ..        .||  .| ||.|| . |.| | ||.   . ..   .|.             
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---KDPVRWPSTIS-------------------PCFKNFLQGLLTKDPRQRLSWPDLLY--HPFI
   ..| . |...|                   |.||.|..  |.|||..| .  .||   ||||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Fused.AA NEK 4-254 35 5.4e-78 265.42 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-286/286
Sequence Identity: 35% (102 aa)

YHVLEMIGEGSFGRVYKGRRKYSAQV-----VALKFIPKLGR-SEKELRNLQ-REIEIMRGLRHPNIVHMLDSFETDK--EVVVVTDYAE--GELFQI--
| ....||.||||.||| |||   ..     ...| |  .|. |||| .|.|  |. | . |.|||||   |||. ..      | .|.|  | |.|   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKIN-MGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIK

-LEDDG----KLPEDQVQAIAAQLVSALYYLHSH-----RILHRDMKPQNILLAKGGG----IKLCDFGFARAMSTNTMVLTS-IKGTPLYMSPELVEER
 ..        ..|.|.  . .|...||.|.|..     .||||| ||||| | | .     .|. ||| .. ....|  ...   ||| |||||.....
SIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

PYDHTADLWSVGCILYELAVG--TPPFYAT--SIFQLVSLILK--DPVRWPST--ISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFI
||.. .| ||.||.|||..     .||.|.  .. .|.  | |  .. . ||.   |.  .|... .|.||| || |  ..| .|||
PYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase Fused.AA CAMKL 4-254 28 2e-77 246.64 In-house 1-297 (297) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-297/297
Sequence Identity: 28% (84 aa)

YHVLEMIGEGSFGRVYKGRR-KYSAQVVALKFIP--KLGRSEKELRN-----------LQREIEIMRGLR---HPNIVHMLDSFETDKE------VVVVT
| ... .|.|||| |  ..  ..  . || |.|   |.   .. ..|           ..|||.||. |.   ||||..... .||..       .. |.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

DYAEGE---LFQILEDD----GKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGG--IKLCDFGFARAMSTN----TMVLTSIKGTPLYM
 |..|    ||. ..      |..||.. . .  |.|||..|.|||.| ||| || |||| . |   ||..||||.  .  .       |.   |.| ||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPELVEE--RPYD-HTADLWSVGCILYELAVGTPPFYATS---------IFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFI
.||...   .|||   .| || | ||| . .|. || . .          . .   ..    . .. .|   .......|...| .| .  ... ||. 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase Fused.AA STE20 4-254 32 1.3e-72 247.5 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-288/288
Sequence Identity: 32% (94 aa)

YHVLEMIGEGSFGRVYKGRRKYSAQV----VALKFIPKLGRSE--KELRNLQREIEIMRGLRHPNIVHMLDSFETD----KEVVVVTDYAEG-ELFQILE
|  || ||.||.| |||.. | . ..    || | ..    ..  .|....| || ||. ..|||||....|.  |     |  .| .| .|  | .|..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---DDGK------LPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMST----NTM-VLTSIKGTPLYMSPELVEE----
    .||      . |.|. .|  ... .| ||||..| ||| | .|||| . | .||.|||..  ...           .. ||| .|.||....    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-RPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLIL--KDPV---RW--PSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFI
  .||. .| ||.|  . |.| | ||..  . ..   .|.  . |    .   |.. ||.|..|.   |.||| .| .  .|| ||||
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase Fused.AA Ciliate-E2 4-254 22 2.2e-72 246.77 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-365/365
Sequence Identity: 22% (87 aa)

YHVLEMIGEGSFGRVYKGRRKYSAQV------------------VALKFIPKLGRSEKELRNLQREIEIMRGLR----------------HPNIVHMLDS
| ....||.|.|| |||....   .                   |. |.. .   ........ .|| ||| ..                ||||. | ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--TDKEVVVVTDYAEG-ELFQILE------------DDGKLPEDQVQAIAAQLVS---------------ALYYLHSHR-ILHRDMKPQNILLAKGGG
|.  .|. .  |..|..| .||....            | ... | ... | .|...               || ||||   |.||| ||.|||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IKLCDFGFAR---------------AMSTNTM-----------------VLTSIKGTPLYMSPELVEERP---------YDHTADLWSVGCILYELAVGT
||..|||...                . ..                   .  .| ||| ||.|| ..  .         ||. .|.||.|.||||.  | 
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

PPFYATSIFQLVSLILKDPVRWP------------------STISPCFKNFLQG----LLTKDPRQRLS-WPDLLYHPFI
|||           |.. ... |                    .|.  |....     .| ||| .|.. | ..| ||..
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Fused.AA Pkinase_Tyr 4-193 26 8.2e-22 74.49 Pfam 1-207 (270) Show / Hide 
Range on Protein: 4-193
Range on HMM: 1-207/270
Sequence Identity: 26% (56 aa)

YHVLEMIGEGSFGRVYKGRRK----YSAQVVALKFIPKLGRSEKE--LRNLQREIEIMRGL-RHPNIVHMLDSFE-TDKE--VVVVTDYAEG-ELFQILE
 . ....|||.||.||||. |       . || | . | | ....  .. . ||..||. | .||||| ..      ..   . .|. |...  |   | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

D----DGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAM-STNTMVLTSIKGTPL---YMSPELVEERPYDHTADLW
.    ...|.  .   ...|  ... ||.|... |||    |.|..... .| |||| ||.. .. .  ... .|..|    |.||   .. . .  | |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SVGCILYEL
| |  ..|.
SFGVLMWEI
Kinase Fused.AA TyrKc 4-254 21 4.3e-16 37.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

YHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGL--RHPNIVHMLDSFETD-------KEVVVVTDYAE-GELFQILED
 . ....||| ||.||||. |   . || | . .       .. . ||..||. |  .||||| ..    ..       . . .|. |.. | | . | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

DGK-LPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTN--------TMVLTSIKGTP--L---YMSPELVEERPYDH
 .. |. ..   .. |  .   ||||... |||    |.|..... .| .||| .|.            . . .. ||.   |    |.||   .. . .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

TADLWSVGCILYELA-VGTPPFYA-----TSIFQLVSLILKDPVRWPSTI---------SPCFKNFLQGLLTKDPRQRLSWPDLLYHPFI
  | || |  ..|.   | .| .       | .... .. .   . .            ..   .  .     || .| .  ..  | ..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
HEAT Fused.AA HEAT 564-597 29 12.734768 2.55 Pfam 1-31 (31) Show / Hide 
Range on Protein: 564-597
Range on HMM: 1-31/31
Sequence Identity: 29% (10 aa)

FLDLLGKLLAQPDDSEQTLRRDSLMCFTVLCEAM
.|..| |.|    |..   |. .. |...||| .
ILPHLLKCLN---DPDWEVREAACWCLGQLCEHC
HEAT Fused.AA HEAT 1113-1140 32 0.085806 10.07 Pfam 4-31 (31) Show / Hide 
Range on Protein: 1113-1140
Range on HMM: 4-31/31
Sequence Identity: 32% (9 aa)

PLRSLLGHPENSVRAHTYRLLGHLLQHS
.| ..| .|. .||. . . ||.|..|.
HLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT Fused.AA HEAT 1153-1183 32 0.000106 20.14 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1153-1183
Range on HMM: 1-31/31
Sequence Identity: 32% (10 aa)

LLSLLLLGLGDKDPVVRCSASFAVGNAAYQA
.|..|| .| |.|. ||..|  ..|. . ..
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT Fused.AA HEAT 1193-1223 25 0.000426 18.05 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1193-1223
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

AVPSMTQLLGDPQAGIRRNVASALGNLGPEG
 .| . ..| || . .|......||.| .  
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT Fused.AA HEAT 1237-1264 32 0.231106 8.58 Pfam 4-31 (31) Show / Hide 
Range on Protein: 1237-1264
Range on HMM: 4-31/31
Sequence Identity: 32% (9 aa)

LLEMACGDPQPNVKEAALIALRSLQQEP
.|  .. || ..|.|||. .| .| .  
HLLKCLNDPDWEVREAACWCLGQLCEHC