Gene FLT4 (Human)

FLT4

Species: Human
Alias: FLT4, VEGFR3, FLT41, PCL
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 5q35.3,

Classification

Group: TK
Family: VEGFR

Sequence

Name Sequence Type Origin Length Description Download
FLT4.NA RNA Sugen Kinome 5857 None Fasta, JSON
FLT4.AA Protein Sugen Kinome 1363 None Fasta, JSON
FLT4.kin_dom Protein Kinase Domain Sugen Kinome 325 None Fasta, JSON

Protein domain

Protein domains of FLT4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG FLT4.AA IG 36-133 10 0.001953 18.66 SMART 1-58 (58) Show / Hide 
Range on Protein: 36-133
Range on HMM: 1-58/58
Sequence Identity: 10% (11 aa)

EESHVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDT---GSYVCYYKYIKARIEGTTAA--SSYV
 . ..   |......|  .  . |                                    | . .| ..|.   | |.|  .       |.. .  . ..
PP-VTVKEGETVTLTC-VS-QIWWY-----------------------------------LTI-NVQPEDSQQHGTYYCQAT------HGQYWSIQGTTL

FVR
 |.
TVQ
IG FLT4.AA IG 237-328 19 4.2e-12 47.47 SMART 1-58 (58) Show / Hide 
Range on Protein: 237-328
Range on HMM: 1-58/58
Sequence Identity: 19% (19 aa)

RKSLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQHDL---GSYVCKANNGIQRFR-ESTEVIVH
 . ..  .|| ..|.| |.       .. |                            ||| ||.  |    | |.| |. . | .  ..|...|.
PP-VTVKEGETVTLTC-VS-------QIWWY---------------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
V-set FLT4.AA V-set 231-327 14 5.5e-07 25.93 Pfam 1-128 (128) Show / Hide 
Range on Protein: 231-327
Range on HMM: 1-128/128
Sequence Identity: 14% (18 aa)

DIQLLP--RK----SLELLVGEKLVLNCTVW--AEFNSGV-TFDWDY-PGK---------------QAERGKWVPERRSQQTHTELSSI-----LTIHNV
..|. .   .    ...  .|... |.|...   . .... .. | .                   . ........| .  ..   .       |||.|.
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

SQHDLGSYVCKANNG-IQRFRESTEVIV
.  | | | | . |. .. | ..|...|
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
IGc2 FLT4.AA IGc2 243-317 24 0.000172 17.94 SMART 1-56 (56) Show / Hide 
Range on Protein: 243-317
Range on HMM: 1-56/56
Sequence Identity: 24% (18 aa)

LVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQHDLGSYVCKANNGIQ
. |. ..|.|   |. | . .. | . |.. .                 .. ||| ||.  | | |.|.| | . 
HEGQSVTLTCP--ATGNPDPNIHWYK-GQPLP----------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set FLT4.AA I-set 295-327 39 0.000391 16.54 Pfam 60-92 (92) Show / Hide 
Range on Protein: 295-327
Range on HMM: 60-92/92
Sequence Identity: 39% (13 aa)

LTIHNVSQHDLGSYVCKANNGIQRFRESTEVIV
||| || . | |.| |.| |       . |..|
LTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 FLT4.AA IGc2 347-406 28 0.002138 7.46 SMART 1-56 (56) Show / Hide 
Range on Protein: 347-406
Range on HMM: 1-56/56
Sequence Identity: 28% (17 aa)

AGDELVKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAA
  .. | |. . ...| |...||| |. |.   .   | .|.||..  |.||    |.. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP---WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FLT4.AA IG 341-419 16 0.012388 13.81 SMART 1-58 (58) Show / Hide 
Range on Protein: 341-419
Range on HMM: 1-58/58
Sequence Identity: 16% (14 aa)

PILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVLKEVTEAST---GTYTLALWNSAAGLRRN-ISLELVVN
|        | |.|.   .     ...||              |.. .|... .   |||. . .   .|      . .| | 
PP-VTVKEGETVTLTC-VS-----QIWWY--------------LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTLTVQ
I-set FLT4.AA I-set 352-380 31 0.022947 10.54 Pfam 18-49 (92) Show / Hide 
Range on Protein: 352-380
Range on HMM: 18-49/92
Sequence Identity: 31% (10 aa)

VKLPVKLAAYPPPEFQWYKDGKALSG---RHS
... ..   .|||. .|.|||. |.    ||.
ARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQ
IG FLT4.AA IG 430-552 10 0.002762 18.16 SMART 1-58 (58) Show / Hide 
Range on Protein: 430-552
Range on HMM: 1-58/58
Sequence Identity: 10% (13 aa)

SSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVS
..    .. ..  ||| .       .|.|.                                                             |.| |. ..
PP-VTVKEGETVTLTC-VS------QIWWY-------------------------------------------------------------LTI-NVQPE

-----AMYKCVVSNKVGQDER--LIYFYVT
     . | |...   ||..    .. .|.
DSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set FLT4.AA I-set 532-544 46 0.608193 5.71 Pfam 73-85 (92) Show / Hide 
Range on Protein: 532-544
Range on HMM: 73-85/92
Sequence Identity: 46% (6 aa)

YKCVVSNKVGQDE
|.||..|..|..|
YTCVATNSFGEAE
IG FLT4.AA IG 563-673 16 1.6e-09 38.85 SMART 1-58 (58) Show / Hide 
Range on Protein: 563-673
Range on HMM: 1-58/58
Sequence Identity: 16% (19 aa)

KPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHE---GHYVCEVQDRR
 |  .  ||..| |.| .      ...||                                              | | .| ||..   | |.|...   
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------------------------------LTI-NVQPEDSQQHGTYYCQAT---

SHDKHC-HKKYLSVQ
...... .  .|.||
HGQYWSIQGTTLTVQ
IGc2 FLT4.AA IGc2 569-660 19 9.1e-07 29.72 SMART 1-56 (56) Show / Hide 
Range on Protein: 569-660
Range on HMM: 1-56/56
Sequence Identity: 19% (18 aa)

LEGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRS
.|||.| | | |. .     .||.   . |                                      .|.| .|.||..|.|.|... . .
HEGQSVTLTCPATGNPDPNIHWYK--GQPLP----------------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set FLT4.AA V-set 557-672 17 0.039571 9.17 Pfam 1-128 (128) Show / Hide 
Range on Protein: 557-672
Range on HMM: 1-128/128
Sequence Identity: 17% (24 aa)

GFTIES--KP----SEELLEGQPVLLSCQAD-SY----KYEHLRWYR-LNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARH-----A--TLS
 ....    .    . .  ||| |.|.|.   .|       .. |||  ..     .... ..  . . |...       ... .| ..        ..|
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPP-----GQKPQWIISY-YTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFS

LSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSV
|.|  . |...| | | | .  ..|   |   | |
LTISNLQPSDSGTYYCAVWNC-NEDYFGHGTRLTV
IGc2 FLT4.AA IGc2 690-755 30 7.3e-18 66.59 SMART 1-56 (56) Show / Hide 
Range on Protein: 690-755
Range on HMM: 1-56/56
Sequence Identity: 30% (20 aa)

NVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKG
.  .|....| ..|...|.| ||| .  |.         .|. |.|..|..||.|.| |...|..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP---------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set FLT4.AA I-set 678-765 26 9.2e-14 49.22 Pfam 1-92 (92) Show / Hide 
Range on Protein: 678-765
Range on HMM: 1-92/92
Sequence Identity: 26% (24 aa)

PRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEE---KSGVDLAD-SNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAV
|. || ..|. |.. .... .| | |   |...|.||.. | .   .  ..  .  ...| |..|  .|.| | | . |  | . ..|.. |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG FLT4.AA IG 684-766 19 1e-12 49.52 SMART 1-58 (58) Show / Hide 
Range on Protein: 684-766
Range on HMM: 1-58/58
Sequence Identity: 19% (17 aa)

LTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDA---GRYLCSVCNAKGCVNS--SASVAVE
   ..|.. ......| |.     .| ||                    | | .|..||.   | | | .   .|.. |  .. . |.
PP-VTVKEGETVTLTC-VS-----QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set FLT4.AA V-set 677-750 15 0.002168 13.52 Pfam 1-112 (128) Show / Hide 
Range on Protein: 677-750
Range on HMM: 1-112/128
Sequence Identity: 15% (18 aa)

APRLTQ-NLT----DLLVNVSDSLEMQCLVA-GA----HAPSIVWYKDERLL-------------------------EEKSGVDLADSNQ----KLSIQR
.  .|| . .     . |.. .|....| .  .     |  .| ||.. . .                         . |  | .. ...     |.|. 
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

VREEDAGRYLCSV
....| | | | |
LQPSDSGTYYCAV
Kinase FLT4.AA VEGFR 845-1169 68 9.80000000001e-264 882.44 In-house 1-332 (332) Show / Hide 
Range on Protein: 845-1169
Range on HMM: 1-332/332
Sequence Identity: 68% (228 aa)

LHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTK--PQGPLMVIVEFCKYGNLSNFLRAK
|.||..||.||||.|.|||||||.|...|.||||||||||||||||||||||||.|||||.||||||.||.|||  ..||||||||.|..|||||.||.|
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

RDAFSPCAEKSPEQRGRFRAMVELARLDRRR---PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLA
|..|.|...|||..| |...|.. .. |..|   .|.|....|..|...........||...||.|..|||||||.||||||||||||||||||||||||
RMYFVPYPDKSPHMRQRKECMGPQDHQDHKRRRDSGNSFQSSFGSFFRMKKSYDDVEPDEVFEDMWKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLA

ARNILLSESDVVKICDFGLARD-IYKDPDYVRKGS-ARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAP
||||||.|..|||||||||||. |||||||||||. .|||.|||||||||||||||.|||||.||.||||||||.||||||||.||||.||.||.|||||
ARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAP

ELATPAIRRIMLNCWSGDPKARPAFSELVEIL
...||.|..|||.||...|..||.||||||.|
DYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase FLT4.AA Pkinase_Tyr 845-1169 39 4.6e-152 515.63 Pfam 1-270 (270) Show / Hide 
Range on Protein: 845-1169
Range on HMM: 1-270/270
Sequence Identity: 39% (131 aa)

LHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASE--HRALMSELKILIHIGNHLNVVNLLGACTKPQGP--LMVIVEFCKYGNLSNFLR
...|..|| ||||.|... ..|  ... . .||||||||||. ..  ....|.|.||. ..|.| |.|.|.|.||. ..|  .....|....|.| ..||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAA
..|                                                             .  ||||.||.....|.|.|||.|.|..||||||||
KHR------------------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAA

RNILLSESDVVKICDFGLARDIYKDPDY-VRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASP-YPGVQINEEFCQRL-RDGTRMRAP
||.|..|. ||||||||||||||.|  | . .|...|| ||||||.|.....||.|||||||||.||||..|..| |||.  |||..... .|| || .|
RNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCP

ELATPAIRRIMLNCWSGDPKARPAFSELVEIL
|.... | ..|. ||  ||. || |||..|.|
ENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FLT4.AA TyrKc 845-1169 34 4.6e-136 459.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 845-1169
Range on HMM: 1-280/280
Sequence Identity: 34% (122 aa)

LHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIG-NHLNVVNLLGACTKPQ------GPLMVIVEFCKYGNLSN
..||..|| ||||.|... .          .||||||||.|    ....|.|..|. ..| .| |.|.|.|.||...      .|||...|....|.| .
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRD
.||..|.                                                                |.|.||. ...|.|.|||.|.|..|||||
YLRKHRPK---------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRD

LAARNILLSESDVVKICDFGLARDIYKD------PDYVRKG---SAR--LPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGV----QINE
|||||.|..|  .|||.||||.|||| |       || ||    ...  ||..|||||.|.....||.||||||||..||||..|..||||.      |.
LAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ

EFCQRLRDGTRMRAPEL--------ATPAIRRIMLNCWSGDPKARPAFSELVEIL
|  .....| ||. |.         ..... .||. ||  ||. || |||..|..
EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FLT4.AA TK 845-1169 26 1.3e-128 433.61 In-house 1-486 (486) Show / Hide 
Range on Protein: 845-1169
Range on HMM: 1-486/486
Sequence Identity: 26% (134 aa)

LHLGRVLGYGAFG---KVVEASAFGIH--------------------KGSSCDTVAVKMLKEGATASEHRALM----------------SELKILIH-IG
..||..|| |.||   .| .. ..|.                     |.  . .|||||||||...|. . ..                .|.|.. | .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHLNVVNLLGACTKPQ-----------GPLMVIVEFCKYGN----LSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTE
.| |.|.|.|.||...           .|.|...|....|.    | ..||..|. |.. ......|.   . .. |  .               .   .
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-LH-HC--------------M---K

GG----ARRASPDQEAEDLWLS--------PLTMEDLVC-------------------YSFQVARGMEFLASRKC------IHRDLAARNILLSESDV--
|.    ....||. . |. ...        |||. ||..                   ...|.|.|||.|.|..|      .||||||||.|..|..|  
GDITYSHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCK

---------VKICDFG--------LARDIYKDPDYVRKG------------------------SARLPLKWMAPESIFDKV---------YTTQSDVWSF
         .||.|||        ||||||.| ||.||.                        ...||..|||||...|.|         .||.||||||
WHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSF

GVLLWEIFSLGASPYPGVQIN---------EEFCQRLRDG--------------TRMRAPELAT--------------PAIRRIMLNCWSGDPKARPAFS
|||.||||..|. ||.|   |         .|....||.|               || .|....              ... ..|. ||. ||. || ||
GVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFS

ELVEIL
.|.| |
QLHEQL
Kinase FLT4.AA TK-Unique 845-1169 36 1.8e-110 373.28 In-house 1-294 (294) Show / Hide 
Range on Protein: 845-1169
Range on HMM: 1-294/294
Sequence Identity: 36% (124 aa)

LHLGRVLGYGAFGKVVEASAFGIHKGSSCD-TVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKR
| .|.|.|.|||| |  . ..|| |... .  |||||||..||  .......|.... ..| | |.|..||.|||...| | | |.| .||| ..|| .|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

DA---------FSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLAS--RK
.|                                                           ... . ..  ..|....||. . .|.|.|||.|||  .|
PAMRQHQTYGNLK-----------------------------------------------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKK

CIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGS-ARLPLKWMAPESIF--DKVY-TTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRL
..||||.|||.||.|  |.||||||.|||.|.. .|....|  |.|..||||||.   ...| ||.|||||||||.||||.||| ||||.   . . ...
IVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECI

RDGTRMRAPELA-TPAIRRIMLNCWSGDPKARPAFSELVEIL
||| ||  ||   ..... .| .||. .|. || |.... .|
RDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FLT4.AA PDGFR 1008-1169 62 4.8e-107 344.78 In-house 197-358 (358) Show / Hide 
Range on Protein: 1008-1169
Range on HMM: 197-358/358
Sequence Identity: 62% (101 aa)

PLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEI
.|| .||.|.|.|||.|||||||  |.||||||||.|| .  ||||||||||||| .|  || ||.||||.|||||||||| ||||||||||.|.|||||
VLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEI

FSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEIL
|||| .||||. ....|    ..| ||  |. |.  |  ||  ||  ||. || |..|...|
FSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase FLT4.AA FGFR 1009-1169 58 5.9e-87 295.19 In-house 133-293 (293) Show / Hide 
Range on Protein: 1009-1169
Range on HMM: 133-293/293
Sequence Identity: 58% (94 aa)

LTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSA-RLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEI
||  |||   .|||||||.|||||||||||||||.| .. .| ||||||||||| .. || || .  ||| ||||||. ||.|||.||||||.|||||||
LTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDI-HCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEI

FSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEIL
. .| .|||..   ||  . |. | ||  |.. .  |  .|  ||   |..|| | .||| |
MTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase FLT4.AA Ret 1008-1171 44 2.4e-69 236.02 In-house 126-293 (293) Show / Hide 
Range on Protein: 1008-1171
Range on HMM: 126-293/293
Sequence Identity: 44% (76 aa)

PLT-----MEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGV
...     | ... .  |. .|| .|.. | .||||||||.|. |  . || |||| ||.| |  ||..   |.| ||||.|| .| ||||.||||||||
VINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGV

LLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGD
|.|||  .||.||||.   |  .| |..| ||  ||    .. |||. ||   |  || |  .   .  
LCWEIVTMGANPYPGI-PPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase FLT4.AA UTK 993-1169 36 8e-67 227.63 In-house 102-296 (296) Show / Hide 
Range on Protein: 993-1169
Range on HMM: 102-296/296
Sequence Identity: 36% (72 aa)

RRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSES-------DVVKICDFG---LARDIY---------KDPDYVRKGS
||..|...|...|   ||.....|.. ..||||..|.|....||||||||.|. ..        |.||.|||   ..|...          .. | . . 
RRHRPTPPACPHW---LTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

ARLPLKWMAPESIFDK-VYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDG--TRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEIL
 |.|..|||||.. .   .||.||||||||..|||.. |. ||||   |.. ......|   ||..|.    .. |.|. ||  ||  || | .||. .
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMS-NMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase FLT4.AA RTKB 1008-1169 45 5.2e-66 221.52 In-house 105-264 (264) Show / Hide 
Range on Protein: 1008-1169
Range on HMM: 105-264/264
Sequence Identity: 45% (74 aa)

PLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQS-DVWSFGVLLWE
.|  . || .. |.|.|| || ... |||||.|||.|.. .   ||||||.|| |  | . .... .||| |||||||. .. |||.| |||||||  ||
SLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREI--DHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTMWE

IFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEIL
|||||. ||.  . | .  . |..| |.  |... .|.. ||  ||. .. .||.|.|||. .
IFSLGGTPYQ-QYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase FLT4.AA PDGFR 845-956 54 1.1e-58 186.83 In-house 1-111 (358) Show / Hide 
Range on Protein: 845-956
Range on HMM: 1-111/358
Sequence Identity: 54% (62 aa)

LHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRD
| .|..|| ||||||||| |.|. |     .|||||||. | .||  ||||||||. | |.|.|.||||||||.  ||  .| |.| || | |.|. ||.
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTH-GGPIYIITEYCCYGDLLNYLHRKRH

AFS-PCAEKSPEQ
.|  . .|| |..
SFHQHHPEK-PKK
Kinase FLT4.AA InsR 997-1171 40 2.8e-57 190.9 In-house 100-278 (278) Show / Hide 
Range on Protein: 997-1171
Range on HMM: 100-278/278
Sequence Identity: 40% (74 aa)

PDQEAEDLWLS----PLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSAR-LPLKWMAPESIFDKVY
|..|  .. .     . . ....    ... || .||..| .|||||.|| . ...  ||| |||..|||| . || |||  . ||  ||||||. | |.
PEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIY-EHDYYRKGGKGMLPVRWMAPESLKDGVF

TTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRL-RDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGD
||.||||||||.|||. .||. || |   ||.  .   .||  .| ||   ..   .|  ||   ||.|| | .....| |
TTHSDVWSFGVVLWEMVTLGEQPYQGLS-NEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase FLT4.AA Tie 1007-1169 47 6.2e-57 171.5 In-house 109-267 (267) Show / Hide 
Range on Protein: 1007-1169
Range on HMM: 109-267/267
Sequence Identity: 47% (77 aa)

SPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWE
| |. . .. .   |||||..|. ..||||||||||||  |  | || ||||.|    |  ||.|   ||| .||| ||.   ||||.|||||.||||||
STLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRG---DEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLWE

IFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEIL
| |||  || |.   | . ..|  | ||  |      .  .|  ||   |  ||.|....  |
IVSLGGTPYCGMTCAELY-EKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase FLT4.AA Pkinase 845-1169 19 5.2e-40 142.56 Pfam 1-293 (293) Show / Hide 
Range on Protein: 845-1169
Range on HMM: 1-293/293
Sequence Identity: 19% (71 aa)

LHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKML-KEGATASEHRALMS--ELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYG----NLSN
.|.||..| |.||.|     .  |. .....|||| . |...  ......    |..|. .. || |.| |..... .. .  .. |.|  |     |. 
YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFD

FLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRD
....                                                            .. ... ...... .|  |..||.|.. |...||||
YIST-----------------------------------------------------------WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRD

LAARNILLSESDVV----KICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIF-DKVYTTQSDVWSFGVLLWEIFSLGASPYPGV------QINEEFCQ
|   |||... ...    ||||||||. ..    ..   .    . .|||| |  .. |.. .|.||.|..|.| .. |  |.||         .. .|.
LKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICR

RLRDGTRMRAPELAT-------------------PAIRRIMLNCWSGDPKARPAFSELVEI--L
...  ..   |.. .                   .. . .. .|.  ||| || . ....   .
IMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase FLT4.AA FGFR 845-943 50 3.1e-38 127.88 In-house 1-100 (293) Show / Hide 
Range on Protein: 845-943
Range on HMM: 1-100/293
Sequence Identity: 50% (51 aa)

LHLGRVLGYGAFGKVVEASAFGIHKG--SSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAK
| || .|| |.||.|. | |.|| .       ||||||||...|  .   | ||. ..  || | |..||||.||  .||| ||||.|. |||  ||||.
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQ-EGPLYVIVEYCHHGNLRDFLRAR

R
|
R
Kinase FLT4.AA Ret 845-943 47 1.8e-35 118.56 In-house 1-100 (293) Show / Hide 
Range on Protein: 845-943
Range on HMM: 1-100/293
Sequence Identity: 47% (48 aa)

LHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEG-ATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQG--PLMVIVEFCKYGNLSNFLRA
| |. .|| | ||.|| | || |       ||||||||.. |. || ..| ||. .|  . || .|. |.|||. ...  |...|||.|||| |  ||| 
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACI-QDDPFPTCLIVEYCKYGCLREFLRL

KR
 |
SR
Kinase FLT4.AA S_TKc 845-1168 21 1.9e-29 105.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 845-1168
Range on HMM: 1-231/231
Sequence Identity: 21% (71 aa)

LHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKY--GNLSNFLRAK
 ...|..| ||||||  .   .     .   ||.|..|        . ...|..|| .  .| |.|.|....    . | .. |.|    |.|  ... .
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKR

RDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARN
.    .                                                          .|..  .  .|  |.....|.. |.. |||||   |
GRHGLR----------------------------------------------------------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPEN

ILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTT-QSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELAT
|||.|  ..||||||||| .          .    . .|||| .    |..  .|.||.|..|.| .. |  |.|  |... | . .            .
ILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG------------S

PAIRRIMLNCWSGDPKARPAFSELVE----------I
|  . .. .|.  ||. ||   |. .          .
PEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FLT4.AA Tie 854-943 43 2.3e-27 79.8 In-house 2-87 (267) Show / Hide 
Range on Protein: 854-943
Range on HMM: 2-87/267
Sequence Identity: 43% (39 aa)

GAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKR
| ||.|. |    | |      ||.||.||.|   .||  | || ..  .| | |..||.||| . .| | | .|. .|||| .|||  |
GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEH-RGYLYVAIEYAPYGNLLDFLRKSR
Kinase FLT4.AA InsR 845-943 33 4.2e-20 64.14 In-house 1-99 (278) Show / Hide 
Range on Protein: 845-943
Range on HMM: 1-99/278
Sequence Identity: 33% (34 aa)

LHLGRVLGYGAFGKVVEASAFGIHKGSSCD--TVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAK
. |.| .| |.||.| |  | || ..       .|.| ..|.|.. |     .|  .   . |. .||.||| |.. | | .|. |. .||.| ..||..
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEF-NCHHVVRLLGVCSRGQ-PMYVVMEMMTYGDLKSYLRSR

R
|
R
Kinase FLT4.AA RTKB 845-943 35 1.1e-17 56.25 In-house 1-97 (264) Show / Hide 
Range on Protein: 845-943
Range on HMM: 1-97/264
Sequence Identity: 35% (35 aa)

LHLGRVLGYGAFGKVVEASAFGIHKGSS-CDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKR
..||. || |||| |    |.  ....     .|.| || ||   |. .  ||. ..  .| | ||. ..| | .   |... ||.| .|||  .||. |
VWLGEKLGNGAFGEVFQ--AWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQ-DEPYILLVELCELGNLRDYLRMCR
Kinase FLT4.AA UTK 845-951 28 5.1e-17 54.76 In-house 1-113 (296) Show / Hide 
Range on Protein: 845-951
Range on HMM: 1-113/296
Sequence Identity: 28% (33 aa)

LHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLK-EGATASEHR---ALMSELK---ILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSN
..||| || |||| | .|..  .   .  . |||| .. ....  |..    .| | .   .. .   | ||..|.| ||. .. .|...|... |.|..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

FLRAKRDAFSPCAE
.||  |... .| .
YLRRHRPTPPACPH