Gene FLT3 (Human)

FLT3

Species: Human
Alias: STK1, CD135, FLT3, FLK2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 13q12.3,

Classification

Group: TK
Family: PDGFR

Sequence

Name Sequence Type Origin Length Description Download
FLT3.NA RNA Sugen Kinome 3476 None Fasta, JSON
FLT3.AA Protein Sugen Kinome 993 None Fasta, JSON
FLT3.kin_dom Protein Kinase Domain Sugen Kinome 334 None Fasta, JSON

Protein domain

Protein domains of FLT3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IGc2 FLT3.AA IGc2 263-337 16 0.000166 18.08 SMART 1-56 (56) Show / Hide 
Range on Protein: 263-337
Range on HMM: 1-56/56
Sequence Identity: 16% (12 aa)

KVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPS
. |......|. .  |..   .|   .. |.                    .  ...|...| |||||. . . .
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP-----------------WNWTLTIKNVTPEDSGYYTCYARNPWG
Kinase FLT3.AA PDGFR 610-943 62 5.1e-274 889.96 In-house 1-358 (358) Show / Hide 
Range on Protein: 610-943
Range on HMM: 1-358/358
Sequence Identity: 62% (223 aa)

LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREK
|.|||.|||||||||..|||||.||......|||||||..|.|||.||||||||.|..||.|.||||||||||..||||.|.||||||||||||..||..
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKRHS

FHR---------TWTEIFKEHNFSFYPTFQSHPN--------SSMPGSREVQ--IHPDSDQISGLHGN---SFHSEDEIEYENQKRL--EEEEDLNVLTF
||.         ||......||||||.....|..        ||...|..|.  .|...|.......|   |.||..|..|..|...  ..|.|.||||.
FHQHHPEKPKKETWSNQQDPHNFSFYKNVHHHKENDGDYMDMSSCEDSQYVPMLMHKGVDKYVDMQRNNYMSPHSNYEDSYIEQDVKNELMEDDSNVLTY

EDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLG
.|||||.||||||||||..|.||||||||||||..|||||||||||||||||.||||||.||||||||||||||.|...||..|||||||||||||||||
WDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLG

VNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL
.|||||.|||..|||.|..|..|.|||.|.||||.|||.||.||..|||.|..|..||
GNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase FLT3.AA Pkinase_Tyr 610-943 40 1.7e-157 534.03 Pfam 1-270 (270) Show / Hide 
Range on Protein: 610-943
Range on HMM: 1-270/270
Sequence Identity: 40% (140 aa)

LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSE--REALMSELKMMTQLGSHENIVNLLGACT-LSGP--IYLIFEYCCYGDLLNYLR
..|||.||.||||.|. .|..| .. .  |.||||||||.|....  ||..|.|.|.|.|||.|.|||.|.|.||  ..|  ||...||...||||.|||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEF
..|                                                                      || . || .|||....|.|||||.|| 
KHR----------------------------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLES

KSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNY-VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNP-YPGIPVDANFYKLI
| |.||||||||.|||...|||||||||||||..|..| ..||...||.||||||....|..|.||||||.|.|.||||..|  | |||.  .. .|..|
KNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYI

-QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL
 ..|  |..| ....||| .|..||..|  .||.|  . ..|
YEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FLT3.AA TyrKc 610-943 33 5.9e-145 488.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 610-943
Range on HMM: 1-280/280
Sequence Identity: 33% (121 aa)

LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLG-SHENIVNLLGACTLS-------GPIYLIFEYCCYGDLLN
...||.||.||||.|. .|..        |||||||||| |    ||..|.|...|..|| .|.|||.|.|.|| .       .|.....||...|||..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEF
|||..|.|                                                                         |. .||| |..|.|.|||.
YLRKHRPK-------------------------------------------------------------------------LCMKDLLSFCWQIACGMEY

LEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD-------SNYVVRG--NAR--LPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYP
|. | |.||||||||.||.....|||.||||.||| .|       . |....  ...  ||..|||||....|..|.||||||.|...||||..|  |||
LHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYP

GI----PVDANFYKLIQNGFKMDQPFY--------ATEEIYIIMQSCWAFDSRKRPSFPNLTSFL
|.      ..  ......|. |.|| .        ...|.| ||..||..|  .||.| .. ...
GMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FLT3.AA TK 610-943 25 1.3e-130 440.2 In-house 1-486 (486) Show / Hide 
Range on Protein: 610-943
Range on HMM: 1-486/486
Sequence Identity: 25% (132 aa)

LEFGKVLGSGAFG---KVMNATAYGIS--------------------KTGVSIQVAVKMLKEKADSSEREALM----------------SELKMMTQ-LG
...||.||.|.||   .|. ....|..                    |.|. ..||||||||....|..| ..                .|.||| . ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHENIVNLLGACTLS------------GPIYLIFEYCCYGD----LLNYLRSKREKF--------------------HRTWTEIFKEHNFSFYPTFQSHP
 |.|||.|.|.|| .            .|.... ||...||    |..|||..|.||                    |.                     
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHC---------------------

NSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEE--EEDLNVLTFEDLLC-------------------FAYQVAKGMEFLEFK------S
   |   ...        |      |..|...  .|.|. ...  ..... ||. |||.                   ...|.|.|||.|. |       
---M---KGD--------I---TY-SHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQN

CVHRDLAARNVLVTHGKV-----------VKICDFG--------LARDIMSDSNYVVRG------------------------NARLPVKWMAPESLFEG
.|||||||||.||....|           .||.|||        ||||| ||..|....                        ...||..|||||.|...
FVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDR

I---------YTIKSDVWSYGILLWEIFSLG-VNPYPGIPV--------DANFYKLIQNG--------------FKMDQPFYAT--------------EE
.         .|.||||||.|.|.||||..| . .|.|..         .. .......|              . | || ...              ||
VFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEE

IYIIMQSCWAFDSRKRPSFPNLTSFL
.|..||.||..| ..||.|  | ..|
YYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FLT3.AA TK-Unique 610-943 36 1.3e-112 380.42 In-house 1-294 (294) Show / Hide 
Range on Protein: 610-943
Range on HMM: 1-294/294
Sequence Identity: 36% (127 aa)

LEFGKVLGSGAFGKVMNATAYGIS-KTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSG-PIYLIFEYCCYGDLLNYLRSKR
||.|.|.|.|||| |  ... ||. . .  ..|||||||..|.  .. ....|..|| .|| |.|||..||.|| |. | ..|.||| .|.|..|||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-EKFHR-TWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEF-
 ...   |   .                                                   .   . ...  .. .. .||. ||.|.|.|||.|.  
PAMRQHQTYGNLK--------------------------------------------------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ

-KSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVR-GNARLPVKWMAPESLF--EGIY-TIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFY
 | .|||||.|||||.|..||.||||||.|||.. .  |.   .  |.|..|||||||   .|.| |.||||||.|.|.||||.||  ||||.| .  . 
RKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IM

KLIQNGFKMDQPFYA-TEEIYIIMQSCWAFDSRKRPSFPNLTSFL
..|..|. |.|| .  ..|.| .|.|||  .  .||||  ... |
ECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FLT3.AA VEGFR 783-943 55 2.1e-95 323.29 In-house 170-332 (332) Show / Hide 
Range on Protein: 783-943
Range on HMM: 170-332/332
Sequence Identity: 55% (91 aa)

LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARD-IMSDSNYVVRGN-ARLPVKWMAPESLFEGIYTIKSDVWSYGILLWE
|| |||.|...|||.|||||. . |.||||||||.|..  .|||||||||||. | .| .|| .|. .||| |||||||.|. .||..|||||||..|||
LTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWE

IFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL
|||||  ||||. .|  |.. . .|  |  | |.| ||| ||..||  .   ||.|  |   |
IFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase FLT3.AA Src 610-943 32 1.4e-88 300.64 In-house 1-255 (255) Show / Hide 
Range on Protein: 610-943
Range on HMM: 1-255/255
Sequence Identity: 32% (108 aa)

LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREK
. . . ||.| || |  ..  |      ...|||| ||..    . ||.  | . |..| .||..|.|.  |.   ||| . || . | || ||.     
IKLCRKLGQGQFGEVWMGYWNG------NTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----

FHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVH
                                                                   ...   | ...|. .| |||.||..|| .  .|
-------------------------------------------------------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIH

RDLAARNVLVTHGKVVKICDFGLARDIMS--DSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFK
|||||||||| .. |.|..|||||| ..   | .|. |  |..|.||.||| . .| .||||||||.||||.||.. |  ||||    .   . ...|..
RDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGM-TNHEVLQQVERGYR

MDQPFYATEEIYI-IMQSCWAFDSRKRPSFPNLTSFL
| .|    .|.|  ||. ||  | ..|| |  | .||
MPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FLT3.AA UTK 610-943 28 3.8e-87 295.83 In-house 1-296 (296) Show / Hide 
Range on Protein: 610-943
Range on HMM: 1-296/296
Sequence Identity: 28% (105 aa)

LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKAD-SSERE---ALMSELK---MMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNY
...|. ||.|||| | .|..  .|  .   .|||| ....||   |.|    .| | .   || |.  |.|...|.| || ..|.... ||.. |||..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFL
||. |...                                                                   ..   || ...||.|...| ||..|
LRRHRPTPP------------------------------------------------------------------ACPHWLTLHQRLCMAWDIARGMQYL

EFKSCVHRDLAARNVLVTHG-------KVVKICDFG---LARDIMS--------DSNYVVR-GNARLPVKWMAPESLFEG-IYTIKSDVWSYGILLWEIF
. . .|||||||||.||..         |.||.|||   ..|.. .        .|.|. . .. |.|..|||||.| ..  .|.||||||.|...|||.
HSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIW

SLGVNPYPGIPVDANFYKLIQNG--FKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL
. |  ||||.  ...  . . ||    | .|    ...| .|..||. | ..||.|. |....
TWGRLPYPGM-SNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase FLT3.AA FGFR 783-943 54 1.4e-85 290.58 In-house 133-293 (293) Show / Hide 
Range on Protein: 783-943
Range on HMM: 133-293/293
Sequence Identity: 54% (88 aa)

LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIF
||. ||  .|||||.|||.|. . |.|||||||||||| . | ||||||||||| .   |  ..| |||.||||||.||. .|| .|||||||.|||||.
LTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIM

SLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL
 .|  |||.||     ||. . |  |. |   ..|||..| .|| | .  ||.|  |   |
TYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase FLT3.AA Ret 782-945 48 4.5e-68 231.6 In-house 126-293 (293) Show / Hide 
Range on Protein: 782-945
Range on HMM: 126-293/293
Sequence Identity: 48% (82 aa)

VLT-----FEDLLCFAYQVAKGMEFL-EFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYG
|..     . ... || |. ||| .| | |  ||||||||||||  |.. || |||| ||.  |  || |   |.||||||.|||.  .|| ||||||.|
VINRFDIGMKMIISFAWQICKGMHYLSEMK-LVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFG

ILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGC
.|.|||  .| ||||||| . . . |   |. || |    ||.| ||  ||.    |||.|  . . .  
VLCWEIVTMGANPYPGIPPE-RLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase FLT3.AA KIN6 782-943 43 4.2e-66 217.38 In-house 140-305 (305) Show / Hide 
Range on Protein: 782-943
Range on HMM: 140-305/305
Sequence Identity: 43% (73 aa)

VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK---VVKICDFGLARDIMSDSNYVVRGNAR-LPVKWMAPESLFEGIYTIKSDVWSYGIL
.... ||. ||.|.. |||.|  | |.|||||||||||| |      || ||||.| .  |..  . .  | ||.||||||.|    . .||||||.|.|
CIRHKDLYMFAWQICDGMEYLHSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKGGRYLPIKWMAPECLKHYEFSYKSDVWSFGVL

LWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL
..|.||||  |||...        .  |  . .| ...|||| ||||||. ..  || |  .   .
MFEMFSLGDVPYPEMQRPTEMIEHHRSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF
Kinase FLT3.AA Tie 783-943 48 2.2e-60 182.23 In-house 111-267 (267) Show / Hide 
Range on Protein: 783-943
Range on HMM: 111-267/267
Sequence Identity: 48% (78 aa)

LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIF
|. . .| ||  ||.||..|  | |.||||||||.||    | || ||||.|   .|  || .   ||||.||| |||   .|| ||||||||.||||| 
LSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSR---GDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLWEIV

SLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL
|||  || |.   |..|. .  |..|.||    .|.| .|. ||     .||.|  .   |
SLGGTPYCGMTC-AELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase FLT3.AA VEGFR 610-710 56 2.6e-50 173.44 In-house 1-104 (332) Show / Hide 
Range on Protein: 610-710
Range on HMM: 1-104/332
Sequence Identity: 56% (59 aa)

LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTL---SGPIYLIFEYCCYGDLLNYLRSK
|  ||.|| ||||.|. |.| || |.   . |||||||| |..||  ||||||||.. .| | | ||.||.||     ||   | ||||.| |.||||.|
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

REKF
|. |
RMYF
Kinase FLT3.AA Pkinase 610-943 20 1.4e-43 155.13 Pfam 1-293 (293) Show / Hide 
Range on Protein: 610-943
Range on HMM: 1-293/293
Sequence Identity: 20% (77 aa)

LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKML-KEKADSSEREALMS--ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYG----DLLNY
...|...|||.||.|     |   . | ...|||| . |....|......    |...|  | .|.||| |..... .. ||...|||  |    ||  |
YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVL--TFEDLLCFAYQVAKGME
..                                                                         .. ...  . ... ...||...|.|
IST------------------------------------------------------------------------WRHGCFYFSEWECKFYMYQILRGLE

FLEFKSCVHRDLAARNVLVTHGKVV----KICDFGLARD--IMSDSNYVVRGNARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGI-
..  ....||||   |.|. .  ..    ||||||||.   . ..|.... |  .    .|||| .     |. |.|.||.|..|.| .. |  |.||  
YCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPW----YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHC

-----PVDANFYKLIQNGFKMDQPFYAT-------------------EEIYIIMQSCWAFDSRKRPSFPNLTSF--L
       .. ...  .  .. | |   .                   ||   .. .|...|  |||... .     .
WHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase FLT3.AA FGFR 610-707 48 4.5e-35 116.96 In-house 1-100 (293) Show / Hide 
Range on Protein: 610-707
Range on HMM: 1-100/293
Sequence Identity: 48% (48 aa)

LEFGKVLGSGAFGKVMNATAYGISKT--GVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKR
|  ||.|| |.||.|  |.| || .      | |||||||. .   .   | ||. ||   | |.||.||||.||  || | | |||  | |  .||..|
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR
Kinase FLT3.AA Tie 619-707 44 7.3e-32 93.74 In-house 2-87 (267) Show / Hide 
Range on Protein: 619-707
Range on HMM: 2-87/267
Sequence Identity: 44% (40 aa)

GAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKR
| ||.|| |.   | | |  ..||.||.|| |   ..   | || .| ..| | ||.||.|||   | .|.  ||  || ||..||. |
GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSR
Kinase FLT3.AA Ret 610-707 42 2.9e-29 97.06 In-house 1-100 (293) Show / Hide 
Range on Protein: 610-707
Range on HMM: 1-100/293
Sequence Identity: 42% (43 aa)

LEFGKVLGSGAFGKVMNATAYGIS-KTGVSIQVAVKMLKEK-ADSSEREALMSELKMMTQLGSHENIVNLLGACTLSG--PIYLIFEYCCYGDLLNYLRS
| ....|| | ||.|. |.|  |  ..|    |||||||.  | |||  .| ||. .  |. .| ... |.|||. ..  |  || ||| || |  .|| 
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTT-VAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRL

KR
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SR
Kinase FLT3.AA S_TKc 610-943 20 2.2e-28 101.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 610-943
Range on HMM: 1-231/231
Sequence Identity: 20% (70 aa)

LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCY--GDLLNYLRSKR
 |.....|.||||||. ..  .        .||.|..|        | ...|.... .   |.|||.|....   . .|...|||    |||. |.....
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

EKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSC
 .  |                                                                     ...  .  ...||.....|..  .  
RHGLR--------------------------------------------------------------------FPFPE-HARFYMYQICCALEYCHSHGI

VHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTI-KSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGF
.||||   |.|...  ..||||||||| .                 .|||| |    |.  |.|.|| |..|.| .. |  |.|    ..  .|.|    
IHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG---

KMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTS---------FL
        ..|   ... |. .| .|||.   .           ..
--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FLT3.AA KIN6 640-708 46 5.5e-18 55.85 In-house 46-114 (305) Show / Hide 
Range on Protein: 640-708
Range on HMM: 46-114/305
Sequence Identity: 46% (32 aa)

QVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKRE
|.||||| . ||  ..  .| |   | ||| |. .||.||  | | . .|. |||| .||| ||| ...
QCAVKMLPSHADEMAHHDFMHEIAFMKQLGHHPHLVNMLGCVTNSYKPCLVVEYCCHMDLLKYLRNRCQ