Gene FGR (Human)

FGR

Species: Human
Alias: FLJ43153, FGR, SRC2, MGC75096, p55c-fgr, p58c-fgr, c-fgr, c-src2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 1p35.3-p36.1,

Classification

Group: TK
Family: Src
Subfamily: SrcA

Sequence

Name Sequence Type Origin Length Description Download
FGR.NA RNA Sugen Kinome 2458 None Fasta, JSON
FGR.AA Protein Sugen Kinome 529 None Fasta, JSON
FGR.kin_dom Protein Kinase Domain Sugen Kinome 250 None Fasta, JSON

Protein domain

Protein domains of FGR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3_1 FGR.AA SH3_1 83-130 40 8e-25 86.54 Pfam 1-49 (49) Show / Hide 
Range on Protein: 83-130
Range on HMM: 1-49/49
Sequence Identity: 40% (20 aa)

IALYDYEARTEDDLTFTKGEKFHILNNTEG-DWWEARSLSSGKTGCIPS
.|||||.|...|.|.|.||...|... ... |||..|....|..| .||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3 FGR.AA SH3 80-137 39 4.4e-24 87.24 SMART 1-58 (58) Show / Hide 
Range on Protein: 80-137
Range on HMM: 1-58/58
Sequence Identity: 39% (23 aa)

TLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVD
  ..|||||.|...|.|.|.||.....|. ....||..|  ..|..| .|||||...|
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_2 FGR.AA SH3_2 81-136 19 1e-13 50.92 Pfam 1-68 (68) Show / Hide 
Range on Protein: 81-136
Range on HMM: 1-68/68
Sequence Identity: 19% (13 aa)

LFIALYDYEA-RTEDD-----LTFTKGEKFHIL---NNTEGDWWEA-RSLSSGKT--GCIPSNYVAPV
..... ||.. . ...     |.|.||......   .   ..||.. .... |..  | .||..|...
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 FGR.AA SH2 144-226 61 1.5e-54 161.96 Pfam 1-81 (81) Show / Hide 
Range on Protein: 144-226
Range on HMM: 1-81/81
Sequence Identity: 61% (51 aa)

WYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHY
||.||| |..|||.|..|||| |.||.||||.|.| |.|| ||...  ||.||||.|...| ||||||.|..|.|.||||.||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP--GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 FGR.AA SH2 142-232 45 9.5e-39 135.97 SMART 1-87 (87) Show / Hide 
Range on Protein: 142-232
Range on HMM: 1-87/87
Sequence Identity: 45% (42 aa)

EEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITT--RVQFNSVQELVQHYMEVNDG
..||.|.| |..||. |..||.| |.||.|.||...|.|.||.|.      ..||||.||..| |.|||..  |..|.|. |||.||.   .|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase FGR.AA SrcA 263-512 85 1.2e-223 714.27 In-house 1-250 (250) Show / Hide 
Range on Protein: 263-512
Range on HMM: 1-250/250
Sequence Identity: 85% (213 aa)

ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDM
|.||||||.||||.||.|||||.||||.||||||||||.|||||||.||.|||||||||||||||||||||||.||.||||||||..||..|.|||||||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVDM

AAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGM
||||||||||||||||||||||||||||||.|.||||||||||||.|.||...||.|||||||||||||.|||||||||||||||||||.||||.|||||
AAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM

NKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFL
|.||||||||.|||||||..||.||.|.|.|.||.|||||||||||||||
NNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase FGR.AA Src 263-512 73 6.7e-198 663.74 In-house 1-255 (255) Show / Hide 
Range on Protein: 263-512
Range on HMM: 1-255/255
Sequence Identity: 73% (187 aa)

ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLK-NPEGQDLRLPQLV
|.|.|.||.|.||.|| |.|||.|||||||||||||||.|||.|||.|| |||.||||||||.|.| |||||||.|.||||||.|| ..||. |.||||.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIK--DDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIP
||||||||||||.|.||||||||.|.|.|||| ..||.||||||||||  ||||.. .|.|||||||||||...||||||||||||||||||..|.||.|
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPGMNKREVLEQVEQGYHMPCPPGCPASLYE-AMEQTWRLDPEERPTFEYLQSFL
||||...|||.|||.||.||||..||..||| .| | |. |||.||||||||.||
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FGR.AA SFK-Src 263-516 61 2.2e-178 533.82 In-house 1-259 (259) Show / Hide 
Range on Protein: 263-516
Range on HMM: 1-259/259
Sequence Identity: 61% (159 aa)

ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAV-VSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVD
| ||..|| | ||||| |.||..| |||||||||.|| . ||.|||||| |||..|.|||||    |||||.|| |  |||||.|..|.|. ||.|||||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLI-KDDE-YNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPY
|||||| ||||.|  |..|||| | |.|||.   ||..|||..| . .||| | . .| |||||||||||..  || |||||||||||..|..| |||||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMNKREVLEQVEQ--GYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF
|||   ||| ||..  || |||||.||  .|. | . |.  |..||||| |.  .||.|
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase FGR.AA SrcB 263-513 66 2.9e-156 525.44 In-house 1-251 (251) Show / Hide 
Range on Protein: 263-513
Range on HMM: 1-251/251
Sequence Identity: 66% (168 aa)

ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDM
. |...||.| ||.||.|..|...||||||.|.|||||.|||.|| ||| | ||.||.|||||. |||||.||.| .|.|||||| .||  | ||.|.||
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKEPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLIDM

AAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGM
.||.||||||.||||||||||||||||| | | ||||||||||.| |.||    | |||||||||||  || ||||||||||||||.|..| ||||||||
SAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGM

NKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLE
   ||....|.|| ||.|  ||  ||. |.. |.  |||||||.|||| |.
TNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase FGR.AA Pkinase_Tyr 263-512 48 6.00000000001e-147 498.3 Pfam 1-270 (270) Show / Hide 
Range on Protein: 263-512
Range on HMM: 1-270/270
Sequence Identity: 48% (130 aa)

ITLERRLGTGCFGDVWLGTWN-----GSTKVAVKTLKPGTMSP----KAFLEEAQVMKLL-RHDKLVQLYAVVS--EEP--IYIVTEFMCHGSLLDFLKN
||. . || |.||.|..|||.     . ..||||.||.|.|..    ..|..||..|| | .|...|.||.|..  .||  ||||.|.|.||.|||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

P--EGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLI-KDDEY-NPCQGSKFPIKWTAPEAALFGRFTIKSDVWSF
.  ..| | ...|..|..|.|.||.| |..|.|||||.| |.||.| . .||.||||||.| .||.|    .|.|.||||.|||.  .|.||.|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLTELITKGRIP-YPGMNKREVLEQV-EQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFL
|.|. |..| |..| ||||   ||.|.. |.|| ||||..||. .|. | | |. |||.||||......|
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FGR.AA Src-Unclassified 263-512 49 7.6e-143 480.85 In-house 1-284 (284) Show / Hide 
Range on Protein: 263-512
Range on HMM: 1-284/284
Sequence Identity: 49% (141 aa)

ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPG---TMSPKAFL--------EEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHGSLLDFLKNPE
. | | || | || ||.| | |.  |||||..||   |||| |||        .|||.|| .|| .||.|||| | |||.||.||.|  ||||..|.   
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GQDLRLPQL------------VDMAAQVAEGMAYMERMNYIHRDLRAANILVGERL-----ACKIADFGLA--RLIKDDEYNPCQGSKFPIKWTAPEAAL
|| | .. .            ||.||||| || | |   |.|||| | |.|.|.         |..|||||  .|. ||.| . .|..||.||.|||...
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

FGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP--PGCPASLYE-AMEQTWRLDPEERPTFEYLQSFL
 | |.|||||||.|||| |. |||..|||||  |||||.|| || || |   .|| ..|| .| . | .||. ||||. |  ..
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase FGR.AA Frk 263-516 65 3.9e-141 475.17 In-house 1-260 (260) Show / Hide 
Range on Protein: 263-516
Range on HMM: 1-260/260
Sequence Identity: 65% (171 aa)

ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHGSLLDFLK--NPEGQDLRLPQL
| | ||||.| ||.|| | || .| ||||||||||| |. || |||.|| ||| ||.|||||   ||||||.|| | ||||...|.  | .|. ....||
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

VDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLAR-LIKDDE--YNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGR
|||||||| ||||.| .||||||| | |.|||| . |||||||||| |.||.|  |   .| .|||||||||||   .||||||||||||||||.|| ||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

IPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF
.|||||  .|||..|..|| ||.||.||  ||| | . |. ||..||||| ||  |||||
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase FGR.AA Src-Echino1 263-512 57 1.9e-130 439.7 In-house 1-252 (252) Show / Hide 
Range on Protein: 263-512
Range on HMM: 1-252/252
Sequence Identity: 57% (144 aa)

ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVD
  .....| | .|.|| | ||| |.|||||||..|||| .|| || ||| .||. .||.||| |.. ||||||| | .|.|.|.||. .........|.|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

MAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPG
| |..| || |... |..|||| | |.|||.   ||||||||||....|.|   || |.|||||||||||.|||||||||||||||.||..| ||.||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

MNKREVLEQVEQGYHMPCPPGCPASLYEA-MEQTWRLDPEERPTFEYLQSFL
| .||||.||..|| || .  || |||.  | . |  ||  |||||.| .|.
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase FGR.AA TyrKc 263-512 42 1.8e-129 437.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 263-512
Range on HMM: 1-280/280
Sequence Identity: 42% (120 aa)

ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLL--RHDKLVQLYAVVSE--------EPIYIVTEFMCHGSLLDFLKNPEGQ
|||.. || |.|| |..|||.  ..||||.||...   ..|..||..|. |  .|. .|.||.|...        ||..||.|.|.||.|.|.|......
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

DLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDD-------EYNPCQ---GSK--FPIKWTAPEAALFGRFTIKSD
 | ...|.... |.|.||.| ...|.||||| | |.||||.. .||.||||.| |.||       .|   .   |.|  .||.|.|||.  .|.||.|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILLTELITKGRIPYPG-----MNKREVLEQVEQGYHMPCPPG--------CPASLYEAMEQTWRLDPEERPTFEYLQSFL
|||||... |. | |  ||||     |. .||.|.|.||| ||.||         ||. .|. |.| |. |||.||||. . ...
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FGR.AA SRM 264-513 50 3.3e-123 414.07 In-house 2-253 (253) Show / Hide 
Range on Protein: 264-513
Range on HMM: 2-253/253
Sequence Identity: 50% (126 aa)

TLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT-MSPKAFLEEAQVMKLLRHDKLVQLYAVVSE-EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVD
|| |.|| | || || | | |. .||.|  |    |  . .  | | || ||| ... |.||.|  .|.||.|| |  |.|. .|. .... |..|.|.|
TLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLLD

MAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPG
.| ||||||.|.|  ||||||| | |.|||. ..||..||||||||||| | |  ... |.||||||||  . . .||||||||||| |. |.| .||||
FACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYPG

MNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLE
|   | . |.. || ||||  ||.. .  | . |. |||.||.|  |   | 
MTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase FGR.AA TK 263-512 26 8.70000000001e-120 403.47 In-house 1-486 (486) Show / Hide 
Range on Protein: 263-512
Range on HMM: 1-486/486
Sequence Identity: 26% (130 aa)

ITLERRLGTGCFG---DVWLGTWNGS--------------------------TKVAVKTLKPG-TMSPKA--------------FLEEAQVMKLLR----
|||.. || | ||   .|..|.|.|                           |.||||.||.| .||...              |||||..||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HDKLVQLYAVVSEE-------------PIYIVTEFMCHGS----LLDFLK--NPEGQD-----------------------------------------
 |. .|.||.|....             |..||.|.|.||.    |.|.|.   |..|.                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LRLPQLVDMAAQVAEGMAYMERM------NYIHRDLRAANILVGERLA-----------CKIADFG---
                               | ..||. |..|.|.||.|....      |..|||| | |.||||..            |||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLI-KDDEYNPCQ------------------------GSKFPIKWTAPEAAL---------FGRFTIKSDVWSFGILLTELITKGRIPYPG-M
     ||| | .||.|   .                        | |.||.|.|||. .         .|.||.||||||||.|. |. | |. ||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NK---------REVLEQVEQG--------------YHMPCPPGCP--------------ASLYEAMEQTWRLDPEERPTFEYLQSFL
.          .||.|....|              . ||.||.||              . .|. | | |..|||.||||. |...|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FGR.AA Tec 263-514 45 6e-106 358.28 In-house 1-254 (254) Show / Hide 
Range on Protein: 263-514
Range on HMM: 1-254/254
Sequence Identity: 45% (115 aa)

ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQ--L
.|. . ||.| || | || | .. .||.|..| |.||   |.|||.||. | | |||||| | |.. |||||||.| ||.||..|.  ... ..  .  |
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHH-FQKNMAIL

VDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPY
 .|  .| ||||| || ..||||| | | |||.    |..|||..| . ||.|    |.|||.|| .||   . |.  |||||.||.|  |  . |..||
LEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPY

PGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLED
. |   || |.| ||. .  |  |. ..|. | . |.  |||||||. | . ...
ENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase FGR.AA S_TKc 263-516 23 5.3e-52 179.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 263-516
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

ITLERRLGTGCFGDVWLGTWNG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCH--GSLLDFLKNPEGQD----LR
 .. | .| | || |.......   .||.| .|      . .. | |..|  .|. .|.|| |  .. .|.|.|.. .  |.|.|..|.  ..     . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTI-KSDVWSFGILLTELITK
  .   ...|......|. ... |||||  .|||. |    ||.||||||..                . |||      ..  |.|.||.|..| |... 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-

GRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQS-----FLEDYF
|. |.|  .  ......            . .. . ... .. |||.|||   .        .  .|
GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FGR.AA Pkinase 263-512 24 7.2e-44 156.19 Pfam 1-293 (293) Show / Hide 
Range on Protein: 263-512
Range on HMM: 1-293/293
Sequence Identity: 24% (73 aa)

ITLERRLGTGCFGDVWLGTWNGSTK-VAVKTLKPGTMSPKAFLE-----EAQVMKLLRHDKLVQLYAVV-SEEPIYIVTEFMCHG----SLLDFLKNPEG
....|..| | || |..... |. | ||||..|  . ...   .     |.|.|| |.|.  |.|| .. ..  ||.|.|.. .|    .| |...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QDL--RLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLAC----KIADFGLAR---LIKDDEYNPCQGSKFPIKWTAPEAAL-FGRFTIKSDV
  .     .. ... |...|..|. .|. |||||  .|||. ..  .    ||.|||||.   . ..  ..   |. .   . |||  .     . |.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKVDM

WSFGILLTELITKGRIPYPGM------NKREVLEQVEQ-GYHMPCPPGCP-------------------ASLYEAMEQTWRLDPEERPTFEYLQSF--L
||.|..| |... || |.||       ......... .  .| ..|  |.                    .. . ..  ...||..|||.| .     .
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF