Gene FGFR4 (Human)

FGFR4

Species: Human
Alias: TKF, JTK2, FGFR4, CD334, MGC20292
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 5q35.2,

Classification

Group: TK
Family: FGFR

Sequence

Name Sequence Type Origin Length Description Download
FGFR4.NA RNA Sugen Kinome 3040 None Fasta, JSON
FGFR4.AA Protein Sugen Kinome 802 None Fasta, JSON
FGFR4.kin_dom Protein Kinase Domain Sugen Kinome 277 None Fasta, JSON

Protein domain

Protein domains of FGFR4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IGc2 FGFR4.AA IGc2 48-108 34 3.3e-10 41.17 SMART 1-56 (56) Show / Hide 
Range on Protein: 48-108
Range on HMM: 1-56/56
Sequence Identity: 34% (22 aa)

ALGQPVRLCCG---RAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMI
  ||.|.| |.   . .   |||| |..|.       |...|.| .. |||.|.| |.||... 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FGFR4.AA IG 42-116 23 1.6e-07 32.26 SMART 1-58 (58) Show / Hide 
Range on Protein: 42-116
Range on HMM: 1-58/58
Sequence Identity: 23% (19 aa)

EQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDA---GRYLCLARGSMIVLQ----NLTLI
 . .|| .|..|.| |  .    .||                  |.| .  |||.   | | | |. .. . .    .||  
PP-VTVKEGETVTLTC-VS--QIWWY------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
V-set FGFR4.AA V-set 35-118 17 0.012301 10.92 Pfam 1-128 (128) Show / Hide 
Range on Protein: 35-118
Range on HMM: 1-128/128
Sequence Identity: 17% (22 aa)

APSLEQ-QEQ----ELTVALGQPVRLCC-GR-------AERGGHWYK-EGS------------RLAPA-----------GRVR------GWRGRLEIASF
. ...| ..     ..||..|| |.| |  .       ..   .||.   .            .. .            |||.      . .  | | . 
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

LPEDAGRYLCLARGS-MIVLQNLTLITG
 |.| | | | . .. ... .. |  | 
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set FGFR4.AA I-set 36-57 27 6.625606 2.19 Pfam 1-22 (92) Show / Hide 
Range on Protein: 36-57
Range on HMM: 1-22/92
Sequence Identity: 27% (6 aa)

PSLEQQEQELTVALGQPVRLCC
|. .|. . ..|  |. .|. |
PKFTQKPKDVEVQEGETARFEC
I-set FGFR4.AA I-set 66-106 31 18.575046 0.67 Pfam 34-80 (92) Show / Hide 
Range on Protein: 66-106
Range on HMM: 34-80/92
Sequence Identity: 31% (15 aa)

WYKEGSRLAP---AGRVRGWRG----RLEIASFLPEDAGRYLCLARGS
|.| |. |.|     ... ..|    .|.|    |.|.| | | |. |
WFKDGQPLRPDSDRHQMT-YDGDGTYTLTISNVQPDDEGKYTCVATNS
IGc2 FGFR4.AA IGc2 163-231 36 1.6e-20 75.38 SMART 1-56 (56) Show / Hide 
Range on Protein: 163-231
Range on HMM: 1-56/56
Sequence Identity: 36% (25 aa)

PAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVG
  |..| ..|||.|||.|.|.|.| ||                 |.|  ..| |.|.|.|||...|..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set FGFR4.AA I-set 162-232 31 9.8e-15 52.51 Pfam 12-83 (92) Show / Hide 
Range on Protein: 162-232
Range on HMM: 12-83/92
Sequence Identity: 31% (23 aa)

VPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRH-QHWSLVMESVVPSDRGTYTCLVENAVGS
|  | |..| | . |.|.|.. |.||||  .  ..   .. .. .. .| .. | |.| |.||| ..| .|.
VQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGE
IG FGFR4.AA IG 157-242 19 2.3e-12 48.31 SMART 1-58 (58) Show / Hide 
Range on Protein: 157-242
Range on HMM: 1-58/58
Sequence Identity: 19% (18 aa)

KKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDR---GTYTCLVENAVGSIRY--NYLLDVL
 . . | .| ||...| ..     .|.|.                       |.. .| |.|    |||.| ..   |..    .  | |.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set FGFR4.AA V-set 162-228 20 0.087002 7.99 Pfam 18-114 (128) Show / Hide 
Range on Protein: 162-228
Range on HMM: 18-114/128
Sequence Identity: 20% (20 aa)

VPAGNTVKFRCPAAGNP----TP-TIRWLKDGQAF------------HGENR------IGGIRLRHQ--------HWSLVMESVVPSDRGTYTCLVEN
|. | .|...|    ..    .. .| | .. |              |  ..       .  . | .        ..|| . .. ||| |||.| | |
VQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWN
IG FGFR4.AA IG 256-351 21 3.4e-16 61.05 SMART 1-58 (58) Show / Hide 
Range on Protein: 256-351
Range on HMM: 1-58/58
Sequence Identity: 21% (22 aa)

PANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDA---GEYTCLAGNSIGLSYQ--SAWLTV
|  .|...|..|.| | |      .|.|.                                 | . ||..||.   |.|.| |    |  ..  ...|||
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTV

L
.
Q
IGc2 FGFR4.AA IGc2 262-340 26 1.2e-08 36.0 SMART 1-56 (56) Show / Hide 
Range on Protein: 262-340
Range on HMM: 1-56/56
Sequence Identity: 26% (21 aa)

VVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIG
  | .|.| |..  .  | |.|.|     |..                        | ..||. ||.|.|||.| |..|
HEGQSVTLTCPATGNPDPNIHWYK-----GQPLP------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set FGFR4.AA V-set 249-350 17 4e-06 23.13 Pfam 1-128 (128) Show / Hide 
Range on Protein: 249-350
Range on HMM: 1-128/128
Sequence Identity: 17% (22 aa)

PI-LQAGLPA----NTTAVVGSDVELLCKVYSDA----QP-HIQWLK-HIVINGSSFGA---------DGFPYVQVLKTADINSSEVEV-----LYLRNV
.. ...  |.      |...| .|.| |.. .|     .. .|.| . .   ... . .         .| .|..  .   .  |         | ..|.
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

SAEDAGEYTCLAGNS-IGLSYQSAWLTV
. .| | |.| . |. ..   .. .|||
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set FGFR4.AA I-set 321-350 50 7.9e-05 18.9 Pfam 63-92 (92) Show / Hide 
Range on Protein: 321-350
Range on HMM: 63-92/92
Sequence Identity: 50% (15 aa)

RNVSAEDAGEYTCLAGNSIGLSYQSAWLTV
.|| ..|.|.||| | || | .  .| |||
SNVQPDDEGKYTCVATNSFGEAECTAELTV
I-set FGFR4.AA I-set 256-285 26 0.085587 8.6 Pfam 7-36 (92) Show / Hide 
Range on Protein: 256-285
Range on HMM: 7-36/92
Sequence Identity: 26% (8 aa)

PANTTAVVGSDVELLCKVYSDAQPHIQWLK
| . .. .|..... |.|  | .| ..|.|
PKDVEVQEGETARFECQVTGDPPPQVSWFK
Kinase FGFR4.AA FGFR 467-743 68 7.4e-232 776.54 In-house 1-293 (293) Show / Hide 
Range on Protein: 467-743
Range on HMM: 1-293/293
Sequence Identity: 68% (202 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARR
|.|||.|||||||||..|||.|.|..||....||||||||.|..||||.|||||||.||.||.|||||||||.||||||||||||....||||.||||||
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PPGPDLSPDGP-------RSSEGP--------LSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRL
|||.| ..|..       |..|..        |... ||||||||||||.||.|||||||||||||||||.|.||||.||||||..|.||||.||.||||
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIP-VEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL
|.|||||||||||||||||||||.|.|||||.|.||.|||.|| ||||...|.|||||..|..|. |.| .|..|||..|.||||||||||.|
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase FGFR4.AA Pkinase_Tyr 467-743 45 1e-156 531.36 Pfam 1-270 (270) Show / Hide 
Range on Protein: 467-743
Range on HMM: 1-270/270
Sequence Identity: 45% (129 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD--LADLVSEMEVMKLIGRHKNIINLLGVCT-QEGP--LYVIVECAAKGNLREF
...|| ||||.||.|......|      ..  .|||||||..|....  ..|. .|...|| .|.|.||..|.|||| |..|  .|...| ...|.|...
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYY-KKTSNGRLPVKWMAPEA
||..|            ....||. . |.. ..|.|.||.||||..||||||||||.||||.||.||.|||||| ... ||| .|...|.||.||||||.
LRKHR------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC

LFDRVYTHQSDVWSFGILLWEIFTLGGSP-YPGIPVEELFSLL-REGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL
......|..|||||||.|.|||||.|..| |||.. ||.. .. ..|.||..|..||.|.| ||..|||. |..||||....| |
INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FGFR4.AA TyrKc 467-743 38 2.9e-151 509.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 467-743
Range on HMM: 1-280/280
Sequence Identity: 38% (120 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG-RHKNIINLLGVCTQE-------GPLYVIVECAAKGNL
..||| ||||.||.|.....            .|||||||..|    ..|. .|...|. .| .|.||..|.|||||.       .||....| ...|.|
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

REFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHI-------DYYKKTS--NG
...||..||                |. . |.| ..|.|.||.||.|..||||||||||.||.|....||.||||.| ...        |||.|..  .|
KDYLRKHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

R--LPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPG-----IPVEELFSLLREGHRMDRPPH--------CPPELYGLMRECWHAAPSQRP
.  ||..|||||.......|..|||||||...|||||.|..||||     .. .|.. ....|.||..||.        ||.|.| .|..|||. |..||
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

TFKQLVEAL
||....| .
TFSEIHECF
Kinase FGFR4.AA TK 467-743 28 2e-137 462.83 In-house 1-486 (486) Show / Hide 
Range on Protein: 467-743
Range on HMM: 1-486/486
Sequence Identity: 28% (138 aa)

LVLGKPLGEGCFG---QVVRAEAFGMDPARPDQA------------------STVAVKMLK--DNASDKDLAD--------------LVSEMEVMKL-IG
..||| |||| ||   .| ..|..|..| .....                   .|||||||  |..|...  |              ...||..|.. .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHKNIINLLGVCTQE------------GPLYVIVECAAKGN----LREFLRARRPPGPDLSPDGP-----------------------------------
.|.||..|.|||||.            .|.....|....|.    ||..||..||.. . .. ..                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----RSSEGPLSFPVLVS-------------------CAYQVARGMQYLESRKC------IHRDLAARNVLVTEDNV-----------MKIADFG----
     . .. ||..  |..                   ...|.|.||.||.|..|      .||||||||.||.|.||            ||||||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LARGVHH------------------------IDYYKKTSNGRLPVKWMAPEALFDRV---------YTHQSDVWSFGILLWEIFTLG-GSPYPGIP
    ||| ...                         |||...|.|.||..|||||.|.|||         .|..|||||||.|.|||||.| . .|.|..
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

V---------EELFSLLREG--------------HRMDRPPHCP--------------PELYGLMRECWHAAPSQRPTFKQLVEAL
          .|.. .||.|              .|| .|||||              .|.| ||..|||. |..||||.||.|.|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FGFR4.AA Ret 467-745 46 2.1e-123 416.27 In-house 1-293 (293) Show / Hide 
Range on Protein: 467-745
Range on HMM: 1-293/293
Sequence Identity: 46% (139 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDN-ASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEG--PLYVIVECAAKGNLREFLR
|.|.. |||| |||||.| || .   .|    |||||||| | |.   . || ||... |..  | ..| |.| |.|..  |. .||| .  | ||||||
LQLDDTLGEGHFGQVVKAQAFHIR-GHPGYT-TVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLR

ARRPP--------------GPDLSPDGPRSSEGPLS-----FPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYK
  |                ..|. |||    . ..      .  ..| | |. .||.|| . | .||||||||||| |  ..|| |||| | |   | | 
LSRKIGPYYEYSIGNRNCSIVDH-PDG----KDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYV

KTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD
| | .|.||||||.|.|.| ||| .|||||||.|.||| |.|..|||||| | |..||. |.|||||  |  |.| .|| ||   |  || || .   . 
KRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFE

K
|
K
Kinase FGFR4.AA TK-Unique 467-743 45 1.7e-120 406.59 In-house 1-294 (294) Show / Hide 
Range on Protein: 467-743
Range on HMM: 1-294/294
Sequence Identity: 45% (133 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEG-PLYVIVECAAKGNLREFLRAR
|..|. .||| |||| |.|..| . .  |. . ||||||||||.| | .|. .| ..|| .|.|.||...||.||  . | . | | ...|||. .|| .
LEVGDVIGEGAFGQVWRGEVWGIW-KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

RPP--GP--------DLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLES--RKCIHRDLAARNVLVTEDNVMKIADFGLARGVHH-IDYYKKTSNGRLP
||.  ..        |.  . .. .. |.|   |.. |.|.|.||.||.|  .|..||||.|||||.|||.| ||.|||.|| |..  .| ...| ||.|
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

VKWMAPEALF--DRVY-THQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHC-PPELYGLMRECWHAAPSQRPTFKQLVEAL
..|||||.|   ...| | .|||||||.|.|||||||. ||||.| ...  ..|.|.||..|.|| ..|.| ||..||.  |..||.| |..  |
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FGFR4.AA UTK 467-743 36 5.8e-109 368.29 In-house 1-296 (296) Show / Hide 
Range on Protein: 467-743
Range on HMM: 1-296/296
Sequence Identity: 36% (111 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK-DNASDKDLA---DLVSEME---VMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLR
. ||..||.| ||.| .|..   .. .....  |||| .. . .. .. .   |.  |     .||    | |...|.||||||.|.....|....|.||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMD--VAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

EFLRARRPPGPDLSPDGPRSSEGPLSFP--VLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTED-------NVMKIADFG---LARGVH---------
 .||  ||  |          . |...    ....|...|||||||.|....||||||||.||...       .| ||||||   ..|.|.         
SYLRRHRPTPP----------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYW

HIDYYKKTSNGRLPVKWMAPEALFDR-VYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREG--HRMDRPPHCPPELYGLMRECWHAAPSQRPT
  .||......|.|..||||||| ..  .|..|||||||...|||.| |  ||||.  ....  ...|  .|| .|..|| ..| ||..|||. |. ||.
ESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPD

FKQLVEAL
|..||...
FEDLVQQM
Kinase FGFR4.AA Src 467-743 41 2.7e-103 349.48 In-house 1-255 (255) Show / Hide 
Range on Protein: 467-743
Range on HMM: 1-255/255
Sequence Identity: 41% (118 aa)

LVLGKPLGEGCFGQVVRAEAFG-MDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRAR
. | . ||.|.|| |  .   | ..         |||| ||      . ...  | ..||   ||.....|. ||.|| | | . |  ..|.| ..|.. 
IKLCRKLGQGQFGEVWMGYWNGNTK---------VAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-

RPPGPDLSPDGPRSSEGP-LSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHI-DYYKKTSNGRLPVKWMAPEALFD
             ..||  |..| |.. | |||.||.||||.. |||||||||||| |.|| |.||||||| . .  | |   .  ..|.||.||||.  
-------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINY

RVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG-LMRECWHAAPSQRPTFKQLVEAL
...|  ||||||||||.||.| |  ||||   .| .  .  | || .|..||.|||  .|..|||. | |||||. | . |
GRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FGFR4.AA VEGFR 589-743 58 5e-97 328.65 In-house 175-332 (332) Show / Hide 
Range on Protein: 589-743
Range on HMM: 175-332/332
Sequence Identity: 58% (93 aa)

LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARG-VHHI-DYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLG
|.. ..|||||| .|.|||||||||||||.|..|.|| || ||||||       || .|.. |||| ||||||..||.||| .|||||.|..|||||.||
LICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLG

GSPYPGIP-VEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL
||||||.   ||... |..| || .|  |.||.|  | .|||  | .||.|  ||| |
GSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase FGFR4.AA RTKB 467-743 40 2.7e-95 321.71 In-house 1-264 (264) Show / Hide 
Range on Protein: 467-743
Range on HMM: 1-264/264
Sequence Identity: 40% (112 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARR
. ||. ||.| ||.| .|    .     ...  .|.| ||  ||  .  |  ||| ||| .| | |.| ..| | |. |. . || .  ||||..||..|
VWLGEKLGNGAFGEVFQAW---VRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCR

PPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVY
         ....  ..|..  ||. . |.|.|| .|.... |||||.||||||. .   ||.|||.|| . | .|  .|   |||.|||||| . .| |
---------ASQHNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECY--ETTCTRLPIKWMAPESWAHRIY

THQS-DVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL
| .| ||||||.  ||||.||| ||.  .. ..|..|. |||.  |   |.. ...|. || . ...||.|. ||.|.
TTKSGDVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase FGFR4.AA InsR 467-745 37 3.4e-95 320.19 In-house 1-278 (278) Show / Hide 
Range on Protein: 467-745
Range on HMM: 1-278/278
Sequence Identity: 37% (104 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARR
.||....|.| || |    | |. |  ..    .|.| ...|||...  .  .| .||| .  ......|||||..  | ||. |  ..|.|. .||.||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEF-NCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRR

PPGPDLSPDGPRS-SEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRV
|   .   ....     . .   ... | ... || ||...| .|||||.|| .| .|   ||.|||..| .   |||.|   | ||| ||||| | | |
PEEEF--NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGV

YTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLL-REGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDK
.| .|||||||..|||. |||  || |   |.      ..|  ...|  ||. .. ||. ||.  |. ||||..... |  
FTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase FGFR4.AA PDGFR 583-743 56 3.4e-90 289.77 In-house 197-358 (358) Show / Hide 
Range on Protein: 583-743
Range on HMM: 197-358/358
Sequence Identity: 56% (91 aa)

PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEI
.|..  |.. .||||.|| .|.|  |.||||||||||...  | || |||||| . .   |    | |||||||||| .|| ||| ||||||.|||||||
VLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEI

FTLGGSPYPGIPVEELF-SLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL
|.|||.||||.||.. |  . .|| ||..| | | | |  |..|| . | .||||.||.. |
FSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase FGFR4.AA S_TKc 467-747 23 2.7e-51 177.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 467-747
Range on HMM: 1-231/231
Sequence Identity: 23% (68 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAK--GNLREFLRA
  .....|.| ||.| ..   .           ||.|..|         .. .|....|   .|.||..|..|.   . ||.. |..    |.|..... 
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

RRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDR
|...|..           |..  .  . .||......|. |.. |||||   |.|..|  . ||.|||||| .         .       .|||| |   
RGRHGLR----------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---

VYTH-QSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVE-----ALDKVL
 |..  .|.||.|..|.| .. |  |.|   ....| ...           .||.  ..| |..  |..|||  .. .     ...  .
GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FGFR4.AA Pkinase 467-743 21 1.9e-48 172.07 Pfam 1-293 (293) Show / Hide 
Range on Protein: 467-743
Range on HMM: 1-293/293
Sequence Identity: 21% (69 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKML-KDNASDKDLADLVS--EMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKG----NLR
...|...|.| ||.| ..    ..   ..   .|||| . |...... .  ..   | ..|| . .|.||. |..... .. .|.. |.. .|     | 
YHIGRKIGSGSFGCVYKC----HHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

EFLRARRPPGPDLSPDGPRSSEGPL--SFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVM----KIADFGLARGV-HHIDYYKKTSNGRLP
.....              ...|..  |  .. ...||..||..|. |...|||||   |.|. ....     ||.|||||. . .  .   .|  | ..
DYIST--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

VKWMAPEALF-DRVYTHQSDVWSFGILLWEIFTLGGSPYPGI----PVEELFSLLREGHRMDRPPHCP-----------------------PELYGLMRE
  .|||| .  .. |.. .|.||.|..|.| .. |  |.||     .  .   ....  . . . ..|                       .|.  ... 
--YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

CWHAAPSQRPTFKQLVEA--L
|..  |..|||..|...   .
CLCKDPKKRPTAEQILQHPWF
Kinase FGFR4.AA VEGFR 467-566 48 2e-37 130.67 In-house 1-101 (332) Show / Hide 
Range on Protein: 467-566
Range on HMM: 1-101/332
Sequence Identity: 48% (50 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCT---QEGPLYVIVECAAKGNLREFLR
| |||.||.| ||||. |.||| .  .     |||||||| .|     . |.||..... || | |  |.|| ||   | ||| ||||   .|||  .||
LKLGKMLGRGAFGQVHEASAFGIR--KMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLR

ARR
. |
TKR
Kinase FGFR4.AA PDGFR 467-566 44 1.5e-31 98.25 In-house 1-98 (358) Show / Hide 
Range on Protein: 467-566
Range on HMM: 1-98/358
Sequence Identity: 44% (44 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARR
|..|| || | ||.|| | |.|.   . . . .|||||||  |       | ||  .|   | | ||.|||| ||  || |.| |    | | ..|. .|
LQFGKTLGSGAFGKVVEATAYGL--SKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR