Gene FGFR2 (Human)

FGFR2

Species: Human
Alias: BEK, K-SAM, ECT1, KGFR, JWS, TK14, CFD1, TK25, CEK3, FGFR2, CD332, BFR-1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 10q26.12,

Classification

Group: TK
Family: FGFR

Sequence

Name Sequence Type Origin Length Description Download
FGFR2.NA RNA Sugen Kinome 4657 None Fasta, JSON
FGFR2.AA Protein Sugen Kinome 841 None Fasta, JSON
FGFR2.kin_dom Protein Kinase Domain Sugen Kinome 277 None Fasta, JSON

Protein domain

Protein domains of FGFR2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IGc2 FGFR2.AA IGc2 72-133 29 1.2e-14 55.87 SMART 1-56 (56) Show / Hide 
Range on Protein: 72-133
Range on HMM: 1-56/56
Sequence Identity: 29% (19 aa)

APGESLEVRCL--LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVD
 .|.|.. .|    .... |.|.| | .|         . .|.|| .|| |||.|.|.|.  . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FGFR2.AA IG 66-144 19 4.2e-12 47.44 SMART 1-58 (58) Show / Hide 
Range on Protein: 66-144
Range on HMM: 1-58/58
Sequence Identity: 19% (16 aa)

PEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDS---GLYACTASRTVDSETW--YFMVNVT
|. ... .||... .|  .    |.|.                  |.| ...| ||   | | |.|.    . .    . . |.
PP-VTVKEGETVTLTC-VS---QIWWY------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set FGFR2.AA V-set 60-139 15 0.000218 16.96 Pfam 1-120 (128) Show / Hide 
Range on Protein: 60-139
Range on HMM: 1-120/128
Sequence Identity: 15% (19 aa)

KYQISQ--PE----VYVAAPGESLEVRCLLK-------DAAVISWTKDGVHLGPNNRTVL---------------IGEY----------------LQIKG
  |..|  |.    . ....|.|.. .| ..       .   |.| ..   .|. ....                 ...                |.|. 
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

ATPRDSGLYACTASRTVDSETWYF
..| ||| | | ..      ..||
LQPSDSGTYYCAVWNC---NEDYF
I-set FGFR2.AA I-set 88-129 33 0.003624 13.26 Pfam 31-78 (92) Show / Hide 
Range on Protein: 88-129
Range on HMM: 31-78/92
Sequence Identity: 33% (16 aa)

VISWTKDGVHLGP-NNRTVLIGEY-----LQIKGATPRDSGLYACTAS
..||.|||  | | ..| .   .      | |....|.|.| | |.|.
QVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVAT
I-set FGFR2.AA I-set 193-267 30 2.9e-15 54.32 Pfam 17-92 (92) Show / Hide 
Range on Protein: 193-267
Range on HMM: 17-92/92
Sequence Identity: 30% (24 aa)

TVKFRCPAGGNPMPTMRWLKNGKEFKQ-EHRIGGYKVRNQH---WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDV
|..| | . |.| |.  |.|.|.. .. ..|   ..... .    .|... | |.| | ||||..|..|.   | .| |
TARFECQVTGDPPPQVSWFKDGQPLRPDSDR---HQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 FGFR2.AA IGc2 189-257 31 3.8e-15 57.56 SMART 1-56 (56) Show / Hide 
Range on Protein: 189-257
Range on HMM: 1-56/56
Sequence Identity: 31% (22 aa)

PAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYG
   ..| ..||| ||| |. .|.| |..                |.|  ..| |.| |.|||...|. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FGFR2.AA IG 183-268 16 8.9e-11 43.04 SMART 1-58 (58) Show / Hide 
Range on Protein: 183-268
Range on HMM: 1-58/58
Sequence Identity: 16% (15 aa)

KRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDK---GNYTCVVENEYGSINH--TYHLDVV
 . . | .  ||...| .      ...|.                       |.. .| |.|    |.|.|...  .|..    . .| | 
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set FGFR2.AA V-set 230-267 33 0.002001 13.64 Pfam 90-128 (128) Show / Hide 
Range on Protein: 230-267
Range on HMM: 90-128/128
Sequence Identity: 33% (13 aa)

NQHWSLIMESVVPSDKGNYTCVVENE-YGSINHTYHLDV
. ..|| . .. ||| | |.|.| |. ...  | ..| |
KNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IG FGFR2.AA IG 282-377 18 1.1e-14 55.97 SMART 1-58 (58) Show / Hide 
Range on Protein: 282-377
Range on HMM: 1-58/58
Sequence Identity: 18% (19 aa)

PANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADA---GEYICKVSNYIGQANQ--SAWLTV
|   . ..|..|.. | |      .|.|                                  | . ||...|.   |.| | ..   ||. .  ...|||
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTV

L
.
Q
I-set FGFR2.AA I-set 348-376 44 7.2e-08 29.21 Pfam 64-92 (92) Show / Hide 
Range on Protein: 348-376
Range on HMM: 64-92/92
Sequence Identity: 44% (13 aa)

NVTEADAGEYICKVSNYIGQANQSAWLTV
||. .|.|.| |...|  |.|  .| |||
NVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 FGFR2.AA IGc2 288-366 20 5.4e-07 30.49 SMART 1-56 (56) Show / Hide 
Range on Protein: 288-366
Range on HMM: 1-56/56
Sequence Identity: 20% (17 aa)

VVGGDVEFVCKVYSDAQPHIQWIK--HVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIG
  |..|.. |..  .  | |.|.|  ...                         .   | . |||..|.|.| |...| .|
HEGQSVTLTCPATGNPDPNIHWYKGQPLP-------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set FGFR2.AA V-set 275-376 13 6.5e-05 18.78 Pfam 1-128 (128) Show / Hide 
Range on Protein: 275-376
Range on HMM: 1-128/128
Sequence Identity: 13% (19 aa)

PI-LQAGLPA----NASTVVGGDVEFVCKVYSDA----QP-HIQWIK-HVEKNGSKYGPDGLPYLKV-----LKHS------GINSSNAEV---------
.. ...  |.      . ..|..|.. |.. .|     .. .|.|.. .          .. | . .     ....      .   .. .          
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPP--------GQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKND

--LALFNVTEADAGEYICKVSNY-IGQANQSAWLTV
  | . |....| | | | |.|. ...  .. .|||
FSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set FGFR2.AA I-set 282-311 30 4.719734 2.69 Pfam 7-36 (92) Show / Hide 
Range on Protein: 282-311
Range on HMM: 7-36/92
Sequence Identity: 30% (9 aa)

PANASTVVGGDVEFVCKVYSDAQPHIQWIK
| ..   .| ...| |.|  | .| ..| |
PKDVEVQEGETARFECQVTGDPPPQVSWFK
Kinase FGFR2.AA FGFR 501-777 74 1e-239 802.65 In-house 1-293 (293) Show / Hide 
Range on Protein: 501-777
Range on HMM: 1-293/293
Sequence Identity: 74% (217 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR
|||||.|||||||||.||||.|||.|.|....||||||||...|.|||||||||||||||||||||||||||.|||.|||||||||...||||..|||||
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PPGMEYSYDIN-------RVPEEQ--------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRL
||||.|..|..       | ||.|        .|.||||||.||.|||||||||.|||||||||||||||...||||.||||||||..||||.|||||||
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
|.|||||||||||||||||||||.|||.|||.|.||.|||.|| ||||.|.|||||||.||.||..|.|.||..|||..|.||||||||||.|
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase FGFR2.AA Pkinase_Tyr 501-777 48 3.9e-159 539.57 Pfam 1-270 (270) Show / Hide 
Range on Protein: 501-777
Range on HMM: 1-270/270
Sequence Identity: 48% (138 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD--LSDLVSEMEMMKMIGKHKNIINLLGACT-QDGP--LYVIVEYASKGNLREY
.|.|| ||||.||.|..... |   |. .. ..|||||||..|....  . |. .|...|| .|.|.||..|.|.|| |..|  .|...||. .|.|..|
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY-KKTTNGRLPVKWMAPEA
||..|             .... | |||..  .| |.|||||.|..||||||||||.|||||||.||.|||||||| | ||| .|...|.||.||||||.
LRKHR------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC

LFDRVYTHQSDVWSFGVLMWEIFTLGGSP-YPGIPVEELFKLL-KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
......|..|||||||||||||||.|..| |||.. ||..... ..|.||..| ||. |.|..|..|||. |..||||....|.|
INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FGFR2.AA TyrKc 501-777 42 5.1e-155 522.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 501-777
Range on HMM: 1-280/280
Sequence Identity: 42% (130 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG-KHKNIINLLGACTQD-------GPLYVIVEYASKGNL
.|||| ||||.||.|. ...           ..|||||||.||    . |. .|...|...| .|.||..|.|.|||.       .||....||...|.|
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI-------DYYKKTT--NG
..|||..||                 . |||.|  .| |.|||||.|..||||||||||.||.||...||.||||.||| .        |||.|..  .|
KDYLRKHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

R--LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG-----IPVEELFKLLKEGHRMDKPAN--------CTNELYMMMRDCWHAVPSQRP
.  ||..|||||.......|..||||||||.||||||.|..||||     .. .|.....|.|.||..|.|        |. |.|..|..|||. |..||
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

TFKQLVEDL
||....|..
TFSEIHECF
Kinase FGFR2.AA TK 501-777 29 7.70000000001e-137 460.9 In-house 1-486 (486) Show / Hide 
Range on Protein: 501-777
Range on HMM: 1-486/486
Sequence Identity: 29% (143 aa)

LTLGKPLGEGCFG---QVVMAEAVGIDKDKPKEA------------------VTVAVKMLK--DDATEKDLSD--------------LVSEMEMMKM-IG
.|||| |||| ||   .| ..|. |......|..                  ..|||||||  |......  |              ...||.||.. .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHKNIINLLGACTQD------------GPLYVIVEYASKGN----LREYLRARRPPGME-----------------------------YSYDINRVPEE-
.|.||..|.|.|||.            .|.....||...|.    ||.|||..||....                             .| . . ..|. 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

-----------QMTFKDLVS-------------------CTYQLARGMEYLASQKC------IHRDLAARNVLVTENNV-----------MKIADFG---
           . |.|||..                   . .|.|.|||||.|..|      .||||||||.||.||||            ||||||   
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARDINN------------------------IDYYKKTTNGRLPVKWMAPEALFDRV---------YTHQSDVWSFGVLMWEIFTLG-GSPYPGI
     |||||..                         |||.....|.||..|||||.|.|||         .|..|||||||||||||||.| . .|.|.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PV---------EELFKLLKEG--------------HRMDKPANCT--------------NELYMMMRDCWHAVPSQRPTFKQLVEDL
.          .|....|..|              .|| .|..|.               |.| .|..|||. |..||||.||.| |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FGFR2.AA Ret 501-779 48 7.50000000001e-125 421.08 In-house 1-293 (293) Show / Hide 
Range on Protein: 501-779
Range on HMM: 1-293/293
Sequence Identity: 48% (144 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD-ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG--PLYVIVEYASKGNLREYLR
| |.. |||| ||||| | |  | . .|    |||||||| . |.   . || ||... | .  | ..| |.|||.||.  |. .||||.  | |||.||
LQLDDTLGEGHFGQVVKAQAFHI-RGHP-GYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLR

ARRPPGMEYSYDI-NR------VPE--EQMT-----FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNG
  |  |  | | | ||       |   .  .     .|...|   |  .|| ||.. | .||||||||||| |  ..|| |||| ||.   | | |   .
LSRKIGPYYEYSIGNRNCSIVDHPDGKDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKD

RLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR
|.||||||.|.|.| ||| .|||||||||.||| |.|..|||||| | |. ||| |.||| | ||  |.| .|| ||   |  || || .  |. .
RIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase FGFR2.AA TK-Unique 501-777 44 1.6e-121 410.02 In-house 1-294 (294) Show / Hide 
Range on Protein: 501-777
Range on HMM: 1-294/294
Sequence Identity: 44% (133 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV-TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEYASKGNLREYLRA
|..|. .||| ||||  .|..||.  |. ..   ||||||||.||. | .|. .| .||| .|.|.||...||.|| .. | . | ||...|||. ||| 
LEVGDVIGEGAFGQVWRGEVWGIW--KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT

RRP---PG-------MEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS--QKCIHRDLAARNVLVTENNVMKIADFGLARDINN-IDYYKKTTNGRL
.||   ..       .   ..  ....|  . |||..  .|.|.|||||||  .|..||||.|||||.||..| ||.|||.|||...  .| .... ||.
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRI

PVKWMAPEALF--DRVY-THQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANC-TNELYMMMRDCWHAVPSQRPTFKQLVEDL
|..|||||.|   ...| | .|||||||||||||||||. ||||.| ... .....|.||..|..| ..|.|  |. ||. .|..||.| |..  |
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FGFR2.AA UTK 501-777 35 1e-104 354.23 In-house 1-296 (296) Show / Hide 
Range on Protein: 501-777
Range on HMM: 1-296/296
Sequence Identity: 35% (108 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DDATEKDLS---DLVSEME---MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR
. ||..||.| ||.| .|... ..   . . . |||| .. .......     |.  |     |||.   | |...|.| |||..|.....||...|.||
VQLGRQLGQGAFGEVHKARFTQCS--EHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

EYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTEN-------NVMKIADFG---LARDIN---------NI
 |||  ||  .         .... |  ..... .. ||||.||.|....||||||||.||...       .| ||||||   ..|..|         . 
SYLRRHRPTPP--------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWES

DYYKKTTNGRLPVKWMAPEALFDR-VYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG--HRMDKPANCTNELYMMMRDCWHAVPSQRPTFK
.||... ..|.|..||||||| ..  .|..||||||||..|||.| |  ||||.  ..... . .|  .|| .|. |  ..|..|..|||. |. ||.|.
YYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFE

QLVEDL
.||. .
DLVQQM
Kinase FGFR2.AA Tie 509-777 46 3e-104 318.24 In-house 1-267 (267) Show / Hide 
Range on Protein: 509-777
Range on HMM: 1-267/267
Sequence Identity: 46% (129 aa)

EGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSY
|| ||||. |    | ||  |  . ||.||.|. | |.|  | . |.|.|  .|.| |||||.||| . | ||| .|||  ||| ..||  |    . ..
EGNFGQVMKAM---IKKDGLK--MEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAF

DINRVP------EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTH
 ...           .. . ..      ||||.||. ..||||||||||.|| || | |||||||.|     . | |.| |||||.||| |.|   ||| 
AREHTTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSR---GDEVYVKKTMGRLPVRWMAIESLNYSVYTT

QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
.|||||.|||.||| .||| || |.   ||.. | .|.||..| || .|.| .|| ||   | .||.| |.. .|
KSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase FGFR2.AA VEGFR 619-777 59 1.9e-99 336.66 In-house 171-332 (332) Show / Hide 
Range on Protein: 619-777
Range on HMM: 171-332/332
Sequence Identity: 59% (97 aa)

TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARD-INNIDYYKKTTN-GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI
| .||..  .| |||||.|||.|||||||||||.|..|||| || ||||||. |   . |.. .. |||| ||||||..||.||| .|||||.||..|||
TMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEI

FTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
|.||||||||.   ||... ||.| || .|  || |.|  | ||||  | .||.|  ||| |
FSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase FGFR2.AA Src 501-777 39 6.5e-98 331.59 In-house 1-255 (255) Show / Hide 
Range on Protein: 501-777
Range on HMM: 1-255/255
Sequence Identity: 39% (111 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR
..| . ||.|.|| | |.        . .  . |||| || .    .  ..  | . ||   .|.....|.  |.|. | | . || |.|.| .||..  
IKLCRKLGQGQFGEVWMG--------YWNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK--

PPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI-DYYKKTTNGRLPVKWMAPEALFDRV
           .  . .. ...|.. . | |.||.|| |.. |||||||||||| |||| |.||||||| | .  | |   .  ..|.||.||||.  ..
-----------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGR

YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYM-MMRDCWHAVPSQRPTFKQLVEDL
.|  |||||||.|..||.| |  ||||   .| .. .. | || .|.||  |||.  |. |||. | |||||. | . |
FTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FGFR2.AA RTKB 501-777 40 4.3e-94 317.57 In-house 1-264 (264) Show / Hide 
Range on Protein: 501-777
Range on HMM: 1-264/264
Sequence Identity: 40% (113 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR
. ||. ||.| ||.|  |    .      ..  .|.| || .| . .  |  ||| .|| .| | |.| ..| | || |. . ||..  ||||.|||.. 
VWLGEKLGNGAFGEVFQAW---VRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMC-

PPGMEYSYDINRVPEEQMT---FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFD
           | .....    .. ||.   | |.|| .| ... |||||.||||||. .   ||.|||.|| | . .|  .||  |||.|||||| . .
-----------RASQHNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECY--ETTCTRLPIKWMAPESWAH

RVYTHQS-DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
| || .| ||||||| |||||.||| ||.  .. ..|..|  |||. ||     . . .|..|| . ...||.|. ||. .
RIYTTKSGDVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase FGFR2.AA PDGFR 615-777 57 2.6e-93 299.93 In-house 195-358 (358) Show / Hide 
Range on Protein: 615-777
Range on HMM: 195-358/358
Sequence Identity: 57% (94 aa)

EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMW
..  |..||.. .|| |.|||.|||  |.||||||||||...  | || |||||||| |   |    | |||||||||| .|| ||| ||||||.|.| |
SNVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLW

EIFTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
|||.|||.||||.||.. | |. ||| ||..|.  . | |  |. || . | .||||.||.. |
EIFSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase FGFR2.AA S_TKc 501-781 23 1.1e-54 188.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 501-781
Range on HMM: 1-231/231
Sequence Identity: 23% (69 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK--GNLREYLRA
 ......|.| ||.|  .  ..           ||.|..|         .. .|....|.  .|.||..|....   . ||.. ||..   |.|..|.. 
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

RRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDR
|...|             ...  .  . .||.....||. |.. |||||   |.|..|  . ||.|||||| .         |       .|||| |   
RGRHGLR----------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---

VYTH-QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVE-----DLDRIL
 |..  .|.||.|....| .. |  |.|   ....||...           . |.  ..| |..  |..|||  .. .      ..  .
GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FGFR2.AA Pkinase 501-777 22 3.1e-48 171.35 Pfam 1-293 (293) Show / Hide 
Range on Protein: 501-777
Range on HMM: 1-293/293
Sequence Identity: 22% (71 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLV---SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG----NLR
...|...|.| ||.|  .  .|  |       .|||| .| . ....        || ..||.. .|.||. |..... .. .|.. ||. .|     | 
YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

EYLRARRPPGMEYSYDINRVPEEQM--TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM----KIADFGLARDINNIDYYKKTTNGRLPV
.|...                .  .  . ... .. ||..||.||. |...|||||   |.|. .|..     ||.|||||. .. .  .  .|      
DYIST--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTP

KWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI----PVEELFKLLKEGHRMDKPANCT-----------------------NELYMMMRDC
 .|||| .  .. |.. .|.||.|....| .. |  |.||     .  .  .....  . . . ..                         |.   ...|
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

WHAVPSQRPTFKQLVED--L
..  |..|||..|....  .
LCKDPKKRPTAEQILQHPWF
Kinase FGFR2.AA VEGFR 501-600 53 1.4e-43 151.07 In-house 1-101 (332) Show / Hide 
Range on Protein: 501-600
Range on HMM: 1-101/332
Sequence Identity: 53% (55 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT---QDGPLYVIVEYASKGNLREYLR
| |||.||.| ||||. |.|.||.| ..    ||||||||  ||      |.||..|.. ||.| |  |.||.||   | ||| |||||  .|||  |||
LKLGKMLGRGAFGQVHEASAFGIRKMET--CTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLR

ARR
. |
TKR
Kinase FGFR2.AA PDGFR 501-600 48 2.2e-35 110.82 In-house 1-98 (358) Show / Hide 
Range on Protein: 501-600
Range on HMM: 1-98/358
Sequence Identity: 48% (48 aa)

LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR
| .|| || | ||.|| | | |. |  .  . .|||||||  |       | ||  .|   |.| ||.|||||||  || |.| ||   | | .||. .|
LQFGKTLGSGAFGKVVEATAYGLSKSQA--VMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR