Gene FES (Human)

FES

Species: Human
Alias: FES, FPS
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 15q26,

Classification

Group: TK
Family: Fer

Sequence

Name Sequence Type Origin Length Description Download
FES.NA RNA Sugen Kinome 2783 None Fasta, JSON
FES.AA Protein Sugen Kinome 822 None Fasta, JSON
FES.kin_dom Protein Kinase Domain Sugen Kinome 256 None Fasta, JSON

Protein domain

Protein domains of FES.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FCH FES.AA FCH 1-94 33 9.5e-29 102.75 SMART 1-103 (103) Show / Hide 
Range on Protein: 1-94
Range on HMM: 1-103/103
Sequence Identity: 33% (35 aa)

MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQ---------DSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHA
|.|..||....|| || |.|...||..| |.|.|..|.|...|||. ||..| |         |  . .   .. .....||... .||. ...  .||.
MCFWWELWCDDGHEVLLQRQKWGLRWCEDMMKFMRERAKIEEEYAKMLHKLSKQYFNKKGSCGDWRAHRMTHPEMGSLNKSWEVMLQQTDQMAKHHKQHS

EDL
|||
EDL
FCH FES.AA FCH 1-94 19 2.2e-17 63.23 Pfam 1-97 (97) Show / Hide 
Range on Protein: 1-94
Range on HMM: 1-97/97
Sequence Identity: 19% (20 aa)

MGFSSEL--CSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDS----GGQSRAISPDSPI--SQSWAEITSQTEGLSRLLRQHAE
|.|.|..  . ..|. ||.. .. .....| .......| ....|||  |.... . .    |....     . .  ...| .. ..|| .... .|.||
MSFWSDDYWQ-WDGFKVLFKRMKQGIQWCEDFAQFFKERAEIEEEYAKKLQKLCKKWFKKKKGSSEY----HGTLSSKKAWHQMLQETEQMAQQHQQFAE

DL
.|
NL
SH2 FES.AA SH2 460-530 39 5.6e-34 101.59 Pfam 1-81 (81) Show / Hide 
Range on Protein: 460-530
Range on HMM: 1-81/81
Sequence Identity: 39% (32 aa)

WYHGAIPRAEVAELLVH----SGDFLVRESQGKQ-EYVLSVLWDG---LPRHFIIQSLDN--LYRLEGEGFPSIPLLIDHL
|||| |.|.|. .||       |.||||||. .. .|.|||..||     .|..||..||  .|. ... |.|.. |..| 
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 FES.AA SH2 458-536 37 9.5e-29 102.75 SMART 1-87 (87) Show / Hide 
Range on Protein: 458-536
Range on HMM: 1-87/87
Sequence Identity: 37% (33 aa)

QLWYHGAIPRAEVAELLVHS----GDFLVRESQG-KQEYVLSVLWDGLPRHFIIQSLD-NLYRLEG---EGFPSIPLLIDHLLSTQQP
| |||| |.|.|. .|| .     ||||||.|.  ...||||| |.|  .|..|...| . |....   . |||.  |..|   . ..
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Pkinase_Tyr FES.AA Pkinase_Tyr 561-814 49 6.7e-150 508.29 Pfam 1-270 (270) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-270/270
Sequence Identity: 49% (135 aa)

LVLGEQIGRGNFGEVFSGRLR----ADNTLVAVKSCRETLPPDL--KAKFLQEARILKQY-SHPNIVRLIGVCT-QKQP--IYIVMELVQGGDFLTFLRT
...|...|.|.||||. |...     ... ||||...|.  ..   ...|..||.|.||. .|||||||.|||| |..|  ||||||....|| |..||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E---GARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREE-ADGVY-AASGGLRQVPVKWTAPEALNYGRYSSESDVWS
    . .| .|.||||  . |.|||||||| |||||||||||||||.|| ||.|||..|    |. |  ..|| . .|.||.|||..|||.....|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVWS

FGILLWETFSLGASP-YPNLSNQQTREFV-EKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQEL
||.|.|| |..|..| ||..||..  |.. |.|.|.||||.||| . .|| |||.|.| .||.|| |...|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc FES.AA TyrKc 561-814 42 6.1e-148 498.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-280/280
Sequence Identity: 42% (121 aa)

LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQY--SHPNIVRLIGVCTQK-------QPIYIVMELVQGGDFLTFLRTE
..||...|.|.||||. |...   . ||||...|      .. |..||||....  .|||||||.|||||.       .|..||||.. .|| . .||  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADG--------VYAASG--GLRQ-VPVKWTAPEALNYGRYSSE
. .| .|.||..  ..|.|||||.||.|||||||||||||.|... ||||||.||.  |.        .| ...  | .  .|..|.|||..|||.....
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SDVWSFGILLWETFSLGASPYPN-----LSNQQTREFVEKGGRLPCPEL--------CPDAVFRLMEQCWAYEPGQRPSFSTIYQEL
|||||||...|| |..|..|||.     .|||. .|.|..|.|.|.|.         |||.....|.|||...| .||.||.|....
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FES.AA Fer 561-815 39 7.6e-138 464.24 In-house 1-283 (283) Show / Hide 
Range on Protein: 561-815
Range on HMM: 1-283/283
Sequence Identity: 39% (111 aa)

LVLGEQIGRGNFGEVFSGR-----LRA-----DNTLVAVKSCRETLPPDL-KAKFLQEARILKQ-YSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFL
 .||...|.|.||||..||     ...     ... |.|| |..... .  ...|..||||... |.|||.|...|||...|||.||||.. ||.....|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RTEGAR-LRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTE-KNVLK--ISDFGMSREEADGVYAASGG--LRQVPVKWTAPEALNYGRYSSESD
...... . ......|. .||.|||||.||.|||||.||||||... |...|  ||||||||...|..|. . .  ...||..|.|||....| ||...|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSFGILLWETFSLGASPYPN------LSNQ--QTREF-VEKGGRLPCPELCPDAVFRLME-QCWAYEPGQRPSFSTIYQELQ
|||||...|| |. || |||.      . |.  |.|.  ..|| ..|.|. .|... ..|. |||...| .||....|.|.| 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase FES.AA TK 561-814 25 6.5e-123 414.14 In-house 1-486 (486) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-486/486
Sequence Identity: 25% (124 aa)

LVLGEQIGRGNFG---EVFSGRLRADN-------------------------TLVAVKSCRETLPPDLKA-------------KFLQEARILKQYS----
..||...|.|.||   ||. |..| .|                         | |||| ..|. . . ..             .||.||...|. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVRLIGVCTQK------------QPIYIVMELVQGGD----FLTFLRTEGAR--------------------------------------------
 |||||||.|||||.            .|..||||....||     ...||.   .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LRVKTLLQMVGDAAAGMEYLESK------CCIHRDLAARNCLVTEKNV-----------LKISDFGMS-
                               | ...|| |  ..|.|||||.||       ..|||||||||||.|.||            ||.|||.| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------REE-ADGVYAASGG-----------------------LRQVPVKWTAPEALN---------YGRYSSESDVWSFGILLWETFSLG-ASPYPNL
       |.   |. | ....                        ...|..|.|||.||         ||.....|||||||.|.|| |..| . .|...
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------QQTREFVEKGGRL--------------PCPELCP--------------DAVFRLMEQCWAYEPGQRPSFSTIYQEL
||         |.  |....||||              |.|..||              .....|| |||.|.| .||.||.....|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FES.AA UTK 561-814 38 4.4e-114 385.32 In-house 1-296 (296) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-296/296
Sequence Identity: 38% (115 aa)

LVLGEQIGRGNFGEVFSGRLRADN-----TLVAVKSCRETLP-PDLKA---KFLQEAR---ILKQYS-HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTF
. ||.|.|.|.||||. .|.. ..      .|||| |... . .. ..   .|. |||   ..|| . |||..||.||||| .|..||.|. ..|| ...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR--TEGAR-----LRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEK-------NVLKISDFG---MSREEA---------DGVYAASGGLRQ
||  .. ..     |.  ..|.|. | |.||.||.|. ..|||||||||||..        .| ||.|||   |||. .         .  |  . . ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

VPVKWTAPEALNYG-RYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG--RLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQEL
.|..|.|||||... |... |||||||...||... |. |||..||.|. ..|..||  |.|||. ||..|.||| .||.|.|  ||.| ...|..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase FES.AA Src 561-814 45 8e-104 351.23 In-house 1-255 (255) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-255/255
Sequence Identity: 45% (119 aa)

LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR--TEGARLRVK
. | ...|.|.||||. |  . .|| ||||. ..       . ||||| |.|. .|...|.|  ||.|. ||||| |. . |  |..|.  .|| .|...
IKLCRKLGQGQFGEVWMGYWN-GNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLP

TLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEA--DGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSL
.|. |    |.||.||||.  ||||||||| || |.|| |. |||  |     | .| |. | . .|.|||||||.||||..  ||||||||||.| .. 
QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAK-FPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTY

GASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFR-LMEQCWAYEPGQRPSFSTIYQEL
|  |||  .|... . ||.| |.|||. ||| ..  .| |||  .| ||| | .... |
GRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FES.AA TK-Unique 561-814 37 3.4e-98 332.54 In-house 1-294 (294) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-294/294
Sequence Identity: 37% (109 aa)

LVLGEQIGRGNFGEVFSGRLRADN------TLVAVKSCRETLPPDLKAKFLQEARILKQYS-HPNIVRLIGVCTQKQ-PIYIVMELVQGGDFLTFLRTEG
|..|..||.|.||.|. | .. ..      . |||| ... . .  |..||.|....|.   |||||...|.|| .. | .|.|| ...|. ...||| .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

AR-------------------------LRVKTLLQMVGDAAAGMEYLES--KCCIHRDLAARNCLVTEKNVLKISDFGMSR-EEADGVYAASGGLRQVPV
                           .  |.|..   . | |||||.|  | ..||||.|||.|.||..|.||.||||.| ....|||. ...   .|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWTAPEALN--YGRY-SSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELC-PDAVFRLMEQCWAYEPGQRPSFSTIYQEL
.| |||.|   .| | ...|||||||.|.|| |.||| |||.... . .| ...| |.| || | ..... ||..|| .|| .||||..| ..|
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FES.AA Tec 561-816 42 2.2e-96 326.53 In-house 1-254 (254) Show / Hide 
Range on Protein: 561-816
Range on HMM: 1-254/254
Sequence Identity: 42% (111 aa)

LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKT
| . . .|.| || |  |..|. .  ||.|  .| .   .    |..||.. .  |||. |.| |||.|..||||| | .. |  | .||... ... ..
LTFMKELGSGQFGVVHLGKWRH-QYDVAIKMIKEGSMSEE---DFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNM

--LLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLG
  ||.|  |   ||.|||..| |||||||||||| ...| |.|||||.|   |  |  |.|    |||| .|| ..| |||| ||||.||.| || ||.|
AILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTK-FPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCG

ASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQS
  ||.|.|| .. | | .| ||  |.||.. ... | .||  .| .||.|.   .... 
KMPYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase FES.AA Eph 561-814 40 1.5e-91 307.77 In-house 1-264 (264) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-264/264
Sequence Identity: 40% (108 aa)

LVLGEQIGRGNFGEVFSGRLRAD----NT---LVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGA
. . . || | |||| .|||..      .   .||.|  ... .   .. || || |. |..||||.|| || |. .|. || |    |   .|||..  
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

RLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE---EA--DGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGI
.. |  |. |    |.|| || .   .|||||||| || .. | |.||||.||.   ..  ...|  .||   .|..||||||. |....| |||||.||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGG--KIPIRWTAPEAIAYRKFTSASDVWSYGI

LLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQEL
..||  | |  || ..|||   . .|.| ||| |  || | ..|| .||.... .|| |..|   |
VMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase FES.AA Csk 561-814 44 2.7e-91 309.63 In-house 1-251 (251) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-251/251
Sequence Identity: 44% (115 aa)

LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQ-PIYIVMELVQGGDFLTFLRTEGAR-LRVK
| |||.|| |.|| |  | ..  |  ||||  ..     . | || || .  | .||| |.||||  ...  .||||| .  |  . .||. |   .  .
LHLGECIGHGEFGDVMQGEYQ--NRKVAVKCIKCDGNGMAQA-FLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRR

TLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVY-AASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLG
 ||.   | ..||.|||.|  .|||||||| || | .| |.|||| ..||  .   ..||     |.||||||||  ...|. |||||||||||| .| |
QLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKEECSQQDDSTSG---KFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFG

ASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQEL
  ||| .. .   . |||| |   || ||..|. .|.|||. .| .||.|  . . |
RVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase FES.AA Abl 561-814 43 2.1e-90 301.83 In-house 1-252 (252) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-252/252
Sequence Identity: 43% (111 aa)

LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR-TEGARLRVKT
... ...| | .|||. |  .  .  ||||. .|   .     ||.|| |.|.  |||.|.|.||||.  | ||. | .  |  | .|| ..   |   .
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTME--VHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVV

LLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGAS
||.|    | ||.|||..  |||||||||||| |....|. |||..|   | .| |  | .  |.||||||.| | ..|| |||| ||.||||    | |
LLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAK-FPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMS

PYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQEL
||| .  ..  . .||| |.  || ||. |..|| ||| ...  ||||  | ...
PYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase FES.AA ALK 561-816 43 2.3e-89 303.18 In-house 1-273 (273) Show / Hide 
Range on Protein: 561-816
Range on HMM: 1-273/273
Sequence Identity: 43% (119 aa)

LVLGEQIGRGNFGEVFSGRLRA-----DNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR----TE
. |.   |.|.||||. |  .          ||.|. .|   ..    |. || |. ...|.|.||.||.| |||| .|| |.  ||| . |||    ..
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP

G----ARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKN---VLKISDFGMSREE-ADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDV
.    . |  | |||   | |.|  |||..  |||| |||||| | |    | || ||||.|.      |   ||    ||||. |||.  | . | .||
ESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSKTDV

WSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQS
||||.|.|| |||| .|||. .||.  ||| .|||.  |  ||  |.|.| |||  .|  ||.| ||   .| 
WSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase FES.AA S_TKc 561-817 25 2.5e-57 197.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 561-817
Range on HMM: 1-231/231
Sequence Identity: 25% (69 aa)

LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQG--GDFLTFLRTEGAR----
  ....||.| ||.|. .| . .. .||.|  .         ....| .|||.  |||||.|..|.   . .|.|||.. |  || .....  | .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSS-ESDVWSFGILLWE
 .   .   ..   . ..||. |.  |||||   | |..|  ..||.|||..|.              .   . ||| |    |.  ..|.||.|..|.|
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

TFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQ-E-----LQSI
 .. |  |.|     |  .  .| |        .. .  ....|. ..| .||.   . | |      . .
MLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FES.AA Pkinase 561-814 22 1.2e-46 166.07 Pfam 1-293 (293) Show / Hide 
Range on Protein: 561-814
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPD--LKAKFL-QEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGG----DFLTFLR-TEG
...|..||.|.||.|. .. . .. .||||  .     .  ...... .|..|.|  .|||||||..... |. ||.|||...||    |  ....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

ARL--RVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVL----KISDFGMSREEADGVYAASGGLRQVPV---KWTAPEALN-YGRYSSESD
 ..    ...  ..   . |.||. |. .|||||   |.|. .....    ||.||| ..         ...  ....    . ||| .. .  |....|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VWSFGILLWETFSLGASPYPNL----SNQQTREFVEKGGR----LPCPELCP-------------------DAVFRLMEQCWAYEPGQRPSFSTIYQE--
.||.|..|.| .. |  |.|.     .    .. ... ..     ..|..|.                   ..   ... |... | .||..  | |   
MWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

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