Gene FAK (Human)

FAK

Species: Human
Alias: FAK1, pp125FAK, FADK, FAK, PTK2, FAKpp125
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 8q24.3,

Classification

Group: TK
Family: FAK

Sequence

Name Sequence Type Origin Length Description Download
FAK.NA RNA Sugen Kinome 4442 None Fasta, JSON
FAK.AA Protein Sugen Kinome 1052 None Fasta, JSON
FAK.kin_dom Protein Kinase Domain Sugen Kinome 255 None Fasta, JSON

Protein domain

Protein domains of FAK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B41 FAK.AA B41 31-258 19 1.5e-41 145.24 SMART 1-232 (232) Show / Hide 
Range on Protein: 31-258
Range on HMM: 1-232/232
Sequence Identity: 19% (48 aa)

GAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKV--KHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRY
  ..|...|. . ..          .... .|... ...... .  .  ..  ..| .. .  .  .|||. .  .  ...|.   |..|.|.. .|...
SPKPRFCRVYFMDGT-------TLEFEVDSSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHED-RHWLDHWKTIMKQDVKW---HKSEPWTLHFRVKF

LPKGF---LNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKA--------
 |. .    ||..||. ..|.||.|...|.. . .   ..| .| |..| ... | ..  .....|.......|....|||.||...||.|.        
YPPDWHGFPNQLQEDPTRYNYFYLQCRHDILQGRHPCPHEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYKSYKRFLPKQWIDSIKQSFMHYQMH

-KTLRKLIQQTFRQFANLNREESILKFFEILSPVY-RFDKECF
 | .|| |.. .........||. ||...|..    ..  |.|
HKEWRKRIMEWHKNHCGMTPEEAKLKYLQICQRWPPMYGVEHF
FERM_M FAK.AA FERM_M 143-248 13 1.5e-08 30.72 Pfam 11-161 (171) Show / Hide 
Range on Protein: 143-248
Range on HMM: 11-161/171
Sequence Identity: 13% (21 aa)

TLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYW-EMR-GNALEKKS-NYEVLEKD------------VGLKRFFP-------------------
|...||.|.|.|.. .    .. | ||.|... ..  .   .   .. ....   |  | .            . . |..|                   
TRHQFYLQAKWDILEGRY-PCSEEEALMLAAYQCQIEFGSDYNPPQKHKSDYMEKEWWE-QQEGMEVWLRCDNEQQERYWPAHCRLASKGRTMADSSYSE

------------KSLLDSVKAKTLRKLIQQTFRQFANL-NREESILKFFEILS
            . .. . |.| ... | . ... ...  .|| .|.. .|..
VSIRINPHCYVSPWYCKKMKQKQWEQRILEQHKNHRGMCSPEEAMLQYIQICQ
Kinase FAK.AA FAK 422-681 70 5.6e-219 733.77 In-house 1-285 (285) Show / Hide 
Range on Protein: 422-681
Range on HMM: 1-285/285
Sequence Identity: 70% (201 aa)

IELGRCIGEGQFGDVHQGIYMSPEN------------------------PALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWI
|.|.|||||||||||.||.|....|                        ....|||||||.|..|...|||.|||..|.||||||||||||...|.|.||
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIWI

IMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKAS-KGKLPIKWMAPESINF
|||||..||||..||..|.||..|.||||.|||..|.||||||.|||||||||||||||.||||||||||||.|.|..||||| |||||||||.||||||
IMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWMHDHSYYKASPKGKLPIKWMSPESINF

RRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILE
||||.||||||||||||||||.||||||.|||||||||||||||||||||||||||||||.|||||||.||||.|||.||. |  
RRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase FAK.AA Pkinase_Tyr 422-676 44 2.7e-146 496.11 Pfam 1-270 (270) Show / Hide 
Range on Protein: 422-676
Range on HMM: 1-270/270
Sequence Identity: 44% (120 aa)

IELGRCIGEGQFGDVHQGIYM-SPENPALAVAIKTCKNCTSDSV--REKFLQEALTMRQF-DHPHIVKLIGVIT--ENP--VWIIMELCTLGELRSFLQV
|..|. .|||.||.|..|..  .|.|. . ||.|..|. ....   ||.|..|| .|.|. .||.||.|.||.|  . |  ..|.||.. .| |...|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM-EDSTY-YKASKGKLPIKWMAPESINFRRFTSASDVWMF
.   | .|..  |. ...| . ...|||||...|||.||||.||..| .|| .||||.|.. .|..| .|...|||||||||||.||...||..||||.|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVCMWEILMHGVKP-FQGVKNNDVIGRI-ENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQL
||.||||.  | .| ..|..|..|. .| |.|.|.|.|.|||. .|.||..||.|||..||.|.|.  ||
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FAK.AA TyrKc 422-676 38 7.6e-132 445.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 422-676
Range on HMM: 1-280/280
Sequence Identity: 38% (113 aa)

IELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQF--DHPHIVKLIGVITE--------NPVWIIMELCTLGELRSFL
|.||. .|||.|| |..|..       . ||.|..|...    || |..||  |...  .||.||.|.||.|.         |..|.||.. .| |...|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDS-------TYYKAS---KGK--LPIKWMAPESINFRRF
. ..  | .. |. ...| .   .||.||...|||.||||.||..| .|| .||||||. .|         ||...    ||  |||.|||||.||...|
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TSASDVWMFGVCMWEILMHGVKPFQG-----VKNNDVIGRIENGERLPMPPN--------CPPTLYSLMTKCWAYDPSRRPRFTELKAQL
|..||||.||||||||.  | .|  |     ..| .|| ....|.|.| |||        ||. .|..|..||..||. ||.|.|.. ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FAK.AA TK 422-676 24 3.9e-119 401.24 In-house 1-486 (486) Show / Hide 
Range on Protein: 422-676
Range on HMM: 1-486/486
Sequence Identity: 24% (118 aa)

IELGRCIGEGQFG---DVHQGIYMS----------------------PENPALAVAIKTCKNCTSDSVRE-------------KFLQEALTMRQFD----
|.||. .||||||   .|..|.. .                      .|.    ||.|..|  ...| .|             .||.||. | ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPHIVKLIGVITEN-------------PVWIIMELCTLGE----LRSFLQVRKYS--------------------------------------------
 ||.||.|.||.|..             |..|.||.. .|     ||..|. ..                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDLASLILYAYQLSTALAYLESK------RFVHRDIAARNVLVSSNDC-----------VKLGDFG---
                               |... |. ...|.. ...||.||      .|||||.||||.||..|.            .|..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRYM-EDSTYYKAS------------------------KGKLPIKWMAPESIN---------FRRFTSASDVWMFGVCMWEILMHGVKPFQGVK
     |.|.. .|. ||..|                        .|||||.|||||..|         ...||..||||.|||.||||...| .|. |  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NN----------DVIGRIEN------------GERLPMP--PNCP--------------PTLYSLMTKCWAYDPSRRPRFTELKAQL
.|          .|. ....            |.|..||  |.||              . .| ||..||.|||..||.|..|. ||
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FAK.AA UTK 422-676 36 2e-101 343.23 In-house 1-296 (296) Show / Hide 
Range on Protein: 422-676
Range on HMM: 1-296/296
Sequence Identity: 36% (109 aa)

IELGRCIGEGQFGDVHQGIYMSPE--NPALAVAIKTCKNCTSDSVRE-----KFLQEAL---TMRQFD-HPHIVKLIGVIT-ENPVWIIMELCTLGELRS
..|||..|.|.||.|| . .  .    . ..||.|.|.  ..|. .|     .|. ||     | ||. ||....|.|| | | | .|..|..  | |||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ-HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRS

FLQ-VRK------YSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSN-------DCVKLGDFG---LSRYME---------DSTYYKAS-KG
.|.  |.       .|.| ... .|.. . ...||.|..|||||.||||.|| ..         .|..|||   .||..          .| ||.|.  .
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD

KLPIKWMAPESINFR-RFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENG--ERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQL
..||.|||||... . |||..|||| ||| .|||...| .|. |  | .|. ...||   |.| |. || ..| ||..||.|||..||.| .| .|.
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase FAK.AA Eph 422-676 42 2.3e-98 331.04 In-house 1-264 (264) Show / Hide 
Range on Protein: 422-676
Range on HMM: 1-264/264
Sequence Identity: 42% (112 aa)

IELGRCIGEGQFGDVHQGIYMSP-ENPAL---AVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVRKY
| . . ||.|.||.| .|    | .  ..   .||||| |   ... |  || || .| |||||.|..| ||.|  .|| |. |   .| | |||  .  
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

SLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDST----YYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCM
 .  . |.   . .  .  || .  .|||| ||||.||.|| . |  |||||| .|| .     |  . || ||.| ||| | .|.|||||||| .|. |
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

WEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQL
||..  | .|.    | |||  || | ||| |..||. |. || .||..|...||.|... . |
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase FAK.AA Ack 422-676 36 7.8e-96 323.74 In-house 1-266 (266) Show / Hide 
Range on Protein: 422-676
Range on HMM: 1-266/266
Sequence Identity: 36% (96 aa)

IELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNC--TSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPV-WIIMELCTLGELRSFLQVRKY--
| |.  .|.| || |..|    | .    ||.|  .    ... . . ||.|. .| . ||||.|.| ||    |    ..||...| |   |   .   
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRTA

SLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSND-CVKLGDFGLSRYM-EDSTYYKASKGK---LPIKWMAPESINFRRFTSASDVWMFGVC
 . .. |  .. |. ....|||.||..||| ||||.|. | |  || .||||.|   .   ||. .  .   .|. |.|||....|.|..|||||||||.
FFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVT

MWEILMHGVKPFQGVKNNDVIGRIE-NGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQL
.||    | .|. |.   ... .|. .||||| |. ||. .|..| .||. .|  ||.| ....||
LWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase FAK.AA Src 422-676 42 1.4e-90 307.21 In-house 1-255 (255) Show / Hide 
Range on Protein: 422-676
Range on HMM: 1-255/255
Sequence Identity: 42% (110 aa)

IELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQ--VRKYSL
| | | .|.||||.| .|..    |    ||.|| |  |     | ||||| .| ...|...|.|  | ..  |. |. |. . | |  .|.   .  .|
IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

DLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME--DSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEIL
 |  ||  | | .   |||||....||| |||||||. | ..| .|||| | ..  |  |   .  |.||||.||| ||..|||  |||| ||. ..|| 
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIV

MHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYS-LMTKCWAYDPSRRPRFTELKAQL
 .|  |  | .| .|. ..|.| |.|.|.|||. ||  .|..||  || .|| |  |   |
TYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FAK.AA Syk 422-670 40 1.9e-90 306.79 In-house 1-257 (257) Show / Hide 
Range on Protein: 422-670
Range on HMM: 1-257/257
Sequence Identity: 40% (105 aa)

IELGRCIGEGQFGDVHQGIYMSP----ENPALAVAIKTCKNCTSDSV-REKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKY
..... || | || ||.| ||      |   . ||||. |.  ..    . |. ||  | | |||.||..||.    .   .||.  || .  .||  . 
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH

SLDL-ASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM-EDSTYYKA-SKGKLPIKWMAPESINFRRFTSASDVWMFGVCMW
.    . | | . | .    |||.| ||||| ||||||       |  |||.|.    ||.||.| . || |.|| |||.|... | ..|||| ||| ||
EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMW

EILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFT
| .  | ||  . |. .|.  ||||.|.. |. ||. .|.|| ||| |..  || | 
EMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase FAK.AA Fer 422-677 33 2.2e-87 296.64 In-house 1-283 (283) Show / Hide 
Range on Protein: 422-677
Range on HMM: 1-283/283
Sequence Identity: 33% (96 aa)

IELGRCIGEGQFGDVHQG------IY-MSPENPALAVAIKTC-KNCTSDSVREKFLQEALTMRQ-FDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFL
..||  .||| ||.|..|      .  .. .....||. |.|  . ...  ...|..||  ||. .|||..||..||.. | |. |.||.|. | |.|.|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

QVRKY-SLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVK---LGDFGLSRY--MEDSTYYKA-SKGKLPIKWMAPESINFRRFTSASD
.  |  .. .. .| ..|| .  ..||.||  .||||||||.|.. .. .|   . |||.||    . ..|...    |.||.|.|||..... .....|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWMFGVCMWEILMHGVKPFQG----VKNNDV----IGR-IENGERLPMPPNCPPTLYSLMT-KCWAYDPSRRPRFTELKAQLS
|| ||| .||| . | .|. |    .|.. |    . . |..| ..|||...||.....|. .||..||. || ..|.. .| 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase FAK.AA TK-Unique 422-676 33 5.7e-87 295.23 In-house 1-294 (294) Show / Hide 
Range on Protein: 422-676
Range on HMM: 1-294/294
Sequence Identity: 33% (99 aa)

IELGRCIGEGQFGDVHQGIYMS---PENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFD-HPHIVKLIGVITEN--PVWIIMELCTLGELRSFLQ---
.|.|. ||||.|| |. | . .   ...    ||.|..| . .|  . .||.|.  |.. . ||.||...|. |..  |. |||| |  | |...|.   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

----------------------VRKYSLDLASLILYAYQLSTALAYLES--KRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASK--GKLPI
                      .|...... .|. .|.|.  ...||.|  |..||||..|||||....  .|..|||..|. .. . |  ..  |..||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWMAPESIN--FRRF-TSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNC-PPTLYSLMTKCWAYDPSRRPRFTELKAQL
.||||||.    . . |. ||||.||| ||||.  |  |. |... |.. .|..| |.| |..| ....|.||  || ..|. || |...| .|
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FAK.AA EGFR 422-677 39 7.3e-87 288.44 In-house 1-258 (258) Show / Hide 
Range on Protein: 422-677
Range on HMM: 1-258/258
Sequence Identity: 39% (102 aa)

IELGRCIGEGQFGDVHQGIYM-SPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDL
. ...  | | || |. ||..   ||    ||||  .. |. .  | .|.||. |   ||||.|.|.||  .. . ..  .  .| |  ...  |  .  
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIGS

ASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME-DSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHG
  |.....|    . ||| .| |||| ||||||| |   ||  ||||.. .| |.. |.|. ||.|||||| |.| .|..|..|||| .|| .||..  |
QHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFG

VKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLS
 ||..|.. ...   .|.||||| ||.|   .| .| |||  |.  ||.| || ....
QKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase FAK.AA S_TKc 422-680 24 1.5e-53 185.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 422-680
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

IELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTL--GELRSFLQVRKYS--
 |..| ||.| || |....  .       ||||  |        |....|   ... .||.||||..|. .. ....||.|    |.|..... |..   
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTS-ASDVWMFGVCMW
   ..      |.||.  ||.|. |....|||.   |.|...  ..|..||||.| .        .       .|||| .    ..  ..|.| .|....
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKA-----QLSTIL
| |  |  ||.    . .. .|            .| . ... ||. .||..||   |. .      .   .
EMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FAK.AA Pkinase 422-676 22 5.8e-41 145.91 Pfam 1-293 (293) Show / Hide 
Range on Protein: 422-676
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

IELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDS--VREKFL-QEALTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLG----ELRSFLQ-
...||.||.| || | ...  . .     ||.|. | .. .|   ..... .|.  |. ..||.||.|...  ... ....||.|  |    .| .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

VRKYSL--DLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCV----KLGDFGLSRY--MEDSTYYKASKGKLPIKWMAPESIN-FRRFTSAS
 |. ..  .   .. |.||.  .|.|. |....|||.   |.|...|. .    |..||||..      .. ..   | ..  .|||| |.  .  ....
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW--YMAPEVIRGGQYYGPKV

DVWMFGVCMWEILMHGVKPFQGV----KNNDVIGRIENGERLPMPPNCP-----------------------PTLYSLMTKCWAYDPSRRPRFTELKAQ-
|.| .|. ..| |  |  ||.|     . .| . .|..  . | . ..|                       ... .....|...||..|| .....   
DMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-L
 .
WF
Focal_AT FAK.AA Focal_AT 914-1052 64 2.5e-100 344.43 Pfam 1-139 (139) Show / Hide 
Range on Protein: 914-1052
Range on HMM: 1-139/139
Sequence Identity: 64% (90 aa)

TANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQ
|||.|||.|.||.||...||.|.||..|....|.||||.|||.|||.||.||..|||..|.|||..|||||||.|.||.|..|||.||.|||||.||.|.
TANMDRSDDYVYCNVMQVVKSVMEMKNKVHKLPSEEYVNMVKNVGLELRKLLQSVDEIYPSLPAQCHREIEMAHKVLNKDMHELISKMRLAQQYAMTTLD

QEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
||.|||||||||.||.|||||||..||||..|.....||
QECKKQMLTAAHVLAMDAKNLLDAVDQARVRMQHAHMPH