Gene Erk3 (Human)

Erk3

Species: Human
Alias: DKFZp686F03189, Erk3, p97MAPK, HsT17250, PRKM6, ERK3, MAPK6, P97MAPK
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 15q21.2,

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK3

Sequence

Name Sequence Type Origin Length Description Download
Erk3.NA RNA Sugen Kinome 4225 None Fasta, JSON
Erk3.AA Protein Sugen Kinome 721 None Fasta, JSON
Erk3.kin_dom Protein Kinase Domain Sugen Kinome 297 None Fasta, JSON

Protein domain

Protein domains of Erk3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Erk3.AA ERK3 20-316 79 7.2e-268 871.84 In-house 1-300 (300) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-300/300
Sequence Identity: 79% (239 aa)

YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDD--VGSLTELNSVYIVQEYMETDLAN
..||.|||||.|||||||||..|.|.||||||||||..|.|||||||||||||||||||||.|.|.|.||...||  .|.|.||..|.|||||||||||.
FCDLRPLGCGSNGLVFSAVDSECCKKVAIKKIVLTDKKSCKHALREIKIIRRLDHDNIVKVYEVLFPKGSDNQDDEDIGILFELRTVCIVQEYMETDLAC

VLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWA
|.||..|.||||||||||||||||||||||||||||||||.|||||||||||||||.|||.||||||||.|||||||||||||||||.||||||||||||
VMEQQRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTEDLVLKIGDFGMARIVDPHYSHKGYLSEGLVTKWYRSPRLLLQPNNYTKAIDMWA

AGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIP-VYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM
||||.|||||||.|||||||||||.|||.|||||||||..|||.|.| .||.|.|..||.||.|||..|...|||||||.|||.||||||||.||.||||
AGCILAEMLTGKMLFAGAHELEQMMLILDSIPVVHEEDKNELLCVMPSKYIKNYMWYPHHPLKQLLCNIDCHALDFLEQMLTFDPMDRLTAEMALQHPYM
Kinase Erk3.AA MAPK 20-316 43 3e-154 518.73 In-house 1-328 (328) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-328/328
Sequence Identity: 43% (143 aa)

YMDLKPLGCGGNGLVFSAVDND------CDKRVAIKKIV--LTDPQSVKHALREIKIIRRL-DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEY
| .|||.| |  |.|.||.|.       |.|.||||||.   ..|.. |...||||. |.. .|.||.|...|. |..   .|| .|| |.| .|||.|.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEM---QDDQNSLEEFNDIYIVMEL

METDLANVLEQGP-LLEEHARLFMYQLLRG--LKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKG-----------HLSEGLVTKW
||||| ....... | ..| . ||||.|||  |||||||||.||||||.|. .|..... ||.||||||. ||.|.|..           |..|  .| |
METDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDL-KICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRW

YRSPRLLLSP--NNYTKAIDMWAAGCIFAEMLT-GKTLFAGAHELEQMQLILESIPVVHEEDRQELL-SVIP-VYIRN---DMTEPHKPLTQLLPG----
||.| ..|..  ..||||.|||..||||||||| .|.|| | . ..|..||.| ..   ||. | .  |  .  ||..   .   | ||.....|.    
YRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFN

ISREALDFLEQILTFSPMDRLTAEEALSHPYM
 ...|.|.||. |.|.|..|.|.||||.|||.
ANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Erk3.AA CMGC 20-316 24 5.5e-114 376.15 In-house 1-513 (513) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-513/513
Sequence Identity: 24% (125 aa)

YMDLKPLGCGGNGLVFSAVD--------------NDCDKRVAIKKIVLT-DPQSVK----------HALREIKIIRRL-----------------DHDNI
|  .|..|.|  | |....|              .. ...|||||| .  ..   |           ||||||| ..|                 .| ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKVFEILGPSGSQLTDDVGS----LTELNSVYIVQEYMETDLANVLEQGP----------LLEEH------------ARLFM------YQLLRGLK--YI
|| ..|. ...|. ... ..    . ..|..|.| |||..||...... .          | | |             . ||      ||.|||||  |.
VKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAN--VLHRDLKPANLFINTEDLV-------------------LKIGDFGLARIMDPHYSHKG------------------HLSEGLVTKWYRSPRLLL
||..  ..||||||.|. || .  .                   |||.||||||. .|| .|..                  ....  || |||.| .||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

SP---------NNYTKAIDMWAAGCIFAEMLTG--------KTLFA-----------GAHELEQMQLILESIPVVH---------------EEDRQELLS
.          ..||..||||..|||||||.||        |.||            |.....|...| . .                   ||.  . ..
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------VIPVYIRN-------DMTEPHKPLTQLLPG-----------------------------------ISREALDFLEQILTFSP
                   ..   ||         . | ||...| |.                                   .. .|.|.|...|.. |
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

MDRLTAEEALSHPYM
 .|.|||.||.||| 
DKRITAEQALQHPYF
Kinase Erk3.AA ERK1 20-316 45 3.7e-94 319.13 In-house 1-289 (289) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-289/289
Sequence Identity: 45% (137 aa)

YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQS-VKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANV
|..|. .| |  |.| ||.|.   .|||||||   . |   .  ||||||. |  |.||... .|.          . .. ..  |||||. |||||  .
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHENIINIQDII---------RADTIEQMRDVYIVQCLMETDLYKL

LEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAA
|   .|  .|   |.||.|||||||||||||||||||.|| .||    ||| ||||||| ||.  | | | |   |.||| | ..|    |||.||.|. 
LKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT-CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSV

GCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTE-PHK---PLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHP
||| ||||  . .| | | |.|. .||    |.    ...|  .|    || .   |||   |. .| |.    |||.|...||| |  |.| |||| ||
GCILAEMLSNRPIFPGKHYLDQLNHILG---VLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHP

YM
|.
YL
Kinase Erk3.AA Pkinase 20-316 29 4.5e-91 313.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-293/293
Sequence Identity: 29% (94 aa)

YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKH--ALR--EIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET--
|  ....| |. | |. ... .  |.||.|.| . .  | |.  ..|  ||.| .||.|.|||. ...                  ...|.|.||.|   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--------------KDHIYMVMEYCEGGL

---DLANVLE---QGPL--LEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVL----KIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPR
   ||. ...   .|..   |.... .|||.||||.|.|| ...||||||.|..|. .. ..    ||.|||||. .|  | ... ..   .| ||..| 
YVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPE

LLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGA----HELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQIL
.... . |....|||..|||..|||.|...| |.    . ..|||.| .  .   ..|.... |. . . ... . . . .. . . .|.|..||.. .|
VIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCL

TFSPMDRLTAEEALSHPYM
.. | .|.|||..| ||..
CKDPKKRPTAEQILQHPWF
Kinase Erk3.AA S_TKc 20-316 27 4.5e-89 303.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-231/231
Sequence Identity: 27% (86 aa)

YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET---DLA
|  |...| |. | |. ..... ...||||.|        .|..|||.| .. .|.|||| ...                  ...|.| ||...   || 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---------------DHLYMVMEYCDGDLGDLF

NVLEQGP-------LLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNY
 .... .       . | ||| .|||....|.|.|| ...||||||.|.....   ..||.||||||..          .   .| ||..| .|     |
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GY

TK-AIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAE
.| ..|.|. |||..|||.|...|   .. . ...|.                                        |.||.||....|.. | .|.|| 
GKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-

EALS-------HPYM
|||        ||..
EALQDEWDIKCHPWF
Kinase Erk3.AA ERK 20-246 42 4.6e-89 302.18 In-house 1-231 (307) Show / Hide 
Range on Protein: 20-246
Range on HMM: 1-231/307
Sequence Identity: 42% (103 aa)

YMDLKPLGCGGNGLVFSAVDND-----CDKRVAIKKI--VLTDPQSVKHALREIKIIRRLD-HDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYM
| ..|..| |. |.|.||.|.      ....||||||  .  .|. .| .|||||. | .. |.||.. | |. |.         | ...| .|.|.|.|
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPN---------SPEQYNDIYCVEELM

ETDLANVLEQG-PLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSH-----KGHLSEGLVTKWYRSPRLLLS
||||. .     .| ..|   ||||.|.||||||||||.|||||| |. .| .. .||| ||||||. |..|.      .....|  .| |||.| ..||
ETDLHQIINSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVN-SNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLS

PNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILE
 ..||||.|.|..|||||||| .|.|| |.  ..|...|..
WQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQ
Kinase Erk3.AA ERK7 20-316 37 4e-84 285.79 In-house 1-292 (292) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-292/292
Sequence Identity: 37% (115 aa)

YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI--VLTDPQSVKHALREIKIIRRLD-HDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLA
|  .| || |  |.|  |.|    . ||.|||     ..       ||| ... .. |.||... ...  .  .             .|.| |.||||| 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDR------------DIYLVFEFMETDLH

NVLEQGPLLEE-HARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHY---SHKGHLSEGLVTKWYRSPRLLLSPNNYTKA
.|  .| .|.. | .  |||||| .||.||.||.||||||.|. ...| .| |. |||||| .        ... | |   | |||.|  ||.  .|||.
AVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMV-KVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKG

IDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDM-TEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEAL
.|||  ||| .|||.|| .|.|   ..|. .|||.|| . .|| . . | . . . . | ....|.| |..|. . .|.| | ..| | |  |||||.||
VDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQAL

SHPYM
.||| 
QHPYV
Kinase Erk3.AA p38 20-316 36 1.1e-80 274.38 In-house 1-289 (289) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-289/289
Sequence Identity: 36% (112 aa)

YMDLKPLGCGGNGLVFSAVDNDCDKR---VAIKKIVLTDP-QSVKHA---LREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYME
| .|.|.| |  | | .|.| . ...   |||||  |  | ||. ||    ||..  . ..|.|...  ..  |          |. ... ||.| . |.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKK--LMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTP-------PAHSMNDFQDVYMVTHFMG

TDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKA
.|| |.. .  | ..| ..  ||.||||||||||.. |||||| |. .| ||  |.| ||||||      .    . .  .|.|||.|  .|.   ||..
ADLNNIMKCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVN-EDCELRILDFGLAR------HCDDEMTGYVATRWYRAPEIMLNWMHYTQT

IDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIP-VYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEAL
.|.|  ||| ||..||.||| |   ..|.| |.. . .  ||  | . |     ||..  . | . ......| .. |.| || .|   |  |.|||||.
VDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAM

SHPYM
.|||.
QHPYF
Kinase Erk3.AA ERK5 20-316 37 5.5e-77 262.07 In-house 1-295 (295) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-295/295
Sequence Identity: 37% (115 aa)

YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI--VLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLAN
|  .  .| |  | | ||.     ..||||||          |  .||.||.|   ||||. . .|| |           . |. .||.| . || ||  
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMP--------KVPYSEMKDVYVVFDLMESDLHQ

VLE-QGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP--HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAID
..  . |.  || | |.||.||||||.|||.|.||||||.|| .| |   |||||||.|| .       |.  . |   |.||| | |..| ..||.|||
IIHSNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAID

MWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLS-VIPVYIRNDMTEPH-KPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALS
.|. |||| ||.. . .| |   ..|.|||.. . .      |   .  .  |.  .. .   |.. .. |.  | ||| | ..| | | .|.|. .|| 
VWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQ

HPYM
||..
HPFL
Kinase Erk3.AA CDK 20-246 35 4e-73 233.26 In-house 1-239 (284) Show / Hide 
Range on Protein: 20-246
Range on HMM: 1-239/284
Sequence Identity: 35% (92 aa)

YMDLKPLGCGGNGLVFSAVDNDCD-----KRVAIKKIVLTD----------PQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTEL-NS
|  |. .| |  | |. | | . .     . ||.||| .            |..   |.|||.. . | |.||||....   . .  ..  ..     |.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPIT---AIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDK---HENK

VYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDL----VLKIGDFGLARIMD-------PH--YSHKGHLSE
.|.| |||..||. ...         . .|.|||||| |.|| ...||||||.|. ||        .|||.||||||..        |   |.|.     
LYMVFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHE-----

GLVTKWYRSPRLLLSPNNYT--KAIDMWAAGCIFAEMLT---GKTLFAGAHELEQMQLILE
  || |||.| |||   .|.   .||||..|||||||.|   .| || |  |..|. .| .
-VVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFR
Kinase Erk3.AA MAPK-Unclassified 20-176 38 7.7e-51 175.22 In-house 1-157 (575) Show / Hide 
Range on Protein: 20-176
Range on HMM: 1-157/575
Sequence Identity: 38% (63 aa)

YMDLKPLGCGGNGLVFSAVDNDC-DKRVAIKKIV--LTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET---
|   | .| |. | |  |.|.    . |||||.    ....  | .|||| | | | | ||... .|       .... ..  |   .||| .||.|   
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDI-------FYNKELHNQEFDDIYIVMDYMQTSLF

DLANVLEQGP--LLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLAR
||  .. .    . ..| . |.||.||||||.|||...||||||.|| || .|. ..| |||..|
DLHQIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLIN-QDCSVRICDFGMSR
Kinase Erk3.AA MAPK-Unclassified 183-246 26 5.4e-19 64.92 In-house 400-494 (575) Show / Hide 
Range on Protein: 183-246
Range on HMM: 400-494/575
Sequence Identity: 26% (25 aa)

SHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTG-----------KTLFAGAH--------------------ELEQMQLILE
.|..|...  || ||| | ..||  .|....|.|..|||||||.             . || |                         | ..|..
HHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFD
Kinase Erk3.AA ERK 276-316 41 4.1e-12 41.59 In-house 265-307 (307) Show / Hide 
Range on Protein: 276-316
Range on HMM: 265-307/307
Sequence Identity: 41% (18 aa)

KPLTQLLPG--ISREALDFLEQILTFSPMDRLTAEEALSHPYM
||.  . |   .. .|.| ||. |.| | .|.|.||.|.||| 
KPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase Erk3.AA TyrKc 20-271 21 2.1e-11 -38.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-271
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRL--DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET-DLA
   .| ||.|  | |. .. .     ||.|..       ..  .||..| ..|  .|.|||. . .   .| .         .   ..|| |||.  || 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-------FMYIEPLMIVMEYMPHGDLK

NVLEQGP--LLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPH---------YSHKGH-LSEG-LVTKWYRSPRLL
. |      |  ..   |..|  .|  |.|| |. ||||   |  .. .  . ||.||||.|  . .         |..|.|  . . |  .|. .|  .
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI

LSPNNYTKAIDMWAAGCIFAEMLT-GKTLFAG----------AHELEQMQLILESIPV--------VHEEDRQELLSVIPV---------YIRNDM
   . .| . | |. |    |..| |..   |          ..|. .    ..  |          ..|  |  ..              |. ..
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Erk3.AA MAPK-Unclassified 288-316 48 3.5e-10 32.48 In-house 547-575 (575) Show / Hide 
Range on Protein: 288-316
Range on HMM: 547-575/575
Sequence Identity: 48% (14 aa)

EALDFLEQILTFSPMDRLTAEEALSHPYM
|..||. . | |.|  | ||..||.|||.
ECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase Erk3.AA CDK 282-316 40 7.3e-10 27.56 In-house 255-284 (284) Show / Hide 
Range on Protein: 282-316
Range on HMM: 255-284/284
Sequence Identity: 40% (14 aa)

LPGISREALDFLEQILTFSPMDRLTAEEALSHPYM
||.      |.|.. |.. |  |..||.||.||| 
LPDY-----DLLNKMLCYDPKKRISAEQALQHPYF
Kinase Erk3.AA Pkinase_Tyr 102-187 35 9.9e-07 23.42 Pfam 80-173 (270) Show / Hide 
Range on Protein: 102-187
Range on HMM: 80-173/270
Sequence Identity: 35% (34 aa)

NSVYIVQEYMET-DLANVLEQG-----PLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIM--DPHY-SHKGH
|..||| |||.  || . | .      ||  ..   . .|  .|. | .| |  ||||   |  ..  ..| ||.|||||| .  |  |   .|.
NQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFGLARDIYNDDYYYRKRGG
Kinase Erk3.AA Pkinase_Tyr 20-79 26 0.023995 8.57 Pfam 1-68 (270) Show / Hide 
Range on Protein: 20-79
Range on HMM: 1-68/270
Sequence Identity: 26% (18 aa)

YMDLKPLGCGGNGLVFSAVDN----DCDKRVAIKKI-VLTDPQS--VKHALREIKIIRRL-DHDNIVK
   .| || |  | |. .. .    . .  ||.|..   ....    .  .||.|| . | .|.|||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVR