Gene Erk1 (Human)

Erk1

Species: Human
Alias: Erk1, P44MAPK, HUMKER1A, ERK1, PRKM3, P44ERK1, MAPK3, MGC20180, HS44KDAP, p44, ERK-1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 16p13.11,

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
Erk1.NA RNA Sugen Kinome 1902 None Fasta, JSON
Erk1.AA Protein Sugen Kinome 379 None Fasta, JSON
Erk1.kin_dom Protein Kinase Domain Sugen Kinome 289 None Fasta, JSON

Protein domain

Protein domains of Erk1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Erk1.AA ERK1 42-330 89 2.3e-246 824.76 In-house 1-289 (289) Show / Hide 
Range on Protein: 42-330
Range on HMM: 1-289/289
Sequence Identity: 89% (260 aa)

YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSND
||.||||||||||||.||||.|.|.|||||||||||||||||||||||.||.||.|||.|.|.||.||.|.|.||||||||.|||||||||||.|.||||
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLSND

HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN
||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN

RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL
||||||||||||||||||.||||||.|||||||.||||||||||.|.||.||.||||.|||||||||.||||||.||||||||||||||
RPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase Erk1.AA MAPK 42-330 55 1.5e-203 682.49 In-house 1-328 (328) Show / Hide 
Range on Protein: 42-330
Range on HMM: 1-328/328
Sequence Identity: 55% (181 aa)

YTQLQYIGEGAYGMVSSAYDHV------RKTRVAIKKIS-PFEHQTYCQRTLREIQILLRF-RHENVIGIRDILRA------STLEAMRDVYIVQDLMET
|. |..||.||||.| ||.|         ...||||||| ||...|.|.||.||| .| .| .|||.|...||...      ..|| ..|.|||..||||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLYKLLKSQQ-LSNDHICYFLYQILRG--LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADP-EHDHTG----------FLTEYVATRWYRAP
||....|||| ||.|||.||.||||||  |||||||||.||||||||.|.|. ||||||||||||..|| .|.|..          ..||||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EIMLN--SKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCII-NMKARNYLQSL---PSKTKVAWAKLFPK----SDSK
|||||  ...|||..|.||||||.||||. ..|.||||.|.||.|.|. .||.||.|...||  . .||||.|||   | ..|. |.|.||.     ...
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALDLLDRMLTFNPNKRITVEEALAHPYL
|.|||..||.|.|.|||||||||.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Erk1.AA ERK 42-330 53 1.2e-178 599.73 In-house 1-307 (307) Show / Hide 
Range on Protein: 42-330
Range on HMM: 1-307/307
Sequence Identity: 53% (165 aa)

YTQLQYIGEGAYGMVSSAYDHV-----RKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFR-HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK
|  .. ||.|||| | || |         ..||||||  .|.|  || |||||| .|  |. |||.|...||.. .  | . |.|.|..|||||| .  .
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SQQ-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHT-----GFLTEYVATRWYRAPEIMLNSKGYTKSIDI
||| || ||. ||.||||.||||||||||.||||||||.|.|  ||||||||||||. |....       .|.||||||||||||||||. . |||..||
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP-SQEDLNCIINMKARNYLQSLPS--KTKVAWAKLFPKSD--SKALDLLDRMLTFNPNKRITVEE
||.|||.||||  .|.|||| |..|.|.|. |.|.| |.|||..| . .|..|. .||   .... | ..||. .  ..|.|||..||.|.|.|||||||
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALAHPYL
.|.|||.
CLEHPYF
Kinase Erk1.AA CMGC 42-330 28 2e-148 491.43 In-house 1-513 (513) Show / Hide 
Range on Protein: 42-330
Range on HMM: 1-513/513
Sequence Identity: 28% (148 aa)

YTQLQYIGEGAYGMVSSAYD--------------HVRKTRVAIKKIS-PFEHQTYCQ----------RTLREIQILLRFR-----------------HEN
|. ...||||.||.| ...|              |  . .||||||. || ... ..          |.||||.|| ...                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIGIRDILRAST-------------LEAMRDVYIVQDLMETDLYKLLKSQQ----------LSNDH------------ICYFL------YQILRGLK--Y
.....||.. .              .  ....|.| ..|..|||...|..|          ||  |            |.||.      ||||||||  |
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IHSAN--VLHRDLKPSNLLINTTCDL--------------------KICDFGLARIADPEHDH------------------TGFLTEYVATRWYRAPEIM
.||..  ..||||||.|.||| .|.|                    |||||||||. .|..||                  . ..|.||.|||||||||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LNS---------KGYTKSIDIWSVGCILAEMLSN--------RPIFP-----------GKHYLDQLNHILGILGSP----------------SQEDLNCI
|..         ..||..||.||||||.|||. .        .|.||           ||...|||..|  .||.|                ..|. |.|
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

I--------------------NMKARNYLQS---LPSKTKVAWAKLFPK-----------------------------------SDSKALDLLDRMLTFN
                     . .||||.||   .| . .  | .|||.                                    |..|.|||..||...
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PNKRITVEEALAHPYL
|.||||.|.||.|||.
PDKRITAEQALQHPYF
Kinase Erk1.AA p38 42-330 48 1.3e-141 476.8 In-house 1-289 (289) Show / Hide 
Range on Protein: 42-330
Range on HMM: 1-289/289
Sequence Identity: 48% (142 aa)

YTQLQYIGEGAYGMVSSAYDHVRKTR---VAIKKIS-PFEHQTYCQRTLREIQILLRFRHENVIGIRDILRA--STLEAMRDVYIVQDLMETDLYKLLKS
| .||..|.|||| |..|.|  ....   |||||.. ||.   .  || ||.  |   ||||||.. |.     . .. ..|||.|  .|..||....|.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL
|.|| ||| . .|||||||||||||.. ||||||||. .|  |.|.| |||||| .| |      .|.|||||||||||||||   ||. .||||||||.
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDE------MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIM

AEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL
||... |. |||. ..|||. |. ..|.|..| .. | . .||||.||.|  ..   ...|.. . .|.|||..||   | ||||.|||..|||.
AELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase Erk1.AA ERK5 42-330 52 8.3e-131 440.86 In-house 1-295 (295) Show / Hide 
Range on Protein: 42-330
Range on HMM: 1-295/295
Sequence Identity: 52% (154 aa)

YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAST-LEAMRDVYIVQDLMETDLYKLLKSQQ-L
|  .  ||.||||.|.||  .    .||||||   |.  |  .||.||..||  |||.|.| |||||.    .  |.|||.| |||| || ... |.| .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADP--EHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILA
. .|| ||||||||||||.|||.|.||||||||||.|  |.||| |||.||        .|  |.|||||||||||||.|. |. ||. ||.||||||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQS-LPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL
||.. | .|||| |..||. |. .|| |.   .  .   . .||.|. .| .. . | |..|| | .||||| ||| | | .|||| .|| ||.|
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase Erk1.AA ERK7 42-330 47 2.9e-119 402.52 In-house 1-292 (292) Show / Hide 
Range on Protein: 42-330
Range on HMM: 1-292/292
Sequence Identity: 47% (139 aa)

YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFR-HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK-SQQL
|  .. .| ||||.|  |||   |  ||.|||   |  ||  ||| ||| .|  |. |.|.| . ...||   .  ||.|.| . |||||    .  . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRA---DNDRDIYLVFEFMETDLHAVIRKGNIL

SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPE--HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL
 . |  | .||.|| .||.||.||.||||||||.|... | .|.||||||| ||. |  ..... |||||||||||||||.| |. ||| .| ||.||||
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

AEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL
.||| ..|.|||   ..|.. || ... |.|||.. |    | | |...... .    ...|..   |.||| |.| |||.||.|.|.||.||| 
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase Erk1.AA ERK3 42-330 43 2e-108 350.09 In-house 1-300 (300) Show / Hide 
Range on Protein: 42-330
Range on HMM: 1-300/300
Sequence Identity: 43% (130 aa)

YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL--RASTLE---------AMRDVYIVQDLMETDLY
.  |.  | |  |.| || |     .||||||.    .  |   ||||.|. |  |.|.. . ..|    | ..          .| |.||| .||||| 
FCDLRPLGCGSNGLVFSAVDSECCKKVAIKKIVLTDKKS-CKHALREIKIIRRLDHDNIVKVYEVLFPKGSDNQDDEDIGILFELRTVCIVQEYMETDLA

KLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTT-CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIW
 ..  |.||..|.  | || ||||||||||||||||||| |..|||    ||| |||.||| ||.  | |.|.| . |.||| |. .|    ||| ||.|
CVMEQQRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTEDLVLKIGDFGMARIVDPHYSHKGYLSEGLVTKWYRSPRLLLQPNNYTKAIDMW

SVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPY
. ||||||||  .. |.| | | |.  ||        ||.| .       |..      .    .| .  |. |||.| .||||.|  |.| |.|| |||
AAGCILAEMLTGKMLFAGAHELEQMMLILDSIPVVHEEDKNELLCVMPSKYIKNYMWYPHHPLKQLLCNIDCHALDFLEQMLTFDPMDRLTAEMALQHPY

L
.
M
Kinase Erk1.AA CDK 42-330 34 4e-105 337.29 In-house 1-284 (284) Show / Hide 
Range on Protein: 42-330
Range on HMM: 1-284/284
Sequence Identity: 34% (109 aa)

YTQLQYIGEGAYGMVSSAYDHVRK-----TRVAIKKIS-PFE----HQTYCQR-TLREIQILLRFRHENVIGIRDILRASTLEAM------RDVYIVQDL
| .|. ||||.|| |  | |. ..       ||.|||    |    . .     ..||| .|    |.|.. ..|.   ....        . .|.| . 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

METDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD-----LKICDFGLARIADPEHD---HTGFLTEYVATRWYRAPEIM
|..||.|...        |  ...|.|||| |.|| ...||||||.|.||| .       ||| ||||||.   .|.    .  .|  | |.||||||. 
MDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELL

LNSKGYT--KSIDIWSVGCILAEMLS---NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRML
| || |.   .||.||||||.|||.    ..|.|||.  .||| .|  |.|.|. ..   .  .                             |||..||
LGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLNKML

TFNPNKRITVEEALAHPYL
...|.|||. |.|| |||.
CYDPKKRISAEQALQHPYF
Kinase Erk1.AA S_TKc 42-330 28 2e-99 337.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-330
Range on HMM: 1-231/231
Sequence Identity: 28% (89 aa)

YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET---DLYKLLKSQQ-
|. |. ||.||.| |  ....  . .||||.|.        ....|||||| . .|.|.. . |. .        ..|.| .....   ||....|... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGR

------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTK-SIDIWS
      ..  |.....|||...|.|.|| ...||||||.|.|...   .|||||||||.           | .. |.||.|||..    ||.| ..|.||
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCDWWS

VGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA----
.||||.|||. .| ||      |.. .. ..|                                     .. |.|.....|...|.||.|. |||.    
CGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HPYL
   ||..
IKCHPWF
Kinase Erk1.AA Pkinase 42-330 30 3.2e-91 314.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 42-330
Range on HMM: 1-293/293
Sequence Identity: 30% (95 aa)

YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR---EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-----DLYKLL
|. .. ||.|..| |  ....    .||.|.|.  .    ...|.|   ||||..|..|.|.. ..|. .       ...|.|....|      ||. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

K---SQQL--SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL----KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTK
.   .  .  | .... ..|||||||.|.|| ...||||||.|.||. ....    ||||||||. .|  . . . .| .. |.||.|||. . ...|..
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

SIDIWSVGCILAEMLSNRPIFPGK----HYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT
..|.||.||||.|||. ||.|||.    . .||.  |  |.| |  .|    ...  .. ..  . .     ...|.. .. ..|.....|...|.||.|
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTFHNWSEECKDFIKWCLCKDPKKRPT

VEEALAHPYL
 |..| ||..
AEQILQHPWF
Kinase Erk1.AA MAPK-Unclassified 42-192 50 1.4e-69 237.49 In-house 1-161 (575) Show / Hide 
Range on Protein: 42-192
Range on HMM: 1-161/575
Sequence Identity: 50% (81 aa)

YTQLQYIGEGAYGMVSSAYDHVR-KTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEA--MRDVYIVQDLMET---DLYKLLK
|.  ..|| |||| |  | |    .  |||||.   |. .| | |.|||| ||    |.|.| |.||...  |.     |.||| |.|.|   ||....|
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SQQ--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IAD
| |  ..  || ||.|||||||||.|||...||||||||||||  | ..|||||..| | |
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIED
Kinase Erk1.AA MAPK-Unclassified 197-330 37 7.2e-59 201.89 In-house 401-575 (575) Show / Hide 
Range on Protein: 197-330
Range on HMM: 401-575/575
Sequence Identity: 37% (65 aa)

HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN-----------RPIFPGKH--------------------YLDQLNHILGILGSPS
| . .|.||.||||||||||| .. |.. .||||.|||.|||...           ||.|||.                     . ||.. |.  ||.| 
HCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPP

QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDS----------KALDLLDRMLTFNPNKRITVEEALAHPYL
.||.| | . .|| |.||.  || | .  |..   .           ..|... || |||.|||| ..|| ||| 
EEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase Erk1.AA TyrKc 42-330 21 8.8e-15 16.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 42-330
Range on HMM: 1-280/280
Sequence Identity: 21% (67 aa)

YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF--RHENVIGIRDILRASTLE-----AMRDVYIVQDLMET-DLYKLL
 | .. .||||.| |  .      . ||.|.. .       .  .||..|. ..  .|.|..    .. . | .         ..||  .|.  || . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVR---LYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KSQQ--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPE------HDHTGF----LTEY-VATRWYRAPEIMLNSK
.. .  |.... ..| .|| .|  |.|| |. ||||   | |..     ||.||||.|  . .      .|         . . .  ||. ||| .  .|
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECINYGK

GYTKSIDIWSVGCILAEMLSNRPIFPGK-----HYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP
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FTTKS-DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-------------------FVCCPDEMYQIMKQCWHEDP

NKRITVEEALAHPYL
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EDRPTFSEI--HECF
Kinase Erk1.AA Pkinase_Tyr 118-189 37 2e-06 22.12 Pfam 82-159 (270) Show / Hide 
Range on Protein: 118-189
Range on HMM: 82-159/270
Sequence Identity: 37% (29 aa)

VYIVQDLMET-DLYKLLKSQ-----QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR
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IYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase Erk1.AA Pkinase_Tyr 42-101 23 0.000138 16.16 Pfam 1-67 (270) Show / Hide 
Range on Protein: 42-101
Range on HMM: 1-67/270
Sequence Identity: 23% (16 aa)

YTQLQYIGEGAYGMVSSAYDH----VRKTRVAIKKISPFEHQTY--CQRTLREIQILLRF-RHENVI
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ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIV