Gene ErbB3 (Human)

ErbB3

Species: Human
Alias: ErbB3, MDA-BF-1, p180-ErbB3, Hs.199067, ERBB3, erbB3-S, c-erbB3, p85-sErbB3, p45-sErbB3, Hs.167387, Hs.167386, HER3, c-erbB-3, ErbB-3, MGC88033
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 12q13.2,

Classification

Group: TK
Family: EGFR

Sequence

Name Sequence Type Origin Length Description Download
ErbB3.NA RNA Sugen Kinome 5516 None Fasta, JSON
ErbB3.AA Protein Sugen Kinome 1342 None Fasta, JSON
ErbB3.kin_dom Protein Kinase Domain None 257 None Fasta, JSON

Protein domain

Protein domains of ErbB3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain ErbB3.AA Recep_L_domain 55-167 36 1.7e-46 158.06 Pfam 1-121 (121) Show / Hide 
Range on Protein: 55-167
Range on HMM: 1-121/121
Sequence Identity: 36% (45 aa)

RCEVVMGNLEIVLTGHN----ADLSFLQWIREVTGYVLVAMN--EFSTLPLPNLRVVRGTQVYDG-KFAIFVMLNYNTNSSHALRQLRLTQLTEILS--G
 |.|..||||| .....     ||||.. |||.|||.|....  .... ..||||..||.|.... ..|.... |.|      |..| .  |..|..  |
NCTVIYGNLEITWRDEHNELEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNM----GLQELWMWNLKNITRKNG

GVYIEKND--KLCHMDT-IDWRDIV
||||..|   |||...| |.|..|.
GVYIHNNPHPKLCYTHTEIMWWMIY
Furin-like ErbB3.AA Furin-like 180-332 45 3.8e-84 276.54 Pfam 1-182 (182) Show / Hide 
Range on Protein: 180-332
Range on HMM: 1-182/182
Sequence Identity: 45% (82 aa)

GRSCP--------PCHEVC--------KGRCWGPGSEDCQTLTKTICAPQCNG-HCFGPNPNQCCHDECAGGCSGPQ-DTDCFACRHFNDSGACVPRCPQ
.|.||        |||..|          |||||....||||||..|..||..  |.|| |..|||..|.|||.||  ||||.|||||...|.||..||.
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKHRRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQCPP

PLVYNKLTFQLEPNPHTKYQY-GGVCV--ASCP-------HNFVV-DQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACE
...||. |||.||||. .||. |  ||  ..||       .|..| ....|.| ||....|...|. .||||| |.||| |.
MMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKLSHNPDCNYYVIHNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
FU ErbB3.AA FU 223-266 40 3e-12 47.93 SMART 1-48 (48) Show / Hide 
Range on Protein: 223-266
Range on HMM: 1-48/48
Sequence Identity: 40% (20 aa)

PNQC--CHDECAGGCSGPQDTDCFACRHFNDS---GACVPRCPQPLVYN
 ..|  ||.|||.||.|| ...| .|.|...    |.||. || |  | 
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCP-PGYYP
FU ErbB3.AA FU 180-220 31 0.043571 7.19 SMART 1-48 (48) Show / Hide 
Range on Protein: 180-220
Range on HMM: 1-48/48
Sequence Identity: 31% (15 aa)

GRSCPPCHEVCKGRCWGPGSEDCQT------LTK-TICAPQCNGHCFG
.. |.|||. |.. ||||| ..|..      | .  .| .||.   ..
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain ErbB3.AA Recep_L_domain 353-474 33 1.4e-44 151.56 Pfam 1-121 (121) Show / Hide 
Range on Protein: 353-474
Range on HMM: 1-121/121
Sequence Identity: 33% (44 aa)

NCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNR-GFSLLIMKNLN--VTSLGFRSLKEI
|||.| ||| ..... ...        ..|.|..|...|||||||.|. . . . |.|.|.||..| ||.|...  ..| |..| |   ..|....||.|
NCTVIYGNLEITWRDEHNE--------LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNI

SA--GRIYISANR--QLCYHHS-LNWTKVL
.   |..||. |   .|||.|. ..| . .
TRKNGGVYIHNNPHPKLCYTHTEIMWWMIY
FU ErbB3.AA FU 490-541 38 2.1e-10 41.84 SMART 1-48 (48) Show / Hide 
Range on Protein: 490-541
Range on HMM: 1-48/48
Sequence Identity: 38% (21 aa)

RRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRG---GVCVTHCNFLNGEPR
.. |    | |.| |.. |||||||.||.||...  .   |.||. |.   |. .
DGVC----KPCHPECAT-GCWGPGPDQCTSCPHGYYLHHNGTCVSQCP--PGYYP
Furin-like ErbB3.AA Furin-like 507-533 42 1e-05 19.34 Pfam 71-98 (182) Show / Hide 
Range on Protein: 507-533
Range on HMM: 71-98/182
Sequence Identity: 42% (12 aa)

GGCWGPG-PGQCLSCRNYSRGGVCVTHC
||| ||. .  |..||...  |.||..|
GGCTGPNNDTDCVACRHFYHNGTCVDQC
FU ErbB3.AA FU 546-595 37 1.6e-09 38.91 SMART 1-48 (48) Show / Hide 
Range on Protein: 546-595
Range on HMM: 1-48/48
Sequence Identity: 37% (20 aa)

EAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPH---CVSSCPHGVLG
. .|  |||||       .|.|.| |.|  |.|.....|   |||.|| |  .
DGVCKPCHPECAT-----GCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
FU ErbB3.AA FU 607-642 22 0.021499 10.87 SMART 1-48 (48) Show / Hide 
Range on Protein: 607-642
Range on HMM: 1-48/48
Sequence Identity: 22% (11 aa)

QNECRPCHENCTQGCKGPELQDCLG--QTLVLIG----------KTHL
...|.|||..|  || ||   .|.     ..| .          ... 
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Kinase ErbB3.AA EGFR 709-966 65 6.5e-187 625.86 In-house 1-258 (258) Show / Hide 
Range on Protein: 709-966
Range on HMM: 1-258/258
Sequence Identity: 65% (170 aa)

LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGP
|.|.||||||.||||.||.||||||..||||.|||.....|........|......|.||.|.|||||.|..|..||||||.|.|.|||.||||....|.
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIGS

QLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFG
|.||||.|||||||.||||| ||||.|||||||.|||..|...|||.|.||..|.|.. ....|.||||||||.||...|||||||||||||.|||||||
QHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFG

AEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFT
..||.|....|.||||||||||.||.||||||||||||||||||..|||||||..|| 
QKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase ErbB3.AA Pkinase_Tyr 709-965 38 1.2e-114 388.9 Pfam 1-270 (270) Show / Hide 
Range on Protein: 709-965
Range on HMM: 1-270/270
Sequence Identity: 38% (103 aa)

LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQS--FQAVTDHMLAIGSL-DHAHIVRLLGLCP--GSS--LQLVTQYLPLGSLLDHVRQ
....|.||.| ||.|.||.| ..... |||| .|.. ...  .    ..    .    .| .| .||||.| |   | .  . .|. | |.|.|||. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H---RGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQ-LLYSEAKTPIKWMALESIHFGKYTHQSDVWSY
|   ...| .. ||.. .|||||| |||.....|| |||||.|.... .| ..||| | .. .||      ...| ||||||.|.|..||.|..|||||.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVTVWELMTFGAEP-YAGLRLAEVPDLL-EKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEF
||. ||..|.|..| |.|.  .|| ... |.|.|...|. |. ..|..| .||. | . ||||.|. ...
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ErbB3.AA TyrKc 709-965 34 3.3e-94 320.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 709-965
Range on HMM: 1-280/280
Sequence Identity: 34% (100 aa)

LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSL--DHAHIVRLLGLCPG--------SSLQLVTQYLPLGSLLDH
....|.||.| ||.|.||.|.       |.| .|.. . .     ..  . .    .|  .| .||||.| |            | .|. | |.|.|.|.
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

VRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQ----LLYSE-----AK--TPIKWMALESIHFGK
 | ||. | .. ||.. .|||.|| ||.... .|| |||||.|.... .| ..||| .  .  ||.|      |.      .|   ||.|||.|.| .||
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YTHQSDVWSYGVTVWELMTFGAEPYAG-----LRLAEVPDLLEKGERLAQPQI--------CTIDVYMVMVKCWMIDENIRPTFKELANEF
.|..|||||.||. ||..|.|..|| |     .  .||  ....|.|. ||.         |. ..|..| .||. | . ||||.|.  .|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ErbB3.AA TK 709-965 20 2.7e-93 313.11 In-house 1-486 (486) Show / Hide 
Range on Protein: 709-965
Range on HMM: 1-486/486
Sequence Identity: 20% (101 aa)

LRKLKVLGSGVFG---TVHKGVWIPE---------------------GESIKIPVCIKVIEDKSGRQSFQAVT----------------DHMLAIGS--L
.. .|.||.| ||   .|.|| |...                     .|  |.|| .|.. .... .. .                     |    .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHAHIVRLLGLCPGSS-------------LQLVTQYLPLGS----LLDHVRQHRGA--------------------------------------------
.| .||||.| |  .              . .|. | |.|.    |.|. |..|.                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LGPQLLLNWGVQIAKGMYYLEEH------GMVHRNLAARNVLLKSPSQ-----------VQVADFG---
                               | .. || . .|||.|| ||...      ..|||.|||||.|. .  .           . .||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----VADLLPPDDKQLLYS------------------------EAKTPIKWMALESIH---------FGKYTHQSDVWSYGVTVWELMTFGAEPYAGLR
      |  ...||     |                         .| ||.||| |..          .||.|..|||||.||..||..|.|.|||.|  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

L----------AEVPDLLEKG--------------ERLAQPQICT--------------IDVYMVMVKCWMIDENIRPTFKELANEF
           .|| ..|..|               |..||. |.               ..| .| .||  | . ||||..| ...
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ErbB3.AA Ack 709-965 33 7.5e-71 238.23 In-house 1-266 (266) Show / Hide 
Range on Protein: 709-965
Range on HMM: 1-266/266
Sequence Identity: 33% (90 aa)

LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDK---SG--RQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSL-QLVTQYLPLGSLLDHVRQH
.. .. ||.| || |..|.|     .  |.| .|.  .    ..   ..|     .|.   ||||.|.||| |.  .. . ..||   |.|||||  |.|
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMH---SLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKH

RG--ALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSP-SQVQVADFGVADLLPPDDKQLLYSEAK---TPIKWMALESIHFGKYTHQSDVWS
 .   .   .|... .|||.|| |||  ...|| |||||.|| |.   | ..|||    |.  .     .. .    |. |.| |.. ... .| ||||.
CRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWM

YGVTVWELMTFGAEPYAGLRLAEVPDLLE-KGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEF
.||| ||  ..| ||.||.. ...  ... .|||| .|  |  |.| .|..||  .   |||| ..   .
FGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase ErbB3.AA TK-Unique 709-965 29 8e-71 241.6 In-house 1-294 (294) Show / Hide 
Range on Protein: 709-965
Range on HMM: 1-294/294
Sequence Identity: 29% (88 aa)

LRKLKVLGSGVFGTVHKGVWIP--EGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLD-HAHIVRLLGLCP-GS-SLQLVTQYLPLGSLLDHVRQHR
|. ..|.|.| ||.|..|   .  .... .. | .|  .|..  .. |. ..      .|. | .||..|| |   . . ...  |.| |.|... |. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GA-------------------------LGPQLLLNWGVQIAKGMYYLEE--HGMVHRNLAARNVLLKSPSQVQVADFGVA-DLLPPDDKQLLYSEAKTPI
.|                         . |..|.....|||.|| ||..  .. |||.|.|||||| .  .. ..||| | |.  . . .   |. ..||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWMALESIH--FGKY-THQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQIC-TIDVYMVMVKCWMIDENIRPTFKELANEF
.|||.||.    | | | .|||||.||. ||..|.|| || |.. ... .....| |. ||. | . ..| .|  ||  ..  ||.| ......
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase ErbB3.AA UTK 709-965 27 5.1e-68 231.79 In-house 1-296 (296) Show / Hide 
Range on Protein: 709-965
Range on HMM: 1-296/296
Sequence Identity: 27% (82 aa)

LRKLKVLGSGVFGTVHKGVW--IP--EGESIK-IPVCIKVIEDKSGRQSFQ---AVTDHML---AIGSLD-HAHIVRLLGLC-PGSSLQLVTQYLPLGSL
.. .. ||.| ||.|||. .  ..  ..|... ..||    ......|.      .  .       . .. | ...||.|.|  .. . .|| | . |.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ---HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDL

LDHVRQHRGALG-PQLLLN------WGVQIAKGMYYLEEHGMVHRNLAARNVLLKSP-------SQVQVADFG---VADLLP---------PDDKQLLYS
.. .| || ... ....|.      . ..|| || ||...| |||.|||||.|. .        ... .||||    . ...          ..     .
RSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQH

EAKTPIKWMALESIHFG-KYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKG--ERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEF
  . ||.||| |..  . ..|..|||||.||..||..|.|. ||.|.  ..|   ...|   |...|. |  .||..|..||. |   ||.|..|  ..
QDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ErbB3.AA Syk 709-959 36 3e-63 216.44 In-house 1-257 (257) Show / Hide 
Range on Protein: 709-959
Range on HMM: 1-257/257
Sequence Identity: 36% (94 aa)

LRKLKVLGSGVFGTVHKGVWIPE---GESIKIPVCIKVIEDKSGRQSFQAVTDHMLA----IGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQ
| . . .|.| ||.||||.       ||   |.| ||.  .  .     | .. ...       ||| .|||..| | . .. .|    .||....   |
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQ---PADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQ

HRGALGP-QLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEA-KTPIKWMALESIHFGKYTHQSDVWSYGV
||        |  |  |.| || ||||   ||| ||||||||    .  . |||    | .|..      . | |.|| | |.| ..|  |.|||||.||
HRHEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGV

TVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFK
| ||    |. ||.. . .|| ...|.|.|. .|  |  ..| .| |||  .   |||| 
TMWEMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase ErbB3.AA Src 709-965 36 9.8e-63 211.95 In-house 1-255 (255) Show / Hide 
Range on Protein: 709-965
Range on HMM: 1-255/255
Sequence Identity: 36% (95 aa)

LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGS-SLQLVTQYLPLGSLLDHVR-QHRGA-
.. .. ||.| || | .|.|       ...| .|..  |.|  | .|      .  .|.| ..|.|.  |        || |   |||||  . . .|  
IKLCRKLGQGQFGEVWMGYW-----NGNTKVAVKTL--KPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH

LGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLP-PDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWEL
|  . |.  . |.|.|| |||.  ..|| |||||||    . . ||||| | |.   ||     ..|| ||||.| | |..|..|  |||||.|.  .|.
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

MTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYM-VMVKCWMIDENIRPTFKELANEF
.|.|  || | . .|| . .|.| |. .|. |   .|. .| .||  |   ||||. | . .
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ErbB3.AA Abl 709-965 37 3.6e-57 189.07 In-house 1-252 (252) Show / Hide 
Range on Protein: 709-965
Range on HMM: 1-252/252
Sequence Identity: 37% (97 aa)

LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVI-EDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSS-LQLVTQYLPLGSLLDHVRQ-HRGA
.   . || | .| | .|||       .  | .| . ||    . | .    |  .    |  .|.||| |   .   ..| ... | |||..|.  |  
IMMKHKLGGGQYGEVYEGVW----KRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEM---KHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREE

LGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELM
| .  ||    ||| || |||..  .|| ||||| |.     |.|||||.| ..  ||       || |||| | ||. . |.  .|||| .|| .||. 
LPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMM-KDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIA

TFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEF
|.|  || |. | .| ..|||| |. .|. |  .|| .| .||  ..  ||.|||. ...
TYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase ErbB3.AA Src-Echino1 709-965 35 4.2e-54 186.06 In-house 1-252 (252) Show / Hide 
Range on Protein: 709-965
Range on HMM: 1-252/252
Sequence Identity: 35% (91 aa)

LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGS-SLQLVTQYLPLGSLLDHVRQHRGA-L
||  | .|.| .| | ||||         || .| .  |.   |  .       .  . |  ||..  .|  .  . .||. .  |.|.|.... ..  .
LRMDKKIGKGHCGEVWKGVW-----NGNTPVAVKTLKEKT--MSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHV

GPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMT
    |.. | .|| || ||..  .|||.|||||||.     ...|||| | ..  .|       || |||| | | . .|..| .|||||.|. . |..|
KMTTLIDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMM-QKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVT

FGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMV-MVKCWMIDENIRPTFKELANEF
||  || |..  || | ...| |. ... |.  .||. |.|||  |   ||||. | . |
FGRYPYPGMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase ErbB3.AA Jak 709-967 23 9.8e-54 184.84 In-house 1-299 (299) Show / Hide 
Range on Protein: 709-967
Range on HMM: 1-299/299
Sequence Identity: 23% (69 aa)

LRKLKVLGSGVFGTVHKGVWIPEG-----ESIKIP---VCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLC---PGSSLQLVTQYLPLGSLLD
| ..  ||.| ||.| ...  ...     |..      | .|.. .....| ...  .   .  ...| |||.. |.|    . ....|. |...|.|.|
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

HVR----QHRGALGP--QLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQ---VQVADFGVADLLPPDDKQLLYSEA--KTPIKWMALESIHFG
 ..     |.. ..   . ..    ||..|| |||... .|....|||.|.... .   |. ..|...| . ..||.... ..    .| | | |..  .
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPW-CSDKEYYREMMDRDERIPWYAPECLTNC

KYTH--QSDVWSYG-VTVWELM-T--------------FGA-EPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTR
| .   ..|.||.| || ||.. .              ..  .|   . ...  ...|.|.|| .| .|   .|..| .||  |.| ||.|  ..  .  
KFYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ
Kinase ErbB3.AA S_TKc 709-966 20 6.5e-33 116.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 709-966
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)

LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPL--GSLLDHVRQHRGA-
 ..|...|.| ||.|.|....      .  | ||.|         . .   .    . .| .||.|.. .  ..| .|. |..   |.|.|. .....  
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTH-QSDVWSYGVT
    . .     .  ||.... |. .|| .|| |   |.|| .  .. ..|||.| .|         .       .|| | .   .|..  .|.|| |..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

VWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELAN--------EFT
..|... |  |.      ..  ...|          . ..   . ||.  | . |||  |. .        .. 
LYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ErbB3.AA Pkinase 709-965 19 4.1e-25 89.88 Pfam 1-293 (293) Show / Hide 
Range on Protein: 709-965
Range on HMM: 1-293/293
Sequence Identity: 19% (60 aa)

LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTD----HMLAIGSLDHAHIVRLLGLC-PGSSLQLVTQYLPLG----SLLDHV
.......||| ||.| |.... .|.     |..|.|. . .. | . .|.          .|.| .||||.. .  .... .|. |.. |    .| |..
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

R-QHRGAL--GPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQV----QVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIH-FGKYTHQ
. . .|..   .. . ..  ||..|..|. ..| .|| |   |.|...  ..     ..|||.| ..    ..  ..     . .|| | |    .|.. 
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDVWSYGVTVWELMTFGAEPYAGL----RLAEVPDLLEKGER----LAQPQICT-------------------IDVYMVMVKCWMIDENIRPTFKELANE
.|.||.|....|... |  |. |     . ..   ....  .       |. |.                    .   .. .|.  | . |||.... . 
VDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--F
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PWF