Gene EphB3 (Human)

EphB3

Species: Human
Alias: ETK2, EphB3, HEK2, TYRO6, EPHB3
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 3q27,

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphB3.NA RNA Sugen Kinome 4234 None Fasta, JSON
EphB3.AA Protein Sugen Kinome 998 None Fasta, JSON
EphB3.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON

Protein domain

Protein domains of EphB3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphB3.AA Ephrin_lbd 39-212 62 1e-136 426.21 Pfam 1-190 (190) Show / Hide 
Range on Protein: 39-212
Range on HMM: 1-190/190
Sequence Identity: 62% (119 aa)

EETLMDTKWVTSELAWTSHPESG---------WEEVSGYDEAMNPIRTYQVC-NVRESSQNNWLRTGFIWRRDVQRVYVELKFTVRDCNSIPNIPGSCKE
|..|||||..||.| ||..| .|         ||||||.|| ..|||||||| ||.|..|||||||..|.||. ||.|||||||.|||||.|. .|.|||
EVVLMDTKTATSDLGWTTYPYNGRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCKE

TFNLFYYEADS-DVASASSPFWMENPYVKVDTIAPDES-FSRLDAG----RVNTKVRSFGPLSKAGFYLAFQDQGACMSLISVRAFYKKC
||||.|||.|. | |....|.||||.|.|.||||.||| |...| |    ..||.|||.|||||.|||||||||||||.|.||| .||||
TFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphB3.AA EPH_lbd 39-212 68 3.9e-128 432.9 SMART 1-184 (184) Show / Hide 
Range on Protein: 39-212
Range on HMM: 1-184/184
Sequence Identity: 68% (126 aa)

EETLMDTKWVTSELAWTSHPESG--WEEVSGYDEAMNPIRTYQVCNVRE---SSQNNWLRTGFIWRRDVQRVYVELKFTVRDCNSIPNIPG-SCKETFNL
|..|||||..|.|| ||..|..|  ||||||.|| .|||||||||||.|   ..|||||||..|.||..||.|||||||.|||||.|. .| ||||||||
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL

FYYEADSDVASASSPFWMENPYVKVDTIAPDESFSRLDAG----RVNTKVRSFGPLSKAGFYLAFQDQGACMSLISVRAFYKKC
.|||.|.|.|.|..||||||||.|.||||.||||.. | |    ..||.|||||||||.|||||||||||||.|.||| |||||
YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 EphB3.AA GCC2_GCC3 274-316 34 9.9e-07 24.86 Pfam 1-44 (49) Show / Hide 
Range on Protein: 274-316
Range on HMM: 1-44/49
Sequence Identity: 34% (15 aa)

GHEPAAKESQCRPCPPGSYKAKQGEGPCLPCPPN-SRTTSPAAS
|.   .  . | ||| |.|. . | . |.||||. . | .|...
GTYYNKGQNPCEPCPRGTYQNEEGQDSCIPCPPGKTTTDYPGST
FN3 EphB3.AA FN3 340-435 18 8.3e-11 43.15 SMART 1-69 (69) Show / Hide 
Range on Protein: 340-435
Range on HMM: 1-69/69
Sequence Identity: 18% (20 aa)

PSPPRG----VISNVNET------SLILEWSEPRDLGGRDDLLYNVICKKCHGAGGASACSRCDDNVEFVPRQLGLTERRVHISHLLAH----TRYTFEV
|.||..    ....|..|      |. |.|..|                                 |...          . ...| ..    |.|.| |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------------------------------IVGYR----------YTVTGLKPGQYPWTEYEFRV

QAVNG-VSGKS
.||||   | .
RAVNGNDAGEG
FN3 EphB3.AA FN3 453-532 24 2.8e-14 54.69 SMART 1-69 (69) Show / Hide 
Range on Protein: 453-532
Range on HMM: 1-69/69
Sequence Identity: 24% (23 aa)

PSEVPT---LRLHSSSGS------SLTLSWAPPERPNGVILDYEMKYFEKSEGIASTVTSQMNSVQLDGLRPD----ARYVVQVRARTV--AGYG
|. .|    ||... . .      |.|||| ||      |. |.                    . ..||.|.     .|...|||..   ||.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR--------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphB3.AA Eph 633-892 85 2.2e-223 748.39 In-house 1-264 (264) Show / Hide 
Range on Protein: 633-892
Range on HMM: 1-264/264
Sequence Identity: 85% (226 aa)

VKIEEVIGAGEFGEVCRGRLKQP-GRREV---FVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDG
.|||.|||||||||||.|||| | |.|||   .|||||||.||||.||.||||||||||||||||||||||||||||||||.||.|||..|||||| .||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

QFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPS-DPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIV
|||||||||||||||.||||||.||||||||||||||||||||||||||||||.|||||| ..|||.. |||||||||||||||||||||||||||||||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTR-GGKIPIRWTAPEAIAYRKFTSASDVWSYGIV

MWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTL
|||||||||||||||||||||.|.||.||||||||||.|||||||||| .||| ||.|.|||..|
MWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphB3.AA Pkinase_Tyr 633-892 43 2.1e-144 489.7 Pfam 1-270 (270) Show / Hide 
Range on Protein: 633-892
Range on HMM: 1-270/270
Sequence Identity: 43% (120 aa)

VKIEEVIGAGEFGEVCRGRLK-QPGRREVFVAIKTLKVGYTERQ--RRDFLSEASIMGQF-DHPNIIRLEGVVT-KSRP--VMILTEFMENCALDSFLRL
... ...|.|.||||..|..| .|.  .. ||.|.|| |....|  |.||..||.|| |. .||||.|| ||.| ...|  ..| .|.|..  |...|| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---DGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTY-TSSLGGKIPIRWTAPEAIAYRKFTSASDV
.   ....|. .|..| . ||.|| ||...|..||||||||.||..|.|.|..||||.| .    .| .| ... |||.||.|.|||.|.|.|||..|||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSYGIVMWEVMSYGERP-YWDMSNQDVINAV-EQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTL
||.|..|||...||| | |..|||..|.... |. ||.|.|..||  ...||..||  | . || ||.|.. |
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphB3.AA TyrKc 633-892 41 2.9e-137 463.24 SMART 1-280 (280) Show / Hide 
Range on Protein: 633-892
Range on HMM: 1-280/280
Sequence Identity: 41% (120 aa)

VKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQF--DHPNIIRLEGVVTKS-------RPVMILTEFMENCALDSFL
.. ....| |.||||..|..|      . ||.|.|| .     |.||..||.|| ..  .||||.|| ||.|..        |.||..|.|.. .|...|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDD----PSDPTYTSSL--GGK--IPIRWTAPEAIAYRKF
| . ..... .|. .   ||.|| ||...|..||||||||.||..|...|.|||||||...||     |. .|...   |||  .||||.|||.| |.||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TSASDVWSYGIVMWEVMSYGERPYWD-----MSNQDVINAVEQDYRLPPPMD--------CPTALHQLMLDCWVRDRNLRPKFSQIVNTL
|..|||||.|..|||...||. ||..     ||||.||. |.| ||.|.| .        ||....|.|..|| .| . || ||.|.  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphB3.AA TK 633-892 25 3.4e-124 418.5 In-house 1-486 (486) Show / Hide 
Range on Protein: 633-892
Range on HMM: 1-486/486
Sequence Identity: 25% (124 aa)

VKIEEVIGAGEFG---EVCRGRLKQ--PGRREVF--------------------VAIKTLKVGYTERQRR-------------DFLSEASIMGQFD----
.......|.|.||   ||..|....  |.. ..|                    ||.|.|| | .. |..             |||.||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIIRLEGVVTKS------------RPVMILTEFMENCA----LDSFLRLNDG---------------------------------------------
 ||||.|| ||.|..            .|.||..|.|..      |...|| ...                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QFTVIQLVGMLRGIAAGMKYLSEM------NYVHRDLAARNILVNSNLV-----------CKVSDFGLSR
                              |.|. ||. | . ||.|| ||...      |.|||||||||.||..|.|           ||..||||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----FLEDDPSDPTYTSSL------------------------GGKIPIRWTAPEAIA---------YRKFTSASDVWSYGIVMWEVMSYG-ERPYWDM
        |..||  |...                         |||.||||.|||...         |.|||..|||||.|..|||...|| | .|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------QDVINAVEQD--------------YRLPPPMDCP--------------TALHQLMLDCWVRDRNLRPKFSQIVNTL
||         |.|.. ...               .|.|.|..||              .....||..|| .| . || |||... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphB3.AA UTK 633-892 37 1.9e-111 376.53 In-house 1-296 (296) Show / Hide 
Range on Protein: 633-892
Range on HMM: 1-296/296
Sequence Identity: 37% (112 aa)

VKIEEVIGAGEFGEVCRGRLKQPG--RREVFVAIKTLKVGYT-ERQRR---DFLSEAS---IMGQFD-HPNIIRLEGVVTKSRPVMILTEFMENCALDSF
|.. . .|.|.||||...|..|.   . |. ||.|..... . .....   ||. ||    .|.||. |||..|| ||.|.. | ||.||.|||  |.|.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR---L----NDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSN-------LVCKVSDFG---LSRFLED------DPSDPTYTSSLGGK
||        .. ..|  |...| . ||.|| ||.....|||||||||.||...       .|||..|||   .|| . .      . ... |...  ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIRWTAPEAIAYR-KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQD--YRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTL
.||||.||||.... .||..|||||.|.|.||....| .|| .|||..|. .|.    ||.|.| ||| .. .||..||  |   || | ..| ..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphB3.AA Src 633-892 42 2.6e-105 356.17 In-house 1-255 (255) Show / Hide 
Range on Protein: 633-892
Range on HMM: 1-255/255
Sequence Identity: 42% (113 aa)

VKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLR-LNDGQ-F
.| .. .|.| ||||  |  ..    .. ||.|||| |    .  .|| || || ...|.....|  |...  |. | ||.|..  |  .|.   .|.  
IKLCRKLGQGQFGEVWMGYWNG----NTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

TVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWE
 . ||. |   .|.||.||..|||.||||||||.||. |.|||| |||| | ...|  |  |... | |.||.||||||| |..||  |||||.|| ..|
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED--DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

VMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQ-LMLDCWVRDRNLRPKFSQIVNTL
...||  ||  |.|..|. .||. ||.| |. ||  |.. .|| || .|   || |  . . |
IVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphB3.AA SFK-Src 633-896 41 2.8e-99 294.9 In-house 1-259 (259) Show / Hide 
Range on Protein: 633-896
Range on HMM: 1-259/259
Sequence Identity: 41% (111 aa)

VKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRL-NDGQFT
.. |.  |.| ||.| .||  .       ||.|||| | .  .   ||.|| .| .  ||| |.|  | |   |. | || | .  |  .|.  .    .
IRLEKKLGSGQFGDVWKGRWNN----TTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

VIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEV
. ||| |   .|.|| || . |.|||||||||.||  | |||| |||.|| |..|  |  ||   | | ||.||||||  . .|   |||||.|| | |.
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQD--DEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEI

MSYGERPYWDMSNQDVINAVEQ--DYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLI
  ||  ||  |.|. |.  |..   ||.| |  || .....|.|||      || |      ..   
VTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphB3.AA Fer 633-893 33 7.5e-98 331.38 In-house 1-283 (283) Show / Hide 
Range on Protein: 633-893
Range on HMM: 1-283/283
Sequence Identity: 33% (95 aa)

VKIEEVIGAGEFGEVCRGR--LKQPGRREVFV---AIKTLKV---GYTERQRRDFLSEASIMGQ-FDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFL
|......| | ||||..||  ||    . ..|   |.|. |.   . |. |...|. || || . .||||.... || .   |.||. ||. . .|||.|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RLNDGQ-FTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNS-NLVCK--VSDFGLSRFLEDDPSDPTYTSSLG---GKIPIRWTAPEAIAYRKFT
. |...  .. ... |. ..|.||.|| ..| .|||.||||.|.   ....|  .||||.|| ..|.    .|.....    |.||||.|||.. .. ..
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDY----GYDYKMKEKACKVPIRWLAPETWQTGIYS

SASDVWSYGIVMWEVMSYGERPYWD----MSNQDV----INAVEQ-DYRLPPPMDCPTALHQLML-DCWVRDRNLRPKFSQIVNTLD
...||||.|...||... |. || .    | .  |    . .... .|..|.|  .|... |.|. .||..| . ||....|...| 
PKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphB3.AA TK-Unique 633-892 33 4.2e-88 299.0 In-house 1-294 (294) Show / Hide 
Range on Protein: 633-892
Range on HMM: 1-294/294
Sequence Identity: 33% (99 aa)

VKIEEVIGAGEFGEVCRGRLKQPG---RREVFVAIKTLKVGYTERQRRDFLSEASIMGQFD-HPNIIRLEGVVTKSR-PVMILTEFMENCALDSFLRLND
.....||| |.||.|.|| ....     . . ||.|.|| . |. ...|||.|...| . . ||||....|. |||  |.||. |....  |...|| . 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-GQFTV---------------------IQ---LVGMLRGIAAGMKYLSE--MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLG-GK
 .....                     |.   |.  . .|| ||.||..  .. |||||.|||.|.....|||..|||..| ...   .  | .. . |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT---NGVYSMMCSQGR

IPIRWTAPEAIA--YRKF-TSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDC-PTALHQLMLDCWVRDRNLRPKFSQIVNTL
||||| |||..   .. . |. |||||.|..|||....|..|| .|.. |....... ||.| |  | . ....||  || ...  || |.||.. |
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphB3.AA Frk 633-896 42 8.4e-87 294.69 In-house 1-260 (260) Show / Hide 
Range on Protein: 633-896
Range on HMM: 1-260/260
Sequence Identity: 42% (114 aa)

VKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLR---LNDGQ
...   .|.| ||||  |.  .    .. ||.|||| |  . .  ||| || || .  || .|.|  | |   |..|.|| |.. .|  .|.    .  |
IQLIRRLGSGQFGEVWEGLWNN----TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

FTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMW
  . ||| |   .|||| || ..||.||||||||.||. ...||. |||| | |  |  |  | |  | ..||.||||||. | |||  |||||.||.. 
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNED-IYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLT

EVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLI
|.. ||  ||  | |..|.. |...||.| | .||  | ..||.||  | . || |  .   |.. .
EIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphB3.AA Tec 633-894 38 2.1e-84 286.73 In-house 1-254 (254) Show / Hide 
Range on Protein: 633-894
Range on HMM: 1-254/254
Sequence Identity: 38% (103 aa)

VKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVG-YTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFT
 .. . .| | || | .|....    . .||||..| |   |    ||. || .|    ||. ..| || .. ||. | ||.||.  | ..|| . ..| 
LTFMKELGSGQFGVVHLGKWRH----QYDVAIKMIKEGSMSE---EDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQ

VIQ--LVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMW
  .  | .|   .  || || . ...|||||||| ||... | ||||||..|.  ||     |||| | | |..| .||   | .. | ||||..|. ||
KNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDD----QYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMW

EVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDK
|| | |  ||  ||| .|. .| | .||  |  |.. . | | .||      || |.|   .. .
EVFSCGKMPYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase EphB3.AA SrcB 633-893 42 5.3e-82 277.18 In-house 1-251 (251) Show / Hide 
Range on Protein: 633-893
Range on HMM: 1-251/251
Sequence Identity: 42% (112 aa)

VKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDG-QFT
.|... .||| ||||  |  ..    .. ||.||.| |    .   || || .| .  |  ..||  ||||  |. |.||.|.. .|  ||. ..| . .
LKLVKKLGAGQFGEVWMGYYNN----HMKVAVKTMKQGTMSPEA--FLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLS

VIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEV
. .|. |   || || |. .|||.|||| | ||||   |.||. |||| | .||.     ||   | | ||.||||||| .  ||  |||||.||.. |.
LPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDN----EYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEI

MSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLD
. ||  ||  |.| .||...|. ||.| |  ||  | ..|  ||      || |  .   ||
VTYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase EphB3.AA S_TKc 633-896 20 1.6e-45 158.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 633-896
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)

VKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMEN--CALDSFLRLNDGQ-
 .| ..|| | ||.|...| |        |||| .|        .....| .|. . .||||..| .|      . . .|....    | .... . .. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTS-ASDVWSY
    |.  .   ... |. ...|. ... .||||   |||...  . |..||||.|.|                    . ||| .   ...  ..|.|| 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVN-----TLDKLI
|....| .. |. |..    | ... .            .  . ...  |...| . ||   .. .      ..  .
GCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphB3.AA Pkinase 633-892 21 3.2e-42 150.38 Pfam 1-293 (293) Show / Hide 
Range on Protein: 633-892
Range on HMM: 1-293/293
Sequence Identity: 21% (66 aa)

VKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTER--QRRDFL-SEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENC----ALDSFLR-
 .|...||.| ||.|.... |  |.    ||.|..|.  ..   ...... ||..||  ..||||.|| .... .. . . .|..|.      | .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

LNDGQF--TVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVC----KVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIA-YRKFTS
 ..| |  .  ..  ... |. |..|. .|. .||||   |||...| ..    |..||||.....       ..   .    ... ||| |  ... ..
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

ASDVWSYGIVMWEVMSYGERPYWDM----SNQDVINAVEQDYRLPPPMDCP-----------------------TALHQLMLDCWVRDRNLRPKFSQIVN
..|.||.|....|... |. |...     .  | .  .... . |.. |.|                        .. ... .|. .| . || . ||..
KVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

T--L
   .
HPWF
SAM_1 EphB3.AA SAM_1 923-987 46 8e-33 119.2 Pfam 1-66 (66) Show / Hide 
Range on Protein: 923-987
Range on HMM: 1-66/66
Sequence Identity: 46% (31 aa)

DYTTFTTVGDWLDAIKMGRYKESFVSAGFASFDLVAQMTAEDLLR-IGVTLAGHQKKILSSIQDMR
||..| .|..||..|.|..|...|..||. ..|...|||.|||.. .||||.||.|||..|||...
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
SAM_2 EphB3.AA SAM_2 922-987 40 7.9e-28 98.34 Pfam 1-71 (71) Show / Hide 
Range on Protein: 922-987
Range on HMM: 1-71/71
Sequence Identity: 40% (29 aa)

PDYTTFTTVGDWLDAIKM-GRYKESFVSAGFASFDLV-AQMTAEDL--L-RIGVTLAGHQKKILSSIQDMR
..|.|| .|..||..|.| ..||..| ..|. .|... |.||..||    |.|.|..||.|||...||.|.
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
SAM EphB3.AA SAM 922-989 41 4.8e-27 97.08 SMART 1-67 (67) Show / Hide 
Range on Protein: 922-989
Range on HMM: 1-67/67
Sequence Identity: 41% (28 aa)

PDYTTFTTVGDWLDAIKMGRYKESFVSAGFASFDLVAQMTAEDLLRIGVTLAGHQKKILSSIQDMRLQ
.|  |. .|.|||..|.|..||. | ..|. ...|..... |||...|.|..||.||||..||.|. |
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
Sam7 EphB3.AA sam7 925-987 38 1.7e-25 88.45 In-house 1-70 (70) Show / Hide 
Range on Protein: 925-987
Range on HMM: 1-70/70
Sequence Identity: 38% (27 aa)

TTFTTVGDWLDAIKM---GRYKESFVSAGF----ASFDLVAQMTAEDLLRIGVTLAGHQKKILSSIQDMR
.|| .|..||..|.|   ..|...| ..|.     ..|....|| |||...|.|. ||.|||...||.||
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR