Gene EphB2 (Human)

EphB2

Species: Human
Alias: EphB2, EPHB2, Hek5, MGC87492, DRT, PCBC, EPHT3, Tyro5, ERK, CAPB, HEK5
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 1p36.1,

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphB2.NA RNA Sugen Kinome 4866 None Fasta, JSON
EphB2.AA Protein Sugen Kinome 986 None Fasta, JSON
EphB2.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON

Protein domain

Protein domains of EphB2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphB2.AA Ephrin_lbd 20-197 63 1e-144 451.14 Pfam 1-190 (190) Show / Hide 
Range on Protein: 20-197
Range on HMM: 1-190/190
Sequence Identity: 63% (120 aa)

EETLMDSTTATAELGWMVHPPSG---------WEEVSGYDENMNTIRTYQVC-NVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKE
|..|||..|||..|||. .|..|         ||||||.|||...||||||| ||.|..|||||||..|.||||.||.||.||..|||.|.| |.|.|||
EVVLMDTKTATSDLGWTTYPYNGRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCKE

TFNLYYYEADF-DSATKTFPNWMENPWVKVDTIAADES-FSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKC
||||||||.|  | |.|..||||||...|.|||||||| |.|.|.|.|.||.||||||.||.|. ||||||||.|.||.|..|||.|.||
TFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphB2.AA EPH_lbd 20-197 67 4.6e-132 445.95 SMART 1-184 (184) Show / Hide 
Range on Protein: 20-197
Range on HMM: 1-184/184
Sequence Identity: 67% (125 aa)

EETLMDSTTATAELGWMVHPPSG--WEEVSGYDENMNTIRTYQVCNVFE---SSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPG-SCKETFNL
|..|||..|.|.||||. .||.|  ||||||.||..|.|||||||||.|   ..|||||||..|.||||.||.||.||..|||.|.| |.| ||||||||
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL

YYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKC
||||.| | ||...| |||||..|.|||||||||.|.|.|.||||.|||||||||.|. ||||||||.| ||.|..|||||.||
YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 EphB2.AA GCC2_GCC3 259-302 28 2e-08 30.37 Pfam 1-45 (49) Show / Hide 
Range on Protein: 259-302
Range on HMM: 1-45/49
Sequence Identity: 28% (13 aa)

GFEAVENGTVCRGCPSGTFKANQGDEACTHCPIN-SRTTSEGATN
|     ..  |  || ||.. . |  .| .|| . . | ..|.|.
GTYYNKGQNPCEPCPRGTYQNEEGQDSCIPCPPGKTTTDYPGSTS
FN3 EphB2.AA FN3 325-417 17 9.4e-09 36.33 SMART 1-69 (69) Show / Hide 
Range on Protein: 325-417
Range on HMM: 1-69/69
Sequence Identity: 17% (19 aa)

PSAPQA----VISSVNET------SLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAH----TQYTFEIQA
|..|.     ....|..|      |. |.|.||                               |.|             ...| ..    |.|.| ..|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------------------------------IVGYR----------YTVTGLKPGQYPWTEYEFRVRA

VNG--VTDQ
|||  .   
VNGNDAGEG
FN3 EphB2.AA FN3 436-517 24 7.4e-13 49.96 SMART 1-69 (69) Show / Hide 
Range on Protein: 436-517
Range on HMM: 1-69/69
Sequence Identity: 24% (24 aa)

PSAVSI---MHQVSRTVD------SITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAG----AIYVFQVRARTV--AGYG
|....     . .. | .      |.||||. |      |. |.                      .|| |||.|      |.|.|||..   ||.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphB2.AA Eph 621-880 86 8.60000000001e-226 756.4 In-house 1-264 (264) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-264/264
Sequence Identity: 86% (228 aa)

VKIEQVIGAGEFGEVCSGHLKLP-GKREI---FVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDG
.|||.|||||||||||.|.|||| ||||.   .|||||||.|||||||.||||||||||||||||.|.|||||||| ||||.||.||||||||||||.||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

QFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTS-DPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIV
|||||||||||||||.|||||.|||||||||||||||||||||||||||||||.||||.| ..|||.. ||||||||||||||.||||||||||||||||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTR-GGKIPIRWTAPEAIAYRKFTSASDVWSYGIV

MWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTL
|||||||||||||||.|||||.||||.||||||||||.||||||||||||||||||.| |||..|
MWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphB2.AA Pkinase_Tyr 621-880 43 4.4e-150 508.91 Pfam 1-270 (270) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-270/270
Sequence Identity: 43% (119 aa)

VKIEQVIGAGEFGEVCSGHLK-LPGKREIFVAIKTLKSGYTEKQ--RRDFLSEASIMGQF-DHPNVIHLEGVVT-KSTP--VMIITEFMENGSLDSFLRQ
... ...|.|.||||. |..| .|.. .| ||.|.|| |....|  |.||..||.|| |. .|||.. | ||.| .. |  ..|..|.|..|.|...||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTY-TSALGGKIPIRWTAPEAIQYRKFTSASDV
.   ....|. .|..| . ||.|| ||...|..||||||||.||..|.|.|..||||.| .   ..| .| ... |||.||.|.|||.|.|.|||..|||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSYGIVMWEVMSYGERP-YWDMTNQDVINAI-EQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTL
||.|..|||...||| | |..|.|..|...| |. ||.|.|..||  ...||..||..| ..|| | .|.. |
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphB2.AA TyrKc 621-880 40 4.2e-141 475.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-280/280
Sequence Identity: 40% (117 aa)

VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQF--DHPNVIHLEGVVTKS-------TPVMIITEFMENGSLDSFL
.. ....| |.||||. |..|      | ||.|.||..     |.||..||.|| ..  .|||.. | ||.|..        |.||..|.|..|.|...|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDD----TSDPTYTSAL--GGK--IPIRWTAPEAIQYRKF
| . ..... .|. .   ||.|| ||...|..||||||||.||..|...|.|||||||...||     |. .|...   |||  .||||.|||.|.|.||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TSASDVWSYGIVMWEVMSYGERPYWD-----MTNQDVINAIEQDYRLPPPMD--------CPSALHQLMLDCWQKDRNHRPKFGQIVNTL
|..|||||.|..|||...||. ||..     |.||.||. ..| ||.|.| .        ||....|.|..||. | . || | .|.  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphB2.AA TK 621-880 24 1.5e-126 426.54 In-house 1-486 (486) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-486/486
Sequence Identity: 24% (119 aa)

VKIEQVIGAGEFG---EVCSGHLKLPG----------------------KREIFVAIKTLKSGYTEKQRR-------------DFLSEASIMGQFD----
.......|.|.||   ||. | .. ..                      . .. ||.|.||.| .. |..             |||.||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVIHLEGVVTKS------------TPVMIITEFMENGS----LDSFLRQNDG---------------------------------------------
 |||...| ||.|..             |.||..|.|..|.    |...||....                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QFTVIQLVGMLRGIAAGMKYLADM------NYVHRDLAARNILVNSNLV-----------CKVSDFGLSR
                              |.|. ||. | . ||.|| ||...      |.|||||||||.||..|.|           ||..||||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----FLEDDTSDPTYTSAL------------------------GGKIPIRWTAPEAIQ---------YRKFTSASDVWSYGIVMWEVMSYG-ERPYWDM
        |. ||  |...                         |||.||||.|||...         |.|||..|||||.|..|||...|| | .|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------QDVINAIEQD--------------YRLPPPMDCP--------------SALHQLMLDCWQKDRNHRPKFGQIVNTL
.|         |.|.. ...               .|.|.|..||               ....||..||..| ..|| | |... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphB2.AA UTK 621-880 36 8.60000000001e-110 371.05 In-house 1-296 (296) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-296/296
Sequence Identity: 36% (109 aa)

VKIEQVIGAGEFGEVCSGHLKLPG--KREIFVAIKTLK-SGYTEKQRR---DFLSEAS---IMGQFD-HPNVIHLEGVVTKSTPVMIITEFMENGSLDSF
|.. . .|.|.||||. .... .     |  ||.|... .. ......   ||. ||    .|.||. ||||. | ||.|.. | ||.||.||||.|.|.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR-------QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSN-------LVCKVSDFG---LSRFLED------DTSDPTYTSALGGK
||       ... ..|  |...| . ||.|| ||. ...|||||||||.||...       .|||..|||   .|| . .      . ... |...  ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIRWTAPEAIQYR-KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQD--YRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTL
.||||.||||. .. .||..|||||.|.|.||....| .|| .|.|..|. ...    ||.|.| ||| .. .||..||..|   || | ..| ..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphB2.AA Src 621-880 44 7.2e-109 367.99 In-house 1-255 (255) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-255/255
Sequence Identity: 44% (116 aa)

VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR-QNDGQ-F
.| .. .|.| ||||  |      . .. ||.||||.|    .  .|| || || ...|.....|  |...  |. |.||.|..|||  .|. . .|.  
IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

TVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWE
 . ||. |   .|.||.||  |||.||||||||.||. |.|||| |||| | ...|  |  |..  | |.||.|||||||.|..||  |||||.|| ..|
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED--DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

VMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQ-LMLDCWQKDRNHRPKFGQIVNTL
...||  ||  |||..|. ..|. ||.| |. ||  |.. .|| ||.||   || |  . . |
IVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphB2.AA SFK-Src 621-884 42 1.8e-105 313.57 In-house 1-259 (259) Show / Hide 
Range on Protein: 621-884
Range on HMM: 1-259/259
Sequence Identity: 42% (114 aa)

VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQ-NDGQFT
.. |.  |.| ||.|  |           ||.||||.| .  .   ||.|| .| .  ||| | |  | |   |. |||| | .|||  .|.. .    .
IRLEKKLGSGQFGDVWKGRW----NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

VIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEV
. ||| |   .|.|| || . |.|||||||||.||  | |||| |||.|| |..|  |  ||   | | ||.|||||| .. .|   |||||.|| | |.
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQD--DEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEI

MSYGERPYWDMTNQDVINAIEQ--DYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMI
  ||  ||  |||. |.  ...   ||.| |  || .....|.||||.    || |.     ..   
VTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphB2.AA Fer 621-881 35 1.5e-99 337.06 In-house 1-283 (283) Show / Hide 
Range on Protein: 621-881
Range on HMM: 1-283/283
Sequence Identity: 35% (102 aa)

VKIEQVIGAGEFGEVCSG--HLKLPGKREIFV---AIKTLKS---GYTEKQRRDFLSEASIMGQ-FDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL
|... ..| | ||||..|   ||.  .. ..|   |.|. |    . |..|...|. || || . .|||||. . || .   |.||. ||. .|||||.|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RQNDGQ-FTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNS-NLVCK--VSDFGLSRFLEDDTSDPTYTSA-LGGKIPIRWTAPEAIQYRKFTSA
. |...  .. ... |. ..|.||.||  .| .|||.||||.|.   ....|  .||||.|| ..|...|  |. .    |.||||.|||..|.. ....
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYD--YKMKEKACKVPIRWLAPETWQTGIYSPK

SDVWSYGIVMWEVMSYGERPYWD----MTNQDV----INAIEQ-DYRLPPPMDCPSALHQLML-DCWQKDRNHRPKFGQIVNTLD
.||||.|...||... |. || .    |..  |    . .|.. .|..|.|  .|... |.|. .||||| . ||.. .|...| 
TDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphB2.AA TK-Unique 621-880 34 9.7e-94 317.73 In-house 1-294 (294) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-294/294
Sequence Identity: 34% (102 aa)

VKIEQVIGAGEFGEVCSGHLKLPG---KREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFD-HPNVIHLEGVVTKST-PVMIITEFMENGSLDSFLRQND
.....||| |.||.|. | .. .     . . ||.|.|| . |. ...|||.|...| . . |||.....|. |||. |.||| |....|.|...||.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-GQFTV---------------------IQ---LVGMLRGIAAGMKYLAD--MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALG-GK
 .....                     |.   |.  . .|| ||.|||   .. |||||.|||.|.....|||..|||..| ...   .  | .  . |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT---NGVYSMMCSQGR

IPIRWTAPEAIQ--YRKF-TSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDC-PSALHQLMLDCWQKDRNHRPKFGQIVNTL
||||| |||...  .. . |. |||||.|..|||....|..|| .| . |....|.. ||.| |  | . ....||  |||... .|| | ||.. |
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphB2.AA Frk 621-884 43 2.6e-91 309.65 In-house 1-260 (260) Show / Hide 
Range on Protein: 621-884
Range on HMM: 1-260/260
Sequence Identity: 43% (117 aa)

VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR---QNDGQ
... . .|.| ||||  |        .. ||.||||.|  . .  ||| || || .  || .|.|  | |   |..|||| |..|||  .|.   ..  |
IQLIRRLGSGQFGEVWEGLWNN----TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

FTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMW
  . ||| |   .|||| || ..||.||||||||.||. ...||. |||| | |  |  |  | |  | ..||.||||||..| |||  |||||.||.. 
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNED-IYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLT

EVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMI
|.. ||  ||  |||..|.. ....||.| | .||  | ..||.||..| ..|| |  .   |.. .
EIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphB2.AA Tec 621-882 37 2e-86 293.45 In-house 1-254 (254) Show / Hide 
Range on Protein: 621-882
Range on HMM: 1-254/254
Sequence Identity: 37% (100 aa)

VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSG-YTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFT
 .. . .| | || |  | ..     ...||||..| |   |    ||. || .|    ||. . | || ..  |. |.||.||.|.| ..||.. ..| 
LTFMKELGSGQFGVVHLGKWRH----QYDVAIKMIKEGSMSEE---DFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQ

VIQ--LVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMW
  .  | .|   .  || ||   ...|||||||| ||... | ||||||..|.  ||     |||  | | |..| .||  .| .. | ||||..|. ||
KNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDD----QYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMW

EVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDK
|| | |  ||  |.| .|. .. | .||  |  |.  . | | .||.     || | |   .. .
EVFSCGKMPYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase EphB2.AA SrcB 621-881 43 2.7e-85 288.51 In-house 1-251 (251) Show / Hide 
Range on Protein: 621-881
Range on HMM: 1-251/251
Sequence Identity: 43% (114 aa)

VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDG-QFT
.|... .||| ||||  |      .... ||.||.| |    .   || || .| .  |  ...|  ||||  |. ||||.|..|.|  ||. ..| . .
LKLVKKLGAGQFGEVWMGYY----NNHMKVAVKTMKQGTMSPEA--FLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLS

VIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEV
. .|. |   || || |.  |||.|||| | ||||   |.||. |||| | .||.     ||   | | ||.|||||||..  ||  |||||.||.. |.
LPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDN----EYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEI

MSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLD
. ||  ||  ||| .||...|. ||.| |  ||  | ..|  ||..    || |  .   ||
VTYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase EphB2.AA S_TKc 621-884 20 2.6e-51 177.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 621-884
Range on HMM: 1-231/231
Sequence Identity: 20% (58 aa)

VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMEN--GSLDSFLRQNDGQ-
 .| ..|| | ||.|. .. |        |||| .|        .....| .|. . .|||...| .|    . . ...|....  |.| ...... .. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTS-ASDVWSY
    |.  .   ... |. ...|. ... .||||   |||...  . |..||||.|.|                    . ||| .   ...  ..|.|| 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVN-----TLDKMI
|....| .. |. |..  . | ... |            .. . ...  |.||| ..||   .. .      ..  .
GCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphB2.AA Pkinase 621-880 22 1.5e-47 169.12 Pfam 1-293 (293) Show / Hide 
Range on Protein: 621-880
Range on HMM: 1-293/293
Sequence Identity: 22% (69 aa)

VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEK--QRRDFL-SEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENG----SLDSFLR-
 .|...||.| ||.|. .| |  ||    ||.|..|   ...  ...... ||..||  ..|||.. | .... .. . ...|..|.|    .| .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

QNDGQF--TVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVC----KVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQ-YRKFTS
...| |  .  ..  ... |. |..|. .|. .||||   |||...| ..    |..||||.....       .. . .    ... ||| |. ... ..
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

ASDVWSYGIVMWEVMSYGERPYWDM----TNQDVINAIEQDYRLPPPMDCP-----------------------SALHQLMLDCWQKDRNHRPKFGQIVN
..|.||.|....|... |. |...     .  | .  |... . |.. |.|                       ... ... .|..|| . || . ||..
KVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

T--L
   .
HPWF
SAM_1 EphB2.AA SAM_1 911-975 48 7.8e-31 112.16 Pfam 1-66 (66) Show / Hide 
Range on Protein: 911-975
Range on HMM: 1-66/66
Sequence Identity: 48% (32 aa)

DYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILR-VGVTLAGHQKKILNSIQVMR
||..|..|.||||.|.|.||...|. ||....| ..|| .||... .||||.||.|||..||| ..
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
SAM EphB2.AA SAM 910-977 38 4.5e-26 93.87 SMART 1-67 (67) Show / Hide 
Range on Protein: 910-977
Range on HMM: 1-67/67
Sequence Identity: 38% (26 aa)

PDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQ
.|  ....| .|||.|.|.|||. |. .|..... .... .||....|.|..||.||||..|| |..|
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
SAM_2 EphB2.AA SAM_2 910-975 40 6.8e-25 88.27 Pfam 1-71 (71) Show / Hide 
Range on Protein: 910-975
Range on HMM: 1-71/71
Sequence Identity: 40% (29 aa)

PDYTSFNTVDEWLEAIKM-GQYKESFANAGFTSFDVV-SQMMMEDI--L-RVGVTLAGHQKKILNSIQVMR
..|..|..| |||..|.| .|||..|  .|.|.|...  .| ..|     | |.|..||.|||.|.|| |.
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
Sam7 EphB2.AA sam7 913-975 41 4.2e-24 83.49 In-house 1-70 (70) Show / Hide 
Range on Protein: 913-975
Range on HMM: 1-70/70
Sequence Identity: 41% (29 aa)

TSFNTVDEWLEAIKM---GQYKESFANAGF----TSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMR
..|..| ||||.|.|   .||...| ..|.    |..|.. .| .||... |.|. ||.|||.|.|| ||
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR