Gene EphA4 (Human)

EphA4

Species: Human
Alias: HEK8, SEK, EphA4, TYRO1, EPHA4
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 2q35-q37,

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphA4.NA RNA Sugen Kinome 6364 None Fasta, JSON
EphA4.AA Protein Sugen Kinome 986 None Fasta, JSON
EphA4.kin_dom Protein Kinase Domain Sugen Kinome 257 None Fasta, JSON

Protein domain

Protein domains of EphA4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphA4.AA Ephrin_lbd 30-204 65 1.1e-145 454.12 Pfam 1-190 (190) Show / Hide 
Range on Protein: 30-204
Range on HMM: 1-190/190
Sequence Identity: 65% (126 aa)

EVTLLDSRSVQGELGWIASPLEGG---------WEEVSIMDEKNTPIRTYQVC-NVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCK
||.|.|.......|||...| . |         ||||| |||...|||||||| |||||.|||||||.|| |.||||.|.|.|||.|||||.|||.||||
EVVLMDTKTATSDLGWTTYPYN-GRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCK

ETFNLYYYESDN--DKE---RFIRENQFVKIDTIAADES-FTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKC
|||||||||||.  | .   ....|||..|||||||||| |||.|.|.|.||||||.|..|||||.||||||||.|||.|||||||.||||
ETFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphA4.AA EPH_lbd 30-204 70 1.6e-132 447.44 SMART 1-184 (184) Show / Hide 
Range on Protein: 30-204
Range on HMM: 1-184/184
Sequence Identity: 70% (130 aa)

EVTLLDSRSVQGELGWIASPLEGG-WEEVSIMDEKNTPIRTYQVCNVME---PSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMG-TCKETFNL
||.|.|.. ..|||||.. | .|| ||||| |||...||||||||||||   |.||||||| || |.||||.|.|.|||.|||||.|||.| .|||||||
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL

YYYESDNDKE---RFIR-ENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKC
|||||||| .   . .. ||...|||||||||||||.|.|||.||.|||.|..||||||||||||||.|||.||||||||||||
YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 EphA4.AA GCC2_GCC3 271-306 29 0.000159 17.68 Pfam 9-45 (49) Show / Hide 
Range on Protein: 271-306
Range on HMM: 9-45/49
Sequence Identity: 29% (11 aa)

GECQACKIGYYKALSTDATCAKCPPH-SYSVWEGATS
..|..| .|.|.  .   .| .|||. .. . .|.||
NPCEPCPRGTYQNEEGQDSCIPCPPGKTTTDYPGSTS
NCD3G EphA4.AA NCD3G 272-299 31 0.000579 13.74 Pfam 27-54 (54) Show / Hide 
Range on Protein: 272-299
Range on HMM: 27-54/54
Sequence Identity: 31% (9 aa)

ECQACKIGYYKALSTDA-TCAKCPPHSYS
.|  |. | |   . |. || .||.. ..
DCIPCPEGEYSNTT-DSYTCTPCPEDQWP
FN3 EphA4.AA FN3 329-420 17 9.9e-11 42.9 SMART 1-69 (69) Show / Hide 
Range on Protein: 329-420
Range on HMM: 1-69/69
Sequence Identity: 17% (19 aa)

PSAPLN----LISNVNET------SVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTKVSITDLLAH----TNYTFEIW
|..| |     ...|..|      ||.|.|. |        ..|                                   . .|.| ..    |.|.| ..
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR----------------------------------YTVTGLKPGQYPWTEYEFRVR

AV----NGVS
||    .| .
AVNGNDAGEG
FN3 EphA4.AA FN3 441-522 22 5.1e-12 47.18 SMART 1-69 (69) Show / Hide 
Range on Protein: 441-522
Range on HMM: 1-69/69
Sequence Identity: 22% (22 aa)

PSSIAL---VQAKEVTRY------SVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPL----TSYVFHVRARTA--AGYG
|..      .....||.       || | | .|      |..|.                        ..|| |     | |.| |||...  ||.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphA4.AA Eph 621-878 87 1.2e-226 759.23 In-house 1-264 (264) Show / Hide 
Range on Protein: 621-878
Range on HMM: 1-264/264
Sequence Identity: 87% (230 aa)

IKIEKVIGVGEFGEVCSGRLKVP-GKREI---CVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDG
|||||||| |||||||.||||.| ||||.   .|||||||||||.|||.||||||||||||||||||.|||||||..||||.||||||||||.|||..||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

RFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDP--EAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM
.|||||||||||||.|||||||||.|||||||||||||||||||||||||.||||||||  ||.||||||||||||||||||||||||||||||||||||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

WEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNML
||||||||||||||||||||||||.||||||||||| ||||||||||||.|..||.| |||..|
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphA4.AA Pkinase_Tyr 621-878 45 3.8e-146 495.58 Pfam 1-270 (270) Show / Hide 
Range on Protein: 621-878
Range on HMM: 1-270/270
Sequence Identity: 45% (123 aa)

IKIEKVIGVGEFGEVCSGRLK-VPGKREICVAIKTLKAGYTDKQ--RRDFLSEASIMGQF-DHPNIIHLEGVVT-KCKP--VMIITEYMENGSLDAFLRK
|.. |..| |.||||. |..|  |.. .| ||.|.|| |....|  |.||..||.|| |. .||||. | ||.| . .|  ..|..|||..|.|. .|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---DGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVL-EDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWS
.   ....|. .|..| . | .|| ||... ..||||||||.||..|.|.|..|||..| . .||    ... |||.||.|.|||.|.|.|||..|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

YGIVMWEVMSYGERP-YWDMSNQDVIKAI-EEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNML
.|..|||...||| | |..|||..|...| |.|||.|.|..||  ...||..||... .||| | .|...|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphA4.AA TyrKc 621-878 41 5.8e-137 462.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 621-878
Range on HMM: 1-280/280
Sequence Identity: 41% (119 aa)

IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQF--DHPNIIHLEGVVTKC-------KPVMIITEYMENGSLDAFL
|. .|..| |.||||. |..|      | ||.|.||..     |.||..||.|| ..  .||||. | ||.|.        .|.||..|||..|.|. .|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDD-----PEAAYTTR---GGK--IPIRWTAPEAIAYRKF
||. ..... .|. .   | .|| ||... ..||||||||.||..|...|.||||.|| ..||      .  |...   |||  .||||.|||.| |.||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TSASDVWSYGIVMWEVMSYGERPYWD-----MSNQDVIKAIEEGYRLPPPMD--------CPIALHQLMLDCWQKERSDRPKFGQIVNML
|..|||||.|..|||...||. ||..     ||||.||. ...|||.|.| .        || ...|.|..||. . .||| | .|.  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphA4.AA TK 621-878 24 3.9e-124 418.29 In-house 1-486 (486) Show / Hide 
Range on Protein: 621-878
Range on HMM: 1-486/486
Sequence Identity: 24% (117 aa)

IKIEKVIGVGEFG---EVCSGRLKVPG----------------------KREICVAIKTLKAGYTDKQRR-------------DFLSEASIMGQFD----
|...|..| |.||   ||. |... ..                      . .. ||.|.||.| .. |..             |||.||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIIHLEGVVTKC------------KPVMIITEYMENGS----LDAFLRKNDGR--------------------------------------------
 ||||..| ||.|.             .|.||..|||..|.    |. .|||....                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FTVIQLVGMLRGIGSGMKYLSDM------SYVHRDLAARNILVNSNLV-----------CKVSDFGMS-
                               .|. ||. | . | .|| ||...       .|||||||||.||..|.|           ||..|||.| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----RVLEDDPEAAYTTRG-------------------------GKIPIRWTAPEAIA---------YRKFTSASDVWSYGIVMWEVMSYG-ERPYWDM
     .  .....  |....                         ||.||||.|||...         |.|||..|||||.|..|||...|| | .|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------QDVIKAIEEG--------------YRLPPPMDCP--------------IALHQLMLDCWQKERSDRPKFGQIVNML
||         |.|.. ...|              .|.|.|..||               ....||..||... .||| | |....|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphA4.AA Src 621-878 43 3e-107 362.59 In-house 1-255 (255) Show / Hide 
Range on Protein: 621-878
Range on HMM: 1-255/255
Sequence Identity: 43% (114 aa)

IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLR-KNDGR-F
|| .. .| | ||||  |  .     .. ||.||||.|    .  .|| || || ...|.....|  |... .|. |.||||..||| ..|. . .||  
IKLCRKLGQGQFGEVWMGYWNG----NTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

TVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAY-TTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEV
 . ||. |   . .||.||. | |.||||||||.||. |.|||| |||  |....| .  |    | |.||.||||||| |..||  |||||.|| ..|.
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED-DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

MSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQ-LMLDCWQKERSDRPKFGQIVNML
..||  ||  |.|..|....| |||.| |. ||  |.. .|| ||.|.  .|| |  . . |
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphA4.AA SFK-Src 621-882 44 1.3e-106 317.07 In-house 1-259 (259) Show / Hide 
Range on Protein: 621-882
Range on HMM: 1-259/259
Sequence Identity: 44% (119 aa)

IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGR-FT
|. ||  | | ||.|  ||          ||.|||| | .  .   ||.|| .| .  ||| | |  | |   |. |||| | .|||  .|.   ||  .
IRLEKKLGSGQFGDVWKGRW----NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

VIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMS
. ||| |   . .|| || .  .|||||||||.||  | |||| ||||||||..| |      | | ||.||||||  . .|   |||||.|| | |.  
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVT

YGERPYWDMSNQDVIKAIEE--GYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLI
||  ||  |.|. |.. ..   |||.| |  || .....|.||||.| .||| |.     ..   
YGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphA4.AA UTK 621-878 36 4.1e-105 355.52 In-house 1-296 (296) Show / Hide 
Range on Protein: 621-878
Range on HMM: 1-296/296
Sequence Identity: 36% (109 aa)

IKIEKVIGVGEFGEVCSGRLKVPG--KREICVAIKTLKAGYTDKQRRD----FLSEAS---IMGQFD-HPNIIHLEGVVTKCKPVMIITEYMENGSLDAF
... . .| |.||||. .|.. .     |  ||.|..... .. | ..    |. ||    .|.||. |||.. | ||.|. .| ||.|||||||.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR-------KNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSN-------LVCKVSDFG---MSRVLE-------DDPEAAYTTRG-GK
||        ..  .|  |...| . | .|| ||. . .|||||||||.||...       .|||..|||   ||| .        ..    |. .. ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIRWTAPEAIAYR-KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEG--YRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNML
.||||.||||.... .||..|||||.|.|.||....| .|| .|||..|......|  ||.|.| ||| .. .||..||... ..|| | ..|  .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphA4.AA Fer 621-879 34 6.6e-97 328.25 In-house 1-283 (283) Show / Hide 
Range on Protein: 621-879
Range on HMM: 1-283/283
Sequence Identity: 34% (97 aa)

IKIEKVIGVGEFGEVCSGR----LKVPGKRE---ICVAIKTL-KAGYTDKQRRDFLSEASIMGQ-FDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFL
....|..| | ||||..||    .| ... .   . |. |..  .. |..|...|. || || . .||||.. . || .   |.||. |.. .|||| .|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RKNDGR-FTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNS-NLVCK--VSDFGMSRVLEDDPEAAYTTR--GGKIPIRWTAPEAIAYRKFTSAS
.||...  .. ... |. .. .||.||  .  .|||.||||.|.   ....|  .||||||| ..|. . .|. .    |.||||.|||.. .. .....
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDY-GYDYKMKEKACKVPIRWLAPETWQTGIYSPKT

DVWSYGIVMWEVMSYGERPYWD----MSNQDV----IKAIEE-GYRLPPPMDCPIALHQLML-DCWQKERSDRPKFGQIVNMLD
||||.|...||... |. || .    | .  |    .|.|.. ||..|.|  .| .. |.|. .||||. .|||.. .|...| 
DVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphA4.AA TK-Unique 621-878 35 1e-96 327.59 In-house 1-294 (294) Show / Hide 
Range on Protein: 621-878
Range on HMM: 1-294/294
Sequence Identity: 35% (106 aa)

IKIEKVIGVGEFGEVCSGRLKVPG---KREICVAIKTLKAGYTDKQRRDFLSEASIMGQFD-HPNIIHLEGVVTKCK-PVMIITEYMENGSLDAFLRKND
.....||| |.||.|. | .. .     . .|||.|.||.. || ...|||.|...| . . ||||....|. ||   |.||| ||...|.|. .||.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-GRFTV---------------------IQ---LVGMLRGIGSGMKYLSD--MSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRG--GKI
 .....                     |.   |.  . .| .||.||.   .  |||||.|||.|.....|||..||||.| ...  . .| . .  |.|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--NGVYSMMCSQGRI

PIRWTAPEAIA--YRKF-TSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDC-PIALHQLMLDCWQKERSDRPKFGQIVNML
|||| |||..   .. . |. |||||.|..|||....|..|| .|.. |....|..|||.| |  | . ....||  |||.|...|| | ||...|
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphA4.AA Frk 621-882 43 3.1e-88 299.46 In-house 1-260 (260) Show / Hide 
Range on Protein: 621-882
Range on HMM: 1-260/260
Sequence Identity: 43% (116 aa)

IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLR--KNDGR-
|.. . .| | ||||  |.  .    .. ||.||||.|  | .  ||| || || .  || .|.|  | |  .|..|||| |..|||  .|.  .. || 
IQLIRRLGSGQFGEVWEGLWNN----TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

FTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGG-KIPIRWTAPEAIAYRKFTSASDVWSYGIVMWE
  . ||| |   . .|| || .. |.||||||||.||. ...||. |||. |||  | |  | .| | ..||.||||||. | |||  |||||.||.. |
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE

VMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLI
.. ||  ||  | |..|.. ...|||.| | .||  | ..||.||...   || |  .   |.. .
IITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphA4.AA FAK 621-883 36 7.8e-85 284.18 In-house 1-285 (285) Show / Hide 
Range on Protein: 621-883
Range on HMM: 1-285/285
Sequence Identity: 36% (106 aa)

IKIEKVIGVGEFGEVCSGRLKVPGK------------------------REICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVM
|.  ..||.| ||.|  |    .                            | ||||| |.  .| ..  |..|| || ||||| |. | |...  .|. 
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEE-MPIW

IITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTR-GGKIPIRWTAPEA
|| | .. | | ..|. |  . ..  |.     .   | ||    .|||| ||||.|| |.   |  |||.|| ..|  .  |     || ||.| .|| 
IIMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWMHD--HSYYKASPKGKLPIKWMSPES

IAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIR
| .| ||.||||| .|. |||...|| .|.  . |.|||  || | ||| |  ||  |  ||  ||  . |.||.| ...  | ..  
INFRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase EphA4.AA SrcB 621-879 43 2.5e-84 285.15 In-house 1-251 (251) Show / Hide 
Range on Protein: 621-879
Range on HMM: 1-251/251
Sequence Identity: 43% (113 aa)

IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDG-RFT
.|..| .| | ||||  |      .... ||.||.| |    .   || || .| .  |  ...|  ||||  |. ||||||..|.|  ||. ..| . .
LKLVKKLGAGQFGEVWMGYY----NNHMKVAVKTMKQGTMSPEA--FLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLS

VIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTR-GGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVM
. .|. |   |  || |.  | |.|||| | ||||   |.||. |||. |..||.    || | | | ||.||||||| .  ||  |||||.||.. |..
LPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDN---EYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIV

SYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLD
 ||  ||  |.| .||...|.|||.| |  ||  | ..|  ||..   .|| |  .  .||
TYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase EphA4.AA S_TKc 621-882 22 4.4e-48 166.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 621-882
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMEN--GSLDAFLRKNDGR-
 .| ..|| | ||.|. .| |        |||| .|        .....| .|. . .||||..| .|    . . ...||...  |.|  ...|. .. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTS-ASDVWSYGI
    |.  .   ... | ....|. ..  .||||   |||...  . |..|||..|.|          .       . ||| .   ...  ..|.|| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVN-----MLDKLI
...| .. |. |..    | ..| |            .  . ...  |.||. ..||   .. .     ...  .
ILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphA4.AA Pkinase 621-878 22 2.2e-44 158.0 Pfam 1-293 (293) Show / Hide 
Range on Protein: 621-878
Range on HMM: 1-293/293
Sequence Identity: 22% (68 aa)

IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDK--QRRDFL-SEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENG----SLDAFLR-
..|...|| | ||.|. .. |  ||    ||.|..|   ...  ...... ||..||  ..||||. | ....  . . ...||.|.|    .| .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

KNDGRF--TVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVC----KVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA-YRKFTSAS
...|.|  .  ..  ... | .|..|. .|. .||||   |||...| ..    |..||| .....        . .    ... ||| |  ... ....
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSYGIVMWEVMSYGERPYWDM----SNQDVIKAIEEGYRLPPPMDCP-----------------------IALHQLMLDCWQKERSDRPKFGQIVNM-
|.||.|....|... |. |...     .  | .. |..  . |.. |.|                        .. ... .|..|  ..|| . ||..  
DMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-L
 .
WF
SAM_2 EphA4.AA SAM_2 908-973 35 5e-25 88.72 Pfam 1-71 (71) Show / Hide 
Range on Protein: 908-973
Range on HMM: 1-71/71
Sequence Identity: 35% (25 aa)

PEFSAVVSVGDWLQAIKM-DRYKDNFTAAGYTTLEAV-VHVNQEDL--A-RIGITAITHQNKILSSVQAMR
...... .|..||..|.|  .|||||...|.|..|..  |....||  . |.|||.  |..||....| |.
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
SAM_1 EphA4.AA SAM_1 909-973 31 2.3e-23 85.73 Pfam 1-66 (66) Show / Hide 
Range on Protein: 909-973
Range on HMM: 1-66/66
Sequence Identity: 31% (21 aa)

EFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHVNQEDLAR-IGITAITHQNKILSSVQAMR
.  .. .|..||..|.| .|.|.|..|||...... .  .||| . .|.| . |. ||..|.| ..
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
Sam7 EphA4.AA sam7 911-973 34 1.7e-22 77.79 In-house 1-70 (70) Show / Hide 
Range on Protein: 911-973
Range on HMM: 1-70/70
Sequence Identity: 34% (24 aa)

SAVVSVGDWLQAIKM---DRYKDNFTAAGY----TTLEAVVHVNQEDLARIGITAITHQNKILSSVQAMR
  . .|..||..|.|   ..|.|||...|.    |..... |...|||...||| . |..||....| ||
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM EphA4.AA SAM 908-975 36 1.3e-21 79.07 SMART 1-67 (67) Show / Hide 
Range on Protein: 908-975
Range on HMM: 1-67/67
Sequence Identity: 36% (25 aa)

PEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHVNQEDLARIGITAITHQNKILSSVQAMRTQ
..   . .|.|||..|.|..|||||...|... . . . ..||| ..|||.. |. |||...| |..|
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ