Gene EphA3 (Human)

EphA3

Species: Human
Alias: HEK4, EPHA3, EphA3, ETK, TYRO4, ETK1, HEK
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 3q11.1,

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphA3.NA RNA Sugen Kinome 5835 None Fasta, JSON
EphA3.AA Protein Sugen Kinome 983 None Fasta, JSON
EphA3.kin_dom Protein Kinase Domain Sugen Kinome 257 None Fasta, JSON

Protein domain

Protein domains of EphA3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphA3.AA Ephrin_lbd 29-202 64 2.2e-142 443.89 Pfam 1-190 (190) Show / Hide 
Range on Protein: 29-202
Range on HMM: 1-190/190
Sequence Identity: 64% (123 aa)

EVNLLDSKTIQGELGWISYPSHG---------WEEISGVDEHYTPIRTYQVC-NVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKE
||.|.|.|| ...|||..||..|         |||.||.||...|||||||| |||...|||||||||..|  ||.||||||||.|||||.| |.|||||
EVVLMDTKTATSDLGWTTYPYNGRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCKE

TFNLYYMESDD--DHG---VKFREHQFTKIDTIAADES-FTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKC
||||||.|||   |.|    ...|.|.||||||||||| |||.|.|.|..|||||.|..||..|.||||||||.|||.||||||||.|||
TFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphA3.AA EPH_lbd 29-202 67 7.6e-130 438.59 SMART 1-184 (184) Show / Hide 
Range on Protein: 29-202
Range on HMM: 1-184/184
Sequence Identity: 67% (124 aa)

EVNLLDSKTIQGELGWISYPSHG--WEEISGVDEHYTPIRTYQVCNVMD---HSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLG-TCKETFNL
||.|.|.||..|||||..||.||  |||.||.|||..|||||||||||.   ..|||||||.|..|..||.||||||||.|||||.| |.| .|||||||
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL

YYMESDDDHG---VKFR-EHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKC
||.|||.||.    .|. |....|||||||||||||.|.|||..|.|||.|..||..||||||||||.|||.|||||||..|||
YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 EphA3.AA GCC2_GCC3 263-301 32 1.2e-07 27.83 Pfam 4-43 (49) Show / Hide 
Range on Protein: 263-301
Range on HMM: 4-43/49
Sequence Identity: 32% (13 aa)

YEERGFMCQACRPGFYKALDGNMKCAKCPPH-SSTQEDGS
|   ...|..|  |.|.  .|. .| .|||. ..| . ||
YNKGQNPCEPCPRGTYQNEEGQDSCIPCPPGKTTTDYPGS
FN3 EphA3.AA FN3 326-418 19 2.1e-07 31.81 SMART 1-69 (69) Show / Hide 
Range on Protein: 326-418
Range on HMM: 1-69/69
Sequence Identity: 19% (21 aa)

PSSPRN----VISNINET------SVILDWSWPLDTGGRKDVTFNIICKKCGWNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAH----TNYTFEIDA
|..|.|    .......|      || | |. |            . ..                             .|||.| ..    |.|.| . |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----------IVGYR-----------------------------YTVTGLKPGQYPWTEYEFRVRA

VNG--VSEL
|||  . | 
VNGNDAGEG
FN3 EphA3.AA FN3 437-518 21 6.6e-15 56.76 SMART 1-69 (69) Show / Hide 
Range on Protein: 437-518
Range on HMM: 1-69/69
Sequence Identity: 21% (21 aa)

PSPVLT---IKKDRTSRN------SISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPD----TIYVFQIRARTA--AGYG
|.|.     ..   ....      |..|||..|      |. |.                      .|.. |||.    | |.|..||...  ||.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphA3.AA Eph 621-878 87 1.3e-224 752.44 In-house 1-264 (264) Show / Hide 
Range on Protein: 621-878
Range on HMM: 1-264/264
Sequence Identity: 87% (230 aa)

ISIDKVVGAGEFGEVCSGRLKLP-SKKEI---SVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDA
| |.||.|||||||||.||||||  |.|.    |||||||.|||||||.|||.|||||||||||||||||||||||.|||||||||||||||||||.|| 
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

QFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDP--EAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVL
||||||||||||||||||||||||.||||||||||||.|||||||||||||||||||||  ||.||||||||||||| |||||||||||||||||||||.
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

WEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSIL
||||||||||||.|||||||||...|||||||||||.||.||||||||||||.||.|.||||||
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphA3.AA Pkinase_Tyr 621-878 45 4.7e-152 515.61 Pfam 1-270 (270) Show / Hide 
Range on Protein: 621-878
Range on HMM: 1-270/270
Sequence Identity: 45% (124 aa)

ISIDKVVGAGEFGEVCSGRLK-LPSKKEISVAIKTLKVGYTEKQ--RRDFLGEASIMGQF-DHPNIIRLEGVVT-KSKP--VMIVTEYMENGSLDSFLRK
|...|. |.|.||||. |..| .|....| ||.|.|| |....|  |.||. ||.|| |. .||||.|| ||.| ...|  ..||.|||..|.|...|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H---DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVL-EDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWS
|   . ..|. .|..| . ||.|| ||......||||||||.|...|.|.|..||||.| . .||    ... |||.||.|..||.|.|.|||..|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

YGIVLWEVMSYGERP-YWEMSNQDVIKAV-DEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSIL
.|...||...||| | |..|||..|.... ..|||.|.|..||. .|.||..||..| ..|| |..|...|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphA3.AA TyrKc 621-878 42 1.6e-142 480.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 621-878
Range on HMM: 1-280/280
Sequence Identity: 42% (123 aa)

ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQF--DHPNIIRLEGVVTKS-------KPVMIVTEYMENGSLDSFL
|. .|. | |.||||. |..|      | ||.|.|| .     |.||. ||.|| ..  .||||.|| ||.|..       .|.|||.|||..|.|...|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDD-----PEAAYTTR---GGK--IPIRWTSPEAIAYRKF
|||  .... .|. .   ||.|| ||......||||||||.|...|...|.||||||| ..||      .  |...   |||  .||||..||.| |.||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TSASDVWSYGIVLWEVMSYGERPYWE-----MSNQDVIKAVDEGYRLPPPMD--------CPAALYQLMLDCWQKDRNNRPKFEQIVSIL
|..|||||.|...||...||. ||..     ||||.||. |..|||.|.| .        ||...||.|..||. | ..|| |..|....
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphA3.AA TK 621-878 24 2e-127 429.53 In-house 1-486 (486) Show / Hide 
Range on Protein: 621-878
Range on HMM: 1-486/486
Sequence Identity: 24% (120 aa)

ISIDKVVGAGEFG---EVCSGRLKL----------------------PSKKEISVAIKTLKVGYTEKQRR-------------DFLGEASIMGQFD----
| . |. |.|.||   ||. |...                       ...... ||.|.|| | .. |..             ||| ||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIIRLEGVVTKS------------KPVMIVTEYMENGS----LDSFLRKHDA---------------------------------------------
 ||||.|| ||.|..            .|.|||.|||..|.    |...|||..                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QFTVIQLVGMLRGIASGMKYLSDM------GYVHRDLAARNILINSNLV-----------CKVSDFGLS-
                              |.|. ||. | . ||.|| ||...      ..|||||||||.|...|.|           ||..||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----RVLEDDPEAAYTTRG-------------------------GKIPIRWTSPEAIA---------YRKFTSASDVWSYGIVLWEVMSYG-ERPYWEM
     .  .....  |....                         ||.||||..||...         |.|||..|||||.|...||...|| | .|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------QDVIKAVDEG--------------YRLPPPMDCP--------------AALYQLMLDCWQKDRNNRPKFEQIVSIL
||         |.|.. . .|              .|.|.|..||              ...|.||..||..| . || |.|... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphA3.AA UTK 621-878 39 8.20000000001e-116 391.05 In-house 1-296 (296) Show / Hide 
Range on Protein: 621-878
Range on HMM: 1-296/296
Sequence Identity: 39% (117 aa)

ISIDKVVGAGEFGEVCSGRLKLPS--KKEISVAIKTLKVGYT-EKQRR---DFLGEAS---IMGQFD-HPNIIRLEGVVTKSKPVMIVTEYMENGSLDSF
. . .  |.|.||||. .|.. .|   .|  ||.|..... . .....   ||. ||    .|.||. |||..|| ||.|...| ||||||||||.|.|.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRKHDA-------QFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSN-------LVCKVSDFG---LSRVLE-------DDPEAAYTTRG-GK
||.|         ..|  |...| . ||.|| ||. .|.|||||||||.|....       .|||..|||   .|| .        ..    |. .. ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIRWTSPEAIAYR-KFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEG--YRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSIL
.||||..|||.... .||..|||||.|.|.||....| .|| .|||..|...| .|  ||.|.| |||...|.||..||..|  .|| ||..|. .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphA3.AA Src 621-878 44 6e-110 371.57 In-house 1-255 (255) Show / Hide 
Range on Protein: 621-878
Range on HMM: 1-255/255
Sequence Identity: 44% (116 aa)

ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLR-KHDAQ-F
|   .  |.| ||||  |      .... ||.|||| |    .  .|| || || ...|.....|  |... .|. ||||||..|||  .|. . . .  
IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

TVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY-TTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEV
 . ||. |   .|.||.||. | |.||||||||.|.. |.|||| |||| |....| .  |    | |.||.|| |||| |..||  |||||.|| |.|.
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED-DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

MSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQ-LMLDCWQKDRNNRPKFEQIVSIL
..||  ||  |.|..|...|. |||.| |. ||. ||. .|| ||.||   || || . . |
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphA3.AA SFK-Src 621-882 43 1.5e-105 313.81 In-house 1-259 (259) Show / Hide 
Range on Protein: 621-882
Range on HMM: 1-259/259
Sequence Identity: 43% (115 aa)

ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRK-HDAQFT
|   |  |.| ||.|  ||      .   ||.|||| | .  .   || || .| .  ||| |.|  | |   |. |.|| | .|||  .|.  |    .
IRLEKKLGSGQFGDVWKGRW----NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

VIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMS
. ||| |   .|.|| || .  .|||||||||.|.  | |||| |||.||||..| |      | | ||.|| |||  . .|   |||||.|| . |.  
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVT

YGERPYWEMSNQDVIKAVDE--GYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLI
||  ||  |.|. |.. ||   |||.| |  || ..|..|.||||.   .|| ||     ..   
YGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphA3.AA Fer 621-879 35 5.3e-103 348.49 In-house 1-283 (283) Show / Hide 
Range on Protein: 621-879
Range on HMM: 1-283/283
Sequence Identity: 35% (100 aa)

ISIDKVVGAGEFGEVCSGR--LKLPSKKEISV---AIKTLKV---GYTEKQRRDFLGEASIMGQ-FDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFL
. ..|. | | ||||..||  ||.  .| . |   |.|. |.   . |..|...|. || || . .||||.... || .   |.||| |.. .|||||.|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RKHDAQ-FTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINS-NLVCK--VSDFGLSRVLEDDPEAAYTTR--GGKIPIRWTSPEAIAYRKFTSAS
.| ...  .. ... |. ..|.||.||  .. .|||.||||.|.   ....|  .||||.|| ..|. . .|. .    |.||||..||.. .. .....
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDY-GYDYKMKEKACKVPIRWLAPETWQTGIYSPKT

DVWSYGIVLWEVMSYGERPYWE----MSNQDV----IKA-VDEGYRLPPPMDCPAALYQLML-DCWQKDRNNRPKFEQIVSILD
||||.|...||... |. || .    | .  |    .|. ...||..|.|  .| ...|.|. .||||| ..||.. .|. .| 
DVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphA3.AA TK-Unique 621-878 34 7.2e-96 324.81 In-house 1-294 (294) Show / Hide 
Range on Protein: 621-878
Range on HMM: 1-294/294
Sequence Identity: 34% (102 aa)

ISIDKVVGAGEFGEVCSGRLKLPS---KKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFD-HPNIIRLEGVVTKSK-PVMIVTEYMENGSLDSFLRKHD
. ...|.| |.||.|. | .. ..    | ..||.|.|| . |. ...||| |...| . . ||||....|. |||  |.||. ||...|.|...||.  
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-AQFTV---------------------IQ---LVGMLRGIASGMKYLSD--MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG--GKI
 |....                     |.   |.  . .||.||.||.   .. |||||.|||.|.....|||..|||..| ...  . .| . .  |.|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--NGVYSMMCSQGRI

PIRWTSPEAIA--YRKF-TSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDC-PAALYQLMLDCWQKDRNNRPKFEQIVSIL
|||| .||..   .. . |. |||||.|...||....|..|| .|.. |..... .|||.| |  | . ..|.||  |||...  || |.||...|
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphA3.AA Frk 621-882 44 6e-91 308.46 In-house 1-260 (260) Show / Hide 
Range on Protein: 621-882
Range on HMM: 1-260/260
Sequence Identity: 44% (119 aa)

ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLR---KHDAQ
| . . .|.| ||||  |.       .. ||.|||| |  . .  ||| || || .  || .|.|  | |  .|..|.|| |..|||  .|.   ..  |
IQLIRRLGSGQFGEVWEGLW----NNTTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

FTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGG-KIPIRWTSPEAIAYRKFTSASDVWSYGIVLWE
  . ||| |   .|.|| || .. |.||||||||.|.. ...||. |||| |||  | |  | .| | ..||.|| |||. | |||  |||||.||.| |
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE

VMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLI
.. ||  ||  | |..|.. ||.|||.| | .||  ||..||.||..| ..|| || .   |.. .
IITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphA3.AA SrcB 621-879 43 4.9e-87 294.47 In-house 1-251 (251) Show / Hide 
Range on Protein: 621-879
Range on HMM: 1-251/251
Sequence Identity: 43% (114 aa)

ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHD-AQFT
. . | .||| ||||  |      .... ||.||.| |    .   ||.|| .| .  |  ..||  ||||  |. |.||||..|.|  ||.  . .. .
LKLVKKLGAGQFGEVWMGYY----NNHMKVAVKTMKQGTMSPEA--FLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLS

VIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR-GGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVM
. .|. |   || || |.  | |.|||| | |||.   |.||. |||| |..||.    || | | | ||.|| |||| .  ||  |||||.||.| |..
LPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDN---EYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIV

SYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILD
 ||  ||  |.| .||.....|||.| |  ||  ||..|  ||..   .|| |. . |.||
TYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase EphA3.AA Syk 621-872 38 8.1e-87 294.74 In-house 1-257 (257) Show / Hide 
Range on Protein: 621-872
Range on HMM: 1-257/257
Sequence Identity: 38% (100 aa)

ISIDKVVGAGEFGEVCSGRLKLP----SKKEISVAIKTLKVGYTEKQ-RRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHD
.  |. .| |.|| | .| ..       |. | ||||.||   ...     |. ||..| | ||| |.|. | . .  . | | |  | |..  .| .| 
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIG-ICHAEMMMMVMEMAELGPMHKYLQQHR

AQFTVIQLVGMLR-GIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVL
   |.   . ..   .|.||.||     |||||||||.|       |.||||.|. |  | .    | .|| |..|  || | |.|| ..|||||.|. .
HEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTM

WEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFE
||  ||| .|| ||..|.|.| .. | |.. |  ||. .|||| .||  .  .|| | 
WEMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase EphA3.AA S_TKc 621-882 22 7.4e-50 172.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 621-882
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMEN--GSLDSFLRKHDAQ-
  | ...| | ||.|. .| |        |||| .|        .... | .|. . .||||..| .|    . . .|.||...  |.| ....|.  . 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTS-ASDVWSYGI
    |.  .   ... |.....|. ..| .||||   |||...  . |..||||.|.|          .       . .|| .   ...  ..|.|| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVS-----ILDKLI
.|.| .. |. |..    | ..| .            .  . ...  |.||| ..||   ..        ..  .
ILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphA3.AA Pkinase 621-878 23 4.9e-45 160.31 Pfam 1-293 (293) Show / Hide 
Range on Protein: 621-878
Range on HMM: 1-293/293
Sequence Identity: 23% (70 aa)

ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEK--QRRDFL-GEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENG----SLDSFLR-
. | ...|.| ||.|. .. |  .|    ||.|..|.  ...  ......  |..||  ..||||.|| .... .. . .|.||.|.|    .| .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

KHDAQF--TVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVC----KVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA-YRKFTSAS
. .  |  .  ..  ... |..|..|. .|| .||||   ||||..| ..    |..||||.....        . .    ... .|| |  ... ....
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSYGIVLWEVMSYGERPYWEM----SNQDVIKAVDEGYRLPPPMDCP-----------------------AALYQLMLDCWQKDRNNRPKFEQIVSI-
|.||.|..|.|... |. |...     .  | .. ...  . |.. |.|                        .. ... .|..|| . || .|||.   
DMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-L
 .
WF
SAM_2 EphA3.AA SAM_2 908-973 26 2.2e-17 62.49 Pfam 1-71 (71) Show / Hide 
Range on Protein: 908-973
Range on HMM: 1-71/71
Sequence Identity: 26% (19 aa)

VDITTFRTTGDWLNGVWT-AHCKEIFTGVEYSSCDTI-AKISTDDM--K-KVGVTVVGPQKKIISSIKALE
|. .|| ....|| ..   ...|..|.. ...... . |... ||.  | . |.| ||..|||...|. ..
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
SAM_1 EphA3.AA SAM_1 909-973 28 3.4e-16 60.32 Pfam 1-66 (66) Show / Hide 
Range on Protein: 909-973
Range on HMM: 1-66/66
Sequence Identity: 28% (19 aa)

DITTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKK-VGVTVVGPQKKIISSIKALE
| ..|.. ..||.    ..... |.  .|...|... .. .|..| .||| .|..||| .||. | 
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
SAM EphA3.AA SAM 908-975 27 1.5e-14 55.6 SMART 1-67 (67) Show / Hide 
Range on Protein: 908-975
Range on HMM: 1-67/67
Sequence Identity: 27% (19 aa)

VDITTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKALETQ
||  |... .||| .   ...|..|.  .... . .. .| .|.|..|.| .|..|||...|. . .|
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
Sam7 EphA3.AA sam7 911-973 20 3.8e-13 44.63 In-house 1-70 (70) Show / Hide 
Range on Protein: 911-973
Range on HMM: 1-70/70
Sequence Identity: 20% (14 aa)

TTFRTTGDWLNGVWT---AHCKEIFTGVEY----SSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKALE
.||.. ..|| ..      .... |.  ..    .. |... .. .|... |.| .|..||| ..|. . 
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR