Gene EphA1 (Human)

EphA1

Species: Human
Alias: MGC163163, EphA1, EPHA1, EPHT, EPHT1, EPH
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 7q36,

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphA1.NA RNA Sugen Kinome 3369 None Fasta, JSON
EphA1.AA Protein Sugen Kinome 976 None Fasta, JSON
EphA1.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON

Protein domain

Protein domains of EphA1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphA1.AA Ephrin_lbd 27-204 47 1.4e-112 351.07 Pfam 1-190 (190) Show / Hide 
Range on Protein: 27-204
Range on HMM: 1-190/190
Sequence Identity: 47% (92 aa)

EVTLMDTSKAQGELGWLLDPPKDG---------WSEQQQI-LNGTPLYMYQDC-PMQGRRDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGP
||.||||..|...|||. .|.. |         |.| ...  ||.|...|| |  .    ....|||.|||.| ..|.|..|||.||.|||.||||.|| 
EVVLMDTKTATSDLGWTTYPYN-GRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNV-MEPNQNNWLRTNWIER-RGAQRIYVELKFTMRDCNSFPGVAG-

LGCKETFNLLYMESDQ--DVG---IQLRRPLFQKVTTVAADQS-FTIRDLVSGSVKLNVERCSLGRLTRRGLYLAFHNPGACVALVSVRVFYQRC
  |||||||.|.|||.  |.|   ...... . |. |.|||.| || ||. |...|||.| .|.| |..||.||||.. |||.|||||||.|..|
-TCKETFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphA1.AA EPH_lbd 27-204 47 7.50000000001e-102 345.59 SMART 1-184 (184) Show / Hide 
Range on Protein: 27-204
Range on HMM: 1-184/184
Sequence Identity: 47% (88 aa)

EVTLMDTSKAQGELGWLLDPPKDG-WSEQQQILNG-TPLYMYQDCPMQGR--RDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPLGCKETF
||.||||....|||||. .||..| |.| ... .. .| ..||.|.....   ....|||..|||| ..|.|..|||.||.|||.|.||.|| . |||||
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYR-RGAQRIYVELKFTMRDCNSMPGVAG-VSCKETF

NLLYMESDQDVG---IQLR-RPLFQKVTTVAADQSFTIRDLVSGSVKLNVERCSLGRLTRRGLYLAFHNPGACVALVSVRVFYQRC
|| |.|||.|..   .. . .. ..|. |.|||.||| ||. . ..|.|.| .|.| |...|.||||.. |||.|||||||||..|
NLYYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
FN3 EphA1.AA FN3 333-429 20 1.9e-12 48.6 SMART 1-69 (69) Show / Hide 
Range on Protein: 333-429
Range on HMM: 1-69/69
Sequence Identity: 20% (23 aa)

PSAPRN---LSFS-ASGT------QLSLRWEPPADTGGRQDVRYSVRCSQCQGTAQDGGPCQPCGVGVHFSPGARGLTTPAVHVNGLEPY----ANYTFN
|..|.|   |...  . |      ...|.|.||        |.|.                                    . | ||.|.     .|.| 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR------------------------------------YTVTGLKPGQYPWTEYEFR

VEAQNG-VSGLG
| | ||   | |
VRAVNGNDAGEG
FN3 EphA1.AA FN3 447-525 17 7e-06 26.83 SMART 1-69 (69) Show / Hide 
Range on Protein: 447-525
Range on HMM: 1-69/69
Sequence Identity: 17% (16 aa)

SLSGLS---LRLVKKEPR------QLELTWAGSRPRSPGANLTYELHVLNQDEERYQMVLEPRVLLTELQPD----TTYIVRVRMLTP--LGPG
  .      ||..   ..      ...|.|   .|      ..|.                  . .| |.|.    |.| .|||  .    |.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK--PP-----IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphA1.AA Eph 624-880 63 2e-196 658.86 In-house 1-264 (264) Show / Hide 
Range on Protein: 624-880
Range on HMM: 1-264/264
Sequence Identity: 63% (168 aa)

LMVDTVIGEGEFGEVYRGTLRLPSQDCKT----VAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLRERED
.....|||.||||||..|.|.|||.....    |||||||....  |.|.||.||.|||||.||.|..|||||||..|.||.||.||||.||.|||....
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

QLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDG---TYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVM
|....|||.||.||||||.|||..|||||||||||||||.||.||||||||.|.|.|...   ||.|.|||||||||||||||.|.||.||||||.||||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

WEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHL
|||.|.|..||..||||.|.|.||.|||||||.|||..|..||..||..||..|||||.....|
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphA1.AA Pkinase_Tyr 624-880 45 1.5e-144 490.16 Pfam 1-270 (270) Show / Hide 
Range on Protein: 624-880
Range on HMM: 1-270/270
Sequence Identity: 45% (122 aa)

LMVDTVIGEGEFGEVYRGTLR-LPSQDCKTVAIKTLKDTSPGGQ--WWNFLREATIMGQF-SHPHILHLEGVVT-KRKP--IMIITEFMENGALDAFLRE
.  . ..|||.|||||.||.. .|.... .||.|.||...   |  .  |.||| || |. .||.|. | ||.| ...|  |.|..|.|..| |. .||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---EDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLL--DDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWS
.   ...| . .|. | . ||.||.||...|..||||||||.||. |...|..||||.|..  ||   .. ..|||.||.|.|||.|....|||.|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGIVMWEVLSFGDKP-YGEMSNQEVMKSI-EDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHL
||..|||....|..| | .|||.||.. | |||||.|.| .||...|.||| ||.|| ..|| |. .. .|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphA1.AA TyrKc 624-880 39 6.1e-131 442.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 624-880
Range on HMM: 1-280/280
Sequence Identity: 39% (115 aa)

LMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQF--SHPHILHLEGVVTKR-------KPIMIITEFMENGALDAFL
.  . ..|||.|||||.||..       .||.|.||. .       |.||| || ..  .||.|. | ||.|.        .|.||..|.|..|.|. .|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

REREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDF------DGTYETQ---GGK--IPIRWTAPEAIAHRIF
|.....| . .|. .   ||.||.||. .|..||||||||.||. |...|.|||||.| ..|       . .| ..   |||  .||||.|||.| ...|
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TTASDVWSFGIVMWEVLSFGDKPYGE-----MSNQEVMKSIEDGYRLPPPVD--------CPAPLYELMKNCWAYDRARRPHFQKLQAHL
||.|||||||..|||....|..|| .     ||||||.. ...|||.|.| .        ||. .|..|| ||..| . || |. .   .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphA1.AA TK 624-880 25 1.3e-118 399.44 In-house 1-486 (486) Show / Hide 
Range on Protein: 624-880
Range on HMM: 1-486/486
Sequence Identity: 25% (123 aa)

LMVDTVIGEGEFG---EVYRGTLRL----------------------PSQDCKTVAIKTLKDTSPGGQWW-------------NFLREATIMGQFS----
. .  ..|||.||   |||.|..|                       ... . .||.|.||....  |               .||.|| .| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPHILHLEGVVTKR------------KPIMIITEFMENGA----LDAFLRERED---------------------------------------------
 ||.|..| ||.|.             .|.||..|.|..|     |. .||.. .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QLVPGQLVAMLQGIASGMNYLSNH------NYVHRDLAARNILVNQNLC-----------CKVSDFGLTR
                              || . ||. | . ||.|| ||. .      |.|||||||||.||..|.            ||..||||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LLDDFD---GTYETQ------------------------GGKIPIRWTAPEAIAHRI---------FTTASDVWSFGIVMWEVLSFGDKPYGE-M
     |  | .     | ..                        |||.||||.|||....|.         |||.|||||||..|||....|..||.. |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------QEVMKSIEDG--------------YRLPPPVDCP--------------APLYELMKNCWAYDRARRPHFQKLQAHL
||         ||||. ...|              .|.|.|..||              . .|.||. ||.|| ..|| |. |.  |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphA1.AA UTK 624-880 38 3.3e-108 365.79 In-house 1-296 (296) Show / Hide 
Range on Protein: 624-880
Range on HMM: 1-296/296
Sequence Identity: 38% (113 aa)

LMVDTVIGEGEFGEVYRGTLRLPSQDCKT--VAIKTLKDTSPGGQWWN----FLREAT---IMGQFS-HPHILHLEGVVTKRKPIMIITEFMENGALDAF
..    .|.|.||||...... .|   ..  ||.|... .... |       |..||.   .|.||. ||..| | ||.|. .|.||.||.|||| |...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR-------EREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQN-------LCCKVSDFG---LTRLLDD--------FDGTYETQG-GK
||       .....|   |.. |   ||.||.||.....|||||||||.||...       . ||..|||   ..|.. .        ..  |  |. ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIRWTAPEAIAHR-IFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDG--YRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHL
.||||.||||..|.  |||.|||||||.|.||....| .||..|||..| .....|  ||.|.| |||.|.|.||. ||.|| ..|| |. | . .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphA1.AA Src 624-880 43 2.2e-106 359.72 In-house 1-255 (255) Show / Hide 
Range on Protein: 624-880
Range on HMM: 1-255/255
Sequence Identity: 43% (114 aa)

LMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLR--EREDQL
.     .|.| ||||. |. .    .   ||.||||  .   .   ||.|| || ...|.....|  |... .|| |.||.|..| | ..|.  ... .|
IKLCRKLGQGQFGEVWMGYWN----GNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

VPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTY-ETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVL
   ||. |   .|.||.||.  ||.||||||||.||..|..||| |||| ||... |  |   .| |.||.||||||| .. ||. |||||||| ..|. 
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIV

SFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYE-LMKNCWAYDRARRPHFQKLQAHL
..|  ||  |.|.||.. .| |||.| |  ||. ||| .|. ||  |  .|| |  ||  |
TYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphA1.AA SFK-Src 624-884 41 1.2e-101 302.04 In-house 1-259 (259) Show / Hide 
Range on Protein: 624-884
Range on HMM: 1-259/259
Sequence Identity: 41% (110 aa)

LMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLRE-REDQLV
       |.| ||.|..|.      .   ||.||||  .   .   ||.|| .| .  ||    |  | |   || |||| | .| |  .|.| .   | 
IRLEKKLGSGQFGDVWKGRW----NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

PGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYET-QGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLS
  ||| |   .|.|| ||   |.|||||||||.|| .|  ||| |||. | | . |  |.  .| | ||.||||||     | . |||||||| | |.  
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVT

FGDKPYGEMSNQEVMKSIED--GYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLL
.| .||  |.|.||.. ..   |||.| |  ||  .|..| .||      || |  |.  .|   
YGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphA1.AA TK-Unique 624-880 36 8.5e-92 311.27 In-house 1-294 (294) Show / Hide 
Range on Protein: 624-880
Range on HMM: 1-294/294
Sequence Identity: 36% (108 aa)

LMVDTVIGEGEFGEVYRGTLRLPS-QDCKT--VAIKTLKDTSPGGQWWNFLREATIMGQFS-HPHILHLEGVVTKRK-PIMIITEFMENGALDAFLRERE
| |. |||||.||.|.||... ..  ..|.  ||.|.||| . . .  .||.|. .| .   ||.|....|. ||   | ||| |....| |. .||.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

DQ-------------------------LVPGQLVAMLQGIASGMNYLSN--HNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQG--GKIP
..                         . |..|.  . .||.||.||.   .. |||||.|||.|.. .. ||..|||..| ... .| |....  |.||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQGRIP

IRWTAPEAIA--HRIF-TTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDC-PAPLYELMKNCWAYDRARRPHFQKLQAHL
||| |||..   |... || |||||||..|||....|  ||..|.. ..|. |.||||.| |  | .  .|.|||.|| ...  || | ..   |
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphA1.AA Fer 624-881 32 4.4e-91 308.9 In-house 1-283 (283) Show / Hide 
Range on Protein: 624-881
Range on HMM: 1-283/283
Sequence Identity: 32% (91 aa)

LMVDTVIGEGEFGEVYRG--TLRL--PSQDCK---TVAIKTLKDTSPGGQ-WWNFLREATIMGQ-FSHPHILHLEGVVTKRKPIMIITEFMENGALDAFL
   . ..||| |||||.|  ||..  . .  .    |. |..| ....      |..|| || . ..||..  . || . . ||||. ||. .|.|| .|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

REREDQ-LVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQ-NLCCK--VSDFGLTRLLDDFDGTYETQ--GGKIPIRWTAPEAIAHRIFTTASD
.. ... .   ... |. ..|.||.||  .| .|||.||||.|. . .. .|  .||||. | ..|   .|.      |.||||.|||..  .|.....|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSFGIVMWEVLSFGDKPYGE----MSNQEV-----MKSIEDGYRLPPPVDCPAPLYELMK-NCWAYDRARRPHFQKLQAHLE
|||||...||. . |..||..    | . .|     .. |..||..|.|  .| .....|. .||..|   ||......  |.
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphA1.AA FAK 624-885 39 8.1e-89 297.73 In-house 1-285 (285) Show / Hide 
Range on Protein: 624-885
Range on HMM: 1-285/285
Sequence Identity: 39% (112 aa)

LMVDTVIGEGEFGEVYRGTLRLPSQ------------------------DCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIM
     .|||| ||.|| |.  .. .                        |   ||||| |      .  .|. || || || ||||  | |...  .|| 
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEE-MPIW

IITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQ-GGKIPIRWTAPEAI
|| | .. | | ..|. . ..|  . |.     ..  | ||   ..|||| ||||.||  . | |  |||| |...| .  |     || ||.| .|| |
IIMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWMHDHS-YYKASPKGKLPIKWMSPESI

AHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLLA
  | |||||||| ||. |||.|..| ||.  . |..|   || | ||| |  ||  || ||  |||||  .|| |..| ..|...  
NFRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase EphA1.AA Csk 624-880 39 5.3e-88 298.68 In-house 1-251 (251) Show / Hide 
Range on Protein: 624-880
Range on HMM: 1-251/251
Sequence Identity: 39% (104 aa)

LMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRK-PIMIITEFMENGALDAFLREREDQLV
| .   ||.|||| |  |...      . ||.| .|. .  |    || || .| | .||    | ||. . |  . |..|.| .| |  .|| |. ...
LHLGECIGHGEFGDVMQGEYQ-----NRKVAVKCIKCDG-NGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVI

PGQLVAML-QGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQ---GGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWE
 ..   .    ...|| ||   . ||||||||||||   .  |||||||..     . ...     .||.|| ||||||  |  |.| |||||||| .||
TRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAK-----EECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWE

VLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHL
. |||  ||  .. ..| | .| |||  .|  || . |..||.||. . |.|| |....  |
IYSFGRVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase EphA1.AA Frk 624-884 43 5.3e-86 292.02 In-house 1-260 (260) Show / Hide 
Range on Protein: 624-884
Range on HMM: 1-260/260
Sequence Identity: 43% (116 aa)

LMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLR---EREDQ
. .   .| | ||||. |           ||.||||  .   .  .||||| || .  || ...|  | |  .||.|||| |..|.|  .|.   ..  |
IQLIRRLGSGQFGEVWEGLW----NNTTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

LVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTR-LLDDFDGTYETQGG-KIPIRWTAPEAIAHRIFTTASDVWSFGIVMWE
.   ||| |   .|.|| || ..||.||||||||.||.... ||. |||| | |. |    ||.. | ..||.||||||.    ||. ||||||||.. |
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE

VLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLL
.. .|  ||  | |.||.. .. |||.| | .||  |||.| .||  |  .|| |  ||  ||. .
IITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphA1.AA S_TKc 624-884 21 2.7e-43 151.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 624-884
Range on HMM: 1-231/231
Sequence Identity: 21% (59 aa)

LMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMEN--GALDAFLREREDQ-
  .  .||.| ||.||... .    . . |||| .|         ...||  |. .  ||.| .| .|    . . ...|....  | |  ....|  . 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTT-ASDVWSFGIV
    . . .   ... |.....|. .|. .||||   |||...  . |..|||| |.|                 . ||| .    ... ..|.||.|..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

MWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQA-----HLEQLL
..| |. |  |.     |...| |            . .. .....|. .| ..||   .. .      . . .
LYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphA1.AA Pkinase 624-880 21 4.4e-38 135.75 Pfam 1-293 (293) Show / Hide 
Range on Protein: 624-880
Range on HMM: 1-293/293
Sequence Identity: 21% (63 aa)

LMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGG-QWWNFLR--EATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENG----ALDAFLR-
. .  .||.| ||.||... .  ..   .||.|..|  .    .. . .|  |. ||  ..||.|. | .... .. | ...|..|.|     | .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

EREDQL--VPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCC----KVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIA-HRIFTTASD
.|.  .   . ..  ..  |..|..|. ... .||||   |||...|  .    |..|||| ...|       ...    ... ||| |  ..  ....|
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VWSFGIVMWEVLSFGDKPYGEM------SNQEVMKSIED-GYRLPPPVDCP-------------------APLYELMKNCWAYDRARRPHFQKLQAH--L
.||.|....|.|. |  |. .       . ..... | .  .. . | .|.                    .. ...|.|...| ..|| .. .  |  .
MWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
SAM_1 EphA1.AA SAM_1 911-975 53 1.1e-31 115.16 Pfam 1-66 (66) Show / Hide 
Range on Protein: 911-975
Range on HMM: 1-66/66
Sequence Identity: 53% (35 aa)

DGIPYRTVSEWLESIRMKRYILHFHSAGLDTMECVLELTAEDLTQ-MGITLPGHQKRILCSIQGFK
|. ....|.||||||.|..|| ||..||...|.|.|..|.||| . ||.|||||.|.|..|||..|
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
Sam7 EphA1.AA sam7 913-975 35 1.4e-23 81.57 In-house 1-70 (70) Show / Hide 
Range on Protein: 913-975
Range on HMM: 1-70/70
Sequence Identity: 35% (25 aa)

IPYRTVSEWLESIRM---KRYILHFHSAGL----DTMECVLELTAEDLTQMGITLPGHQKRILCSIQGFK
 . ..|.||||.|.|   ..|. .|...|     .........| ||| .||||.|||.|.|...|| ..
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM EphA1.AA SAM 910-976 44 1.1e-20 75.93 SMART 1-66 (67) Show / Hide 
Range on Protein: 910-976
Range on HMM: 1-66/67
Sequence Identity: 44% (30 aa)

SDGIPYRTVSEWLESIRMKRYILHFHSAGLDTMECVLELTAEDLTQMGITLPGHQKRILCSIQGFKD
 |  . ..|..|||||.| .|. .| ..|.|.|. ..... |||..||||.|||.|.||..||..||
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKD
SAM_2 EphA1.AA SAM_2 910-975 35 2.6e-18 65.68 Pfam 1-71 (71) Show / Hide 
Range on Protein: 910-975
Range on HMM: 1-71/71
Sequence Identity: 35% (25 aa)

SDGIPYRTVSEWLESIRM-KRYILHFHSAGLDTMECV-LELTAEDL--T-QMGITLPGHQKRILCSIQGFK
 .     .|.|||.||.| ..|   | ..|....| . . .|..||  . .||||..||.|.|...|| .|
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK