Gene DNAPK (Human)
DNAPK
Sequence
Protein domains of DNAPK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| HEAT | DNAPK.AA | HEAT | 293-323 | 22 | 0.000496 | 17.82 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 293-323 Range on HMM: 1-31/31 Sequence Identity: 22% (7 aa) LFEVLLKWCAHTNVELKKAALSALESFLKQV ....|||.. ... | ..||...| ...... ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
|||||||||
| HEAT | DNAPK.AA | HEAT | 1009-1040 | 21 | 0.141289 | 9.32 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 1009-1040 Range on HMM: 1-31/31 Sequence Identity: 21% (7 aa) LLEAILDGIVDPVDSTLRDFCGRCIREFLKWS .|...| .. || |. |. . .|. .... . ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC |
|||||||||
| HEAT | DNAPK.AA | HEAT | 1059-1089 | 12 | 1.391634 | 5.88 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 1059-1089 Range on HMM: 1-31/31 Sequence Identity: 12% (4 aa) LFKRLYSLALHPNAFKRLGASLAFNNIYREF .. | .. .|.. |. | .. .... . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
|||||||||
| NUC194 | DNAPK.AA | NUC194 | 1813-2210 | 52 | 8.4e-255 | 857.56 | Pfam | 1-446 (446) | Show / Hide |
Range on Protein: 1813-2210
Range on HMM: 1-446/446
Sequence Identity: 52% (236 aa)
SFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTK--LNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCIT----
. .||...||...|||||||.|....||| ...|..|...||||| || .|..||.|||..|| . |||||||||..| ....||| ..|| |
NNVRQTMLDRYCCTLLWHCSYDTIVQFFSRHIKDIMDMIMSRFTKYLTNEWEFEHQIIKKMCCYKMIEVMYSRLPKDEIHSDDCCINQAYYGSDHTTLGA
--EGNELTKTLIKLCYDAFTENM-AGENQLLERR--RLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFENLIDLKRRY---NFPVEVEVPM
|||||||.|.|.|.||||||| .|..||||.| |.||||||||.|..| |.|.|||||..|||.|.||||..|.|||||..| | .||.|.||||
PIEGNELTKALMKSCHDAFTENMPTGDSQLLEKRLCRKYHCAAYNCLIALISCTFTELKFYHVFLFRENPEKNEYIWENLIDCDRCYLYDEFPQEIEVPM
ERKKKYIEIRKEAR------EAANGDSDGPSYMSSL-SYLADSTLSEEMSQFDFSTGVQS--YSYSSQD-----PRPATGRFRRREQRDP--TVHDDVLE
||||||..|||||| .|.|. .| |.|.|| ||..|| ||.||||||||||||| ..||||| ... ||..|. . . ||| |
ERKKKYVAIRKEARVQSDQVDAWNSHQDEPKYLSSQLSYMMDSSLSQEMSQFDFSTGVQSSTFNYSSQDDGIIMQKASQHHFRKQEIAEDMSMTQDDVME
LEMDELNRHECMAPLTALVK-HMHRSLGPPQG-----EEDSVPR----DLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLA
|||||.|.|||||..... | ||||. |.. .... | |.|.||||||.||||. ..||||||.||..||.|..||||||.|..||.||.
LEMDEINQHECMATMCGCIKFHMHRNNITPKVSILFGDQGAQPKPTVGDMPPWMKFLHQKLGNQQQHLNIRLFIAKVIINCEQWFRPYAKFWIGPLMQLI
A----SENNGGEGIHYMVVEIVATILSWTGLATPT----GVPKDEV
...|||.|.|||||.|..||||||..|||. |...||.
VKLIECDGNGGRGLHYMVVDICVTILSWTSIATPQDGGGGNTRDEH
|
|||||||||
| FAT | DNAPK.AA | FAT | 3023-3470 | 18 | 1e-102 | 344.17 | Pfam | 1-408 (408) | Show / Hide |
Range on Protein: 3023-3470
Range on HMM: 1-408/408
Sequence Identity: 18% (89 aa)
NPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQSLLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVD--RAKYYIQNGIQSFMQNYSS-IDV
.|..... |. ....|||....|... | || || || | ||||... | . .. ...|....|| .... | .|..|| ...| ....... ..
APLAAEAAWRLGQWDETYMDEYISVMKK-LL-GE-DQ-L-TFIDEDSPDE---PTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPG
LLHQSRLTKLQSVQALTEIQEFISFISKQGNL------SSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGD
.. .........||.|.|..|.| ..|. .. .|. .|....||..|.|. |......|..|.|.|....|||.....
ESYNRHYPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYM---------------
PSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDW----LVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDE
... ... .. . |..|. ...||.....|..| ||.|........|| ...|. .|... ...... .. . | .
-----------NSFCYRGPHEDMWMWIKFANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQ----------QEAFQHL-R
NNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQ-RAFQHLSEAVQAAEEEAQPPSWSCGPAAG
.|....... ......|. |.|| .|...... |.. ..|.. |.. ..........|| .. | . .
EFTSCHMQHDLGVHNNNEIN-GLTY--------------------------NLEVINNTNLEYFYTKLLAMRCYHKQGMWQWKLYEEQYMN-WNQEQKDE
VIDAYMTLADFCDQQLRKEEENASVIDSAELQAYP------------------ALVVEKMLKALKLNSN-EARLKFPRLLQ
....||| |..|...| ..| . ...|.|. .|........|... ..| ...|||.
ILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW
|
|||||||||
| Kinase | DNAPK.AA | DNAPK | 3716-4015 | 69 | 9.3e-262 | 875.87 | In-house | 1-301 (301) | Show / Hide |
Range on Protein: 3716-4015 Range on HMM: 1-301/301 Sequence Identity: 69% (210 aa) HVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDL |||||||||||||||||||||||||||||||||||..||.||||||||.||||||||.|...|..|.||.||||||...|||.|||||||..|||.|||. HVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDI LLNTMSQEE-KAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICIS |.|.|.|.. |..|.|..|.|||.|.|||..|..||||..|..||.|.||...|.||||.|.|.|.|...||||||||..|..|.||.||....|.|||| LNNEMQQKMGKKEYISQDREPPCMYRDWLKQMDRKHDVAEYHIMYQGENRDKIVQSFRKQEDKIPRDVFRRAFVRMSTTCETYLYLREHFIRNYAVICIS HWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWK ||||||||||||||||.||.|..|.|||||.||||||||||||||||||||.|||||.|||..|.||.||.|...|||.|...|||..|||...|||||| HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK N | N |
|||||||||
| Kinase | DNAPK.AA | PIKK | 3718-4005 | 43 | 2.5e-171 | 575.47 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 3718-4005 Range on HMM: 1-290/290 Sequence Identity: 43% (126 aa) RIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLL ||...|..|||||....||.|.|||||..|.|.|.||.|||||||||.||||.||..|..|..|..|.|..|||||.||..|.|||||..|.||||... RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK NTMSQEE-KAAYLSDPRAPPCEYKDWLTKMS-GKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISH ....... .... .......|.|.|||..|| .||.......||......|.|..||......|.|..|..|.|....||.....|.....|.|..|... QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG WILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVF .|||.||||..|.|..|.||....||||..|.||.|.|||||..||||||...|.| ||...|.......|.....|.... |.....|| YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
|||||||||
| Kinase | DNAPK.AA | PI3Kc | 3749-4068 | 24 | 9.5e-100 | 338.6 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 3749-4068 Range on HMM: 1-336/336 Sequence Identity: 24% (84 aa) PFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLL--------------NTMSQEEKAAYLSDPRA ....|.|.|||||.|. |.|..|| |...|..|..| |..|.|...|. .. |.||| |..|| .. .| . . .. . . . AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQ-K-N PPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSP-EAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAME . .|... . |.||. ....|....|.. .... . |. |......| |.. . |..|..|.| |. ..||||||||..|.|. |. MY--MMIWHQQACHW------MMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMK TGGVIGIDFGHAFGSATQFLPVP-----ELMPFRLTRQFINLML----PMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPS-FDWKNFEQKMLKK || ...|||||.||.. ...|.. |..|||||......| |... |........|.||.|... |..|.. ..|. | ..|. . .|..|. TGHCFHIDFGHIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-EKDIKY GGSWIQEINVAEKNWYPRQ----KICYAKRKLAGANPAVITCDELLLGH ......... ....... .... . ... .............. LRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY |
|||||||||
| Kinase | DNAPK.AA | PI3_PI4_kinase | 3747-4015 | 24 | 3.3e-93 | 320.76 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 3747-4015
Range on HMM: 1-300/300
Sequence Identity: 24% (79 aa)
EHPFLVKGGEDLR--QDQRVEQLF-----------------------QVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMS
..||..|||.||| ||.|..|.. ..||... .|... .| .|...|...|. .. |.|||..|..|.. .. ..|
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV
QEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSP-EAFLALRSHFASSHALICISHWILGI
... ... .. . . ..||...| |...| |..|..|.| . | . |....... |.... |..|..|.| .|. ..|||.
KCKHKHFNKEHKMWMKMWPDWWHLM-----------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGN
GDRHLNNFMV--AMETGGVIGIDFGHAFG-SATQFLPVPELMPFRLTR------QFINLM------LPMKETGLMYSIMVHALRAFRSDPGLLTNTM---
||||..|.|| ..|| ...|||||.|. ........||..|||.|. .....| |....|.. ....||.||.|.. .|..|..
GDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKA
----DVFVKEPSFDWKN
. .|. ....|.
VMRGECMVHDGLPMWRS
|
|||||||||
| Kinase | DNAPK.AA | ATR | 3717-3816 | 36 | 2.2e-23 | 76.16 | In-house | 1-100 (267) | Show / Hide |
Range on Protein: 3717-3816 Range on HMM: 1-100/267 Sequence Identity: 36% (36 aa) VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLL |||||. | ..|||..||.| ..| | . . . | .|||.| | . ...| .. .| .| ...|||.|.|. .. ..||| .||.||. .| AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL |
|||||||||
| Kinase | DNAPK.AA | ATR | 3887-4005 | 31 | 4e-20 | 64.87 | In-house | 150-267 (267) | Show / Hide |
Range on Protein: 3887-4005 Range on HMM: 150-267/267 Sequence Identity: 31% (37 aa) FVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVH | | |. . . |. . | | .|. .|.|.|||| .| .. .| .. .|. |.| || |||..|||||. .. | ||| || .. FNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEV ALRAFRSDPGLLTNTMDVF .. .| . .| | IMMCMRDHRDDIMSVWDCF |
|||||||||
| Kinase | DNAPK.AA | FRAP | 3747-3816 | 40 | 5.6e-18 | 62.72 | In-house | 1-70 (251) | Show / Hide |
Range on Protein: 3747-3816 Range on HMM: 1-70/251 Sequence Identity: 40% (28 aa) EHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLL |. || || ||.||| || ||| .| .|. . .. | .. ||..|. . ||| | .. ||. |. EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILI |
|||||||||
| Kinase | DNAPK.AA | FRAP | 3891-3971 | 39 | 1.3e-15 | 53.98 | In-house | 127-207 (251) | Show / Hide |
Range on Protein: 3891-3971 Range on HMM: 127-207/251 Sequence Identity: 39% (32 aa) STSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLM | . | . | . | | . . .|||.||||. | | || .. |||| | | . ||. |||||| .| | SPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAM |
|||||||||
| Kinase | DNAPK.AA | ATM | 3751-3818 | 41 | 2.2e-15 | 45.22 | In-house | 3-70 (304) | Show / Hide |
Range on Protein: 3751-3818 Range on HMM: 3-70/304 Sequence Identity: 41% (28 aa) LVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLN |||| .||||| . | ||. | .| .| | . || |||. | | .|| |. | | LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDKFLIN |
|||||||||
| Kinase | DNAPK.AA | SMG1 | 3726-3807 | 32 | 1.8e-13 | 40.84 | In-house | 1-82 (242) | Show / Hide |
Range on Protein: 3726-3807 Range on HMM: 1-82/242 Sequence Identity: 32% (27 aa) VTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLE .|.. .||... | | . |.| || ||| | |. | ..| . | | ||| |. | ||| | . ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVD |
|||||||||
| Kinase | DNAPK.AA | ATM | 3907-3971 | 41 | 2.5e-11 | 32.04 | In-house | 143-206 (304) | Show / Hide |
Range on Protein: 3907-3971 Range on HMM: 143-206/304 Sequence Identity: 41% (27 aa) SHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLM | | | .|||.|||| | .. .. || | || . || || .|||||| . | SVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAF-EQGKILPTPETVPFRLTRDIVDGM |
|||||||||
| Kinase | DNAPK.AA | SMG1 | 3879-3957 | 34 | 6.1e-08 | 22.23 | In-house | 165-242 (242) | Show / Hide |
Range on Protein: 3879-3957 Range on HMM: 165-242/242 Sequence Identity: 34% (27 aa) PADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPE | .|| . | |. . .| | | . . .|.|.||||| | .. | || |. ||. | . | ||| PPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICF-EKGKKLNVPE |
|||||||||
| FATC | DNAPK.AA | FATC | 4096-4128 | 45 | 1.1e-11 | 40.48 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 4096-4128 Range on HMM: 1-33/33 Sequence Identity: 45% (15 aa) SGLSEETQVKCLMDQATDPNILGRTWEGWEPWM .|| | || .| ..||||. | . . || ||. EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
|||||||||