Gene DMPK2 (Human)

DMPK2

Species: Human
Alias: DMPK2, CDC42BPG, MRCKgamma, HSMDPKIN, KAPPA-200
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 11q12-q13.1,

Classification

Group: AGC
Family: DMPK
Subfamily: GEK

Sequence

Name Sequence Type Origin Length Description Download
DMPK2.AA Protein Sugen Kinome 1551 None Fasta, JSON
DMPK2.kin_dom Protein Kinase Domain Sugen Kinome 267 None Fasta, JSON
DMPK2.NA RNA Sugen Kinome 5375 None Fasta, JSON

Protein domain

Protein domains of DMPK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DMPK2.AA DMPK 71-337 72 6.9e-301 755.76 In-house 1-270 (270) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-270/270
Sequence Identity: 72% (195 aa)

FEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPE
||||||||||.|||| |||.. |....||||..|||||||||||||.||||..|.|.|||.|.||||||||.|||.||.|..|||||||.||.|||.|..
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

LAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEG-KGHYGPQCDWWSLGVCAYEL
.|.||||||||||||.||.||||||.||||.|||..|||.|||||||...| .|||.|.||||||||||||.|||||.. ||.|||.|||||.|||.||.
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

LFGETPFYAESLVETYGKIMNH-EDHLQFPPDVP-DVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFF
|.|||||||.|||||||||||| ..||.||.|.. ||...|.|||.||||..||||||.|..||..||||
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF
Kinase DMPK2.AA GEK 71-337 78 2.3e-205 688.57 In-house 1-269 (269) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-269/269
Sequence Identity: 78% (210 aa)

FEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPE
|||||||||||||||.||....|.|..|||.|.|||||||||||||||||||||.||.||.|.||||||||.|||||||||.|||||||||.||||||..
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

LAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELL
.|.||.||||.||.|.|||.|||||.||||||||.||||||||||||||.|..|||.|.||||||||||||||||||.|||.|||.|||||||||.||.|
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML

FGETPFYAESLVETYGKIMNHEDHLQFPPDVP--DVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFF
.||||||||||||||||||||.||.|||...   ||...|.||||||.|.||.||||.|..||..||||
YGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase DMPK2.AA AGC 71-337 30 8.99999999999e-171 445.85 In-house 1-395 (395) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-395/395
Sequence Identity: 30% (125 aa)

FEILKVIGRGAFGEVTVVRQR------DTGQIFAMKMLHKWE--------MLKRAETAC-------FREERDVLVKGD----------SRWVTT-LHYAF
||.|||||.|.||.|  || .      |||...|||.| |..        |.... |..       ..|||..|.| .          . ...  |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDEEY--LYLVMDYYA---------GG-DLLTLLS-R-FEDRLPPELAQFYLAE-------MVLAIHSLHQ-LGYVHRD-VKPDNVLLDVNGHIRLADFG
||...  ||.||.|.          || .|.. |  |  | |.. | |.||.||       .|||...||. .|..||| .||.|.||| .|||.|.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

SCLRLNTNG-------------------------------------------------MVDSSVAVG--TPDYISPEILQAMEEGKGHYGPQCDWWS--L
.| .....|                                                 ..  .  .|  ||.|..||||         ||..|||||  |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL---------YGKACDWWSFGL

GVCAYELLFGETPFYAESLV----------ETYGKIMNH----EDHLQFP-------PDVPDVPASAQDLIRQLLC-RQEERLGRG-------GLDDFRN
|.. ||.|.| .|||... .          |.. ||||.    .. ..||       |... .   |.|||..|||   |.||| |       | .. .|
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

HPFF
||.|
HPWF
Kinase DMPK2.AA CRIK 71-337 48 1.7e-138 444.31 In-house 1-272 (272) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-272/272
Sequence Identity: 48% (134 aa)

FEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPE
||.  .||.| ||.| ||| . |. |.||| .|| ..| . . . | ||||..    | |.. | |||||.. |||.| |  ||||| |..|..| .  .
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

LAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEE---GKGHYGPQCDWWSLGVCAY
.|.||||| ..|.||||. ||||||.||.|.|.|  ||| ||||||   .| |..|.|   ||||||. ||.|| | .   .|| ||  |||||.|. ||
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

ELLFGETPFYAESLVETYGKIMN--HEDHLQ----FPPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFF
|.  | |||   . ..|| .|||   | |.|    || | . |   . |||..||| | .||.  .|    .||||
EMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDPK-VSPNYRDLIQSLLCNQSKRLKYEQL---CCHPFF
Kinase DMPK2.AA ROCK 71-337 55 1.4e-134 453.36 In-house 1-263 (263) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-263/263
Sequence Identity: 55% (147 aa)

FEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPE
|...||||||||||| .||.. . ...||||| | ||.||.. | | ||||..    | |.  |||||||. |||.||||  ||||  |.| ..  .|  
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYD--VPEK

LAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELL
 |.|| .|.|||. ..| .|..||||||||.|||  ||..||||| |...| |||| .. |||||||||||.|..   . |.||  ||||| ||  ||.|
WARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKS-QGQDGEYGRECDWWSVGVFIYEML

FGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFF
.|.|||||.||| ||.|||.| . |.||.|| ..   |.|||.. |  .|.|||| |.|| ..|.||
VGDTPFYADSLVGTYSKIMDHKNSLKFPDDV-EISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF
Kinase DMPK2.AA S_TKc 71-337 31 7.3e-91 309.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-231/231
Sequence Identity: 31% (88 aa)

FEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAG--GDLLTLLSRFEDR--
.|||..||.||||.|  .| ..||.|.|.|...            .| |...| | .  .. .|...||| ..||.||.|  |  |||.... .   .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGP-QCDWWSL
   .|.  |.||......|.  .|..| .|||.||.|.|||   || ..|||.. .|        .  .|||.|..||.|        .||.  |||||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL--------GYGKCKCDWWSC

GVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLC-RQEERLGRGGLDD----FRNHPFF
|.. ||.| |..||.   . ... ||.               . .| |.||..|.   |.|..   .       ..||.|
GCILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DMPK2.AA NDR 71-215 53 5.1e-86 265.21 In-house 1-149 (350) Show / Hide 
Range on Protein: 71-215
Range on HMM: 1-149/350
Sequence Identity: 53% (80 aa)

FEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGD--SRWVTTLHYAFQDEEYLYLVMDYYAGGDLLT---LLSRFED
|||.|.||.|||||| .|| .|||.|.||| . | ||... ..|  | |||.... |  ..||. | |.|||. ||||||.| .|||. |   ||... |
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKM-D

RLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFG
 .. ..|.|| ||||.||.|.|..||.|||.|||| |.|  ||| | |||
IFTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG
Kinase DMPK2.AA RSK 74-337 37 9.7e-83 281.18 In-house 1-278 (278) Show / Hide 
Range on Protein: 74-337
Range on HMM: 1-278/278
Sequence Identity: 37% (107 aa)

LKVIGRGAFGEVTVVRQR---DTGQIFAMKMLHKWEMLKRAE-TACFREERDVLVKGD-SRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDR--
||| |.|..|.| ..|     |||||.||| |.| .. .|.  |.  ..||..|     .  . |||||||.|..|||.|.|  ||.|.| |.. .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDV---NGHIRLADFG-SCL-RLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWS
.  . |.||.|| |||.  |||.| .||| ||.|.|.|    .|||.| ||| ... |.. |.. ..   ..| .|. ||.|   . ..| .. .|||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT--FCYTIEYMAPEMLKRAN-QQGGHDKACDWWS

LGVCAYELLFGETPFYA---ESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEE-RLG--RGGLDDFRNHPFF
|||  ||.|.| .||..   ..  |.  .|.. .  | .| . . . . |.||||..|.| .. |||  ...... ..||.|
LGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNW-QYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase DMPK2.AA Akt 71-337 36 6.3e-78 248.67 In-house 1-264 (264) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-264/264
Sequence Identity: 36% (99 aa)

FEILKVIGRGAFGEVTVVRQRDTGQIF-AMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPP
|..|||.|.|.|| |  |.. ||.... |||.| |   ... . .    || .|.. ..  .. |||.||....||.||||  ||.| ..|.| . | . 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQR-KRRFSE

ELAQFYLAEMVLAIHSLHQLGYVHRD-VKPDNVLLDVNGHIRLADFGSCLRL-NTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWS-LGVCA
. | || ||..|||  ||. . . ||  || |.|.| .|||.|.||| | .   ... .  ..  ||| |..||||    .|.| .. ..|||. ||.  
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTF-CGTPEYLAPEIL----NGNG-HTKAVDWWGSLGCVM

YELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQ-EERLG--RGGLDDFRNHPFF
||...|  |||..   . . ||.| .  ..||.  . .   ..|||..|| .. ..|||   ..... ..||.|
YEMMCGRPPFYNQDHHQMFKKIKNQP--VKFPDK-DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase DMPK2.AA Pkinase 71-337 25 7.7e-65 226.52 Pfam 1-293 (293) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-293/293
Sequence Identity: 25% (78 aa)

FEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFR-EERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGG----DLLTLLS-RFE
..|...||.|.||.|   . ..||.|.|.| . | .  .  . . .|  |  .. . ..  . .|...|.|. ..|.||.|  ||    || ...| . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DRL--PPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHI----RLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCD
 ..  ... ..||. ... ..  .|. | .|||.||.|.|.| ||||    ...|||..  ...   .  .. .|||.|..||...    |  .||| .|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVD

WWSLGVCAYELLFGETPFYAE------SLVETYGKIMNHEDHLQFPPDVP----------------DVPASAQDLIRQLLCR-QEERLGRGGLDDFRNHP
.||.|.  ||.|.|..||. .      .  . . .||  . | ..| . .                 .. ...|.|. .||.  ..|..    ..  .||
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHP

FF
.|
WF
Kinase DMPK2.AA MAST 71-215 40 1e-59 180.82 In-house 1-147 (337) Show / Hide 
Range on Protein: 71-215
Range on HMM: 1-147/337
Sequence Identity: 40% (59 aa)

FEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQD--EEYLYLVMDYYAGGDLLTLLSRFEDRLP
||..|.|..||.| |  |. ..|...|||| . .  ....      . ||..|.  .  .|  . |.||   ..||..||.|  |||  .||. .  ..|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

PELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFG
 ..|..|.|| ||..  ||  | ||||.||||.|.| |||| |.|||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase DMPK2.AA MAST 71-215 41 9e-59 187.95 In-house 1-144 (334) Show / Hide 
Range on Protein: 71-215
Range on HMM: 1-144/334
Sequence Identity: 41% (60 aa)

FEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPE
||. |.|..||.| |  |. ..|...|||| . | .|...  .   . ||..|   .. .|  . |.|| ..||..||.|  |||. .||. .  ... .
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYG-YFDEW

LAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFG
.|..|.||.||..  ||. | ||||.||||.|.| |||| |.|||
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase DMPK2.AA NDR 231-337 42 1.1e-44 135.28 In-house 241-350 (350) Show / Hide 
Range on Protein: 231-337
Range on HMM: 241-350/350
Sequence Identity: 42% (49 aa)

AVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHL-----QFPPDVPDVPASAQDLIRQLLC-RQEERLG
.||||||. ||..|    .|. |...|||||||.  ||.|.| .||....  ||. |||| .  .     .|||... .   |.||||.|.|  ...|||
TVGTPDYMAPEVFQ----QKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEAN-LSPEAWDLIRRLCCPDPDHRLG

RGG--LDDFRNHPFF
..|   |....||||
SHGKGVDEIKSHPFF
Kinase DMPK2.AA MAST 232-337 39 3.5e-35 104.44 In-house 229-337 (337) Show / Hide 
Range on Protein: 232-337
Range on HMM: 229-337/337
Sequence Identity: 39% (45 aa)

VGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVE-TYGKIMNHEDHLQFPPD-VPD----VPASAQDLIRQLLCRQ-EERLG
.||||||.||..     |.| ||.  ||||.|.  ||.| |..|| ...  | . ..| ||.... .|..  |.    ... |||||..||     .|||
CGTPDYIAPEVIL----GQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLG

RGGLDDFRNHPFF
 .| |.  .||||
ANGADEIKQHPFF
Kinase DMPK2.AA MAST 232-337 36 5.4e-30 93.63 In-house 225-334 (334) Show / Hide 
Range on Protein: 232-337
Range on HMM: 225-334/334
Sequence Identity: 36% (42 aa)

VGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHE-DHLQFPPD-VPD----VPASAQDLIRQLLCR-QEERLG
.||||||.||..     |.| .|.  ||||.|.. ||.| | .||  ..  |....| |..     .|..  ..     .  |||||..||    ..|||
CGTPDYIAPEVIL----GQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLG

RG-GLDDFRNHPFF
 . | |.  .||||
ANNGADEVKQHPFF
Kinase DMPK2.AA S_TK_X 338-400 24 2.4e-14 54.92 SMART 1-79 (79) Show / Hide 
Range on Protein: 338-400
Range on HMM: 1-79/79
Sequence Identity: 24% (20 aa)

EGVDWERLAS----STAPYIPELR----GPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLP----------FVGFTYTS
 |.||..| .     ..|..|...    .| |||||| . .       | |.. ....... .          | ||||  
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM--LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase DMPK2.AA Pkinase_C 355-402 35 1.1e-12 47.86 Pfam 1-46 (46) Show / Hide 
Range on Protein: 355-402
Range on HMM: 1-46/46
Sequence Identity: 35% (17 aa)

ELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGS
....| ||||||....   .. |  |..   .||...||.||||.. .
QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD
Kinase DMPK2.AA TyrKc 71-315 18 2.7e-11 -40.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 71-315
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

FEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKG--DSRWVTTLHYAFQDE-------EYLYLVMDYYAGGDLLTLLS
 . .|..|.||||||   . .   .  | |||..         . |..|  .. |   .   .  |. .  ..       | |..|| | ..|||.  | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTN-------GMVDSSVAVGTPD-----YISPEILQAMEEG
. ...|...    .          ||. ...|||    |.|.. |.... .||| .  .           . ...   |. .       .|| .      
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----N

KGHYGPQCDWWSLGVCAYELL-FGETPFYA-----ESLVETYGKIMNHEDHLQFPPD-----------------------VPDVPASAQDLIRQL
.| . .. | || ||| .|.. .|..| .       |  | . ....  . .  ||.                        |.   . .......
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-GYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase DMPK2.AA Pkinase_Tyr 71-85 53 0.004181 11.14 Pfam 1-15 (270) Show / Hide 
Range on Protein: 71-85
Range on HMM: 1-15/270
Sequence Identity: 53% (8 aa)

FEILKVIGRGAFGEV
 ...|..|.||||||
ITFGKKLGEGAFGEV
Kinase DMPK2.AA Pkinase_Tyr 186-215 33 0.069772 7.0 Pfam 127-156 (270) Show / Hide 
Range on Protein: 186-215
Range on HMM: 127-156/270
Sequence Identity: 33% (10 aa)

LHQLGYVHRDVKPDNVLLDVNGHIRLADFG
|.. ...|||.   |.|.. |.... .|||
LESKNCIHRDLAARNCLVTENNVVKICDFG
DMPK_coil DMPK2.AA DMPK_coil 445-459 60 9.423038 1.72 Pfam 47-61 (61) Show / Hide 
Range on Protein: 445-459
Range on HMM: 47-61/61
Sequence Identity: 60% (9 aa)

ELEQLRKEVQTLRDR
|.|||.||   || |
EMEQLKKEMEMLRAR
DMPK_coil DMPK2.AA DMPK_coil 486-504 36 5.968001 2.4 Pfam 43-61 (61) Show / Hide 
Range on Protein: 486-504
Range on HMM: 43-61/61
Sequence Identity: 36% (7 aa)

DLRQELDRLHRELAEGRAG
.| ||...|  |. . || 
ELEQEMEQLKKEMEMLRAR
DMPK_coil DMPK2.AA DMPK_coil 542-574 27 1.546637 4.41 Pfam 29-61 (61) Show / Hide 
Range on Protein: 542-574
Range on HMM: 29-61/61
Sequence Identity: 27% (9 aa)

ALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQ
. ...| || .  ||||... .|      |. .
QFECKLQEAEKKNRELEQEMEQLKKEMEMLRAR
DMPK_coil DMPK2.AA DMPK_coil 609-626 22 25.625928 0.23 Pfam 44-61 (61) Show / Hide 
Range on Protein: 609-626
Range on HMM: 44-61/61
Sequence Identity: 22% (4 aa)

LRKEVAALREQLEQAHSH
| .|.. |.. .|   . 
LEQEMEQLKKEMEMLRAR
C1_1 DMPK2.AA C1_1 727-737 16 49.375423 0.1 Pfam 1-12 (55) Show / Hide 
Range on Protein: 727-737
Range on HMM: 1-12/55
Sequence Identity: 16% (2 aa)

HQWKAR-RLQKM
|.|... .. ..
HHWVHHWNFKQP
DMPK_coil DMPK2.AA DMPK_coil 744-801 55 5.1e-26 91.75 Pfam 1-61 (61) Show / Hide 
Range on Protein: 744-801
Range on HMM: 1-61/61
Sequence Identity: 55% (34 aa)

ELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREEL---RAR
||||||||||||||...|.|..|..|..|.|..||||||....|.||...|..|.   |||
ELQSALEAEIRAKQSIHEELNKVKAANIQFECKLQEAEKKNRELEQEMEQLKKEMEMLRAR
C1_1 DMPK2.AA C1_1 879-931 34 2.8e-11 45.07 Pfam 1-55 (55) Show / Hide 
Range on Protein: 879-931
Range on HMM: 1-55/55
Sequence Identity: 34% (19 aa)

HTLRPR-SFPSPTKCLRCTSLMLG-LGRQGLGCDACGYFCHTTCAPQAPPCPVPP
|  ... .|..||.|  | ... | ||.||. |..|.| ||  |....||.  . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 DMPK2.AA C1 879-927 27 1.8e-10 42.07 SMART 1-61 (61) Show / Hide 
Range on Protein: 879-927
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HTLRPRSFPSPTKCLRCTSLMLGLGRQ-----GLGCDACGYFCHTTCAPQAP--------PC
|. . ..| .||.|  | ... |. .|     |. | .|.| ||  |....|        .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
PH DMPK2.AA PH 948-1068 14 8.8e-14 53.03 SMART 1-82 (82) Show / Hide 
Range on Protein: 948-1068
Range on HMM: 1-82/82
Sequence Identity: 14% (17 aa)

TAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLL
. .||.|..      . .|..... | ...|.... .         ..  ...|.| ...  |                 |.... .        | .. 
VIKEGWLYKKS----K-RWKKRWFVLFNDCLYYYKDK---------KPKGSIPLSDCTVRE-P----------------CFEIHH-DR-------TYYFQ

AESEGERERWLQVLGELQRLL
.||| |...|.| . .... .
CESEEEMQEWMQAIQKAIHNN
PH DMPK2.AA PH 948-1066 19 2.5e-11 43.51 Pfam 1-92 (92) Show / Hide 
Range on Protein: 948-1066
Range on HMM: 1-92/92
Sequence Identity: 19% (23 aa)

TAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLL
  .||.|..      |..|..... | ...|.... ..         .  ...|.| |.  .|            . | .|...| .        |... 
VIKEGWLHKKG---KRKSWKKRWFVLFNNCLYYYKDDK-------YRPKGSIPLSDCQVTKVPDN----------KRPHCFQIRT-DR------RTYYFQ

AESEGERERWLQVLGELQR
|||| |...|.| . ...|
AESEEEMNDWMQAIQSACR
CNH DMPK2.AA CNH 1097-1363 20 7.4e-74 256.47 Pfam 1-336 (336) Show / Hide 
Range on Protein: 1097-1363
Range on HMM: 1-336/336
Sequence Identity: 20% (69 aa)

CAAILDQDRLALG-TEEGLFVIHL--RSNDIFQVGECRR----VQQLTLSPSAGLLVVL--CGRGPSVRLFALAELENIEVAGA----------------
.... ....|..| |.|||.|...  ... . ....|      |.|. . .  ..|...  |......... |  |.. |.. .                
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSRRVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRIERI

---------KIPESRGCQVLAAGSILQARTPVLCVAVKR-----QVLCYQLGPGPGPWQ------------RRIRE-LQAP----ATVQSLGLL---GDR
         |.|....|.  . ..  . ..  ||.||||     ...||.  .   ...            | .|| ...|    ....|. .|    ..
MPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLPPMTECFSMHWLPQEKPK

LCVGAAGGFALYPLLNEAAPLAL---GAGLVPEELPP-SRGGLGEALGAVELSLS-EFLLLFTTAGIYVDGAGR-KSR--GHELLWPAAPMGWGYAAPYL
|||| . ||....| ....|  |   .   |  ...  .|.   ......... . |||| ..  ..||.  |. .||   .|. |...|. . .  |||
LCVGCQKGFHIVNLDGTGQPWWLHDPADHSV--QQDFMARRENCKPICMHRINDDEEFLLCYDECCVYVNKQGWPRSRKHDWEIMWEGMPQSFACCYPYL

TVFSENSIDVFDVRRA-EW---VQTVPLKKVRPLNPEG
..|..|.|....|.   ||   ||..|....|.|. ..
LAFHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS
CNH DMPK2.AA CNH 1092-1372 14 3.3e-08 17.93 SMART 1-375 (375) Show / Hide 
Range on Protein: 1092-1372
Range on HMM: 1-375/375
Sequence Identity: 14% (54 aa)

LPHTLCAAILDQ----DRLALGTEEGLFVIHLRSN-------DIFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAEL--------------ENI
.  . |..|...    . | .|||.|.... .  .          .  . |.|.....   . .|. . |. | .. . |  |              ...
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

EVAG---------AKIPESRG-CQVLAA-GSILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIR------------------ELQAPATVQSLGLLGDR
. ..          |||. .| |  ... . . ... ..||.|..  |  |   . |      ..                   .  |. | .. .  ..
CNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDSF

----LCVGAAG------GFALYPLLNE---------AAPLALGAGLVPEELPPSRGGLG--EALGAVELSL------SEFLLLFTTAGIYVDGAG---RK
    .|.|. .      ||. .               . . . .   .  . .. .  .  ... .. .        ...|| .. .|..|.  |   |.
ERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEWRR

SRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEW-VQTVP------LKKVRPLNP---EGSLFLYGTEK
.| ..| |. .|..  |  ||. .|..|.|.....  .|| .|..       ..| | | .     .  .| ...
WRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
PBD DMPK2.AA PBD 1437-1473 39 0.000156 22.31 SMART 1-38 (38) Show / Hide 
Range on Protein: 1437-1473
Range on HMM: 1-38/38
Sequence Identity: 39% (15 aa)

ISPPT-NFNHLVHVGPANGRPGARDKSPAPEEKGRVAR
|| || ||.| ||||| .|. |  .  |   ..     
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
PBD DMPK2.AA PBD 1436-1450 62 0.000182 18.51 Pfam 1-16 (60) Show / Hide 
Range on Protein: 1436-1450
Range on HMM: 1-16/60
Sequence Identity: 62% (10 aa)

LISPP-TNFNHLVHVG
 || | ||| | .|||
MISTPLTNFKHTMHVG