Gene DLK (Human)
DLK
Sequence
Protein domains of DLK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | DLK.AA | LZK | 158-397 | 78 | 4.8e-213 | 714.05 | In-house | 1-241 (241) | Show / Hide |
Range on Protein: 158-397 Range on HMM: 1-241/241 Sequence Identity: 78% (189 aa) ILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGM | .|||.|||||||||.|.|..|.||||||||||||||||||||||||||.|||||||.|||||.||.|..||||||||..|..||.|.||||..||.|| ISELQWLGSGAQGAVFRGWFRNETVAVKKVRDLKETDIKHLRKLKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVLRERRTITPQLMVDWSKQIAQGM NYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDK-STKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVG .|||.||||||||||||.||...|||||.|||||...... ||||||.|||||||||||||||.|||||||||||||||.||.|||||||||.||||||| HYLHQHKIIHRDLKSPNILISHNDVVKICDFGTSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVG SNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHL |||||||.||.||.|||.|..|||..||||||||||||.|. SNSLHLPMPSTCPEGFKLLMKQCWSQKPRNRPSFRQILMHW |
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| Kinase | DLK.AA | MLK | 158-397 | 44 | 1e-146 | 493.75 | In-house | 1-291 (291) | Show / Hide |
Range on Protein: 158-397 Range on HMM: 1-291/291 Sequence Identity: 44% (129 aa) ILDLQWVGSGAQGAVFLGRFHGEE-----VAVKKVR-------------DLKETDIKHLRKLKHPN----IITFKGVCTQAPC-YCILMEFCAQGQLYEV |. ..|.|||..|.|..||..... ||||.|| . .|....|||.|.||| || |.|||.| || .||.||.|. |.||.| IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV LRAGRP--------------VTPSLLVDWSMGIAGGMNYLHLHK---IIHRDLKSPNMLIT------YDDVVKISDFGTSKELSDK-STKMSFAGTVAWM |...|. ........|.. .| ||.||| .. ||||||||.|.||. ....||.|||||...... ...||.|||.||| LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM APEVI---RNEPVSEKVDIWSFGVVLWELLTGEIPYK-DVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHL ||||| |.|..|||.|.||.||||||.||.|.||| ..|..||.|.|. |.|..|.||.||...| |. ||||..|..|||||||. || APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | DLK.AA | TKL | 164-397 | 28 | 3.4e-101 | 342.48 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 164-397
Range on HMM: 1-364/364
Sequence Identity: 28% (104 aa)
VGSGAQGAVFLGRFHG----------EEVAVKKVR----------------------------------DLKETDIKHLRKLKHPNIITFKGVCTQAPC-
.|||. | |. |...| ..||||| . . .| |.....|.||||. |.|.|.. ||
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------YCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHK--------IIHRDLKSPNMLIT--------------YDDVVK
.|| ||.| | |...| ......|...|| |||||| .. ||||||||.| |. .|...|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK
ISDFGTSKELSDKS--------------------TKMSFAGTVAWMAPEVIRNE----------------PVSEKVDIWSFGVVLWELLTGEIPYKDVDS
|.|||.|...| .. |.|. || .||||||.|.. . |||.|..|||.||||.||...||.| ..
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY
S---------AIIWGVGSNSLHLPVP------------SSCPDGFKILLRQCWNSKPRNRPSFRQILLHL
. .....|....|..|.| ..||...| |. .||...|..|||| .|| .|
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | DLK.AA | TKL-Unique | 160-397 | 32 | 5.8e-79 | 268.63 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 160-397
Range on HMM: 1-290/290
Sequence Identity: 32% (96 aa)
DLQWVGSGAQGAVFLGRFHGEEVAVKKVR-------DLKETDIKHL---RKLK-HPNIITFKGVCT----QAPCYCILMEFCAQGQLYEVLR--------
.. .|.|..|.|. | ..|..||.|. ..... .... ||. |||| .. |.|. ..| .|| ||.| | ||.||
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN
--AGRPVTPSLLVDWSMGIAGGMNYLHLHK--IIHRDLKSPNMLITYD-----DVVKISDFGTSKELSDKSTKMSFA-----------GTVAWMAPEVIR
. .... |. ||.||.||| . ||||||||.| |.. . .||.|||.|| ...|..||.. |. ||||||.|
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSK-FNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR
N--EPVSEKVDIWSFGVVLWELLTGEI------PYKDVDSSAIIWGVGS--NSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHL
. . |||.|..|||.||||..|..| ||...|. ... | . ....|.|..|| .. |..|||.. | .|||| .|. |
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
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| Kinase | DLK.AA | ZAK | 161-396 | 41 | 4.2e-75 | 255.83 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 161-396
Range on HMM: 1-257/257
Sequence Identity: 41% (107 aa)
LQW---VGSGAQGAVFLGRFHGEE-----VAVKKVRDL-KETDIKHLRKLKHPNIITFKGVCTQAPC-YCILMEFCAQGQLYEVLRAGRPVTPS------
.| .| | |.|. .. .||||| . || | | |..| ||| | |.| | | | |. | || |
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKKVFKIEKEAEI--LSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSNRSQEMDSSSGGN
---LLVDWSMGIAGGMNYLHLH---KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVI-RNEPVSEKVDIWSFGVVLWELL
. | || || ||| ||||||||| | | . |.|| |||||... . | ||. || .|||||.| |||.| |.||.||||||.|
SMDHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVIDKNGVCKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQSEPVTETCDVWSYGVVLWEML
TGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLH
| |.|||| . | | . | .|.||| || |. ||| |. ||..|||
TREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI
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| Kinase | DLK.AA | Dicty4 | 158-399 | 34 | 1.3e-70 | 234.78 | In-house | 1-277 (277) | Show / Hide |
Range on Protein: 158-399 Range on HMM: 1-277/277 Sequence Identity: 34% (96 aa) ILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETD----IKHLRK-------LKHPNIITFKGVCT----QAPCYCILMEFCAQGQLYEVLRA----- | | |.|. | |..|. | |||||| ..... .. .|| . ||||..|.| || . . || .|.. .| ||..|.. INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ GRPVTPS--LLVD---WSMGIAGGMNYLHL--HKIIHRDLKSPNMLITYDDVVKISDFGTSK---ELSDKST-KMSFAGTVAWMAPEVIRNEPVSEKVDI .... | .| |||.|| |||||||| | |. . .||..||| |. . .|... |. .||..|||||| ...| ||.| QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV WSFGVVLWELLTGEIPYK--DVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLH--LDI ||| ||||.||...|| . .. .|.. | .|.|..||. .| |. ||. | .|||| .|. |. YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| Kinase | DLK.AA | Pkinase | 158-397 | 26 | 3.4e-70 | 244.31 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 158-397 Range on HMM: 1-293/293 Sequence Identity: 26% (79 aa) ILDLQWVGSGAQGAVFLGRFHGEE--VAVKKVRDLKETD-----------IKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQG----QLYEVLR--AG . .. .|||. | |.... .|.. ||||... .| . |. ...|.||||........ . ... ||.| | |..... .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH RPV--TPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVV----KISDFGTSKE--LSDKSTKMSFAGTVAWMAPEVIR-NEPVSEKVDIWSF ... .. . .. |. |..|.| ..|||||||. | || .... ||.||| .| . .| ..|.|| .||||||| ... . |||.||. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GVVLWELLTGEIPYKDV------DSSAIIWGVGSNSLHLPVPSSCP-------------------DGFKILLRQCWNSKPRNRPSFRQILLH--L |..|.|.|.|. |... | ..| ... || . | .|. . .| ... |.. .| ||...||| | . GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | DLK.AA | S_TKc | 158-405 | 26 | 2.5e-64 | 220.92 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 158-405 Range on HMM: 1-231/231 Sequence Identity: 26% (70 aa) ILDLQWVGSGAQGAVFLGRFHG--EEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQ--GQLYEVLRAGRP------VTPSLLV |. .|.|| | |...| .. ..||.|.... . |. |.| .||||.....|. .... ||.| . | |..... .. .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR DWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSE-KVDIWSFGVVLWELLTGEIPYKDV . |. ...|.| |.||||||| | |.. ..||.||| ...| ..| || .|||||. . . |.|.||.|..|.|.|.|. |. FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-- DSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILL-HLDIASADVL . ... .| .. .| ..|.|.. |..||. ..| .||.. . QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | DLK.AA | Pkinase_Tyr | 165-397 | 32 | 7.5e-64 | 216.87 | Pfam | 8-270 (270) | Show / Hide |
Range on Protein: 165-397 Range on HMM: 8-270/270 Sequence Identity: 32% (87 aa) GSGAQGAVFLGRFH------GEEVAVKKVRDLKETD----------IKHLRKL-KHPNIITFKGVCT-QAPC--YCILMEFCAQGQLYEVLRA----GRP |.|| | |..|. . . .||||.... . .| ...| .||||. . |||| | ..| ||... | |.. ||. ..| GEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQP VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKEL----SD-KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWE .|.. |..... || ||.||. ...||||| | |.| . ||||.||| .. . .... . . |||||.|.. ..| |.|||||..|| LTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVWSFGVLMWE LLT-GEIP-YKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHL ..| ||.| |.... . .. .. . .| | ||| |..|||. .| .||.|..|. .| IFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | DLK.AA | DRK | 164-399 | 36 | 2.9e-59 | 199.35 | In-house | 7-258 (258) | Show / Hide |
Range on Protein: 164-399 Range on HMM: 7-258/258 Sequence Identity: 36% (93 aa) VGSGAQGAVFLGRFHGEEVAVKKVRDLKET----------DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWS--- .| | | ||.| | .||||. . . | . .| ||||. | | |. | || ||. | || .| .|. ||. IGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNIL-----HDESIEMDWPLMK -MGI--AGGMNYLHLHK--IIHRDLKSPNMLITYDDVVKISDFGTSK---ELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIP |.. | ||.||| |||||||| | |. ||..||| | .. . | || | |||| ||.. || |..||..||||..| ..| QMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQDP YKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDI | . .. || . .|.| || . |. ||| | |||. ..| |. YFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA |
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| Kinase | DLK.AA | TyrKc | 158-397 | 31 | 4.1e-59 | 203.61 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 158-397 Range on HMM: 1-280/280 Sequence Identity: 31% (89 aa) ILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETD-----IKHLRKL--KHPNIITFKGVCTQA-------PCYCILMEFCAQGQLYEVLRAGRP-VT | .. |.|| | |..|. ..||||.... . .. ..|| .||||. . ||||| . ..|.||... | | . ||. || .. ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC PSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDK--------STKMSF--AGT----VAWMAPEVIRNEPVSEKVDIWS .. |.... || ||.||| ...||||| | |.. . .||||||| |... |. ... | . |||||.|. ..| |.|| MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWS FGVVLWELLT-GEIPYKDV----DSSAIIWGVGSNSLHLPVPSS--------CPDGFKILLRQCWNSKPRNRPSFRQILLHL |||..||..| |. || .. | . . . .| | . ||| . .|||. .| .||.|..| . FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | DLK.AA | TK | 158-397 | 17 | 1.2e-58 | 194.87 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 158-397
Range on HMM: 1-486/486
Sequence Identity: 17% (86 aa)
ILDLQWVGSGAQG---AVFLGRFHG---------------------------EEVAVKKVRDLKETDIK---------------------HLRKLK----
| .. |.|. | |..|. .| ..|||| ... ... . . ...
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
-HPNIITFKGVCTQAPC------------YCILMEFCAQGQ----LYEVLRAGRP---------------------------------------------
||||. . ||||| . ..|.||... | | . ||. ||
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------VTPSLLVDWSMGIAGGMNYLHLH------KIIHRDLKSPNMLITYDDV-----------VKISDFG---
.|. |. ... || || ||| . ...|||| | |.. ..| .||.|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----TSKELSD--KSTKMSFAGT-------------------------VAWMAPEVIR---------NEPVSEKVDIWSFGVVLWELLT-GEIPYKDVD
.... . ...| || . |||||... . ..| |.|||||..||..| |. ||
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
SS---------AIIWGVGSN--------------SLHLPVPSSCP--------------DGFKILLRQCWNSKPRNRPSFRQILLHL
|. . . . . .| | || . . .|..|||. .|. ||.|.|.. |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | DLK.AA | TK-Unique | 158-397 | 30 | 5.1e-56 | 191.64 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 158-397 Range on HMM: 1-294/294 Sequence Identity: 30% (90 aa) ILDLQWVGSGAQGAVFLGRFHG--------EEVAVKKVR-DLKETD-------IKHLRKLK-HPNIITFKGVCTQAP-CYCILMEFCAQGQLYEVLRAGR . .. .|.|| | |. | . | ||||... .. .|| |.....|. ||||... |.|| .|.||.|..| | || | LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR P--------------------------VTPSLLVDWSMGIAGGMNYLHL--HKIIHRDLKSPNMLITYDDVVKISDFGTSKELSD----KSTKMSFAGTV | ..| .|. . .|| ||.||. .||.|||| . | |.| | |.||.||| ...... ... .. . PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI AWMAPEVIR--NEPV-SEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSC-PDGFKILLRQCWNSKPRNRPSFRQILLHL .|||||... .. ..| |.|||||..||..| |. || ..... |. . . .|.|..| .. . |...||...| |||||||. | RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECI-RDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | DLK.AA | MLK | 280-397 | 49 | 7e-55 | 179.73 | In-house | 164-280 (280) | Show / Hide |
Range on Protein: 280-397 Range on HMM: 164-280/280 Sequence Identity: 49% (58 aa) DDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQC . . || ||| |. .|| ||| ||||||||. |. |.||.||.|||||||| ||. .| |. .|| | | ||.||.||. .. |.. | NKQLKITDFGLAREWHKTT-RMSAAGTYAWMAPEVIKESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDC WNSKPRNRPSFRQILLHL || | ||.| .|| | WNQDPHKRPKFSEILQQL |
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| Kinase | DLK.AA | MLK | 159-277 | 42 | 1.7e-32 | 104.53 | In-house | 1-136 (280) | Show / Hide |
Range on Protein: 159-277 Range on HMM: 1-136/280 Sequence Identity: 42% (58 aa) LDLQ-WVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHL--------------RKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTP |... .|.| | |. . ..||||||| | | |. ||||||| .||| . | |..||.|. | | |. ||. . | LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVC-AGKRIPP SLLVDWSMGIAGGMNYLHLHK---IIHRDLKSPNMLI ||.| . || |||||| |||||||| | || HVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILI |
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