Gene CYGF (Human)

CYGF

Species: Human
Alias: ROS-GC2, GUCY2F, CYGF, GC-F, GUC2F, GUC2DL, RETGC-2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: Xq23,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
CYGF.kin_dom Protein Kinase Domain Sugen Kinome 280 None Fasta, JSON
CYGF.NA RNA Sugen Kinome 3700 None Fasta, JSON
CYGF.AA Protein Sugen Kinome 1108 None Fasta, JSON

Protein domain

Protein domains of CYGF.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor CYGF.AA ANF_receptor 71-412 22 7.6e-83 286.34 Pfam 1-364 (364) Show / Hide 
Range on Protein: 71-412
Range on HMM: 1-364/364
Sequence Identity: 22% (84 aa)

LPEVAARLAIERINRDPS-FDLSYSFEYVILNE----DCQTSRALSSFISHHQMASGFIGPTNPGYCEAASLLGNSWDKGIFSWACVNYELDN--KISYP
 .. |.|.|||.||.||. ..  ....|.....    || .  |.  .  | ... ..|||.....|.... . | |.. ..||.| ...|..  |..||
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAKNRYP

TFSRTLPSPIRV-LVTVMKY----FQWAHAGVISSDEDI--WVHT---ANRVASALRSHGLPVGVV--LTTGQDS-QSMRKALQRIHQ--ADRIRIIIMC
.| ||.||.  .   .....    |.|.. .|| .|.|   |...   .... ..||.||...  .   .. ... ......| .|..  ... |.|.||
YFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKARVIVMC

MHSALIGGETQMHLLECAHDLKMTDGTYVFVPYDALLYSLPYKHTPYRVLRNNPKLREAYDAVLTITVESQEKTFYQAFTEAAARGEIPEKLEFDQVSPL
......| . |  ....||.| |..| ||....|....|...   .|... .|.|.|||...||..|.     ...| |.. . .       . ..... 
CYPDDMG-LLQRQIMQQAHELGMMSGGYVWIYTDWWMHSYDMQ-WWYDDDMDNDKFREAMKGVLGFTMH-P-SPEFQEFMQRWKK-------TDTEMNYY

FGTIYNSIYFIAQAMNNAMKENGQAGAAS----------LVQHSRN-MQFHGFNQLMRTDS-NGNG-ISEYVILDTN
....|...| .|.|..|. ..........          |... .| ..| |. . .. |. .|.   . |.|....
AAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNWD
Kinase CYGF.AA RGC 567-811 37 4.6e-124 418.46 In-house 1-300 (300) Show / Hide 
Range on Protein: 567-811
Range on HMM: 1-300/300
Sequence Identity: 37% (113 aa)

EGDWVWLKKFSLGDFGDLKSIKSRASDVFEMMKDLRHENINPLLGFFYDSG------MFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKY
||||||.||.  ..... . ..  . . . .|..|.|.|.|. .| . |.       ...||.|.||||||.||| | |.|.|||||.|.. |..||| |
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHHREF-VHGRLKSRNCVVDGRFVLKVTDYGF-----NDILEM-------------LRLSEEESSMEELLWTAPELLRAP---------RGSRLGSFAGD
|||... .||.|||.|||||.|.|.|.||.|.     .   ..             .| ..|. .....||||||.||..         |....|...||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYSFAIIMQEVMVRGT-----PFCMM----DLPAQEIINRLKKPPP-----VYRPVVPPE------HAPPECLQLMKQCWAEAAEQRPT-FDEIFNQFKT
||||.|||.|...|.      ||||.    .|  .||| ..|.||.     ..|| ....       ..|..|.||..||||  |.||. || |..|.||
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase CYGF.AA RGC 567-811 37 4.6e-124 418.46 In-house 1-300 (300) Show / Hide 
Range on Protein: 567-811
Range on HMM: 1-300/300
Sequence Identity: 37% (113 aa)

EGDWVWLKKFSLGDFGDLKSIKSRASDVFEMMKDLRHENINPLLGFFYDSG------MFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKY
||||||.||.  ..... . ..  . . . .|..|.|.|.|. .| . |.       ...||.|.||||||.||| | |.|.|||||.|.. |..||| |
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHHREF-VHGRLKSRNCVVDGRFVLKVTDYGF-----NDILEM-------------LRLSEEESSMEELLWTAPELLRAP---------RGSRLGSFAGD
|||... .||.|||.|||||.|.|.|.||.|.     .   ..             .| ..|. .....||||||.||..         |....|...||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYSFAIIMQEVMVRGT-----PFCMM----DLPAQEIINRLKKPPP-----VYRPVVPPE------HAPPECLQLMKQCWAEAAEQRPT-FDEIFNQFKT
||||.|||.|...|.      ||||.    .|  .||| ..|.||.     ..|| ....       ..|..|.||..||||  |.||. || |..|.||
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase CYGF.AA TKL 597-809 22 3.4e-43 149.83 In-house 78-364 (364) Show / Hide 
Range on Protein: 597-809
Range on HMM: 78-364/364
Sequence Identity: 22% (66 aa)

MMKDLRHENINPLLGFFYDSGM-------------FAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHRE--------FVHGRLKSRN
||. |||.|| ...|.  ...              ..||.|.|..|||...|.       |  . .. ||  .|| ||| ..         .|  |||.|
MMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN

CVVDGRFV--------------LKVTDYGFNDILEM------------------LRLSEEESSMEELLWTAPELLRAPR------------GSRLGSFAG
. ||  .               .|..|.|.   ...                  .. .   .    . | |||.||               ...  | . 
ILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKC

DVYSFAIIMQEVMVRGTPFCMMDLP------------AQEIINRLKKPPP-----VYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQF
|||||.|.. |.. | .|.  .. .            .. . ..|. |.|     ... ..|....||.  .||..||.. .|.||.|.||  ..
DVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHK-MCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase CYGF.AA TK 596-809 17 3e-34 111.64 In-house 93-486 (486) Show / Hide 
Range on Protein: 596-809
Range on HMM: 93-486/486
Sequence Identity: 17% (70 aa)

EMMKD--LRHENINPLLG-------------FFYDSGMFAIVTEFCSRGS----LEDILTNQDVK-----------------------------------
.||.   ..|.||  |.|             .  ... . ||.|... |.    | | | . . |                                   
KMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESN

----------------------------------------LDWMFKSSLLLDLIKGMKYLHHR------EFVHGRLKSRNCVVDGRFV-----------L
                                        |.   .    ... .|| ||| .       |||. |  ||| |. . |            
SPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVC

KVTDYGFNDILE--MLRLSEEESSMEELL-------------------------------WTAPELLRAPRGSRL-----GSFAGDVYSFAIIMQEVMVR
|..|.|  .  .  . |  ....                                     |.||| |.  . |.       . . ||.|| . | |.. .
KIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTY

G-TPFC--MM-------DLPAQEIINRLKK------------------PPPVYRPV------VPPEHAPPECLQL-MKQCWAEAAEQRPTFDEIFNQF
| .|.   |        . . ||....|..                  |.|.. |         |.|.||| ... |.|||.. .|.||||... .|.
GQEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMH-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase CYGF.AA TKL-Unique 598-809 29 4.5e-33 114.03 In-house 49-290 (290) Show / Hide 
Range on Protein: 598-809
Range on HMM: 49-290/290
Sequence Identity: 29% (74 aa)

MKDLR-HENINPLLGFFY----DSGMFAIVTEFCSRGSLEDILT---------NQDVKLDWMFKSSLLLDLIKGMKYLHHRE--FVHGRLKSRNCVVDGR
|| |. |.||  . |.      . . . ||.|.|..||| | |.         |.  ||..  . .. .|  .|| ||||.|    |. |||.|  || .
MKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNN

-----FVLKVTDYGFNDILEML---RLSEE-----ESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGT------PFCMMDLP-AQEII
     .  |. | |.  ..       ..|      .. . ...| |||.|| .    . |   |||||.|.. |   |        |.  ||     |..
SNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF--CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMV

NR--LKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQF
     ...||.      |.| |.|   |..|||.   .|||.|||| .  
HYMEENYRPPI------PNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase CYGF.AA RIPK 596-809 25 1.9e-29 97.53 In-house 48-290 (290) Show / Hide 
Range on Protein: 596-809
Range on HMM: 48-290/290
Sequence Identity: 25% (62 aa)

EMMKDLRHENINPLLGFFYDS------GMFAIVTEFCSRGSLEDILTNQDVK----LDWMFKSSLLLDLIKGMKYLHHRE--FVHGRLKSRNCVVDGRFV
..|. ||.|.| |..||  .       ....||.|.   |||.. |. .  .    . |  .  ..   . || |||       |  ||  |  ||. | 
KHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFH

LKVTDYGFNDILEMLRLSEEES---------SMEE---LLWTAPELLRAPRGSRL--GSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAQEIINRLKKPPP
 |. | |    ...  .  ..          | ..   |   .||..|    ...   . . |||||||.| ||. .  |.    .. . ..   ..  |
VKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRP

VYRPVVPPEHAPPECLQ---LMKQCWAEAAEQRPTFDEIFNQF
   || ..   ||.| |   ||..||. ....||.| |.  ..
CLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase CYGF.AA Abl 597-809 31 5e-26 83.4 In-house 48-252 (252) Show / Hide 
Range on Protein: 597-809
Range on HMM: 48-252/252
Sequence Identity: 31% (67 aa)

MMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQD-VKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDIL
.||...|.|.  |||       | |.||| . | | | | . |  .|. .    .   .  ||.|| .|.|.|  |  |||.|    ..|| |.|   ..
IMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMM

EMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRG-TPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAE
.      .      . ||||| |         |   ||. | ... |.   | .|.  .||  ... ..| |    || .  ||  ||.  .||.|||  
KDDTYTAHAGAKFPIKWTAPESLAY----NKFSSKSDVWAFGVLLWEIATYGMSPYPGIDL--SHVYHKLEK---GYR-MERPEGCPPKVYELMRQCWQW

AAEQRPTFDEIFNQF
 .  ||.| || ...
SHTDRPSFKEIHHAM
Kinase CYGF.AA TK-Unique 595-809 23 9.3e-23 75.38 In-house 54-294 (294) Show / Hide 
Range on Protein: 595-809
Range on HMM: 54-294/294
Sequence Identity: 23% (60 aa)

FEMMKDLR-HENINPLLGFFYDSG-MFAIVTEFCSRGSLEDILT---------------------NQDVKLDWMFKSSLLLDLIKG----MKYLHH--RE
..||| |  |.||  .||   .|.  . |. |.|..|.|.. |                      . | ...   .. .|.  ...    |.||.   ..
IQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKK

FVHGRLKSRNCVVDGRFVLKVTDYGFND------ILEMLRLSEEESSMEELLWTAPELLR-APRGSRLGSF---AGDVYSFAIIMQEVMVRGTPFCMMDL
.||..| .||. . ...|.|..|.|. .       ..| . ... . .    | ||| |. .      | .    .||.||...| |..  |  .   ..
IVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIR----WMAPESLKCY-----HGMYHTTKSDVWSFGVLMWEIFTLGA-CPYPGM

PAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQF
|. .|......    ||. .|.. ...|. .|||.|| . .|.||.|..| ...
PWKDIMECIRD---GYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase CYGF.AA DRK 596-690 36 3.9e-18 58.05 In-house 49-145 (258) Show / Hide 
Range on Protein: 596-690
Range on HMM: 49-145/258
Sequence Identity: 36% (35 aa)

EMMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHRE--FVHGRLKSRNCVVDGRFVLKVTDYG
..|. ||| ||   .|    .    |..|. .||||  || .. ...||    .. .|  ||| ||| ..   .|  ||| |  ||  .  || |.|
NLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFG
Kinase CYGF.AA TyrKc 570-809 27 6.2e-15 18.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 570-809
Range on HMM: 1-280/280
Sequence Identity: 27% (80 aa)

WVWLKKFSLGDFGDL-----------KSIKSRASDVFE------MMKDL--RHENINPLLGFFYDS-------GMFAIVTEFCSRGSLEDILTNQDVKLD
 . .||   | ||             |..|. |  . .      .|. |  .|.||  |.|   ..       .   ||.|... |.| | | .   || 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

WMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDIL----------EMLRLSEEESSM--EELLWTAPELLRAPRGSRLG--SF
.  . |  ..  .|| |||.. ..|  |  ||| |. ... |..| |    .          .. | .|....     . |.||| .      . |  ..
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI------NYGKFTT

AGDVYSFAIIMQEVMVRG-TPFCMM---DLPAQEIINRLKKPPPVYRPVVPPE-------HAPPECLQLMKQCWAEAAEQRPTFDEIFNQF
. ||.|| . | |.. .| .|   |   ....||.|...|.    ||.  ||.       ..|.|  |.|||||.| .|.|||| ||  .|
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG---YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CYGF.AA S_TKc 570-810 17 9.6e-15 39.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 570-810
Range on HMM: 1-231/231
Sequence Identity: 17% (49 aa)

WVWLKKFSLGDFGDLKSIKSRASDVF--------------EMMKDLRHENINPLLGFFYDSGMFAIVTEFCSR--GSLEDILTNQDVK-----LDWMFKS
.  |.|   | ||  .  . . ..                ...|  .|.||  |...|.| . . .|.|.|.   |.| |.. ..  .     ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

SLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSMEE---LLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMV
...  ......|.| . ..|  ||  |  .|   ..|..| |.  .|           .     . . |||.|        | .. |..|. .|. | ..
FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEMLC

RGTPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFN--------QFK
. .||.      |.......               .||.......|.    |.|||  |...        .. 
GYPPFP----QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CYGF.AA Pkinase_Tyr 596-690 30 9e-14 47.27 Pfam 55-156 (270) Show / Hide 
Range on Protein: 596-690
Range on HMM: 55-156/270
Sequence Identity: 30% (31 aa)

EMMKDL-RHENINPLLGFFY-DSGM--FAIVTEFCSRGSLEDILTNQ---DVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTD
..|| | .|.||  |.|  . ...     ||.|..  |.| | | ..   . .|.   . .  ..  ||| ||. . ..|  |  ||| |.  .| |..|
KIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICD

YG
 |
FG
Kinase CYGF.AA MLK 732-809 27 4.4e-13 41.84 In-house 218-291 (291) Show / Hide 
Range on Protein: 732-809
Range on HMM: 218-291/291
Sequence Identity: 27% (22 aa)

DVYSFAIIMQEVMVRGTPFC-MMD--LPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQF
||.|..... |.. | .|.  ..|    | ....  . ||      .|.. .|.   .|||||| . ...||.|..|  ..
DVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPP------IPST-CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase CYGF.AA Pkinase_Tyr 712-809 33 9.2e-13 43.84 Pfam 180-270 (270) Show / Hide 
Range on Protein: 712-809
Range on HMM: 180-270/270
Sequence Identity: 33% (34 aa)

WTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRG-TP-FCMMDLPAQEIINRL-KKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQ
|.||| ..  .     . . ||.|| . | |.. .| .| .  |  . .|..... ..    ||   .||..|.|  .||||||.. .|.|||| || .|
WMAPECINYGK----FTTKSDVWSFGVLMWEIFTYGEQPTYPGM--SNEEVYEYIYED---GYR-MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQ

F
.
L
Kinase CYGF.AA Pkinase 596-691 24 6.6e-12 43.18 Pfam 52-158 (293) Show / Hide 
Range on Protein: 596-691
Range on HMM: 52-158/293
Sequence Identity: 24% (26 aa)

EMMKDLRHENINPLLGFFYDSGMFAIVTEFCSRG----SLEDILT-NQDVKL--DWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFVL----
..|| |.|.||  |...|.|..   .|.|.|  |    .| |...  .. ..  ..    . .. ...|..|.| . ..|  ||. |. .| . ..    
QIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACV

KVTDYGF
|..| |.
KICDFGL
Kinase CYGF.AA Pkinase 714-809 19 5.7e-11 39.86 Pfam 179-293 (293) Show / Hide 
Range on Protein: 714-809
Range on HMM: 179-293/293
Sequence Identity: 19% (23 aa)

APELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMM----DLPAQEIINRLKKPPPVYRPVVPPEHAP-----------------PECLQLMKQCW
|||..|   |..  . . |..|. .|. |.. . .||.      .   |  . .....||. ..   .   .                 .||....| |.
APEVIR---GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

AEAAEQRPTFDEIFNQ--F
.   ..|||...|..   |
CKDPKKRPTAEQILQHPWF
Kinase CYGF.AA MLK 601-690 26 1.4e-10 33.1 In-house 62-178 (291) Show / Hide 
Range on Protein: 601-690
Range on HMM: 62-178/291
Sequence Identity: 26% (31 aa)

LRHEN----INPLLGFFYDSGM-FAIVTEFCSRGSLEDILTNQD-------------VKLDWMFKSSLLLDLIKGMKYLHHREF---VHGRLKSRNCVVD
|.|.|    | ...|   ...  |.||.|.|. ||| ..| ...             .  |  .. .  |.  .|| |||  .    .|  |||.| ..|
LSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILID

------GRFVLKVTDYG
      .  .||..| |
EICHDMHHGTLKICDFG
Kinase CYGF.AA DRK 712-811 35 1.2e-09 28.86 In-house 168-258 (258) Show / Hide 
Range on Protein: 712-811
Range on HMM: 168-258/258
Sequence Identity: 35% (36 aa)

WTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAQEI--INRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQF
||||| ||     |    | |||||||.  |.. |  |.  |  . | .  . | .  ||.      |.  ||   |||. || |   .||...|.    
WTAPEVLRN---QRYTEKA-DVYSFAIVLWECVTRQDPYFGMP-TFQVVFSVGRHGMRPPM------PQWCPPKYIQLMNDCWNEDPQHRPSMQECLERL

KT
  
EA
CYCc CYGF.AA CYCc 848-1043 47 1.8e-109 370.93 SMART 1-231 (231) Show / Hide 
Range on Protein: 848-1043
Range on HMM: 1-231/231
Sequence Identity: 47% (109 aa)

IEKQKTEKLLTQMLPPSVAESLKKGC-TVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHD-----VYKVETIGDAYMVASGL
.||||...||.||||..||..|| |  .|.|. .| ||..|.||||||.......|..||..|||.|| || ||. |.     .||||||||||||.||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PKRNGS-------------------RHAAEIANMSLDILSSVGTFKMRHM----PEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGL
| ||..                   .|| .||...||......||...|     |. |.|.|||.|.||||.||||..|||||.||||||.||||||||.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

PYRIHVSLSTVTIL------QNLSEGYEVEL
| .|||| .|  .|      .. ....|.| 
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc CYGF.AA Guanylate_cyc 875-1062 42 6.1e-92 316.55 Pfam 1-214 (214) Show / Hide 
Range on Protein: 875-1062
Range on HMM: 1-214/214
Sequence Identity: 42% (90 aa)

VEPEGFDLVTLYFSDIVGFTTISAMSE----PIEVVDLLNDLYTLFDAIIGSH--DVYKVETIGDAYMVASGLPKR-----NGSRHAAEIANMSLDILSS
|... .| ||..|.|||||| ... ..    |...|..|||.|| || ... |  ..|||.||||.||..||||..     ..  ||. .|.|.||.. .
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

VGTFKMRHMPEVP-----VRIRIGLHSGPVVAGVVG--LTMPRYCLFGDTVNTASRMESTGLPY--RIHVSLSTVTILQNLS-EGYEV--ELRGRTELKG
....   | .  |     ...|||.|.|||||||.|  . |||||..|||||.||||||||.|.  .|||| .|...|...  . .|.  . ||  ..||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGTE---ETFWLIG
|| .   ||..|.|
KGKMGEMETYFLHG
HNOBA CYGF.AA HNOBA 839-869 48 1.1e-09 36.52 Pfam 204-234 (234) Show / Hide 
Range on Protein: 839-869
Range on HMM: 204-234/234
Sequence Identity: 48% (15 aa)

IRERTEELEIEKQKTEKLLTQMLPPSVAESL
... ..||| ||.||..|| .|.|.|||. |
LEQMHRELEEEKKKTDDLLYSMFPKSVANRL