Gene CSK (Human)

CSK

Species: Human
Alias: MGC117393, CSK, CYL
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 15q24.1-q25 ,

Classification

Group: TK
Family: Csk

Sequence

Name Sequence Type Origin Length Description Download
CSK.AA Protein Sugen Kinome 450 None Fasta, JSON
CSK.kin_dom Protein Kinase Domain Sugen Kinome 246 None Fasta, JSON
CSK.NA RNA Sugen Kinome 2754 None Fasta, JSON

Protein domain

Protein domains of CSK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 CSK.AA SH3 12-69 30 4.4e-20 73.95 SMART 1-58 (58) Show / Hide 
Range on Protein: 12-69
Range on HMM: 1-58/58
Sequence Identity: 30% (18 aa)

TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNK-VGREGIIPANYVQKRE
 ...|.|.. .. ...|.| |||..|..  . |..|.|....  |.||..|.|||.. .
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 CSK.AA SH3_1 15-62 28 1.6e-18 65.38 Pfam 1-49 (49) Show / Hide 
Range on Protein: 15-62
Range on HMM: 1-49/49
Sequence Identity: 28% (14 aa)

IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPA
.|.| . .. ...|.| |||...... ..|..|.|....  |.||..|.
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 CSK.AA SH3_2 13-68 19 5.7e-08 30.79 Pfam 1-68 (68) Show / Hide 
Range on Protein: 13-68
Range on HMM: 1-68/68
Sequence Identity: 19% (14 aa)

ECIAKYNFHG-TAEQD-----LPFCKGDVLTIVAVT-----KDPNWYKA-KN-KVGRE--GIIPANYVQKR
 ...  .. . | ...     | |.|||   ...|.     ...||...  . . ||.  | .| ..|.. 
YYRVHCDYVPATYCNENHEPQLHFKKGD---VIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 CSK.AA SH2 82-156 49 1.7e-44 132.43 Pfam 1-81 (81) Show / Hide 
Range on Protein: 82-156
Range on HMM: 1-81/81
Sequence Identity: 49% (40 aa)

WFHGKITREQAERLLYP--PETGLFLVRESTNYPGDYTLCVSCDG---KVEHYRIMYHASK-LSIDEEVYFENLMQLVEHY
|.||||.|..|||||.   .. | |||||| ..||||||.| .||   .|.||||. .. . . | ....|..|..|||||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 CSK.AA SH2 80-162 46 1.9e-37 131.61 SMART 1-87 (87) Show / Hide 
Range on Protein: 80-162
Range on HMM: 1-87/87
Sequence Identity: 46% (41 aa)

MPWFHGKITREQAERLLYP--PETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHA-SKLSIDE--EVYFENLMQLVEHYTSDADG
.||.||.|.||.||.||    .. | ||||.| . ||||.|.| ..||| ||||   . .| .|||  ...|..| .||.||.  ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase CSK.AA Csk 195-440 74 3e-205 688.16 In-house 1-251 (251) Show / Hide 
Range on Protein: 195-440
Range on HMM: 1-251/251
Sequence Identity: 74% (186 aa)

LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKND--ATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL
|.|...||.|||||||.|.|...||||||||.|  ..||||||||||||||||.|||||.|||...|..||||.|||.||.||||||||||.|.....||
LHLGECIGHGEFGDVMQGEYQNRKVAVKCIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRRQLL

KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD---TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPR
||..||||.|.|||...||||||||||.|||||.|||||||||.||..|.||   .||.|.|||||||||.|||||||||||||||||||||||||||||
KFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKEECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGRVPYPR

IPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQL
|||||||..|||||.|.||.||||.||.|||.||||..|.||.|.|.||||
IPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase CSK.AA Pkinase_Tyr 195-440 41 6.6e-137 464.3 Pfam 1-270 (270) Show / Hide 
Range on Protein: 195-440
Range on HMM: 1-270/270
Sequence Identity: 41% (112 aa)

LKLLQTIGKGEFGDVMLGDYR------GNKVAVKCIKNDATAQA-----FLAEASVMTQL-RHSNLVQLLGVIVEEKGG--LYIVTEYMAKGSLVDYLRS
.......|.|.||.|..| ..      . .||||..|..|. ..     |..||..|.|| .| |.|.|.||......   .|||.|||..|.| ||||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA-----S-STQDTGKLPVKWTAPEALREKKFSTKSDVWS
.   ....   | ||.........||||| .|..||||||||.||.|.||.|..||||..          ... ||||.||.|||.....||.|||||||
HREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGILLWEIYSFGRVP-YPRIPLKDVVPRV-EKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQL
||.|.|||...|. | || ..  .|. .. |.|| |..|..||. .|..|| ||| |...||.| ...|||
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase CSK.AA TyrKc 195-440 38 1.7e-133 450.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 195-440
Range on HMM: 1-280/280
Sequence Identity: 38% (108 aa)

LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQL--RHSNLVQLLGVIVEEK------GGLYIVTEYMAKGSLVDYLRSRGRSVL
..|....| |.|| |..| ..  .||||..|.||  ..|. ||..|..|  .| |.|.|.||.....      . |.||.|||..|.| ||||....  |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-L

GGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST--------QDT------GK--LPVKWTAPEALREKKFSTKSDVW
  . ||.|...... ||||. .|..||||||||.||.|....|.|||||...  .           .      ||  ||..|.|||.....||.||||||
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVW

SFGILLWEIYSFGRVPYPR-----IPLKDVVPRVEKGYKMDAPDG--------CPPAVYEVMKNCWHLDAAMRPSFLQLREQL
|||...|||...|  |||      .. ..|. .|..|| |. |.         ||...|..|| ||| |...||.| ...|..
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CSK.AA TK 195-440 22 9.1e-116 389.75 In-house 1-486 (486) Show / Hide 
Range on Protein: 195-440
Range on HMM: 1-486/486
Sequence Identity: 22% (111 aa)

LKLLQTIGKGEFG---DVMLGDYRGN---------------------------KVAVKCIK--NDATAQAFLA--------------EASVMTQLR----
..|....|.|.||   .|..| .||                            .||||..|  .......|..              ||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HSNLVQLLGVIVEEK-----------GGLYIVTEYMAKGS----LVDYLRSRG----------------------------------------------
 | |.|.|.||.....           . ..||.|||..|.    | ||||..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------RSVLGGDCLLKFSLDVCEAMEYLEGN------NFVHRDLAARNVLVSEDNV-----------AKVSDFGLTK
                            .. |   .|| ........||||. .      |||||||||||.||.|.||           .|..||||..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----EASSTQD--------------------------------TGKLPVKWTAPEALR---------EKKFSTKSDVWSFGILLWEIYSFGRVPYPR-I
      |   ..                                 ||||..|.|||.|.         ..||.|||||||||.|.|||...|..||.  .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PL---------KDVVPRVEKG--------------YKMDAPDGCP--------------PAVYEVMKNCWHLDAAMRPSFLQLREQL
.          ..|. ....|              . | .|..||              ...|..|. |||.|.. ||.| ||.|||
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase CSK.AA Src 195-440 47 7.4e-110 371.26 In-house 1-255 (255) Show / Hide 
Range on Protein: 195-440
Range on HMM: 1-255/255
Sequence Identity: 47% (122 aa)

LKLLQTIGKGEFGDVMLGDYRG-NKVAVKCIKNDA-TAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR-SRGRSVLGGDCL
.||.. .|.| ||.|  | ..|  ||||| .| .    .|||.|| .|..||| .||||. |  .|.   |||||||..||| |||. ..  . |    |
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE-PIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQL

LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS------STQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRV
. ..  | | |.||| .|..|||||||||||.|.||.|| |||| .         . .   |.|.|||||||... .|..|||||||||||.|| ..|||
IDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRV

PYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYE-VMKNCWHLDAAMRPSFLQLREQL
|||    ..|. .||.||.|  |..||. .|| .|. ||| |.  || |  |.. |
PYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase CSK.AA SFK-Src 195-444 44 7.2e-106 314.79 In-house 1-259 (259) Show / Hide 
Range on Protein: 195-444
Range on HMM: 1-259/259
Sequence Identity: 44% (117 aa)

LKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDAT-AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS-RGRSVLGGDCL
 .| .  | | ||||  |   .   ||||  |  |. |. ||.|| || .||| ||.||  |    .  .||.|| |. ||| |||.. .||| |    |
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCT-DGEPIYIITELMKYGSLLDYLHEPHGRS-LRMPQL

LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK--EASST----QDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRV
     .|   | |||..|||||||||||||| . || || |||.    .. .     ..  | |.|||||||    .||.||||||||||. ||  .||.
VDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRI

PYPRIPLKDVVPRVEK--GYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIK
|||    . |. .|..  || |..| .||.. |..| .||   .  || |  |. |.|   
PYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase CSK.AA UTK 195-440 34 4.1e-105 355.52 In-house 1-296 (296) Show / Hide 
Range on Protein: 195-440
Range on HMM: 1-296/296
Sequence Identity: 34% (101 aa)

LKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIK---NDATAQA----FLAEAS---VMTQLR-HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVD
..|....|.|.||.| .....         .||||  .   .. ....    |. ||    .| |.. | |...|.|| . |.. ..||||||..|.|..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

YLRSRGRSV------LGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSED-------NVAKVSDFG---LTKEASS--------------TQDTG
|||. ....      |  ...|....|. ..|.||.. .||||||||||.|| ..       .|.|..|||   .......               |. .
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD

KLPVKWTAPEALREK-KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG--YKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQL
..|..|.||||| .  .|.|||||||||...|||...||.||| .   .|. .|..|  | | .|..|| .||..|. ||| | ..||.| .|..|.
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase CSK.AA Tec 195-442 42 8.9e-99 334.47 In-house 1-254 (254) Show / Hide 
Range on Protein: 195-442
Range on HMM: 1-254/254
Sequence Identity: 42% (109 aa)

LKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATA-QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD-CL
|.... .|.| || | || .|.. .||.| ||  .     |. || ||. | |..|||| || ....  .|||||||..|.| .|||...    .    |
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQR-PIYIVTEYMEHGCLLNYLREHKHHFQKNMAIL

LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVP
|.  .||||.|.||| ..|.|||||||| ||....| ||||||.|      .  |   | | |||| .|| .   ..| |||||.||.| ||..| |..|
LEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGT-KFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMP

YPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEH
|..    .|| .| .|...  |. |.  .|..|. |||  .  ||.| || .|.. 
YENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase CSK.AA TK-Unique 195-440 34 6.4e-95 321.65 In-house 1-294 (294) Show / Hide 
Range on Protein: 195-440
Range on HMM: 1-294/294
Sequence Identity: 34% (102 aa)

LKLLQTIGKGEFGDVMLGDYRG--------NKVAVKCIKNDATAQA---FLAEASVMTQLR-HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG
|.....||.|.|| |  |...|        ..||||  | .|| .    || |...| .|  | |.||.||. ..  .  .|. ||...|.| .|||...
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

R------------------------SVLGGDCLLKFSLDVCEAMEYLEG--NNFVHRDLAARNVLVSEDNVAKVSDFGLTKE------ASSTQDTGKLPV
.                        . .    |. |  ... .||||..   ..|||||.|||||..||.|.|..|||....       |...  |..|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWTAPEALR--EKKF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGC-PPAVYEVMKNCWHLDAAMRPSFLQLREQL
.| |||.|.  .. . .|||||||||.|.||| ..|  |||..| ||.. ....|| |. |..| ....|..||.||.... .|||| |.. .|
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase CSK.AA Abl 195-440 46 1.2e-93 312.84 In-house 1-252 (252) Show / Hide 
Range on Protein: 195-440
Range on HMM: 1-252/252
Sequence Identity: 46% (117 aa)

LKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA-QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCL
. . . .| | .|.|  | ..  .. |||| .| |. . . ||.|| .| ...| ||||||||   |    ||.||.|..| |.||||. .|. |    |
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREP-PFYIITEFMCYGNLLDYLRECDREELPAVVL

LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT---KEASSTQDTG-KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPY
|     .  .|.||| ..|.|||||||| ||.|... || ||||.   |.   |   | | |.||||||.|  .|||.||||| ||.|||||  .|  ||
LYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPY

PRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQL
| | |..|  ..||||.|. |.|||| |||.|..||. ... |||| .. ...
PGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase CSK.AA Src-Unclassified 195-440 38 9e-90 304.55 In-house 1-284 (284) Show / Hide 
Range on Protein: 195-440
Range on HMM: 1-284/284
Sequence Identity: 38% (111 aa)

LKLLQTIGKGEFGDVMLGDYRG-NKVAVKCIKND-----ATAQAFL--------AEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS
..||  .| | || | .| .||   ||||  . .     ... |||        .|| .|...|| |||.|..|  .|.   ||.|||| .||| ..|| 
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPE-AFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEE-PYYIITEYMINGSLLQWLRE

RGRSVLGGDCL------------LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDN-----VAKVSDFGLT------KEASSTQDTGKLPVKWTAPEA
 | . |.   .               .  |   |.||| .  |||||||||||. . |     |.|| ||||        .        ..|.||.|||.
GGGQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPEC

LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAP--DGCPPAVYE-VMKNCWHLDAAMRPSFLQLREQL
  . .||.||||||.|||||||   |..|||    . |.  || || |  |   .||  .|| .|| |||.|   || |  |   .
FIYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase CSK.AA SFK-Abl 197-440 42 1.2e-88 289.47 In-house 3-251 (251) Show / Hide 
Range on Protein: 197-440
Range on HMM: 3-251/251
Sequence Identity: 42% (105 aa)

LLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDAT-AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS-RGRSVLGGDCLLKF
|    | |..| |  | .   .||.| ||...  .  |. || .| ...| |||.|.||   | | .|||.|.|  | | |||.| ..|  .    ..  
LGHRLGEGQYGEVYKGIWNNHRVAIKTIKDESMETKDFMKEAHIMKRMQHPNLVRLIGVCTRE-GPMYIVQEFMNYGNLLDYLQSPQSRIQIDHVSMMHC

SLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS---TQDTG-KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRI
 . . . |  ||  .|.|||||||| || .    || |||.    .|   .  .| |.|.||||||.|    |. ||||||||| ||||  .| |||| |
AQQIADGMSFLEEQHFIHRDLAARNCLVGDNLQIKVADFGMARFVDSDFYEARIGTKMPIKWTAPESLCYDIFTIKSDVWSFGITLWEIATYGDVPYPGI

PLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQL
  .||. . . || |  |..||  .|..|  || ..   |||| .|. ||
HHRDVINQLMMGYRMQRPQDCPMEIYNIMTQCWDVNPDERPSFHDLQHQL
Kinase CSK.AA S_TKc 195-449 26 2.1e-55 191.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 195-449
Range on HMM: 1-231/231
Sequence Identity: 26% (70 aa)

LKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAK--GSLVDYLRSRGR----SVL
 ..|..|||| || |...  ..   .||.|.||     . .. | ... . .| |.|.|..|...  . ||.|.||.    |.| ||...|||    ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

GGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFST-KSDVWSFGILLWEIYSFGRV
      ..   .|.|.||.  ....||||   |.|..|  . |..|||| ..     .|      . ||| |   .... |.|.||.|..|.| .. |. 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYP

PYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELH
|.|   .. .  ..            .| . . ...|.. | . ||.  .. .  ..|| |.  
PFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CSK.AA Pkinase 195-440 22 1.3e-42 151.79 Pfam 1-293 (293) Show / Hide 
Range on Protein: 195-440
Range on HMM: 1-293/293
Sequence Identity: 22% (68 aa)

LKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQAFL------AEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKG----SLVDYLR-SR
......||.| || | ..  .|.   ||||.|| . .   ..      .|...|  |.| | |.|...  . |. .|.|.||. .|    .| ||.. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

GRSV-LGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVA----KVSDFGLTK---EASSTQDTGKLPVKWTAPEALR-EKKFSTKSDVWSF
.... .  . . .. . .....||.  ....||||   |.|......     |..|||| |   . ... .|      . ||| .|  .. ..|.|.||.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILLWEIYSFGRVPYPRI----PLKDVVPRVEKGYKMDAPDGCP-----------------------PAVYEVMKNCWHLDAAMRPSFLQLREQ--L
|..|.| .. || |.|      .  |   ....  . . .  .|                       ..  ...|.|...| . ||.. |. .   .
GCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF