Gene CHED (Human)

CHED

Species: Human
Alias: CDC2L5, CHED, CDC2L, KIAA1791, FLJ35215
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 7p13-p14.1,

Classification

Group: CMGC
Family: CDK
Subfamily: CRK7

Sequence

Name Sequence Type Origin Length Description Download
CHED.AA Protein Sugen Kinome 1512 None Fasta, JSON
CHED.kin_dom Protein Kinase Domain Sugen Kinome 294 None Fasta, JSON
CHED.NA RNA Sugen Kinome 6985 None Fasta, JSON

Protein domain

Protein domains of CHED.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CHED.AA CRK7 705-998 64 2.3e-241 808.12 In-house 1-343 (343) Show / Hide 
Range on Protein: 705-998
Range on HMM: 1-343/343
Sequence Identity: 64% (220 aa)

FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNE---KEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGL
...|..||||||||||||..|.|||||||||||.|||   ||||||||||||||||||.||.|.|.|||||||.||..|||.||.||.||||||||||||
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

LESG-LVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEE-SRPYTNKVITLWYRPPELLLGEERY--------
|||. ..||.....|.||.||.||.|||||||||||||||||||.||.|..|.||||||||| ||| .|||||.||||||||||||||||||        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------TPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLR
                              .|.||.||||||||||||||||||.|.|.||||.|..|||||.|..||.|.|||..||||||.||.|.||
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

EEFV------FIPAAALDLFDYMLALDPSKRCTAEQALQCEFL
|||.      |.|...|||.|.||.|||.||.|||..||....
EEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CHED.AA CDK 705-998 43 5.1e-171 551.54 In-house 1-284 (284) Show / Hide 
Range on Protein: 705-998
Range on HMM: 1-284/284
Sequence Identity: 43% (140 aa)

FDIIGIIGEGTYGQVYKARDKDTG-----EMVALKKVRLDN-----EKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDK--GAFYLVFE
....  |||||||.|||||||.||     ..|||||.|..|     |||||||||||||..|..| |. |.. ......|... .. |||    .|.|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

YMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQ-----IKLADFGLARLYSSE-----ESRPYTNKVITLWYRPP
||||||.....          ||..|.||..||.|||.....|||.|..|||.||.|.     .|.|||||||.....     ..|.||..|.|||||.|
YMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP

ELLLGEERYT--PAIDVWSCGCILGELFT---KKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDY
|||||...|.  ..||.||.|||..|.||   .||.|. ..|. ||..|.||||.|.. .||.| |||..                         || . 
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNK

MLALDPSKRCTAEQALQCEFL
||..||.||..||||||....
MLCYDPKKRISAEQALQHPYF
Kinase CHED.AA CMGC 705-998 26 2.2e-139 461.15 In-house 1-513 (513) Show / Hide 
Range on Protein: 705-998
Range on HMM: 1-513/513
Sequence Identity: 26% (138 aa)

FDIIGIIGEGTYGQVYKARD--------------KDTGEMVALKKVRLDN---------EKEGFPITAIREIKILRQLT-----------------HQSI
..||. |||||||.|||.||              ..|.|.||.||....          ||.||||.|.||||||..|                  |  |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

INMKEIVTDKEDALDFKKDK-------GAFYLVFEYMDHDLMGLLES--------GLVHFNENH------------IKSFM------RQLMEGLD--YCH
.....|...|... . ..||         .||||||||||| .....        . ....| |            ||.||      .|. .||.  |||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

KKN--FLHRDIKCSNILLNNR--------------------GQIKLADFGLARLYSSE--------------------ESRPYTNKVITLWYRPPELLLG
...  ..|||.| .|||.|..                    |..|..|||||| |...                    ..||||. | |.|||.||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

EERYT---------PAIDVWSCGCILGELFTK--------KPIFQANQE-----------LAQLELISRICGSPC---------------PAVWPDVIKL
 ..||         ..||.||.|||..|..|.        ||.|. . |           . ||..| ...|.|.               .  ||..|||
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PYFNT-------------MK------------PKKQYRRKLREEFVF-----------------------------------IPAAALDLFDYMLALDPS
|..|.             ..             .......... | .                                   ..  |.|| . || .||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRCTAEQALQCEFL
|| ||||||| ...
KRITAEQALQHPYF
Kinase CHED.AA CDC2 705-998 38 5.70000000001e-119 367.42 In-house 1-301 (301) Show / Hide 
Range on Protein: 705-998
Range on HMM: 1-301/301
Sequence Identity: 38% (121 aa)

FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEG--FPITAIREIKILRQLT-HQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGL
.  |  ||||||| |||..|..|...|||||.||..| ||  .| |||||| .|  |  |. |.  ....                |.||||.|.||  .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-----------NKLYMVFEYLDMDLKKY

LESGLV---HFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYT--NKVITLWYRPPELLLGEERYTPAID
..  ..   |. .. .||.| |. .|...|| .  .|||.| .|||... |.||.|||||||   .  .|.||    |.|||||.||.|||..||. ..|
MDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAF-GIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVD

VWSCGCILGEL---FTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPK---KQYRRKLRE-----EFVFIPAAALDLFDYMLALDPSK
.|| |||. |.    ||||.|..  |  ||  | || |.|    ||.| .||....  |.   .. .. .       .. ...  ..|| . ||..||.|
MWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQK

RCTAEQALQCEFL
| .|..|||  ..
RISAKEALQHPYF
Kinase CHED.AA PITSLRE 705-998 41 1.5e-113 383.53 In-house 1-295 (295) Show / Hide 
Range on Protein: 705-998
Range on HMM: 1-295/295
Sequence Identity: 41% (125 aa)

FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLD--NEKEGFPITAIREIK-ILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGL
| ..  |.||||| ||.|.|| |.| ||||.. ..   ||||||||..|||. ||. | |  |.| ||||          ...   |.|.||..||| .|
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIV--------MGSNMDKIYMVMEYVEHDLKSL

LESGL---VHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVW
.|        | .  ||..| ||  | .. |..  .||| |.||.|... |. |..|||||| | |   .|||  |.||||| |||||| . |....|.|
MENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSP-IKPYTPCVVTLWYRAPELLLGCKKYSTPVDMW

SCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMK-PKKQYRRKLREEFV---FIPAAALDLFDYMLALDPSKRCTAEQALQ
| |||..|. |.||.|| . |. |.. |    | |    ||.. .|| .. |.  ...    ||. |     |   ..||   || ..| .| ||..||.
SVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALK

CEFL
 .. 
HPWF
Kinase CHED.AA CDK7 705-998 37 8.49999999999e-113 301.78 In-house 1-288 (288) Show / Hide 
Range on Protein: 705-998
Range on HMM: 1-288/288
Sequence Identity: 37% (113 aa)

FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVR----LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMG
...|  ||||... ||||.|. ||. || ||..     .  | |   |||||||||. . |  .|..  |   |             .|||..|| ||  
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKS----------NIQLVFDFMDWDLEV

LLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSC
  .   . .   |||..| ..  || |||.   ||||.|  | |.|  ||.|.||||||| | |   | || .|.| ||| |||| |   |....|.|| 
VIKDKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPN-RIYTHQVVTRWYRAPELLFGARHYGTGVDMWSV

GCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQY-RRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFL
|||. ||    |..    .. ||. | .. | | .. ||.. ... ....|.   | |  ||. |   .  .|||   |....|.||.|. |.|. .. 
GCIFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CHED.AA CDK9 705-958 47 8.20000000001e-108 364.48 In-house 1-277 (340) Show / Hide 
Range on Protein: 705-958
Range on HMM: 1-277/340
Sequence Identity: 47% (132 aa)

FDIIGIIGEGTYG-----------QVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEY
.. .  || ||.|            |.||| | .. |||.||| ..|||||||||| ||||.| .| |  ..|. ||   |  |    ||.  |||||..
YEKLAKIGQGTFGQVLQGRKSRNSEVFKARHKKNKRMVAMKKVLMENEKEGFPITALREIKMLQLLKHENVVNLIEICRTKATAYNRYKDRATFYLVFDF

MDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYS----SEESRP-YTNKVITLWYRPPELLLGE
 .||| |||   .| |   |||. |..|| || | |.   |||| |  |.|    |  ||||||||| .|    .   || ||| |.||||||||||||.
CEHDLAGLLSNMNVKFSLGHIKKMMQHLMNGLYYIHRNKILHRDMKAANVLITKDGILKLADFGLARAFSQPKNDAPNRPLYTNRVVTLWYRPPELLLGD

ERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTM-------KPKKQYRR
  | |.||.|  |||. |. |  || | | |  || |||  |||  |.||| . ... .|.|        || |.|.
RNYGPPIDMWGAGCIMAEMWTRSPIMQGNTEQHQLQLISQLCGSITPDVWPNCENMELWNKMSSEPNSELPKGQKRK
Kinase CHED.AA CDK5 705-998 40 1.9e-102 324.53 In-house 1-287 (287) Show / Hide 
Range on Protein: 705-998
Range on HMM: 1-287/287
Sequence Identity: 40% (122 aa)

FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIV-TDKEDALDFKKDKGAFYLVFEYMDHDLMGLLE
.. .  ||||||| |||||.|.|.|.||||.||||.| || | |||||| .|. | |. |. .  .. ..|              ||||..| ||   ..
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKK-----------LTLVFEFCDQDLKKYMD

SGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCI
|  .  . . ||||| ||. || .||... |||| |  | | | .|. ||||||||| .     | |.  |.|||||||  |.|   |.  ||.||||||
SCNGEMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGI-PVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCI

LGELF-TKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFN---TMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFL
. |.  . .| |  |..  || .| .| |.||   || . ||| ..   .  |. . .  . .      .  .||   || ..| .| .|..||.  . 
FAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CHED.AA Pkinase 705-998 32 2.8e-98 337.62 Pfam 1-293 (293) Show / Hide 
Range on Protein: 705-998
Range on HMM: 1-293/293
Sequence Identity: 32% (100 aa)

FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIR--EIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-----D
. |...||.|..|.|||...|.||..||.|......||.....|..|  ||.|.. | |  |. ......|          |.  |.|.||...     |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----------KDHIYMVMEYCEGGLYVMD

LMGLLE-SGLVHF--NENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQI----KLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEER
|. ... .    |   |...|..|.|. .||.|||.....|||.| .|||..|.|.|    |..|||||....   .. .|  . |.||..||...| . 
LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQY

YTPAIDVWSCGCILGELFTKKPIFQAN----QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKR
|.|..|.||||||| |.....|.|.        . |...| || | | .  ||  .  .||.  .. .   . ...  . .. ...|. ...|..||.||
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKR

CTAEQALQCEFL
.||||.|| ...
PTAEQILQHPWF
Kinase CHED.AA S_TKc 705-998 28 4.2e-96 326.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 705-998
Range on HMM: 1-231/231
Sequence Identity: 28% (89 aa)

FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH---DLMGL
..|. .||.|..|.|||.|.|.||. ||.|...         ....|||.||..  |  |......  |           . .|.|.||.|.   ||. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----------DHLYMVMEYCDGDLGDLFDY

LESGLVH-----FNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTP-AI
...   |     |.| |....|.|. ..|.|||.....|||.| .||||..  .||..||||||..        |  . |.||..||.|     |.. ..
IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKC

DVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQ-
|.||||||| |... .| |.      |.... ...|                                    .  |.|. . .|  ||.|| || .||| 
DWWSCGCILYEMLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQD

------CEFL
       ...
EWDIKCHPWF
Kinase CHED.AA CDK10 705-998 41 1e-93 317.66 In-house 1-285 (285) Show / Hide 
Range on Protein: 705-998
Range on HMM: 1-285/285
Sequence Identity: 41% (122 aa)

FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLES
|. .  .|||||| ||.|||  . |.|||||||.| ||.| || ..|||..| |. |. |....|.|  ..  ||      . .|| .| . ||  ||. 
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQH--LD------SIFLVMQYCEQDLASLLDN

GLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCIL
    | | ..|  | |.. || | |..  .|||.| ||.|.  .| ||.||||||| | .   .| | |..||||| ||||||    | |||.|  ||||
MPQPFTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMY-GVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCIL

GELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFL
|||  .||..  | |..|...|  . |.|  ..||   .||  .    |||    |.. | ..  . . | ....  .| || |||..|. .. 
GELLVHKPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase CHED.AA CDK-Unclassified 705-998 30 4e-86 283.32 In-house 1-324 (324) Show / Hide 
Range on Protein: 705-998
Range on HMM: 1-324/324
Sequence Identity: 30% (100 aa)

FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKE----------GFPITAIREIKILRQLTHQSIINMKEIVTDKEDAL---DFKKDKGAFYLVF
  .. ..||||.| |.||.| .|   || ||. . |.|            ..||. |||..|... |  || . ... |         .      ||.| 
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM

EYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRG-----QIKLADFGLARLYS----------SEE-SRPYTNKVI
|||. .. . |..         |. ||.|. ||. | | . . ||||| .||.. |..      .|.||||.|..|           ... .. |.  | 
EYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVS

TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLP-YFNTMKPKKQYRRKLREEFVFIPAAALDL
| ||| ||||.|   |....|.|| |||. |.| .||||| . |. |.  |... |.||   |||  ..| |  .. . || ..   .   .  |  ...
TRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKCKHASENNC

FDYMLALDPSKRCTAEQALQCEFL
   |....| .| .....|| . .
EFQMVMYQPYNRWKCMEILQHPWF
Kinase CHED.AA Pkinase_Tyr 705-861 28 5e-20 68.45 Pfam 1-160 (270) Show / Hide 
Range on Protein: 705-861
Range on HMM: 1-160/270
Sequence Identity: 28% (49 aa)

FDIIGIIGEGTYGQVYKARDK----DTGEMVALKKVRLDNEKEGFPITA------IREIKILRQL-THQSIINMKEIVTDKEDALDFKKDKGA--FYLVF
  ..  .||| .|.|||.. |    .|.  || |...     ||    .      .||.||..||  |. |...  ..|         ....    |.|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT---------DQGEPNQIYIVM

EYMDH-DLMGLLESG---LVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARL
||| | ||   | .      ...  .. .. .|  .|..| . ||. |||. . |.|... ...| .||||||.
EYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase CHED.AA TyrKc 705-998 23 1.3e-15 29.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 705-998
Range on HMM: 1-280/280
Sequence Identity: 23% (75 aa)

FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQL--THQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGL
   . ..||| .|.|||.. |   ..|| |... |          .||..|...|   |. |...  ..|...    |    .  ..|.|||.| ||   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--F-MYIEPLMIVMEYMPHGDLKDY

LESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSE----ESRPYT------NKV--ITLWYRPPELLLGEE
| .   ...  .  ||. |  .| .| |.||. |||. . |.|.......| .||||.|   ..    ||  |       ..   . .   .|| .  . 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYG

RYTPAIDVWSCGCILGELFT--KKPIFQ------ANQELAQLELISRICGSPCPAV----WPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDY
..|.. |||| |  . |.||  ..|          |||.  .|.. .    |.|.                                 | . .  .... 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEV--IEYVKQGYRMPQPPNDYPMS---------------------------F-VCCPDEMYQI

ML---ALDPSKRCTAEQALQCEFL
|.   . ||..|.| ..   .|..
MKQCWHEDPEDRPTFSEI--HECF
Kinase CHED.AA CDK9 971-998 35 1.9e-07 21.5 In-house 313-340 (340) Show / Hide 
Range on Protein: 971-998
Range on HMM: 313-340/340
Sequence Identity: 35% (10 aa)

ALDLFDYMLALDPSKRCTAEQALQCEFL
|..| | .|..|| || ....||   . 
ACHLIDKLLNIDPKKRMDSDEALDHDWF