Gene ChaK2 (Human)

ChaK2

Species: Human
Alias: CHAK2, HSH, ChaK2, HMGX, FLJ20087, TRPM6, HOMG
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 9q21.13,

Classification

Group: Atypical
Family: Alpha
Subfamily: ChaK

Sequence

Name Sequence Type Origin Length Description Download
ChaK2.NA RNA Sugen Kinome 8431 None Fasta, JSON
ChaK2.AA Protein Sugen Kinome 2022 None Fasta, JSON
ChaK2.kin_dom Protein Kinase Domain None 219 None Fasta, JSON

Protein domain

Protein domains of ChaK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ChaK2.AA ChaK 1754-1972 90 8.60000000001e-197 660.06 In-house 1-219 (219) Show / Hide 
Range on Protein: 1754-1972
Range on HMM: 1-219/219
Sequence Identity: 90% (199 aa)

SMSSWSQRGRAAMIQVLSREEMDGGLRKAMRVVSTWSEDDILKPGQVFIVKSFLPEVVRTWHKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIP
||||||||||.||||.|||||||||||.||||..||||.||||||.|.|.||||||||||||||.||.|||||||||||||||||||||||||.||||||
SMSSWSQRGRCAMIQFLSREEMDGGLRRAMRVQCTWSEHDILKPGHVYIIKSFLPEVVRTWHKIYQEDTVLHLCLREIQQQRAAQKLIYTFNQMKPQTIP

YTPRFLEVFLIYCHSANQWLTIEKYMTGEFRKYNNNNGDEITPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEVKQSRGMVFGPAN
|||||||||||||||||||.||||.||||||||||||||||.|||||||.|||||||||||||||||||||||||||||||||||||.|||..|||||||
YTPRFLEVFLIYCHSANQWFTIEKCMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEEKQSCDMVFGPAN

LGEDAIRNFIAKHHCNSCC
|||||||||.|||||||||
LGEDAIRNFRAKHHCNSCC
Kinase ChaK2.AA Alpha 1763-1972 38 3.9e-140 401.51 In-house 1-215 (215) Show / Hide 
Range on Protein: 1763-1972
Range on HMM: 1-215/215
Sequence Identity: 38% (83 aa)

RAAMIQVLSREEMDGGLRKAMRVVSTWSEDDILKPGQVFIVKSFLPEVVRTWHKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIPYTPRFLEVF
....||..|...|.|..|.||.....|......|.......||| ..|...|.|......|.|.|.||..|....|.....|||.|||.|..........
QCTKIQMSSYPFMEGAMRYAMHAWDCWLHQKMVKKQHKKQWKSF-KYVWHHWIKDVERQMVCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYE

LIYCHSAN-QWLTIEKYMTGEFRKYNNNNGDE--ITPTNTLEELMLAFSHWTYEYTRGELLVLDLQ-GVG-ENLTDPSVIKPEVKQSRGMVFGPANLGED
||.||..| .. ..|.||.||..|||||.|..  .|..|....||.||||||..|..|.|.|.||| ||| ..||||....| .|...||.||..|.|..
LIHCHNHNIKYYSVENYMEGEYQKYNNNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCP-AKLDQGMKFGDGNCGYE

AIRNFIAKH--HCNSCC
....|...|  .||..|
GMFRFFYTHHVQCNHYC
Kinase ChaK2.AA Alpha_kinase 1755-1972 29 8.2e-93 315.56 SMART 1-255 (255) Show / Hide 
Range on Protein: 1755-1972
Range on HMM: 1-255/255
Sequence Identity: 29% (76 aa)

MSSWSQRGRAAMIQVLSREEMDGGLRKAMRVVSTWSEDDIL-KPGQVFIVKSFLPEVVRTW--HKIFQESTVLHLCLREIQQQRAAQKLIYTFNQ---VK
...|..     .|   ..  . |..|.... . .|||.... ..|.....|.|..|..|||  .. | | | ||||||....|......   |||    .
DNKWTCQETCVKI-KEPKPFAKGAMRWCYW-GCDWSEHMHCFCHGWECVAKYFKKEYKRTWDEERYFHE-T-LHLCLRDVEMQMMCKHWANEFNQEAQHN

P--QTIPYTPRFLEVFL-----IYCHSANQW----------------LTIEKYMTGEFRKYNNNNGDEITPTNTLE---------ELMLAFSHWTYEYTR
|    | ..| .. .|.     .|...  .|                ...| .|.|||.|||||||....... ..         |...||||||||...
PCPKKIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEWSN

GELLVLDLQGV----GE--NLTDPSVIKPEVKQSRGMVFGPANLGEDAIRNFIAKHHCNSCC
...|| |.|||    |.  ..||| ... . .   |. ||..|||...|..|...|.||..|
HQMLVCDIQGVIHKNGDLYYYTDPQIHTEDQN---GYGFGMGNLGQEGIEKFFQTHQCNQIC
Kinase ChaK2.AA Alpha_kinase 1774-1972 25 1.3e-68 238.74 Pfam 1-225 (225) Show / Hide 
Range on Protein: 1774-1972
Range on HMM: 1-225/225
Sequence Identity: 25% (59 aa)

EMDGGLRKAMRVVSTWSEDDILKPGQVFIVKSFLPEVVRTWHKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKP--QTIPYTPRFLEVFLIYCHSANQ
 ..|..|.. |.. ||  |. ....|....| ..... ... |. ..... .........|. .|...  ||| ..  . .|....|......|... ..
FAQGAMRWCFRMFDTW--DPNWRNNQNCVAKWYKKIK-NYNQKQ-SIYVEEDYYFQDCKMQMICQQWMEKFNQKLQEHNNPPPPIEFYDCCIVYELEDHN

------------------WLTIEKYMTG-EFRKYNNNNG---DEITPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVG--E---NLTDPSVIKPEVKQS
                  . ..| |..| ||.||||| |   |.  ... ....| ||||.||....|...| |.||||  .    ||||..  .. .. 
KPDCYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKD-GNY

RGMVF--GPANLGEDAIRNFIA-KHHCNSCC
. |.|  |..|||...|..|.. .| || .|
E-MDFDEGMGNLGQEGIEKFFQNQHKCNHIC
Kinase ChaK2.AA Alpha-Unclassified 1874-1972 30 3.1e-23 72.51 In-house 109-215 (215) Show / Hide 
Range on Protein: 1874-1972
Range on HMM: 109-215/215
Sequence Identity: 30% (35 aa)

TIEKYMTGEFRKYNNNNGDEITPTNTLEE---LMLAFSHWTYEYTRGELLVLDLQG-VG------ENLTDPSVIKPEVKQSRGMVFG--PANLGEDAIRN
..| |. |||.||.|| | ||    .  |   ......||||. | . ..| |||| |.        .||| .     ...|   ..    | |   |  
SVEPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIH---TIRQR---YQGFKTNCGMRFIDY

FIAKH--HCNSCC
... |   ||  |
WFNNHHVQCNHYC
Kinase ChaK2.AA VWL 1875-1977 38 3.3e-22 63.08 In-house 107-206 (206) Show / Hide 
Range on Protein: 1875-1977
Range on HMM: 107-206/206
Sequence Identity: 38% (40 aa)

IEKYMTGEFRKYNNNNGDEITPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVG-ENLTDPSVIKPEVKQSRGMVFGPANLGEDAIRNFIAKHHCNSCCR
.|.|. |.. ||||| |  .  ..    |  |||| |. |. | ... ||||..   |||| .     .||.   ||  |||   .  |   | ||  |.
VENYIEGDYQKYNNNAGWCNQTDMEYNQLSQAFSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHC--LDQSH--KFGQGNLGYEGMLRFFMTHQCNKYCQ

KLKL
|| |
KLQL