Gene ChaK1 (Human)

ChaK1

Species: Human
Alias: FLJ25718, FLJ20117, CHAK, ChaK1, LTRPC7, CHAK1, TRP-PLIK, TRPM7
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 15q21.2,

Classification

Group: Atypical
Family: Alpha
Subfamily: ChaK

Sequence

Name Sequence Type Origin Length Description Download
ChaK1.AA Protein Sugen Kinome 1865 None Fasta, JSON
ChaK1.NA RNA Sugen Kinome 7255 None Fasta, JSON
ChaK1.kin_dom Protein Kinase Domain None 219 None Fasta, JSON

Protein domain

Protein domains of ChaK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ion_trans ChaK1.AA Ion_trans 888-1096 11 0.000133 19.39 Pfam 1-199 (199) Show / Hide 
Range on Protein: 888-1096
Range on HMM: 1-199/199
Sequence Identity: 11% (26 aa)

IVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVR---LLDFLAVNQ
. ..... ...| .  ...        ...  | |..|. | ...| ..|.. ..|  ..               ..  |... |  |   .| .. . .
FDYVFTVWFTFEMILKFWAFGFKF---HPFHYFRDWWNWFDFFVVIPSYIDLIWFFFNWD---------------WFRVLRVFRWL-RVLRPLRLFRRWP

Q-AGPY-VMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSW-----------TLAKDIVFHPYWMI-------FGEVYAYEIDVCANDSVIPQ
   ... | |........|........... |..    . .  . ...           |   ....  .|..       .|....  .           
GWMRTLWVWMLMRSMPSIFNVMLLCFFFWFIFAIIGMQLFMGYFHWCCDWAWRNWNNGNTNFDNYPWAFWWLFQCMTTEGWGDIMYDCM-----------

ICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFF
   .|||.  ..  .. ..  ..|.|..||  
---CGTWWGYIYFVIFIIICGFFMLNMFIAVI
Kinase ChaK1.AA ChaK 1598-1816 87 5.70000000001e-197 660.65 In-house 1-219 (219) Show / Hide 
Range on Protein: 1598-1816
Range on HMM: 1-219/219
Sequence Identity: 87% (191 aa)

SMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIP
|||||||.|.||.|.|||.|||.||||||..||||||||||||.||.|||||||||||.||..||.|||||||||||||||||||||...||||||..||
SMSSWSQRGRCAMIQFLSREEMDGGLRRAMRVQCTWSEHDILKPGHVYIIKSFLPEVVRTWHKIYQEDTVLHLCLREIQQQRAAQKLIYTFNQMKPQTIP

YSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPAN
|.||||||||.|||||.|||..|.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||.||||||||||
YTPRFLEVFLIYCHSANQWFTIEKCMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEEKQSCDMVFGPAN

LGEDAIKNFRAKHHCNSCC
||||||.||||||||||||
LGEDAIRNFRAKHHCNSCC
Kinase ChaK1.AA Alpha 1607-1816 35 1.3e-138 397.07 In-house 1-215 (215) Show / Hide 
Range on Protein: 1607-1816
Range on HMM: 1-215/215
Sequence Identity: 35% (78 aa)

LCAKIEFLSKEEMGGGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVF
.|.||...|...|.|..|.|......|......|..|....||| ..|...|........|.|.|.||..|....|..|..||||||..|.. .......
QCTKIQMSSYPFMEGAMRYAMHAWDCWLHQKMVKKQHKKQWKSF-KYVWHHWIKDVERQMVCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYE

LLYCHSAG-QWFAVEECMTGEFRKYNNNNGDE--IIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQ-GVG-ENLTDPSVIKAEEKRSCDMVFGPANLGED
|..||... ....||..|.||..|||||.|..  ....|.....|.||||||..|..|.|.|.||| ||| ..||||..... .|....|.||..|.|..
LIHCHNHNIKYYSVENYMEGEYQKYNNNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCP-AKLDQGMKFGDGNCGYE

AIKNFRAKH--HCNSCC
....|...|  .||..|
GMFRFFYTHHVQCNHYC
Kinase ChaK1.AA Alpha_kinase 1599-1816 30 5.6e-93 316.11 SMART 1-255 (255) Show / Hide 
Range on Protein: 1599-1816
Range on HMM: 1-255/255
Sequence Identity: 30% (80 aa)

MSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQCTWSEHDIL-KSGHLYIIKSFLPEVVNTW--SSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQ---MK
...|..  .| || . .|  . |..|.. .  |.||||... ..|. ...|.|..|...||  .. ..| | ||||||....|......  .|||   ..
DNKWTCQETCVKI-KEPKPFAKGAMRWCYW-GCDWSEHMHCFCHGWECVAKYFKKEYKRTWDEERYFHE-T-LHLCLRDVEMQMMCKHWANEFNQEAQHN

P--KSIPYSPRFLEVFL-----LYCHSAGQW----------------FAVEECMTGEFRKYNNNNGDEIIPTNTLE---------EIMLAFSHWTYEYTR
|  |.| . | .. .|.      |... ..|                |..|..|.|||.|||||||... ... ..         |...||||||||...
PCPKKIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEWSN

GELLVLDLQGV----GE--NLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSCC
...|| |.|||    |.  ..||| .......    . ||..|||...|..| ..|.||..|
HQMLVCDIQGVIHKNGDLYYYTDPQIHTEDQN---GYGFGMGNLGQEGIEKFFQTHQCNQIC
Kinase ChaK1.AA Alpha_kinase 1618-1816 23 5.5e-68 236.56 Pfam 1-225 (225) Show / Hide 
Range on Protein: 1618-1816
Range on HMM: 1-225/225
Sequence Identity: 23% (55 aa)

EMGGGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKP--KSIPYSPRFLEVFLLYCHSAGQ
 . |..| . ... ||  .. ..... ...| ..... |..... ..... .........|. .|..   |||...  ...|....|......|...  .
FAQGAMRWCFRMFDTW--DPNWRNNQNCVAKWYKKIK-NYNQKQ-SIYVEEDYYFQDCKMQMICQQWMEKFNQKLQEHNNPPPPIEFYDCCIVYELEDHN

------------------WFAVEECMTG-EFRKYNNNNG---DEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVG--E---NLTDPSVIKAEEKRS
                  .. .|  ..| ||.||||| |   |.  ... ....| ||||.||....|...| |.||||  .    ||||..  .. .. 
KPDCYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKD-GNY

CDMVF--GPANLGEDAIKNFRA-KHHCNSCC
. |.|  |..|||...|..| . .| || .|
E-MDFDEGMGNLGQEGIEKFFQNQHKCNHIC
Kinase ChaK1.AA Alpha-Unclassified 1719-1816 30 1.5e-21 66.95 In-house 110-215 (215) Show / Hide 
Range on Protein: 1719-1816
Range on HMM: 110-215/215
Sequence Identity: 30% (34 aa)

VEECMTGEFRKYNNNNGDEIIPTNTLEE---IMLAFSHWTYEYTRGELLVLDLQG-VG------ENLTDPSVIKAEEKRSCDMVFG--PANLGEDAIKNF
||. . |||.||.|| | ||    .  |    .....||||. | . ..| |||| |.        .||| .       . .  ..    | |   |  .
VEPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIH------TIRQRYQGFKTNCGMRFIDYW

RAKH--HCNSCC
 . |   ||  |
FNNHHVQCNHYC
Kinase ChaK1.AA VWL 1719-1778 39 6.5e-17 47.04 In-house 107-167 (206) Show / Hide 
Range on Protein: 1719-1778
Range on HMM: 107-167/206
Sequence Identity: 39% (24 aa)

VEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVG-ENLTDP
||  . |.. ||||| |  .  ..    .  |||| |. |. | ... ||||..   ||||
VENYIEGDYQKYNNNAGWCNQTDMEYNQLSQAFSHFTWQYSQGYCMIVDLQGNEDGMLTDP
Kinase ChaK1.AA VWL 1810-1821 58 0.190659 0.18 In-house 195-206 (206) Show / Hide 
Range on Protein: 1810-1821
Range on HMM: 195-206/206
Sequence Identity: 58% (7 aa)

HHCNSCCRKLKL
| ||  |.|| |
HQCNKYCQKLQL