Gene CDKL1 (Human)

CDKL1

Species: Human
Alias: KKIALRE, CDKL1, p42
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 14q22.1,

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
CDKL1.AA Protein Sugen Kinome 358 None Fasta, JSON
CDKL1.kin_dom Protein Kinase Domain Sugen Kinome 284 None Fasta, JSON
CDKL1.NA RNA Sugen Kinome 1177 None Fasta, JSON

Protein domain

Protein domains of CDKL1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDKL1.AA CDKL 5-288 72 5.5e-231 773.64 In-house 1-286 (286) Show / Hide 
Range on Protein: 5-288
Range on HMM: 1-286/286
Sequence Identity: 72% (207 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLV
|||.||.||||||||.||||..||||||||||.||||||..||||.|||.|||||||.|.|||.|||||||.||||||||||||||||..|..||.||.|
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

KSITWQTLQAVNFCHKHNCIHRDVKPENILIT-KHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLW
....||.|.|.||||||||||||.|||||||| |....|||||||||.|..|...|||||||||||.|||||||||||.|||.||||||.||...| |||
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLW

PGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNIS-YPALGLLKGCLHMDPTQRLTCEQLLHHPYF
||.||.||||.|.|.||.||||||..||.|..|.|.|.|..|.|||||...||.| . || ..|.||||||..|.|||||.|||||
PGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase CDKL1.AA CMGC 5-288 26 1.1e-132 438.73 In-house 1-513 (513) Show / Hide 
Range on Protein: 5-288
Range on HMM: 1-513/513
Sequence Identity: 26% (134 aa)

YEKIGKIGEGSYGVVFKCRN--------------RDTGQIVAIKKFLESEDDPVIKK----------IALREIRMLKQLK-----------------HPN
||.|.|||||.||||.|||.              ..|..||||||. . . ..  .|          .|||||..||.|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNLLEVFRRKR-----------------RLHLVFEYCDHTVLHELDRYQ------RGVPE-------------HLVKSIT------WQTLQAVN--FCH
.|.|...|..|                   |.|||||.||. .. ....|      |..|              |..|...      .| |....  .||
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

KHN--CIHRDVKPENILITKH--------------------SVIKLCDFGFARLLTGPSDY---------------------YTDYVATRWYRSPELLVG
.|.   |||| |||||||..                      ..|.||||.|| .  .||                      ||.||.|||||.||.|.|
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

D---------TQYGPPVDVWAIGCVFAELLSG--------VPLWPGKSD-----------VDQLYLIRKTLGDLI---------------PR--------
.         ..|..|.|.|..||.|||.. |         ||.||.|.           .|||..| |.||                  ..        
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

-----------------HQQVFSTNQYFSGVKIPDPE--DMEPLELKFPN--------------------------------ISYPALGLLKGCLHMDPT
                 |.  |  |. .|. . | .   . ..|. ..||                                ..  |. |||..|..||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

QRLTCEQLLHHPYF
.|.|.|| | ||||
KRITAEQALQHPYF
Kinase CDKL1.AA Pkinase 5-288 32 7.50000000001e-125 425.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 5-288
Range on HMM: 1-293/293
Sequence Identity: 32% (99 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALR--EIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHT----VLHELDR--YQ
|....|||.||.|.|.||....||.|||.|..  .....  .....|  ||...| |.||| | |...|..|.....|.|||...     |... .  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RGV--PEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVI----KLCDFGFARLL-TGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAI
...  .|. .|.. .|.|.....||....||||.||||||| .. .|    |.||||.|... . ..  .|... |.||..||.. |.. |||.||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCVFAELLSGVPLWPGK----SDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHH
||...|.|.| |..||.    . .||...|....|  .... .  ... ||. ... . .  . .... .|.| ... ..|.||..||..|.|.||.|.|
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PYF
|.|
PWF
Kinase CDKL1.AA S_TKc 5-288 32 6.30000000001e-108 365.77 SMART 1-231 (231) Show / Hide 
Range on Protein: 5-288
Range on HMM: 1-231/231
Sequence Identity: 32% (96 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDH---TVLHELDRYQRG---
||.. |||.|..|.|.|||...||.|||||.           . ..|||..||. .|||.|.|..||.   .|..|.||||.   .... .....|.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGP-PVDVWAIGCVFAE
   ||  ......|...|...||.|. ||||.||||||...  .||.||||.||.|       | .. |.||..||.|    .||. ..|.|..||...|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLH-------HPYF
.|.| |..|      |.... | .|                                     | .|. ....||..||..|.|. ..|.       ||.|
MLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDKL1.AA CDK 5-220 39 7.50000000001e-105 336.41 In-house 1-242 (284) Show / Hide 
Range on Protein: 5-220
Range on HMM: 1-242/284
Sequence Identity: 39% (99 aa)

YEKIGKIGEGSYGVVFKCRNRDTG-----QIVAIKKF-LESE----DDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRK-----------RRLHLVFEY
|||. |||||.||||.|.|...||     ||||.||. .|.|    ..  .   |.||| .||.| ||| |.|..|.  |           ..| .||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSV-----IKLCDFGFARLLTG------PSDYYTDYVATRWYRSPE
.||   . .|          .|...|| |.....||... .||| || ||||..  .     .|. |||.||.         |.  ||  | |.|||.||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLVGDTQYG--PPVDVWAIGCVFAELLS---GVPLWPGKSDVDQLYLIRKTLG
|| |...|.  .|.|.|..||.|||..    . || ||.|. ||| .| ...|
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICG
Kinase CDKL1.AA CDC2 5-220 47 8.6e-97 298.0 In-house 1-226 (301) Show / Hide 
Range on Protein: 5-220
Range on HMM: 1-226/301
Sequence Identity: 47% (108 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKF-LESEDDP-VIKKIALREIRMLKQLK-HPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQR---G
|.|| |||||.||||.||....|.||||.||. ||.||.   .   |.|||  || || |||.| | .|.   ..| .||||.|.     .|...     
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

VPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYT--DYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAEL
.|..||||...| ||.|.||| .  .||| || |||| |  .||. ||| ||  . |.. ||    | |.|||.||.| |. .|  |||.|.|||.|||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---LSGVPLWPGKSDVDQLYLIRKTLG
    .  || .|.|  |||. | ..||
FMDVTKKPLFHGDSEIDQLFKIFRILG
Kinase CDKL1.AA RCK 5-220 40 8.3e-86 272.21 In-house 1-231 (298) Show / Hide 
Range on Protein: 5-220
Range on HMM: 1-231/298
Sequence Identity: 40% (96 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK-HPNLVNLLEVFRRKR--RLHLVFEYCDHTVLHELDRY----QR
|  | ..|.|.||.|.| .| .||.||||||    .       . ||||. |. |. |||...|.||.| .   .|..||||.| . | .. .     ..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMD-MNLYQMMKDFKERRK

GVPEHL--VKSITWQTLQAVNFCHKHNCIHRDVKPENILITK---------HSVIKLCDFGFARLLTGPSDY-YTDYVATRWYRSPELLVGDTQYGPPVD
 .||    .|.|  |.||. ...|||.  |||.|||||..|.           .||..||| .|     |   ||||| |||||.||.|  .|.|  |.|
YLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIR--SKPPYTDYVSTRWYRAPECLLRCTYYNSPMD

VWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLG
.||.||...|| .  ||.|| | .||.. | | .|
IWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMG
Kinase CDKL1.AA CDK5 5-220 43 4e-84 265.65 In-house 1-217 (287) Show / Hide 
Range on Protein: 5-220
Range on HMM: 1-217/287
Sequence Identity: 43% (95 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLV
|||. ||||| ||.|.| ||..|. |||.|.    ..|  .   |.||| .|| |||.| | |  |    ..| ||||.||      .|  . ..  |..
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELL-SGVPLW
||. .| |. . |||.|.  ||| || | || |.   || ||| ||    |   |.  | | ||| |  | |  .|  ..|.| .||.|||.  .| || 
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGKSDVDQLYLIRKTLG
|| .. ||| .| | .|
PGNDVEDQLKRIFKIMG
Kinase CDKL1.AA MAPK 5-288 30 4e-72 245.94 In-house 1-328 (328) Show / Hide 
Range on Protein: 5-288
Range on HMM: 1-328/328
Sequence Identity: 30% (102 aa)

YEKIGKIGEGSYGVVFKCRNRD------TGQIVAIKKFLESEDDPVIKKIALREIRMLKQL-KHPNLVNLLEVFRRK-----------RRLHLVFEYCDH
|. . .||.|.||||.... .       .|..|||||.    ..|.  | ..|||..|. . .|.| ..||..|. .           . . .|.|....
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

TVLHELDRYQRGVPEHLVKSITWQTLQA--VNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTG-PSDYY-------------TDYVATRWYRS
  || . . |.   .. ......| | .  . . |  | |||| ||.|||...    |.|||| || .    .. .             |.||||||||.
D-LHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PELLVGD--TQYGPPVDVWAIGCVFAELLS-GVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFST-N----QYFSGVKIPDPEDMEPLELKFPN----IS
||.. .   . |   ||.|..|| |||.|. . || |||. .||. || ..||   ...   . . .    .|... . . . .  |.|  |||     .
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTP-SEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNAN

YPALGLLKGCLHMDPTQRLTCEQLLHHPYF
  |. ||.  |..|| .|.| |. | ||||
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDKL1.AA ERK7 5-288 34 1.2e-69 237.36 In-house 1-292 (292) Show / Hide 
Range on Protein: 5-288
Range on HMM: 1-292/292
Sequence Identity: 34% (103 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK-HPNLVNLLEVFRRK--RRLHLVFEYCDHTVLHELDRYQRGVPE
|| . ..| | ||.| |   . |.|.||.||      ...      ||| .|.... |||.. |..|.| .  | . ||||. . | ||   |  .   .
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFME-TDLHAVIRKGNILKD

HLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPS------DYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAE
  ...| .| |.|. . |  | ||||.|| |||.    ..|.|||| || ..            |.||||||||.|| |.| ..| . || | |||. .|
IHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

LLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGV---KIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYF
.| | |. || | ..|. .| .|..   | .. . . .  .. .   ...  .  ..|.  .|. .  |. |||  | . | .||| || |.||| 
MLRGKPMFPGTSTMNQIEKILETIPK--PTQEDIEAIGSHYAWNMLEQMN-QQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase CDKL1.AA MAK 5-220 36 1.2e-67 214.3 In-house 1-265 (352) Show / Hide 
Range on Protein: 5-220
Range on HMM: 1-265/352
Sequence Identity: 36% (99 aa)

YEKIGKIGEGSYGVVFKCRN------------------------------RDTGQIVAIK----KFLESEDDPVIKKIALREIRMLKQLK-HPNLVNLLE
|  | ..| |.|| | . .                                ||| .||||    ||   |.      . |||.  || |. |||.| |.|
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEE-----CMNLREVKSLKKLNAHPNIVKLKE

VFR--RKRRLHLVFEYCDHTVLHEL--DRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKH-----------------SVIKLCDFGF
|.|      |..||||     | ..  ||  |  ||  ...| .| ||.  | |||.  ||| |||||...                    .||. ||| 
VIRDSENDHLYFVFEYMKEN-LYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGL

ARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLG
|| .      ||||| |||||.|| |   |.|. |.|.||.||. ||| .  || || | .||.. | . ||
AREIRS-KPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLG
Kinase CDKL1.AA CDK7 104-220 48 9.5e-60 157.59 In-house 104-220 (288) Show / Hide 
Range on Protein: 104-220
Range on HMM: 104-220/288
Sequence Identity: 48% (57 aa)

VKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLW
.|... .||| . .||..   ||| || | |. .  ..|. ||| ||    |   ||  | |||||.|||| |  .||. ||.|..||.||||.  ||  
IKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPYL

PGKSDVDQLYLIRKTLG
|| ||.|||  | .|||
PGDSDIDQLTRIFQTLG
Kinase CDKL1.AA CDK7 5-85 42 4.6e-33 85.07 In-house 1-85 (288) Show / Hide 
Range on Protein: 5-85
Range on HMM: 1-85/288
Sequence Identity: 42% (36 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFL----ESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCD
|||| .|||| ...|.| .   |||||||||       || .  |   |.||| .|. ..|.| ..|. .|  |  . |||.. |
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMD
Kinase CDKL1.AA Pkinase_Tyr 5-160 29 5.5e-22 75.09 Pfam 1-169 (270) Show / Hide 
Range on Protein: 5-160
Range on HMM: 1-169/270
Sequence Identity: 29% (51 aa)

YEKIGKIGEGSYGVVFKCRNR----DTGQIVAIKKFLESEDDPV--IKKIALREIRMLKQL-KHPNLVNLLEVFR-RKRR--LHLVFEYCDH-TVLHELD
 ... |.|||..|.|.|.. .    .|.. ||.|.  |. ...   ...  .||....||| .|||.|.|. |   ...   . .|.||. |   |. | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF-MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RY---QRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYY-T
.    .. .. .   .. ||  .. .. . .||||||.   |.|.|.  |.| |||| ||..  . ||| .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYR
Kinase CDKL1.AA TyrKc 5-288 22 3.1e-17 55.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 5-288
Range on HMM: 1-280/280
Sequence Identity: 22% (73 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQL--KHPNLVNLLEVFRRK-------RRLHLVFEYCDHTVLHELDRY
 ... |.||| .|.|.|.. .   . ||.|.  |.     .. . .||.|....|  .|||.|.|. | . .         | .|.||..|  |..  |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDF-MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QRG-VPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGP------SDYYT------DY--VATRWYRSPELLVGDTQY
 |. ..     |. ||  .  .. |..||||||    |.|...  ..| .||| .| ..        .|||.          .  ||. .|| .  .  .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

GPPVDVWAIGCVFAELLS-GVPLWPG-----KSDVDQLYLIRKTLGDLIPRH----QQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLH
 .  |||. | .  |... | . .||     .|. . . ....     .| .                               |.  .     . | | |
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------FVCCPDEMYQIMKQCWH

MDPTQRLTCEQLLHHPYF
 || .| | ...  | .|
EDPEDRPTFSEI--HECF
Kinase CDKL1.AA CDK7 261-288 46 1.3e-11 26.73 In-house 261-288 (288) Show / Hide 
Range on Protein: 261-288
Range on HMM: 261-288/288
Sequence Identity: 46% (13 aa)

ALGLLKGCLHMDPTQRLTCEQLLHHPYF
.| |..| . |.| .|.|| | | .|||
LLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDKL1.AA CDK 264-288 52 2.9e-11 32.14 In-house 260-284 (284) Show / Hide 
Range on Protein: 264-288
Range on HMM: 260-284/284
Sequence Identity: 52% (13 aa)

LLKGCLHMDPTQRLTCEQLLHHPYF
|| ..| .||..|...|| |.||||
LLNKMLCYDPKKRISAEQALQHPYF
Kinase CDKL1.AA RCK 249-288 42 8.1e-10 27.03 In-house 259-298 (298) Show / Hide 
Range on Protein: 249-288
Range on HMM: 259-298/298
Sequence Identity: 42% (17 aa)

PLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYF
||.  .||.|. .. |.. .|  ||  | | .|.| ||||
PLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase CDKL1.AA MAK 249-288 41 6.5e-09 24.05 In-house 312-352 (352) Show / Hide 
Range on Protein: 249-288
Range on HMM: 312-352/352
Sequence Identity: 41% (17 aa)

PLELKFPNISY-PALGLLKGCLHMDPTQRLTCEQLLHHPYF
||.   ||.|   |. |.| .|  ||  | | .|.. .|||
PLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase CDKL1.AA CDK5 264-288 48 2.8e-08 21.73 In-house 263-287 (287) Show / Hide 
Range on Protein: 264-288
Range on HMM: 263-287/287
Sequence Identity: 48% (12 aa)

LLKGCLHMDPTQRLTCEQLLHHPYF
||.. | ..| ||.. .. ||||||
LLQKMLQCNPNQRISAKAALHHPYF
Kinase CDKL1.AA CDC2 261-288 39 2.9e-07 17.82 In-house 274-301 (301) Show / Hide 
Range on Protein: 261-288
Range on HMM: 274-301/301
Sequence Identity: 39% (11 aa)

ALGLLKGCLHMDPTQRLTCEQLLHHPYF
.. ||.  |. || .|.. .. | ||||
GIDLLMQMLQYDPQKRISAKEALQHPYF