Gene CDK7 (Human)

CDK7

Species: Human
Alias: CDKN7, CDK7, CAK1, STK1, TFIIH, p39MO15
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 5q13.2,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK7

Sequence

Name Sequence Type Origin Length Description Download
CDK7.NA RNA Sugen Kinome 1534 None Fasta, JSON
CDK7.AA Protein Sugen Kinome 346 None Fasta, JSON
CDK7.kin_dom Protein Kinase Domain Sugen Kinome 284 None Fasta, JSON

Protein domain

Protein domains of CDK7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK7.AA CDK7 12-295 75 8.49999999999e-299 807.33 In-house 1-288 (288) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-288/288
Sequence Identity: 75% (216 aa)

YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIK-LGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLT
|||....|||||||||||.|..|.||||||||| |||||||||||||||.||||.|||..|.|.|||.|.|.|||||.||||||..||||.|||.|..||
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRV
|.||||||.||||||||.|..|||||||||||||..|||.||.||||||...|||||.||||||||||||||||||||.||.|||||.||||.|||.|||
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG---IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF
|.||||||.|||||||.||||||||.||.||...||..||.|||   .||.|||.||.||||||..|....|||.|.|.||.|||.||
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDK7.AA CDK 12-295 43 4.2e-172 555.07 In-house 1-284 (284) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-284/284
Sequence Identity: 43% (139 aa)

YEKLDFLGEGQFATVYKARDKNTN-----QIVAIKKIKLGH--RSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHK-----------SNISLVFDF
||||. .||| ...|||||||.|.     ||||.|||.. .  |.|.|.|.. ||.|||.||.|| ||||. |.| . .|           .....||..
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

METDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGV-----LKLADFGLAKSFGS------PNRAYTHQVVTRWYRAPE
|..||  ...          || ||.. |.||.|.|..||.||||||.|.|...||.     ||.||||||. ||.      |||.|||.|||.||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLFGARMYG--VGVDMWAVGCILAELLL---RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFL
||.|.. |.   ..|||.||||.||...   | |..||||..||| .||...|||||..||....||||                       ||..... 
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------DLLNKMLC

FNPCARITATQALKMKYF
..|. ||.|.|||...||
YDPKKRISAEQALQHPYF
Kinase CDK7.AA CMGC 12-295 27 1.1e-146 485.55 In-house 1-513 (513) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-513/513
Sequence Identity: 27% (144 aa)

YEKLDFLGEGQFATVYKARD--------------KNTNQIVAIKKIKLGHRSE-------AKDGINRTALREIKLLQELS-----------------HPN
||... .||| ...|||.||              ..||.||||||||. .  |       .|||....||||||.|..|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIGLLDAFGHKS-----------------NISLVFDFMETDLEVIIKDNS--------LVLTPSH------------IKAYM------LMTLQGLE--YL
|..|.| | ||                  .. |||..|..||  .||.|.        . |.. |            || .|       . |.||.  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HQHW--ILHRDLKPNNLLLDEN--------------------GVLKLADFGLAKSFGSP---------------------NRAYTHQVVTRWYRAPELLF
|.||  |.|||||| |.|...|                    |.||..|||||......                     ||.|||.||||||||||.|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GARMY---------GVGVDMWAVGCILAELLLR--------VPFLPGDSD-----------LDQLTRIFETLGTPT---------------EEQWPDMCS
|.. |         . ..|||.||||.||....         |. ||.|.           .||| .||..|||||               ||.||.| .
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

LPDYVT---------------------------FKSFPGIPLHHIFSA-----------------------------------AGDDLLDLIQGLFLFNP
||.| .                           |. .|..|.. .|                                     . ....||..... ..|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

CARITATQALKMKYF
  |||| |||.. ||
DKRITAEQALQHPYF
Kinase CDK7.AA CDC2 12-295 42 1.8e-132 409.64 In-house 1-301 (301) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-301/301
Sequence Identity: 42% (128 aa)

YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIK-DNSL--
|.|.  .||| .  |||..|. ||||||.|||.| . .|   |.  ||.||| .|.||  ||||. | | .   ... .||.... ||    .  ..   
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGD-GVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNK

VLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT--HQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAE
...|. .| ||   |||....||. |.|||||| |.|.|..|..|.||||||. || | |.||  | |||.||||||.|.|.. | ..||||..|||.||
HMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAE

L---LLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV-TFKSFPGIPLHHIFSA---------AGDDLLDLIQGLFLFNPCARITATQALKM
.     . |. .|||  ||| .||..||||.|. ||....||||  ||  .. . | .|.           . .. .||.. .   .|  ||.| .||. 
MFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQH

KYF
.||
PYF
Kinase CDK7.AA CDK5 12-295 43 2.6e-118 375.57 In-house 1-287 (287) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-287/287
Sequence Identity: 43% (127 aa)

YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTP
|||.. .||| ..||||||.|.|  |||.|...|    |   |.  ||.||| ||.|| |.||. | |       . ||| |.  ||   . .    . .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDE---GVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDM

SHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL-LRV
  || .|.  |.||.. |.| .||||||| |||   || |||||||||  || | | |.| ||| |||.|  |.|...|   .||| .|||.||.     
HIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGR

PFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY----VTFKSFPGIP-LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF
|  || .. ||| |||. .|||.|..|| .  ||||    . . ..|. . .  |       ..|| |..  .||  ||.| .||.  ||
PLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK7.AA Pkinase 12-295 36 6.2e-105 359.7 Pfam 1-293 (293) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-293/293
Sequence Identity: 36% (110 aa)

YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-----DLEVIIK-DN
|...  .|.| |..|||...|.|..|||.|.||. |... || ..| . .||.....|.||||. |.|.|  |..| .|....|      ||  .|. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

SLVL--TPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVL----KLADFGLAKSF-GSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWA
. ..  .. ..| ||. .|.||||.|...|.|||||| |.|.|.||..    |..|||||| |   .|. .|. ..|.||.|||.. |...||  ||||.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGCILAELLLRVPFLPGD----SDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKY
.||||.|.|.. |  ||.    . .||. .|....|.|....||  || ...  |.  .  . |  | .. ....|.| ... ..|  |.||.|.|. ..
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

F
|
F
Kinase CDK7.AA PITSLRE 12-295 40 4.7e-104 351.99 In-house 1-295 (295) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-295/295
Sequence Identity: 40% (121 aa)

YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK-LLQELSHPNIIGLLDAF--GHKSNISLVFDFMETDLEVIIKDNS--
...|.  .|| .  ||.|.|| |. |||.|..|.. . | |.|.  |.||||. .| .| ||||. ..       .  | .|....| ||  ..   .  
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKE-KEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRR

-LVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAE
    .|. ||  |.  | | |..| .||.|||||  |||.  .|.||..|||||  .||| ..||  ||| |||||||| |.. |   |||| ||||.||
NQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAE

LLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIP---LHHIFS---AAGDDLLDLIQGLFLFNPCARITATQALKMKYF
...  | ..|.|..||. .||  .|||||  ||.  .||    ...||  |   |  .|       |  .|| ...  .|| .||||..|||  .|
FITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDK7.AA S_TKc 12-295 31 1e-101 345.17 SMART 1-231 (231) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-231/231
Sequence Identity: 31% (93 aa)

YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMET---DLEVIIKDNSLV
||.|. .|.| |..|||.|.|.|..|||||.||            ....|||..|..  ||||. |.|.| . ... .|......   ||  .||..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGV-GVDMWAVGCI
     ... |.. ||  ....|||.|.|.|.|||||| |.||||  ..|..|||||. .       |....|.||.|||.|     ||   .|.|..|||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

LAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK-------MKYF
|.|.| . |  |      |. ..|. .|                                   ....|.|.... ..|  |.|| .||.       . .|
LYEMLCGYPPFP------QMQMMFKKIG----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDK7.AA CCRK 12-295 47 9.6e-97 327.71 In-house 1-285 (285) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-285/285
Sequence Identity: 47% (136 aa)

YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPN-IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLT
|  || .|||    |.||.   |  |||.||. |       |||  .|||||| |||.     .. | | | | .   |||.||  ||  ....    |.
YCILDRIGEGAHGIVFKAKHVETGEIVALKKVAL---RRLDDGIPNQALREIKALQEIEDNQYVVQLKDVFPHGTGFVLVFEFMLSDLAEVVRHAQRPLA

PSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN-RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLR
.  .|.||.| |.|. . |.  |.|||||| |||. | | ||.||||||. |   . | ||||| ||||||||||.||| |  |||.||||||. |||  
EAQVKSYMQMLLKGVAHCHENNIMHRDLKPANLLISESGHLKIADFGLARVFSNDEGRQYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNN

VPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY--VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF
 |  ||. |..||  .   |||||.  ||.|  ||||  ..||  | .|| ..   |  . |||..   .. |  ||.| |||  .||
SPIFPGENDIEQLCCVLRILGTPTPKVWPEMKDLPDYNKISFKEQPPMPLEQVVPDASPQALDLLKQFLVYPPRQRIAASQALLHQYF
Kinase CDK7.AA MAPK 12-295 35 9.1e-95 321.14 In-house 1-328 (328) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-328/328
Sequence Identity: 35% (119 aa)

YEKLDFLGEGQFATVYKARDKN------TNQIVAIKKIK--LGHRSEAKDGINRTALREIKLLQEL-SHPNIIGLLDAFGHK-----SNIS------LVF
|. | ..|.| . .| .|.||       ....||||||     .   .|      ..||||||...  |.|||.||| |  .     ....      .|.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK-----RTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVM

DFMETDLEVIIK-DNSLVLTPSHIKAYMLMTLQG--LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGS-PNRAY-------------THQVV
..|||||  ||| ..   |.  ||.  |   | |  | |.|   ..|||||| |.|..||. ||..||||| |. .  .  .             |  |.
ELMETDLHQIIKSQQ--PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVA

TRWYRAPELLFG--ARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC-S-LP-DYVT----FKSFPGIPLHHIFSA-
||||||||....  .. |  .||||.||||.||.|  | |..||.. .||...|.|.||||.|| .  .| |  . .|.     ..  |..|....|.  
TRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNA

---AGDDLLDLIQGLFLFNPCARITATQALKMKYF
   | .. .||.. .  |.|  |||. .||   ||
NFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDK7.AA CDK10 12-295 42 6.3e-92 311.71 In-house 1-285 (285) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-285/285
Sequence Identity: 42% (121 aa)

YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAF--GHKSNISLVFDFMETDLEVIIKDNSLVL
.|||  .||| .  ||.|||  .. |||.||...    . |||.   .||||.|| .. |.||. | .     |   | || .. | ||  ..   .   
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRM---DKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQPF

TPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLR
| ...|  ||  |.|| |||.....|||||  |||. ..| .|.||||||. .| | .  | ..|| ||||||||.|.|     .|||||||||.|||. 
TETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVH

VPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP--DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF
 | .|| |.. |.  | . |||| |. ||    ||  .  | |  |   |.| |   ..  . |.. ||..||  | || ..|. .||
KPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase CDK7.AA CDK-Unclassified 12-295 31 2.5e-91 300.72 In-house 1-324 (324) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-324/324
Sequence Identity: 31% (104 aa)

YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKD----------GINRTALREIKLLQELSHPNIIGLLDAFGHKSNIS-------------
|. .  .||| |. |.||.| .|...|||||| .   .  |.           .  |..|||..|| . | ||| ..| .   .  |             
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMV---NNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFY

LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENG-----VLKLADFGLAKSFG------------SPNRAYTH
.| . |  ..    . |   |    |. .|.  | |. |||   | |||.|| |.... |.     .||.||||.|                 |.. |. 
MVMEYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYST

QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY--VTFKSFPGIP---LHHIFSAAGD
||.|||||||||||| . |. |||.|..|||.||.. ..| ..| ....|.  || .||||.|..|||. ..|||  ..||  ...    .   .. | .
QVSTRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKCKHASE

DLLDLIQGLFLFNPCARITATQALKMKYF
  .... ..  ..|  | .. ..|.  .|
--NNCEFQMVMYQPYNRWKCMEILQHPWF
Kinase CDK7.AA Pkinase_Tyr 12-160 32 6.3e-18 61.34 Pfam 1-159 (270) Show / Hide 
Range on Protein: 12-160
Range on HMM: 1-159/270
Sequence Identity: 32% (52 aa)

YEKLDFLGEGQFATVYKARDK----NTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL-SHPNIIGLLDAFG-HKSN--ISLVFDFMET-DLEVII
 ...  ||||.| .|||.. |    ||.. ||.|..| |. .|.   . .  .||.|.. .| .||||. |. .   ..    | .|. .|.  ||    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN--CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KDN---SLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK
...      ||....  . .   .|.|||... . ||||   | |..||.| | .|||||.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase CDK7.AA TyrKc 12-295 20 3.9e-14 5.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-280/280
Sequence Identity: 20% (64 aa)

YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL--SHPNIIGLLDAFGHK-------SNISLVFDFMET-DLEVI
 .... ||||.| .|||.. |   . ||.|..| ..         .  .||.... .|  .||||. |. .  ..         . .|. .|.  ||   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP------NRAYT------HQ--VVTRWYRAPELLFGA
....   |....   ...   .| ||||.. . ||||   | |..||.. | .||||..  ..          |.          .  ||. ||| .   
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NY

RMYGVGVDMWAVGCILAELLLR--VPFLP------GDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFN
...    | |. |  . |.. .   |          .... .. .  . .  | .   | |                    |  . |.. ....    ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-------------------FVCCPDEMYQIMKQCWHED

PCARITATQALKMKYF
|  | | ..    ..|
PEDRPTFSEI--HECF